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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | Pore structure and pore size controls of ordered mesoporous carbons prepared from resorcinol/formaldehyde/triblock polymers显示文摘 | Jill Jin Nishiyama N Egashira Y | 2009 | Microporous and Mesoporous Materials2009，118，13： | 1 |
| 3 | Inclusion complex of astaxanthin with hydroxypropyl-13-cyclodextrin: U, FTIR, 1H NMR and molecular modeling studies 显示文摘 | Yuan C Jill Z Xu Y | 2012 | Carbohydrate Polymers2012，89，2： | 1 |
| 4 | Aberrant promoter lnethylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients显示文摘 | Liu Y Lan Q Jill MS | 2006 | Neoplasia2006，8，： | 1 |
| 5 | Central role of Toll-like reeceptor 4 signaling and host defense in experimental pneumonia caused by gramngative bacteria 显示文摘 | Jill R Schurr Erana Y Pat Byme | 2005 | Infection & Immunity2005，，1： | 1 |
| 6 | 显示文摘 | Jill F M Zhou Z Y Takehiko M | 2005 | Environmental Science and Technology2005，39，6： | 1 |
| 7 | 显示文摘 | Jill F M Zhou Z Y Enomoto H | 2004 | Chemistry Letters2004，33，2： | 1 |
| 8 | Combination anti-HIV therapy with the self-assemblies of an asymmetric bolaamphiphilic zidovudinc/didano- sine prodrug显示文摘 | Jill Y Xin R Tong L | 2011 | Mol Pharm2011，8，3： | 1 |
| 9 | Formation of positively charged copper hydroxide nanostrands and their structural characteriz- ation显示文摘 | Luo Y H Huang J G Jill J | 2006 | Chemistry of Materials2006，18，7： | 1 |
| 10 | Topological chaos of universal elementary cellular automata rule 显示文摘 | Jill W F Chen F Y | 2011 | Nonlinear Dynamics2011，63，： | 1 |
| 11 | Heat transfer and flow behaviour of aqueous suspensions of TiO2 nanoparticles (nanofluids) flowing upward through a vertical pipe 显示文摘 | He Y R Jill Y Chen H S | 2007 | International Journal of Heat and Mass Transfer2007，50，： | 1 |
| 12 | Effect of polyunsaturated fatty acid (PUFA) supplementation on intestinal inflammation and necrotizing enterocolitis (NEC) in a neonatal rat model 显示文摘 | Caplan MS Russell T Xiao Y Amer M Kaup S Jilling T | 2001 | Pediatr Res2001，49，5： | 1 |
| 13 | Genomic Imprinting of IGF2 is Maintained in Infantile Hemangioma despite its High Level of Expression显示文摘 | Yu Y Jill W S Elisa B | 2004 | Mol Med2004，10，712： | 1 |
| 14 | 显示文摘 | Cao Y Jill R Mirkin C A | 2001 | J Am Chem Soc2001，123，： | 1 |
| 15 | Pore structure and pore size controls of ordered mesoporous carbons prepared from resor- cinol/formaldehyde/triblock polymers 显示文摘 | Jill J Nishiyama N Egashira Y | 2009 | Micro Meso Mater2009，118，： | 1 |
| 16 | Eco - toxic effects of sulfadiazine sodium, sulfamonomethoxine sodium and enrofloxacill on wheat, Chinese cabbage and tomato 显示文摘 | Jill C X Chen Q Y Sun R L | 2009 | Ecotoxicology2009，18，7： | 1 |
| 17 | Face recognition based on uncorrelated discriminant transformation 显示文摘 | ZHONG Jill YANG J Y HUoZ S | 2001 | Pattern Recognition2001，33，7： | 1 |
| 18 | Studies on the performance of a rotating drum bioreactor for bioleaching processes oxygen transfer, solids distribution and power consumption显示文摘 | Jill J Liu G L Shi S Y | 2010 | Hydrometallurgy2010，103，14： | 1 |
| 19 | Coronary atherosclerosis in diabetes mellitus显示文摘 | Tauqir Y Goraya Cynthia L Leibson Pasquale J Palumbo Susan A Weston Jill M Killian Eric A Pfeifer Steven J Jacobsen Robert L Frye Véronique L Roger | 2002 | Journal of the American College of Cardiology2002，，： | 1 |
| 20 | Geographic patterns of air passenger transport in China 1980-1998: imprints of economic growth, regional inequality, and network development 显示文摘 | Jill F J Wang F H Liu Y | 2004 | The Professional Geographer2004，56，4： | 1 |
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