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| 1 | Studies of the Genotoxicity of Glycidyl Methacrylate (GMA)显示文摘The following experiments were conducted to evaluate the genotoxic effects of GMA (glycidyl methacrylale) on mammalian and human cells.(1) Using the absorption spectrum shift method in vitro, we observed that the maximums of calf thymus DNA and GMA were shifted toward longer wavelengths (a change of more than 15nm) and the absorbance decreased after incubation at room temperature for 15min or more.The result indicates that binding of DNA and GMA had occurred.The binding force is strong, not affected by the addition of concentrated sodium chloride solution, and only slightly decreased by the addition of 8 M urea solution.Therefore the bond between DNA and GMA might be covalent.(2) In cell cultures, unscheduled DNA synthesis (UDS) in human and/or rat lymphocyte was induced and DNA semiconserva-tive replication was inhibited by GMA at concentrations of less than 5.2 mM.(3) Sperm abnormality tests and assays of UDS in germ cells of male mice were conducted to study the in vivo genotoxicity of GMA.The results revealed that GMA could damage DNA, increase sperm abnormality frequency, and reduce the number of sperm cells, 1990 Academic Press.Inc. | DAYING XIE, WEI ZHANG, LAIFU CAO, WENQING SUN, ZHONGSHENG LI, QING GAO, YILI WU, HUILAN GAO, HUIFANG YANG, JIM ZUO,~* AND FUDE FANG~* Institute oF Occupational Medicine. Chinese Academy ol Preventive Medicine. Beijing 100050. and *Institute of Basic Medical Sciences, Chinese Academy ol Medical Sciences. Beijing 100730, China | 1990 | Biomedical and Environmental Sciences1990，3，3： | 7 |
| 2 | Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells, and subsequently blocking PKCε-dependent activation of TRPV1显示文摘瞄准:严重痛苦的感觉神经病经常发生在 paclitaxel 化疗期间。,后来, paclitaxel 能激活桅杆房间和 basophils 橡黄素, polyphenolic flavonoid 在各种各样的植物包含了,它能明确地作为桅杆房间 stabilizer 禁止组织安版本。在这研究,我们探索橡黄素是否能改善导致 paclitaxel 的神经病的疼痛和阐明的位于 \O 下面 mechanisms.Methods:组织安版本上的橡黄素抑制被从白血病(RBL-2H3 ) 房间与 paclitaxel 刺激了的老鼠 basophilic 检测组织安版本在 vitro 验证(10 μ mol/L ) 。在里面在里面 vivo 实验,老鼠和老鼠收到了橡黄素(20, 40 mg·为 40 和 12 d 的 kg -1·d-1) 分别地。同时,动物与 paclitaxel 被注射(2 mg/kg, ip ) d 上的四次 1, 3, 5 和 7。热痛觉过敏和机械 allodynia 在不同时间点被评估。动物是 euthanized 和针的绳索,背面的根中心为分析 PKCε 被收获;并且 TRPV1 表示铺平。血浆组织安层次在 d 上在老鼠被估计 31 .Results:有橡黄素的预告的处理(3, 10, 30 μ mol/L ) 从在 vitro 的刺激 paclitaxel 的 RBL-2H3 房间的 dose-dependently 禁止的过多的组织安版本,和橡黄素管理显著地在对待 paclitaxel 的老鼠压制了高血浆组织安层次。橡黄素管理 dose-dependently 在对待 paclitaxel 的老鼠和老鼠为热痛觉过敏和机械 allodynia 提起了阀值。而且,橡黄素管理 dose-dependently 压制了 PKCε 的增加的表示层次;并且在对待 paclitaxel 的老鼠和老鼠的针的绳索和 DRG 的 TRPV1。而且,橡黄素管理可以禁止了 PKCε 的 translocation;从细胞质到在对待 paclitaxel 的 rats.Conclusion 的针的绳索和 DRG 的膜:我们的结果揭示导致 paclitaxel 的外部神经病的内在的机制并且为对待这个副作用表明橡黄素的治疗学的潜力。 | Wei GAO Yan ZAN Zai-jie Jim WANG Xiao-yu HU Fang HUANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 5 |
| 3 | Steroids and triterpenoids from Rosa laevigata 显示文摘 | Fang Jim -min Kao Shufang | 1991 | Phytochemistry1991，30，10： | 1 |
| 4 | Differential roles of TLR2 and TLR4 in acute focal cerebral ischemia/reperfusion injury in mice显示文摘 | Fang Hua Jing Ma Tuanzhu Ha Jim L. Kelley Race L. Kao John B. Schweitzer John H. Kalbfleisch David L. Williams Chuanfu Li | 2009 | Brain Research2009，，： | 1 |
| 5 | Preconditioning with a TLR2 specific ligand increases resistance to cerebral ischemia/reperfusion injury显示文摘 | Fang Hua Jing Ma Tuanzhu Ha Jim Kelley David L. Williams Race L. Kao John H. Kalbfleisch I. William Browder Chuanfu Li | 2008 | Journal of Neuroimmunology2008，，1： | 1 |
| 6 | In Vitro Characterization of the Metabolism of Haloperidol Using Recombinant Cytochrome P450 Enzymes and Human Liver Microsomes 显示文摘 | Jim Fang Gordon Mckay Jiuxue Song | 2001 | Drug Metab Dispos2001，12，29： | 1 |
| 7 | Lysophosphatidic acid is a bioactive mediator in ovarian cancer显示文摘 | Xianjun Fang Michel Schummer Muling Mao Shuangxing Yu Fazal Haq Tabassam Ramona Swaby Yutaka Hasegawa Janos L Tanyi Ruthie LaPushin Astrid Eder Robert Jaffe Jim Erickson Gordon B Mills | 2002 | BBA - Molecular and Cell Biology of Lipids2002，，1： | 1 |
| 8 | Tumor-targeted drug delivery and MRI contrast enhancement by chlorotoxin-conjugated iron oxide nanoparticles显示文摘 | Conroy Sun Chen Fang Zachary Stephen Omid Veiseh Stacey Hansen Donghoon Lee Richard G Ellenbogen Jim Olson Miqin Zhang | 2008 | Nanomedicine2008，，4： | 1 |
| 9 | A new method for solving the inverse conduction problem in steady heat flux measurement. Int显示文摘 | Fang Z H Xie D L Diao N R Grace J R and Jim C J | | 0，，： | 1 |
| 10 | POLYMER-TRIRUTHENIUM CLUSTER CATALYZED OXIDATION OF STYRENE显示文摘POLYMER-TRIRUTHENIUMCLUSTERCATALYZEDOXIDATIONOFSTYRENE￥ChengGuoJIA;ChunWeiCHEN;FangYouJIM;MeiYuHUANG;YingYanJIANG(Instituteof... | Cheng Guo JIA Chun Wei CHEN Fang You JIM Mei Yu HUANG Ying Yan JIANG(Institute of Chemistry,Academia Sinica, Beijing 100080) | 1994 | Chinese Chemical Letters1994，5，2： | 0 |
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