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| 1 | The Research of Indoor Positioning Based on Visible Light Communication显示文摘The key techniques in indoor positioning based on visible light communication and the state of the art of this research were surveyed. First, the significance of indoor positioning based on visible light communication from two aspects of the limitations of current indoor positioning technology and the advantages of visible light communication was discussed; And then, the main four technology of indoor positioning based on visible light communication were summarized and the triangulation of RSS method and the principle of image positioning were introduced in detail; Next, the performance characteristics of various typical algorithms were compared and analyzed; In the end, several suggestions on future research of indoor positioning based on visible light communication were given. | WANG Chunyue WANG Lang CHI Xuefen LIU Shuangxing SHI Wenxiao DENG Jing | 2015 | China Communications2015，12，8： | 7 |
| 2 | Chromobox homolog 4 overexpression inhibits TNF-α-induced matrix catabolism and senescence by suppressing activation of NF-κB signaling pathway in nucleus pulposus cells显示文摘Intervertebral disc degeneration(IDD)is featured as enhanced catabolism of extracellular matrix(ECM)in the nucleus pulposus(NP),in which tumor necrosis factor-alpha(TNF-α)-related cell senescence is involved.Chromobox homolog protein 4(CBX4)exhibits anti-inflammatory effects and shows promising therapeutic potential.Thus,in the present study,we explore the role of CBX4 in IDD.Immunohistochemistry staining reveals that CBX4 expression is decreased in severe degenerative NP tissues compared to mild degenerative tissues,and real-time PCR and western blot analysis results show that CBX4 expression is downregulated under TNF-αstimulation in NP cells.siRNA and adenoviruses are used to knockdown or overexpress CBX4,respectively.The results demonstrate that CBX4 knockdown augments the catabolism of ECM in human NP cells,while CBX4 overexpression in rat NP cells restores the ECM degradation induced by TNF-α,as illustrated by immunofluorescence and western blot analysis.In addition,transcriptome sequencing results reveal the regulatory effect of CBX4 on the cell cycle,and further western blot analysis and senescence-associatedβ-galactosidase staining assay indicate that CBX4 overexpression alleviates cell senescence in the presence of TNF-α.Moreover,the phosphorylation of p65,which indicates the activation of NF-κB signaling,is measured by western blot analysis and immunofluorescence assay,and the results reveal that CBX4 overexpression reduces the TNF-α-induced increase in the p-p65/p65 ratio.In addition,the effect of CBX4 overexpression in NP cells is suppressed by NF-κB agonist.In summary,our results indicate that CBX4 overexpression can suppress TNF-α-induced matrix catabolism and cell senescence in the NP by inhibiting NF-κB activation.This study may provide new approaches for preventing and treating IDD. | Yangyang Zhang Shuangxing Li Junmin Hong Jiansen Yan Zhengqi Huang Jiajun Wu Zhihuai Deng Tianyu Qin Kang Xu Wei Ye | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 2 |
| 3 | Convergence of Multiple signaling cascades at glycogen synthase kinase-3:Edg receptor-mediated phosphorylation and inactivation by lysophosphatidie acid through a protein kinase C-dependent intraeellular pathway显示文摘 | Fang xiangjun Yu shuangxing Tangyi janos L | 2002 | Mol Cell Biol2002，22，7： | 1 |
| 4 | MiR-483–5p suppresses the proliferation of glioma cells via directly targeting ERK1显示文摘 | Li Wang Ming Shi Shuangxing Hou Bojun Ding Lijuan Liu Xituan Ji Jian Zhang Yanchun Deng | 2012 | FEBS Letters2012，，9： | 1 |
| 5 | Two engineering approaches to hydroelastic analysis of slender ships显示文摘 | WU Yousheng XIA Jinzhu DU Shuangxing | 1991 | Dynamics of Marine Vehicles and Structures in Waves1991，6，23： | 1 |
| 6 | Lysophosphatidic acid is a bioactive mediator in ovarian cancer显示文摘 | Xianjun Fang Michel Schummer Muling Mao Shuangxing Yu Fazal Haq Tabassam Ramona Swaby Yutaka Hasegawa Janos L Tanyi Ruthie LaPushin Astrid Eder Robert Jaffe Jim Erickson Gordon B Mills | 2002 | BBA - Molecular and Cell Biology of Lipids2002，，1： | 1 |
| 7 | miR-183 potentially inhibits NF-KB1 expression by directly targeting its 3'-untranslated region显示文摘 | Fushen Sha | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 1 |
| 8 | Preliminary interpretation of Tertiary climate by using megafossil floras in China 显示文摘 | | 1985 | Palaeontolologia Cathayana1985，2，： | 1 |
| 9 | Interest-driven model for human dynamics 显示文摘 | Shang Mingsheng Chen Guanxiong Dai Shuangxing | 2010 | Chin Phys Lett2010，27，04： | 1 |
| 10 | Two response patterns to negative environmental changes:Cases from Populus and Metasequoia显示文摘Traditionally,plant distribution is thought to be closely related to environmental factors.But recently,it is found that Populus,quite different from other plant taxa,adapted to negative environmental changes,and successfully migrated to different climate zones from its origin places of warm temperate zone.Conversely,Metasequoia is gradually tending to extinction from the Miocene to Quaternary.Based on above contrary cases,two response patterns of plant to negative environmental changes are proposed.One is active adaptation represented by Populus,the other is passive adaptation represented by Metasequoia.The plants of passive strategy characterized for desert prevention might be easily replaced by those of active strategy characterized for desert utilization.Fast growing plants,such as Populus with characteristics of drought and salt tolerance,wind and sand resistance,are selected in Tarim Basin in southern Xinjiang,China,as a good example of desert utilization in the construction of new highways and towns,not only serve as farmland shelterbelt in sandy area.In addition,Populus with high-altitude and cold adaptation has also been selected as an ideal tree planted in Tibet.Therefore,the idea of using Populus as one of the preferred pioneer trees to colonize Mars is proposed. | ZHANG Yi XIONG Zhifeng GUO Shuangxing | 2023 | Global Geology2023，26，2： | 0 |
| 11 | Dynamic Security SFC Branching Path Selection Using Deep Reinforcement Learning显示文摘Security service function chaining(SFC)based on software-defined networking(SDN)and network function virtualization(NFV)technology allows traffic to be forwarded sequentially among different security service functions to achieve a combination of security functions.Security SFC can be deployed according to requirements,but the current SFC is not flexible enough and lacks an effective feedback mechanism.The SFC is not traffic aware and the changes of traffic may cause the previously deployed security SFC to be invalid.How to establish a closed-loop mechanism to enhance the adaptive capability of the security SFC to malicious traffic has become an important issue.Our contribution is threefold.First,we propose a secure SFC path selection framework.The framework can accept the feedback results of traffic and security service functions in SFC,and dynamically select the opti-mal path for SFC based on the feedback results.It also realizes the automatic deployment of paths,forming a complete closed loop.Second,we expand the protocol of SFC to realize the security SFC with branching path,which improve flexibility of security SFC.Third,we propose a deep reinforcement learning-based dynamic path selection method for security SFC.It infers the optimal branching path by analyzing feedback from the security SFC.We have experimented with Distributed Denial of Service(DDoS)attack detection modules as security service functions.Experimental results show that our proposed method can dynamically select the optimal branching path for a security SFC based on traffic features and the state of the SFC.And it improves the accuracy of the overall malicious traffic detection of the security SFC and significantly reduces the latency and overall load of the SFC. | Shuangxing Deng Man Li Huachun Zhou | 2023 | Intelligent Automation & Soft Computing2023，37，9： | 0 |
| 12 | Rosuvastatin suppresses TNF-α-induced matrix catabolism,pyroptosis and senescence via the HMGB1/NF-κB signaling pathway in nucleus pulposus cells显示文摘Intervertebral disc degeneration is mainly caused by irregular matrix metabolism in nucleus pulposus cells and involves inflammatory factors such as TNF-α.Rosuvastatin,which is widely used in the clinic to reduce cholesterol levels,exerts anti-inflammatory effects,but whether rosuvastatin participates in IDD remains unclear.The current study aims to investigate the regulatory effect of rosuvastatin on IDD and the potential mechanism.In vitro experiments demonstrate that rosuvastatin promotes matrix anabolism and suppresses catabolism in response to TNF-αstimulation.In addition,rosuvastatin inhibits cell pyroptosis and senescence induced by TNF-α.These results demonstrate the therapeutic effect of rosuvastatin on IDD.We further find that HMGB1,a gene closely related to cholesterol metabolism and the inflammatory response,is upregulated in response to TNF-αstimulation.HMGB1 inhibition or knockdown successfully alleviates TNF-α-induced ECM degradation,senescence and pyroptosis.Subsequently,we find that HMGB1 is regulated by rosuvastatin and that its overexpression abrogates the protective effect of rosuvastatin.We then verify that the NF-κB pathway is the underlying pathway regulated by rosuvastatin and HMGB1.In vivo experiments also reveal that rosuvastatin inhibits IDD progression by alleviating pyroptosis and senescence and downregulating HMGB1 and p65.This study might provide new insight into therapeutic strategies for IDD. | Weijian Chen Zhihuai Deng Jianxiong Zhu Liang Yuan Shuangxing Li Yangyang Zhang Jiajun Wu Zhengqi Huang Tianyu Qin Wei Ye | 2023 | Acta Biochimica et Biophysica Sinica2023，55，5： | 0 |
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