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| 1 | Multi-Stage Hydrocarbon Accumulation and Formation Pressure Evolution in Sinian Dengying FormationCambrian Longwangmiao Formation, Gaoshiti-Moxi Structure, Sichuan Basin显示文摘Sichuan Basin is a typical superimposed basin, which experienced multi-phase tectonic movements, meanwhile Sinian–Cambrian underwent complex hydrocarbon accumulation processes, causing exploration difficulties in the past 60 years. Based on the microscopic evidence of fluid inclusions, combined with basin-modelling, this paper determines stages and time of hydrocarbon accumulation, reconstructs evolution of formation pressure and dynamic processes of hydrocarbon accumulation in Sinian Dengying Formation-Cambrian Longwangmiao Formation of Gaoshiti-Moxi structure. Three stages of inclusions are detected, including a stage of yellow-yellowgreen fluorescent oil inclusions, a stage of blue fluorescent oil-gas inclusions and a stage of non-fluorescent gas inclusions, reflecting the study area has experienced a series of complex hydrocarbon accumulation processes, such as formation of paleo-oil reservoirs, cracking of crude oil, formation of paleo-gas reservoirs and adjustment to present gas reservoirs, which occurred during 219–188, 192–146 and 168–0 Ma respectively. During the period of crude oil cracking, Dengying Formation-Longwangmiao Formation showed weak overpressure to overpressure characteristics, then after adjustment of paleo-gas reservoirs to present gas reservoirs, the pressure in Dengying Formation changed into overpressure but finally reduced to normal pressure system. However, due to excellent preservation conditions, the overpressure strength in Longwangmiao Formation only slightly decreased and was still kept to this day. | Juan Wu Shugen Liu Guozhi Wang Yihua Zhao Wei Sun Jinming Song Yanhong Tian | 2016 | Journal of Earth Science2016，27，5： | 8 |
| 2 | A Brief Introduction to BNU-HESM1.0 and Its Earth Surface Temperature Simulations显示文摘Integrated assessment models and coupled earth system models both have their limitations in understanding the interactions between human activity and the physical earth system. In this paper,a new human–earth system model,BNUHESM1.0,constructed by combining the economic and climate damage components of the Dynamic Integrated Model of Climate Change and Economy to the BNU-ESM model,is introduced. The ability of BNU-HESM1.0 in simulating the global CO2 concentration and surface temperature is also evaluated. We find that,compared to observation,BNU-HESM1.0underestimates the global CO2 concentration and its rising trend during 1965–2005,due to the uncertainty in the economic components. However,the surface temperature simulated by BNU-HESM1.0 is much closer to observation,resulting from the overestimates of surface temperature by the original BNU-ESM model. The uncertainty of BNU-ESM falls within the range of present earth system uncertainty,so it is the economic and climate damage component of BNU-HESM1.0 that needs to be improved through further study. However,the main purpose of this paper is to introduce a new approach to investigate the complex relationship between human activity and the earth system. It is hoped that it will inspire further ideas that prove valuable in guiding human activities appropriate for a sustainable future climate. | YANG Shili DONG Wenjie CHOU Jieming FENG Jinming YAN Xiaodong WEI Zhigang YUAN Wenping GUO Yan TANG Yanli HU Jiacong | 2015 | Advances in Atmospheric Sciences2015，32，12： | 8 |
| 3 | Dissolved barium as a tracer of Kuroshio incursion in the Kuroshio region east of Taiwan Island and the adjacent East China Sea显示文摘From May to June 2014, the geochemical characteristics of dissolved barium(Ba) in sea water and its influx from the Kuroshio into the East China Sea(ECS) were studied by investigation of the Kuroshio mainstream east of Taiwan Island and the adjacent ECS. This allowed for the scope and extent of the Kuroshio incursion to be quantitatively described for the first time by using Ba as a tracer. The concentration of Ba in the Kuroshio mainstream increased gradually downward from the surface in the range 4.91–19.2 μg L.1. In the surface layer of the ECS, the Ba concentration was highest in coastal water and gradually decreased seaward, while it was higher in coastal and offshore water but lowest in middle shelf for bottom layer. The influx of Ba from Kuroshio into the ECS during May to October was calculated to be 2.19×108 kg by a water exchange model, in which the subsurface layer had the largest portion. The distribution of Ba indicated that Kuroshio upwelled in the sea area northeast of Taiwan Island. The north-flowing water in the Taiwan Strait restrained the incursion of Kuroshio surface water onto the ECS shelf, while Kuroshio subsurface water gradually affected the bottom of the ECS from outside. The results of end member calculation, using Ba as a parameter, showed that the Kuroshio surface water had little impact on the ECS, while the Kuroshio subsurface water formed an intrusion current by climbing northwest along the bottom of the middle shelf from the sea area northeast of Taiwan Island into the Qiantang Estuary, of which the volume of Kuroshio water was nearly 65%. Kuroshio water was the predominant part of the water on the outer shelf bottom and its proportion in areas deeper than the 100 m isobath could reach more than 95%. In the DH9 section(north of Taiwan Island), Kuroshio subsurface water intruded westward along the bottom from the shelf edge and then rose upward(in lower proportion). Kuroshio water accounted for 95% of the ocean volume could reach as far as 122°E. Ba was able to provide detailed tracing of the Kuroshio incursion into the ECS owing to its geochemical characteristics and became an effective tracer for revealing quantitative interactions between the Kuroshio and the ECS. | LIU Wei SONG JinMing YUAN HuaMao LI Ning LI XueGang DUAN LiQin | 2017 | Science China Earth Sciences2017，60，7： | 8 |
| 4 | Global warming projections using the human–earth system model BNU-HESM1.0显示文摘Future climate change is usually projected by coupled earth system models under specific emission scenarios designed by integrated assessment models(IAMs),and this offline approach means there is no interaction between the coupled earth system models and the IAMs.This paper introduces a new method to design possible future emission scenarios and corresponding climate change, in which a simple economic and climate damage component is added to the coupled earth system model of Beijing Normal University(BNU-ESM). With the growth of population and technological expertise and the declining emission-to-output ratio described in the Dynamic Integrated Climate-Economy model, the projected carbon emission is 13.7 Gt C, resulting in a 2.4 °C warming by the end of the twenty-first century(2080–2099) compared with1980–1999. This paper also suggests the importance of the land and ocean carbon cycle in determining the CO2 concentration in the atmosphere. It is hoped that in the near future the next generation of coupled earth system models that include both the natural system and the social dimension will be developed. | Shili Yang Wenjie Dong Jieming Chou Jinming Feng Zhigang Wei Yan Guo Xiaohang Wen Ting Wei Di Tian Xian Zhu Zhiyong Yang | 2016 | Science Bulletin2016，61，23： | 7 |
| 5 | Anti-PD-L1/TGF-BR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer显示文摘Background:Second-generation programmed cell death-protein 1/pro-grammed death-ligand 1(PD-1/PD-L1)inhibitors,such as bintrafusp alfa(M7824),SHR-1701,and YM101,have been developed to simultaneously block PD-1/PD-L1 and transforming growth factor-beta/transforming growth factor-beta receptor(TGF-P/TGF-βR).Consequently,it is necessary to identify predictive factors of lung cancer patients who are not only resistant to PD-1/PD-LI inhibitors but also sensitive to bifunctional drugs.The purpose of this study was to search for such predictors.Methods:Multivariable Cox regression was used to study the association between the clinical outcome of treatment with PD-1/PD-L1 inhibitors and lym-phocyte recovery after lymphopenia in lung cancer patients.Murine CMT167 lung cancer cells were engineered to express the firefly luciferase gene and implanted orthotopically in the lung of syngeneic mice.Bioluminescence imag-ing,flow cytometry,and immunohistochemistry were employed to detrmine response to immunotherapy and function of tumor-infiltrating immune cells.Results:For lung cancer patients treated with anti-PD-1/PD-LI antibodies,poor lymphocyte recovery was associated with a shorter progression-free survival(PFS;P<0.001),an accumulation of regulatory T cells(Tregs),and an elimi-nation of CD8+T cells in the peripheral blood.Levels of CD8+T cells and Treg cells were also imbalanced in the tumors and peripheral immune organs of mice with poor lymphocyte recovery after chemotherapy.Moreover,these mice failed to respond to anti-PD-1 antibodies but remained sensitive to the anti-PD-LI/TGF-βR fusion protein(SHR-1701).Consistently,SHR-1701 but not anti-PD-1 antibod-ies,markedly enhanced IFN-γproduction and Ki-67 expression in peripheral CD8+T cells from patients with impaired lymphocyte recovery.Conclusions:Lung cancer patients with poor lymphocyte recovery and suffer-ing from persistent lymphopenia after previous chemotherapy are resistant to anti-PD-1/PD-L1 antibodies but might be sensitive to second-generation agents such as SHR-1701. | Bo Cheng Kaikai Ding Pengxiang Chen Jianxiong Ji Tao Luo Xiaofan Guo Wei Qiu Chunhong Ma Xue Meng Jian Wang Jinming Yu Yuan Liu | 2022 | Cancer Communications2022，42，1： | 5 |
| 6 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 7 | The preparation and performance of lignin-based activated carbon fiber adsorbents for treating gaseous streams显示文摘 | Min Song Wei Zhang Yongsheng Chen Jinming Luo John C. Crittenden | 2017 | Frontiers of Chemical Science and Engineering2017，11，3： | 4 |
| 8 | CMIP5/AMIP GCM Simulations of East Asian Summer Monsoon显示文摘The East Asian summer monsoon(EASM) is a distinctive component of the Asian climate system and critically influences the economy and society of the region. To understand the ability of AGCMs in capturing the major features of EASM, 10 models that participated in Coupled Model Intercomparison Project/Atmospheric Model Intercomparison Project(CMIP5/AMIP), which used observational SST and sea ice to drive AGCMs during the period 1979–2008, were evaluated by comparing with observations and AMIP II simulations. The results indicated that the multi-model ensemble(MME) of CMIP5/AMIP captures the main characteristics of precipitation and monsoon circulation, and shows the best skill in EASM simulation, better than the AMIP II MME. As for the Meiyu/Changma/Baiyu rainbelt, the intensity of rainfall is underestimated in all the models. The biases are caused by a weak western Pacific subtropical high(WPSH) and accompanying eastward southwesterly winds in group I models, and by a too strong and west-extended WPSH as well as westerly winds in group II models. Considerable systematic errors exist in the simulated seasonal migration of rainfall, and the notable northward jumps and rainfall persistence remain a challenge for all the models. However, the CMIP5/AMIP MME is skillful in simulating the western North Pacific monsoon index(WNPMI). | FENG Jinming WEI Ting DONG Wenjie WU Qizhong WANG Yongli | 2014 | Advances in Atmospheric Sciences2014，31，4： | 4 |
| 9 | A polyphenol-assisted IL-10 mRNA delivery system for ulcerative colitis显示文摘With the development of synthesis technology, modified messenger RNA(mRNA) has emerged as a novel category of therapeutic agents for a broad of diseases. However, effective intracellular delivery of mRNA remains challenging, especially for its sensitivity to enzymatic degradation. Here, we propose a polyphenol-assisted handy delivery strategy for efficient in vivo delivery of IL-10 mRNA.IL-10 mRNA binds to polyphenol ellagic acid through supramolecular binding to yield a negatively charged core, followed by complexing with linear polyetherimide and coating with bilirubin-modified hyaluronic acid to obtain a layer-by-layer nanostructure. The nanostructure specifically up-regulated the level of IL-10, effectively inhibited the expression of inflammatory factors, promoted mucosal repair, protected colonic epithelial cells against apoptosis, and exerted potent therapeutic efficacy in dextran sulfate sodium salt-induced acute and chronic murine models of colitis. The designed delivery system without systemic toxicity has the potential to facilitate the development of a promising platform for mRNA delivery in ulcerative colitis treatment. | Zhejie Chen Wei Hao Caifang Gao Yangyang Zhou Chen Zhang Jinming Zhang Ruibing Wang Yitao Wang Shengpeng Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 2 |
| 10 | DNA methylation and alternative splicing modulate FBXW11 gene expression in Holstein bull testis and are correlated with sperm quality显示文摘F-box and WD-40 domain protein 11(FBXW11)is an important component of the E3 ubiquitin-ligase enzyme that plays a key role in the ubiquitin-dependent regulation of spermatogenesis.In our previous research,the mRNA expression of FBXW11 in bull sperm with high motility is significantly higher than that with low motility.In the present study,the protein expression levels of FBXW11 in bull testicular tissues with low-performance sperm quality groups were significantly higher than those in normal performance groups.The immunohistochemistry result demonstrated that FBXW11 protein was located in the periphery of Leydig cells and seminiferous tubules.Three splice variants of the FBXW11 gene,namely,FBXW11-tv1,FBXW11-tv2,and FBXW11-tv3,were identified in testicular tissues.The splicing patterns of the three variants are exon skipping.The transcript FBXW11-tv2 expressions were the highest in each sample.The low-performance groups displayed higher FBXW11-tv1 and FBXW11-tv2 transcript expressions than the normal performance groups.Two CpG islands were located within the 5’UTR and exon 1-2 region of the FBXW11 gene.Bisulfite sequencing PCR results demonstrated that the methylation levels of 11 methylation sites in the CpG island 2 from−99 to−43 in the normal performance groups were significantly lower than those in the low-performance groups.Pearson correlation analysis suggested that the CpG island 2 methylation level was negatively correlated with sperm motility and the transcript FBXW11-tv2 expression level.Our data revealed that alternative splicing and DNA methylation jointly regulated FBXW11 gene expression and were correlated with sperm quality traits during spermatogenesis in Holsteins. | YONG LIU ZHIHUA JU QIANG JIANG WENHAO LIU CHUNHONG YANG YARAN ZHANG XIUGE WANG YAPING GAO XIAOCHAO WEI YAN SUN JINPENG WANG MINGHAI HOU LING YANG JINMING HUANG | 2021 | BIOCELL2021，45，1： | 1 |
| 11 | Characteristics of Channeling Flow in Cultivated Horizon of Saline Rice Soil显示文摘By applying bromide ion as tracer,the channeling flow has been quantitatively described in saline rice soil and alkaline soil of Da,an City,Jilin Province of China.Breakthrough curves of bromide ion in the saline rice soils after 1-year cultivation and 5-year cultivation and alkaline soil have been attained.Results show that the rice cultivation practice can improve the alkaline soil structure,however,it can accelerate the development of channeling flow pathway.Therefore,the channeling flow pathway has been developed widely in saline rice soil,but rarely in the alkaline soil.Three models of convection-dispersion equation(CDE),transfer functional model(TFM) and Back-Progation Network(BP Network) were used to simulate the transportation process of bromide ion.The peaks of probability density function of saline rice soil are higher with left skewed feature compared with that of the alkaline soil.It shows that the TFM and CDE can simulate the transportation process of the bromide ion in saline rice soil after 5-year cultivation,however,some deviation exists when it was used to simulate transportation process of bromide ion in saline rice soil after 1-year cul-tivation and alkaline soil;BP network can effectively simulate transportation process of bromide ion in both saline rice soil and alkaline soil. | LUO Jinming DENG Wei ZHANG Xiaoping YANG Fan LI Xiujun | 2006 | Chinese Geographical Science2006，16，4： | 1 |
| 12 | Catalyzed degradation of azo dyes under ambient conditions显示文摘 | WU Jinming WEN Wei | 2010 | Environmental Science & Technology2010，44，91： | 1 |
| 13 | Optical Measurement of Wet Steam in Turbines显示文摘 | Wang Naining Wei Jinming Cai Xiaoshu | 1998 | Transactions of the ASME Journal of Engineering for Gas Turbines and Power1998，120，4： | 1 |
| 14 | Separation and determination of norepinephrine, epinephrine andisoprinaline enantiomers by capillary electrophoresis in pharmaceutical formulation and human serum 显示文摘 | Wei Shoulian Song Guanqun Lin Jinming | 2005 | Journal of Chromatography A2005，1098，： | 1 |
| 15 | Plant exploitation of the last foragers at Shizitan in the Middle Yellow River Valley China: evi- dence from grinding stones 显示文摘 | Liu Li Wei Ge Sheahan Bestel Duncan Jones Jinming Shi Yanhua Song and Xingcan Chen | 2011 | Journal of Archaeological Sci- ence2011，，38： | 1 |
| 16 | Numerical simulation and data assimilation of the water-energy cycle over semiarid northeastern China显示文摘The default fractional vegetation cover and terrain height were replaced by the estimated fractional vegetation cover, which was calculated by the Normalized Difference Vegetation Index(NDVI) of Earth Observing System Moderate-Resolution Imaging Spectroradiometer(EOS-MODIS) and the Digital Elevation Model of the Shuttle Radar Topography Mission(SRTM) system. The near-surface meteorological elements over northeastern China were assimilated into the three-dimensional variational data assimilation system(3DVar) module in the Weather Research and Forecasting(WRF) model. The structure and daily variations of air temperature, humidity, wind and energy fields over northeastern China were simulated using the WRF model. Four groups of numerical experiments were performed, and the simulation results were analyzed of latent heat flux, sensible heat flux, and their relationships with changes in the surface energy flux due to soil moisture and precipitation over different surfaces. The simulations were compared with observations of the stations Tongyu, Naiman, Jinzhou, and Miyun from June to August, 2009. The results showed that the WRF model achieves high-quality simulations of the diurnal characteristics of the surface layer temperature, wind direction, net radiation, sensible heat flux, and latent heat flux over semiarid northeastern China in the summer. The simulated near-surface temperature, relative humidity, and wind speed were improved in the data assimilation case(Case 2) compared with control case(Case 1). The simulated sensible heat fluxes and surface heat fluxes were improved by the land surface parameterization case(Case 3) and the combined case(Case 4). The simulated temporal variations in soil moisture over the northeastern arid areas agree well with observations in Case 4, but the simulated precipitation should be improved in the WRF model. This study could improve the land surface parameters by utilizing remote sensing data and could further improve atmospheric elements with a data assimilation system. This work provides an effective attempt at combining multi-source data with different spatial and temporal scales into numerical simulations. The assimilation datasets generated by this work can be applied to research on climate change and environmental monitoring of arid lands, as well as research on the formation and stability of climate over semiarid areas. | WEN XiaoHang LIAO XiaoHan YUAN WenPing YAN XiaoDong WEI ZhiGang LIU HuiZhi FENG JinMing LU ShiHua DONG WenJie | 2014 | Science China Earth Sciences2014，57，10： | 1 |
| 17 | Heat conduction in a carbon chain显示文摘 | Wei Na Wa Gang Dong Jinming | 2004 | Phys Lett A2004，325，56： | 1 |
| 18 | Research on the design and simulation of a ship course controller based on ADRC显示文摘 | ZHOU Fengyu SHAN Jinming WANG Wei | 2009 | Journal of Shandong University(Engineering Science)2009，39，1： | 1 |
| 19 | Identification and Characterization of Side Population Cells from Adult Human Dental Pulp after Ischemic Culture显示文摘 | Jinming Wang Xi Wei Junqi Ling Yijun Huang Qimei Gong Yongbiao Huo | 2012 | Journal of Endodontics2012，，11： | 1 |
| 20 | Energy Efficient Resource Allocation in Timesharing Multiuser Systems with Hybrid Energy Harvesting Transmitter显示文摘An energy effi cient resource allocation scheme in timesharing multiuser system with a hybrid energy harvesting transmitter is studied in this paper. Specially, the operation energy of system is supplied by constant energy and energy harvesting, which harvests energy from external environment. Our goal is to maximize the energy effi ciency of timesharing multiuser systems by considering jointly allocation of transmission time and power control in an off-line manner. The original nonconvex objective function is transformed into convex optimization problem via the fractional programming approach. Then, we solve the convex problem by Lagrange dual decomposition method. Simulation results show that the proposed energy efficient resource allocation scheme has a better performance than the scheme which decomposes optimization problem into two parts(power allocation, time allocation) to solve iteratively. | Jinming Hu Wei Heng Guodong Zhang Xiang Li | 2017 | China Communications2017，14，8： | 1 |
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