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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Changing trends of disease burden of gastric cancer in China from 1990 to 2019 and its predictions:Findings from Global Burden of Disease Study显示文摘Objective:China is one of the countries with the heaviest burden of gastric cancer(GC)in the world.Understanding the epidemiological trends and patterns of GC in China can contribute to formulating effective prevention strategies.Methods:The data on incidence,mortality,and disability-adjusted life-years(DALYs)of GC in China from1990 to 2019 were obtained from the Global Burden of Disease Study(2019).The estimated annual percentage change(EAPC)was calculated to evaluate the temporal trends of disease burden of GC,and the package Nordpred in the R program was used to perform an age-period-cohort analysis to predict the numbers and rates of incidence and mortality in the next 25 years.Results:The number of incident cases of GC increased from 317.34 thousand in 1990 to 612.82 thousand in2019,while the age-standardized incidence rate(ASIR)of GC decreased from 37.56 per 100,000 in 1990 to 30.64 per 100,000 in 2019,with an EAPC of-0.41[95%confidence interval(95%CI):-0.77,-0.06].Pronounced temporal trends in mortality and DALYs of GC were observed.In the next 25 years,the numbers of new GC cases and deaths are expected to increase to 738.79 thousand and 454.80 thousand,respectively,while the rates of incidence and deaths should steadily decrease.The deaths and DALYs attributable to smoking were different for males and females.Conclusions:In China,despite the fact that the rates of GC have decreased during the past three decades,the numbers of new GC cases and deaths increased,and will continue to increase in the next 25 years.Additional strategies are needed to reduce the burden of GC,such as screening and early detection,novel treatments,and the prevention of risk factors. | Tongchao Zhang Hui Chen Xiaolin Yin Qiufeng He Jinyu Man Xiaorong Yang Ming Lu | 2021 | Chinese Journal of Cancer Research2021，33，1： | 19 |
| 3 | The Current Situation of the Study on Twisted Tape Inserts in Pipe Exchangers显示文摘热转移改进包括热 exchangers,空调,和制冷系统在许多应用程序被使用;因此许多研究人员在热转移改进上进行了试验性、数字的研究并且开发了各种各样的技术和方法。作为一种被动的热转移技术,扭曲了磁带广泛地为他们他们容易被建立的费用积蓄,更低的维护要求和事实在各种各样的工业被使用。这篇论文介绍扭曲的磁带的热转移改进的原则并且考察一些研究人员在最近的年里在这种技术上做的试验性的工作。不同地修改的扭曲的磁带插入广泛地被研究并且过去常为热 exchangers 提高热转移效率。扭曲的磁带处于低 Re 条件并且在方形的试管更好表现。然而,他们能也引起更高的压力落下。如果他们能在传统的热 exchangers 被使用,扭曲的磁带有大潜在、深刻的含意。除这以外,在 Nusselt 数字和磨擦因素之间的一些关联在这篇论文被介绍。 | Changzhong Man Chong Wang Jinyu Yao | 2014 | Journal of Marine Science and Application2014，13，4： | 3 |
| 4 | Treating COVID-19 with Chloroquine显示文摘A novel coronavirus disease 2019(COVID-19)emerged around December 2019 in Wuhan,China and has spread rapidly worldwide(Lu et al.,2020).Until March 27,2020,the Chinese health authorities had reported 82082 confirmed COVID-19 cases in China with 3298 deaths and 381443 confirmed cases with 20787 deaths outside China.The World Health Organization(WHO)named the virus SARS-CoV-2,which belongs to a distinct clade from the human severe acute respiratory syndrome CoV(SARS-CoV)and Middle East respiratory syndrome CoV(MERSCoV)(Zhu et al.,2020). | Mingxing Huang Tiantian Tang Pengfei Pang Man Li Ruolan Ma Jiahui Lu Jingxian Shu Yingying You Binghui Chen Jiabi Liang Zhongsi Hong Huili Chen Ling Kong Dajiang Qin Duanqing Pei Jinyu Xia Shanping jiang Hong Shan | 2020 | Journal of Molecular Cell Biology2020，12，4： | 1 |
| 5 | The role of glutathione-mediated triacylglycerol synthesis in the response to ultra-high cadmium stress in Auxenochlorella protothecoides显示文摘Under ultra-high cadmium(Cd)stress,large amounts of glutathione are produced in Auxenochlorella protothecoides UTEX 2341,and the lipid content increases significantly.Glutathione is the best reductant that can effectively remove Cd,but the relationship between lipid accumulation and the cellular response to Cd stress has not been ascertained.Integrating analyses of the transcriptomes and lipidomes,the mechanism of lipid accumulation to Cd tolerance were studied from the perspectives of metabolism,transcriptional regulation and protein glutathionylation.Under Cd stress,basic metabolic pathways,such as purine metabolism,translation and pre-m RNA splicing process,were inhibited,while the lipid accumulation pathway was significantly activated.Further analysis revealed that the transcription factors(TFs)and genes related to lipid accumulation were also activated.Analysis of the TF interaction sites showed that ABI5,MYBrel and NF-YB could further regulate the expression of diacylglycerol acyltransferase through glutathionylation/deglutathionylation,which led to increase of the triacylglycerol(TAG)content.Lipidomes analysis showed that TAG could help maintain lipid homeostasis by adjusting its saturation/unsaturation levels.This study for the first time indicated that glutathione could activate TAG synthesis in microalga A.protothecoides,leading to TAG accumulation and glutathione accumulation under Cd stress.Therefore,the accumulation of TAG and glutathione can confer resistance to high Cd stress.This study provided insights into a new operation mode of TAG accumulation under heavy metal stress. | Chao Xing Jinyu Li Sin Man Lam Hongli Yuan Guanghou Shui Jinshui Yang | 2021 | Journal of Environmental Sciences2021，33，10： | 1 |
| 6 | One-Pot Synthesis of Fully-Conjugated Chemically Stable Two-Dimensional Covalent Organic Framework显示文摘Covalent organic frameworks(COFs)with good chemical stability coupled with extended-conjugation structures are highly prefera-ble.Herein,a fully-conjugated and chemically stable two-dimensional COF was synthesized by a one-pot,three-components synthe-sis through a successful conversion of amine,aldehyde,and alkyne groups into the quinoline units as linkages with B(C6F5)3 serving as a Lewis acid catalyst,whilst 2,3-dichloro-5,6-dicyano-1,4-benzoquinone(DDQ)was employed as an oxidant.The obtained fully conjugated 2D COF shows excellent stability in acid or base. | Hui Liu Yuxi Han Xuhan Zheng Jinyu Zhao Yixiao Man Lishui Sun Yingjie Zhao | 2022 | Chinese Journal of Chemistry2022，40，6： | 1 |
| 7 | Heteroatom Doped Graphdiyne and Analogues:Synthesis,Structures and Applications显示文摘As a new carbon allotrope,graphdiyne(GDY)has shown intensive practical application prospects in the energy field,catalysis,gas separation,etc.,due to its unique 2Dπ-conjugated structure,rich sp-hybridized carbon atoms and semiconductor characteristics.Considerable efforts have been made to the development of well-defined GDY materials in recent years.The doping heteroatoms can further tune the structures,semiconductor properties of GDY,and expand the promising applications.This review summarized a comprehensive development of heteroatom doped GDYs,including their synthesis,structures,properties,applications in nanotechnology,as well as the forecast in the future. | MAN Yixiao ZHAO Jinyu LIU Shipeng PAN Qingyan ZHAO Yingjie | 2021 | Chemical Research in Chinese Universities2021，37，6： | 0 |
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