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| 1 | The global oxygen budget and its future projection显示文摘Atmospheric oxygen (O_2 ) is the most crucial element on earth for the aerobic organisms that depend on it to release energy from carbon-based macromolecules. This is the first study to systematically analyze the global O_2 budget and its changes over the past 100 years. It is found that anthropogenic fossil fuel combustion is the largest contributor to the current O_2 deficit, which consumed 2.0 Gt/a in 1900 and has increased to 38.2 Gt/a by 2015. Under the Representative Concentration Pathways (RCPs) RCP8.5 scenario, approximately 100Gt (gigatonnes) of O_2 would be removed from the atmosphere per year until 2100,and the O_2 concentration will decrease from its current level of 20.946%to 20.825%. Human activities have caused irreversible decline of atmospheric O_2 . It is time to take actions to promote O_2 production and reduce O_2 consumption. | Jianping Huang Jiping Huang Xiaoyue Liu Changyu Li Lei Ding Haipeng Yu | 2018 | Science Bulletin2018，63，18： | 14 |
| 2 | Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs显示文摘干皮病 pigmentosum (XP ) 是联系 XP 的基因的变化引起的一组基因混乱,导致 DNA 修理的缺陷。XP 病人经常展出神经病学的退化,而是内在的机制是未知的,部分地由于合适的疾病模型的缺乏。这里,我们产生了包括 XPA, XPB, XPC, XPG,和 XPV 在五不同 XP 基因怀有变化的病人特定的导致的 pluripotent 干细胞(iPSCs ) 。这些 iPSCs 进一步被区分到神经房间,并且他们到 DNA 损坏应力的危险性被调查。在神经干细胞(NSC ) 或神经原的 XPA 的变化导致了严重 DNA 损坏修理缺点,并且有变异的 XPA 的这些神经房间对 DNA 导致损坏的 apoptosis 过分敏感。因此, XP 变异的神经房间代表珍贵工具在 XP 病人澄清神经病学的畸形的分子的机制。 | Lina Fu Xiuling Xu Ruotong Ren Jun Wu Weiqi Zhang Jiping Yang Xiaoqing Ren Si Wang Yang Zhao Liang Sun Yang Yu Zhaoxia Wang Ze Yang Yun Yuan Jie Qiao Juan Carlos Izpisua Belmonte Jing Qu Guang-Hui Liu | 2016 | Protein & Cell2016，7，3： | 11 |
| 3 | CRISPR/Cas9-mediated targeted gene correction in amyotrophic lateral sclerosis patient iPSCs显示文摘 | Lixia Wang Fei Yi Lina Fu Jiping Yang Si Wang Zhaoxia Wang Keiichiro Suzuki Liang Sun Xiuling Xu Yang Yu Jie Qiao Juan Carlos Izpisua Belmonte Ze Yang Yun Yuan Jing Qu Guang-Hui Liu | 2017 | Protein & Cell2017，8，5： | 10 |
| 4 | Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity显示文摘血大脑障碍(BBB ) 是在 endothelial 房间和星形细胞之间形成的一条紧密的边界,它在循环把大脑与大多数病原体以及神经毒素分开并且保护。然而,详细说明了涉及 BBB 的形成的分子的播放器完全不被知道。牙质矩阵蛋白质 1 (DMP1 )-proteoglycan (PG ) 被知道涉及骨头和牙质的矿化作用,也与未知功能包括大脑在软纸巾被表示。在现在的学习,我们报导 DMP1-PG 在大脑星形细胞被表示并且在 BBB 充实单位。DMP1 的唯一的 glycosylation 地点在在鼠标的蛋白质的 N 终端域是 serine89 (S89 ) 。有 DMP1 的变异的老鼠削尖把 S89 改变到 glycine (S89G ) 的变化,它蛋白质的完全根除的 glycosylation,表明的严重 BBB 混乱。DMP1 变异的鼠标的另一个品种,缺乏 DMP1 的 C 终端域,表明了正常 BBB 功能。S89G-DMP1 星形细胞的极性被破坏,房间房间粘附被松开。通过一组分析,我们发现 DMP1 glycosylation 极其在 vitro 并且在 vivo 为星形细胞成熟被要求。S89G-DMP1 变异的星形细胞没能表示 aquaporin 4 并且减少了 laminin 和 ZO1 表示,它导致了 BBB 的混乱。有趣地,在 nestin 倡导者驾驶的老鼠大脑的野类型的 DMP1-PG 的 overexpression 在野类型层次以外提高了 laminin 和 ZO1 表示并且能有效地抵抗的静脉内的导致甘露糖醇的 BBB 可逆的洞。一起拿,我们的学习不仅揭示了一个新奇元素,即, DMP1-PG,调整了 BBB 形成,而且把新功能分到 DMP1-PG。 | Bo Jing Chunxue Zhang Xianjun Liu Liqiang Zhou Jiping Liu Yinan Yao Juehua Yu Yuteng Weng Min Pan Jie Liu Zuolin Wang Yao Sun Yi Eve Sun | 2018 | Protein & Cell2018，9，3： | 5 |
| 5 | Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury显示文摘Spinal cord injury(SCI)involves diverse injury responses in different cell types in a temporally and spatially specific manner.Here,using single-cell transcriptomic analyses combined with classic anatomical,behavioral,electrophysiological analyses,we report,with single-cell resolution,temporal molecular and cellular changes in crush-injured adult mouse spinal cord.Data revealed pathological changes of 12 different major cell types,three of which infiltrated into the spinal cord at distinct times post-injury.We discovered novel microglia and astrocyte subtypes in the uninjured spinal cord,and their dynamic conversions into additional stage-specific subtypes/states.Most dynamic changes occur at 3-days post-injury and by day-14 the second wave of microglial activation emerged,accompanied with changes in various cell types including neurons,indicative of the second round of attacks.By day-38,major cell types are still substantially deviated from uninjured states,demonstrating prolonged alterations.This study provides a comprehensive mapping of cellular/molecular pathological changes along the temporal axis after SCI,which may facilitate the development of novel therapeutic strategies,including those targeting microglia. | Chen Li Zhourui Wu Liqiang Zhou Jingliang Shao Xiao Hu Wei Xu Yilong Ren Xingfei Zhu Weihong Ge Kunshan Zhang Jiping Liu Runzhi Huang Jing Yu Dandan Luo Xuejiao Yang Wenmin Zhu Rongrong Zhu Changhong Zheng Yi Eve Sun Liming Cheng | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 4 |
| 6 | Reliable flight performance assessment of multirotor based on interacting multiple model particle filter and health degree显示文摘Multirotor has been applied to many military and civilian mission scenarios. From the perspective of reliability, it is difficult to ensure that multirotors do not generate hardware and software failures or performance anomalies during the flight process. These failures and anomalies may result in mission interruptions, crashes, and even threats to the lives and property of human beings.Thus, the study of flight reliability problems of multirotors is conductive to the development of the drone industry and has theoretical significance and engineering value. This paper proposes a reliable flight performance assessment method of multirotors based on an Interacting Multiple Model Particle Filter(IMMPF) algorithm and health degree as the performance indicator. First, the multirotor is modeled by the Stochastic Hybrid System(SHS) model, and the problem of reliable flight performance assessment is formulated. In order to solve the problem, the IMMPF algorithm is presented to estimate the real-time probability distribution of hybrid state of the established SHS-based multirotor model, since it can decrease estimation errors compared with the standard interacting multiple model algorithm based on extended Kalman filter. Then, the reliable flight performance is assessed with health degree based on the estimation result. Finally, a case study of a multirotor suffering from sensor anomalies is presented to validate the effectiveness of the proposed method. | Zhiyao ZHAO Peng YAO Xiaoyi WANG Jiping XU Li WANG Jiabin YU | 2019 | Chinese Journal of Aeronautics2019，32，2： | 4 |
| 7 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 8 | Single-cell transcriptomics reveals gene signatures and alterations associated with aging in distinct neural stem/progenitor cell subpopulations显示文摘Aging associated cognitive decline has been linked to dampened neural stem/progenitor cells (NSC/NPCs) activities manifested by decreased proliferation, reduced propensity to produce neurons, and increased differentiation into astrocytes. While gene transcription changes objectively reveal molecular alterations of cells undergoing various biological processes, the search for molecular mechanisms underlying aging of NSC/NPCs has been confronted by the enormous heterogeneity in cellular compositions of the brain and the complex cellular microenvironment where NSC/NPCs reside. Moreover, brain NSC/NPCs themselves are not a homogenous population, making it even more difficult to uncover NSC/NPC sub-type specific aging mechanisms. Here, using both population-based and single cell transcriptome analyses of young and aged mouse forebrain ependymal and subependymal regions and comprehensive “big-data” processing, we report that NSC/NPCs reside in a rather inflammatory environment in aged brain, which likely contributes to the differentiation bias towards astrocytes versus neurons. Moreover, single cell transcriptome analyses revealed that different aged NSC/NPC subpopulations, while all have reduced cell proliferation, use different gene transcription programs to regulate age-dependent decline in cell cycle. Interestingly, changes in cell proliferation capacity are not influenced by inflammatory cytokines, but likely result from cell intrinsic mechanisms. The Erk/Mapk pathway appears to be critically involved in regulating age-dependent changes in the capacity for NSC/NPCs to undergo clonal expansion. Together this study is the first example of using population and single cell based transcriptome analyses to unveil the molecular interplay between different NSC/NPCs and their microenvironment in the context of the aging brain. | Zhanpinq Shi Yanan Geng Jiping Liu Huina Zhang Liqiang Zhou Quan Lin Juehua Yu Kunshan Zhang Jie Liu Xinpei Gao Chunxue Zhang Yinan Yao Chong Zhang Yi E. Sun | 2018 | Protein & Cell2018，9，4： | 3 |
| 9 | Evaluation of the relative risk of stroke in patients with hypertension using cerebrovascular hemodynamic accumulative score显示文摘The relative risk(RR)of stroke in patients with hypertension was evaluated by using synthetic index of cerebrovascular hemodynamics.A total of 7,371 patients with hypertension with ages i40 years were selected from a population-based cohort study of the risk factors for stroke.The data on the baseline investigation of risk factors,the determination of cerebrovascular hemodynamic parameters(CVHP),and stroke follow-up were analyzed.The RR of stroke in patients with hypertension was evaluated by CVHP scores.Univariate analysis indicated that hypertension,complicated by other risk factors,had significant statistical association with the onset of stroke.RRs for stroke when hypertension complicated with decrease of hemodynamic scores,heart disease,cigarette smoking and alcohol consumption were 4.93(95%CI,3.26–7.45),1.90(95%CI,1.36–2.66),1.99(95%CI,1.42–2.79)and 1.73(95%CI,1.19–2.53)respectively.In multivariate analysis,hemodynamic score,age,sex,cigarette smoking,family history of stroke and systolic blood pressure were selected by the Cox regression for inclusion in the final analysis.Among them,the RR of hemodynamic score was highest.The analysis of doseresponse relationships indicated that when the hemodynamic scores in patients with hypertension were lower than 75 points,the RR of stroke at 75,60,45,30 and 15 points were 2.85,4.43,4.54,5.40 and 9.88,respectively.The risk of stroke in patients with hypertension is closely asso ciated with hemodynamic impairment and the hemodynamic score may be used for quantitative evaluation of relative risks of stroke. | HUANG Jiuyi WANG Guiqing GUO Jiping CAO Yifeng WANG Yan YANG Yongju YU Xuehai | 2007 | Frontiers of Medicine2007，1，3： | 2 |
| 10 | Micro RNA ‐212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2显示文摘 | Zeng Jiping Fang Ming Wang Lixiang Liang Xiuming Shen Yuqun Yu Han Liu Zhifang Sun Yundong Liu Shili Chen Chunyan Jia Jihui | 2013 | J Cell Biochem2013，，12： | 2 |
| 11 | FoxM1 is Overexpressed in Helicobacter pylori–Induced Gastric Carcinogenesis and Is Negatively Regulated by miR-370显示文摘 | Yimin Feng Lixiang Wang Jiping Zeng Li Shen Xiuming Liang Han Yu Shili Liu Zhifang Liu Yundong Sun Wenjuan Li Chunyan Chen Jihui Jia | 2013 | Molecular Cancer Research2013，，8： | 2 |
| 12 | Neuroprotection of brain-derived neurotrophic factor against hypoxic injury in vitro requires activation of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase显示文摘 | Xiaomei Sun Hui Zhou Xiaoli Luo Shengfu Li Dan Yu Jiping Hua Dezhi Mu Meng Mao | 2007 | International Journal of Developmental Neuroscience2007，，3： | 1 |
| 13 | Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation显示文摘亲爱的编辑, | Hongmei Zhang Mei Li Yu Gao Chenjun Jia Xiaowei Pan Peng Cao Xuelin zhao Jiping Zhang Wenrui Chang | 2015 | Protein & Cell2015，6，2： | 1 |
| 14 | Nitric oxide participates in the regulation of LeCBF1 gene expression and improves cold tolerance in harvested tomato fruit显示文摘 | Ruirui Zhao Jiping Sheng Shengnan Lv Yang Zheng Jian Zhang Mengmeng Yu Lin Shen | 2011 | Postharvest Biology and Technology2011，，2： | 1 |
| 15 | Ethylene and cold participate in the regulation of LeCBF1 gene expression in postharvest tomato fruits显示文摘 | Danying Zhao Lin Shen Bei Fan Mengmeng Yu Yang Zheng Shengnan Lv Jiping Sheng | 2009 | FEBS Letters2009，，20： | 1 |
| 16 | A plasma microRNA panel for early detection of colorectal cancer显示文摘 | Shuyang Wang Jianbin Xiang Zhaoyong Li Shaohua Lu Jie Hu Xue Gao Lei Yu Lei Wang Jiping Wang Ying Wu Zongyou Chen Hongguang Zhu | 2015 | Int. J. Cancer2015，，1： | 1 |
| 17 | Nitric oxide participates in the regulation of LeCBF1 gene expression and improves cold tolerance in harvested tomato fruit显示文摘 | Ruirui Zhao Jiping Sheng Shengnan Lv Yang Zheng Jian Zhang Mengmeng Yu Lin Shen | 2011 | Postharvest Biology and Technology2011，，： | 1 |
| 18 | An Unprecedented Record Low Antarctic Sea-ice Extent during Austral Summer 2022显示文摘Seasonal minimum Antarctic sea ice extent(SIE)in 2022 hit a new record low since recordkeeping began in 1978 of 1.9 million km^(2) on 25 February,0.17 million km^(2) lower than the previous record low set in 2017.Significant negative anomalies in the Bellingshausen/Amundsen Seas,the Weddell Sea,and the western Indian Ocean sector led to the new record minimum.The sea ice budget analysis presented here shows that thermodynamic processes dominate sea ice loss in summer through enhanced poleward heat transport and albedo-temperature feedback.In spring,both dynamic and thermodynamic processes contribute to negative sea ice anomalies.Specifically,dynamic ice loss dominates in the Amundsen Sea as evidenced by sea ice thickness(SIT)change,while positive surface heat fluxes contribute most to sea ice melt in the Weddell Sea. | Jinfei WANG Hao LUO Qinghua YANG Jiping LIU Lejiang YU Qian SHI Bo HAN | 2022 | Advances in Atmospheric Sciences2022，39，10： | 1 |
| 19 | Nitric oxide synthase as a postharvest response in pathogen resistance of tomato fruit显示文摘 | Yang Zheng Lin Shen Mengmeng Yu Bei Fan Danying Zhao Lingyi Liu Jiping Sheng | 2010 | Postharvest Biology and Technology2010，，1： | 1 |
| 20 | Methyl jasmonate-induced defense responses are associated with elevation of 1-aminocyclopropane-1-carboxylate oxidase in Lycopersicon esculentum fruit显示文摘 | Mengmeng Yu Lin Shen Aijun Zhang Jiping Sheng | 2011 | Journal of Plant Physiology2011，，15： | 1 |
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