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| 1 | Community structure of ammonia-oxidizing bacteria under long-term application of mineral fertilizer and organic manure in a sandy loam soil显示文摘 | Chu HY Fujii T Morimoto S Lin XG Yagi K Hu JL Zhang JB | 2007 | 中国生物学文摘2007，21，6： | 77 |
| 2 | Oncofetal antigen glypican-3 as a promising early diagnostic marker for hepatocellular carcinoma显示文摘BACKGROUND:Hepatocellular carcinoma (HCC) is characterized by a multi-cause,multi-stage and multi-focus process of tumor progression.Its prognosis is poor and early diagnosis is of utmost importance.This study was undertaken to investigate the dynamic expression of oncofetal antigen glypican-3 (GPC-3) and GPC-3 mRNA in hepatocarcinogenesis and to explore their early diagnostic value for HCC.METHODS:A hepatoma model was induced in male Sprague-Dawley rats with 0.05% 2-fluorenylacetamide and confirmed by hematoxylin and eosin staining and gamma-glutamyltransferase (GGT) expression.Total RNA was purified and transcribed into cDNA by reverse transcription.Fragments of the GPC-3 gene were amplified by nested RT-PCR,and confirmed by sequencing.GPC-3 was analyzed by immunohistochemistry,Western blotting or ELISA.RESULTS:Positive GPC-3 expression showed as brown granule-like staining localized in the cytoplasm.Histological examination of hepatocytes revealed three morphological stages of granule-like degeneration,atypical hyperplasia (precancerous),and cancer formation,with a progressive increase of liver total RNA and GGT expression.The incidence of liver GPC-3 mRNA and GPC-3,and serum GPC-3 was 100%,100% and 77.8% in the HCC group,100%,100%,and 66.7% in the precancerous group,83.3%,83.3%,and 38.9% in the degeneration group,and no expression in the liver or blood of the control group,respectively.There was a positive correlation between liver GPC-3 mRNA and total RNA level (r=0.475,P<0.05) or liver GPC-3 (r=1.0,P<0.001) or serum GPC-3 (r= 0.994,P<0.001).CONCLUSION:Abnormal oncofetal antigen GPC-3 and GPC-3 mRNA expression in hepatocarcinogenesis may be promising molecular markers for early diagnosis of HCC. | Research Center of Clinical Medicine,Affiliated Hospital of Nantong University,Nantong 226001,China (Yao M,Yao DF,Qiu LW,Wu W,Sai WL,Yang JL and Zhang HJ) Department of Oncology,Yancheng First People’s Hospital,Yancheng 224001,China (Bian YZ) Department of Oncology,Second Affiliated Hospital,Nanjing Medical University,Nanjing 210011,China (Zhang CG) | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 51 |
| 3 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 4 | 溶栓时间(入院到用药时间)的延迟及其对脑卒中治疗时间与预后的影响显示文摘尽管美国心脏协会/美国脑卒中协会关于脑卒中的治疗均提出了倡议,大量急性缺血性脑卒中患者仍然在到达就诊60min后才开始启动组织型纤溶酶原激活剂(阿替普酶)溶栓治疗。该研究旨在描述延迟的原因及其与患者预后之间的关系。 | 刘莉 叶鹏 Kamal N Sheng S Xian Y Matsouaka R Hill MD Bhatt DL Saver JL Reeves MJ Fonarow GC Schwamm LH Smith EE | 2017 | 中华高血压杂志2017，25，4： | 15 |
| 5 | 血压变异性预测自发性脑出血患者的院内不良预后显示文摘越来越多的证据表明,较高的收缩压变异性(systolicblood pressure variability ,SBPV)可能与脑出血患者的不良预后相关。该研究探讨了 SB PV 与院内脑出血预后之间的关系。研究者在2个医疗系统中收集了10年的自发性脑出血患者的连续数据。记录人口统计学、病史、实验室测试、计算机断层扫描数据、院内治疗情况以及神经和功能评估。在入院后24h内获取血压记录。 | 刘青 叶鹏 Divani AA Liu X Di Napoli M Lattanzi S Ziai W James ML Jafarli A Jafari M Saver JL Hemphill JC Vespa PM Mayer SA Petersen A | 2019 | 中华高血压杂志2019，27，8： | 6 |
| 6 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 7 | 4例虹膜蔓状血管瘤光学相干体层成像术血管造影特征显示文摘血管畸形中失调的TGF-β/BMP信号通路
血管树正确的结构要求调控管腔形成,血管生长和重塑的信号通路激活并达到平衡。当这一平衡被打破时,会出现血管发育畸形。该文旨在回顾转化生长因子(TGF)-β、骨形成蛋白(BMP)信号通路在血管形成和发展中的作用。胚胎期灭活这些信号通路,将导致血管组织变异。 | Chien JL Sioufi K Ferenczy S Say EAT 张凌 Cunha SI Magnusson PU Dejana E | 2017 | 中国口腔颌面外科杂志2017，15，6： | 6 |
| 8 | 饮食防癌研究进展显示文摘本文作者对最近进行的有关纤维素、脂肪、热量、维生素A、饮酒等膳食因素与多种部位癌症危险性关系的流行病学研究和动物实验结果作了较为全面的综述和评价。指出今后除需进一步阐明单一膳食因素的致癌作用外,还应加强膳食成分之间以及膳食与其它因素之间的相互作用对癌症危险性影响的研究。 | Freudenheim JL Graham S 余丽莉 | 1991 | 国外医学(卫生学分册)1991，18，2： | 3 |
| 9 | 运用手机进行改进的个体化健康促进干预以提高HIV阳性冰毒使用者的服药依从性显示文摘运用手机进行健康促进( mobile health, mHealth)干预在提高抗病毒治疗依从性上显示了明显的效果,但是对于HIV阳性的冰毒使用者来说,有必要对干预内容进行有效的调整,以满足该人群的特殊需要。 | Montoya JL Georges S Poquette A 胡翼飞 吴迪 | 2014 | 中华预防医学杂志2014，48，11： | 2 |
| 10 | Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa显示文摘 | Fiorucci S Santucci L Wallace JL | 2003 | PNAS2003，100，10： | 2 |
| 11 | 益生菌抑制自发性高血压大鼠的菌群失调和血压升高:短链脂肪酸的作用显示文摘该研究旨在评估益生菌短双歧杆菌CECT7263(BFM)及发酵乳酸杆菌CECT5716(LC40)、短链脂肪酸丁酸盐及醋酸盐对自发性高血压大鼠(spontaneously hypertensive rat,SHR)心血管的作用。方法和结果:5周龄的Wistar Kyoto大鼠(WKY)10只和周龄匹配的SHR 50只随机分为6组:对照WKY、对照SHR、BFM干预的SHR、LC40干预的SHR、丁酸盐干预的SHR和醋酸盐干预的SHR。 | 袁源(译) 练桂丽(审校) Robles-Vera I Toral M de la Visitación N Sánchez M Gómez-Guzmán M Romero M Yang T Izquierdo-Garcia JL Jiménez R Ruiz-Cabello J Guerra-Hernández E Raizada MK Pérez-Vizcaíno F Duarte J | 2020 | 中华高血压杂志2020，28，9： | 2 |
| 12 | Isolated olistoliths from the Lower Triassic Xikou Formation in southwestern Fujian and its geological significance显示文摘ISOLATED olistoliths refer to massive blocks of rock occurring out of place, but with sedimentary contact relationship, within unrelated sediments. They were transported as single masses into the basins in which they occurred. In this note we will first report examples found from the Lower Triassic Xikou Formation in southwestern Fujian and discuss its geological significance. | Li, PJ Hou, QL Li, JL Sun, S | 1997 | Chinese Science Bulletin1997，42，2： | 2 |
| 13 | Global malaria mortality between 1980 and 2010: a systematic analysis显示文摘 | Christopher JL Murray Lisa C Rosenfeld Stephen S Lim Kathryn G Andrews Kyle J Foreman Diana Haring Nancy Fullman Mohsen Naghavi Rafael Lozano Alan D Lopez | 2012 | The Lancet2012，，9814： | 2 |
| 14 | The Movement of Solutes and Ceils across Tight Junctions 显示文摘 | Madara JL Parkos C Colgan S | 1992 | Ann NY Acad Sci1992，664，： | 1 |
| 15 | Prospective detection of preclinical lung cancer: results from two studies of heterogenous nuclear ribonucleoprotein A2/B1 overexpession 显示文摘 | Tockman M S Mulshine JL Piantadosi S | 1997 | Clin Cancer Res1997，3，： | 1 |
| 16 | Anticoagulation in continuous renal replacement therapy显示文摘 | Abramsom S Niles JL | 1999 | Curr Opin Nephrol Hypertens1999，8，6： | 1 |
| 17 | Frontal-subcortical neuronal circuits and clinical neuropsychiatry:an update显示文摘 | Tekin S Cummings JL | 2002 | J Psychosom Res2002，53，： | 1 |
| 18 | Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicana strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients显示文摘 | Perea S Lopez-Ribot JL Kirkpatrick WR | 2001 | Antimicrob Agents Chemother2001，45，10： | 1 |
| 19 | Complement factor H varient increases the risk of age-related macular degeneration显示文摘 | Haines JL Hauser MA Schmidt S | 2005 | Science2005，308，5720： | 1 |
| 20 | Is there a case for cisplatin in the treatment of sinail-cell lung cancer?A meta-analysis of randomized trims of a cisplatin-containing regimen versus a regimen without this alkylating agent显示文摘 | Pujol JL Carestia L Daurès JP | 2000 | Br J Cancer2000，83，1： | 1 |
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