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| 1 | Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。 | Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang | 2014 | Cell Research2014，24，8： | 12 |
| 2 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 3 | A large outbreak of acute gastroenteritis caused by the human norovirus GII.17 strain at a university in Henan Province,China显示文摘Background:Human noroviruses are a major cause of viral gastroenteritis and are the main etiological agents of acute gastroenteritis outbreaks.An increasing number of outbreaks and sporadic cases of norovirus have been reported in China in recent years.There was a large acute gastroenteritis outbreak at a university in Henan Province,China in the past five years.We want to identify the source,transmission routes of the outbreak by epidemiological investigation and laboratory testing in order to provide the effective control measures.Methods:The clinical cases were investigated,and analysed by descriptive epidemiological methods according to factors such as time,department,grade and so on.Samples were collected from clinical cases,healthy persons,the environment,water,and food at the university.These samples were tested for potential bacteria and viruses.The samples that tested positive for norovirus were selected for whole genome sequencing and the sequences were then analysed.Results:From 4 March to 3 April 2015,a total of 753 acute diarrhoea cases were reported at the university;the attack rate was 3.29%.The epidemic curve showed two peaks,with the main peak occurring between 10 and 20 March,accounting for 85.26%of reported cases.The rates of norovirus detection in samples from confirmed cases,people without symptoms,and environmental samples were 32.72%,17.39%,and 9.17%,respectively.The phylogenetic analysis showed that the norovirus belonged to the genotype GII.17.Conclusions:This is the largest and most severe outbreak caused by genotype GII.17 norovirus in recent years in China.The GII.17 viruses displayed high epidemic activity and have become a dominant strain in China since the winter of 2014,having replaced the previously dominant GII.4 Sydney 2012 strain. | Xue-Yong Huang Jia Su Qian-Chao Lu Shi-Zheng Li Jia-Yong Zhao Meng-Lei Li Yi Li Xiao-Jing Shen Bai-Fan Zhang Hai-Feng Wang Yu-Jiao Mu Shu-Yu Wu Yan-Hua Du Li-Cheng Liu Wei-Jun Chen John David Klena Bian-Li Xu | 2017 | Infectious Diseases of Poverty2017，6，1： | 10 |
| 4 | Seismogenesis and occurrence of earthquakes as observed by temporally continuous gravity variations in China显示文摘In the last decade and a half, a number of earthquakes of magnitude 4-5 have occurred in the Beijing_Tianjin_Tangshan_Zhangjiakou (BTTZ) region. On the basis of the analysis of the temporally continuous gravity variation data principally from the Baijiatuan (BJTN) semi_permanent gravity base station, a general picture of gravity variation related to the seismogenesis and occurrence of earthquakes has emerged.\;As gravity variation is generally observed on the earth’s surface, the predominant influence is that of the near_surface groundwater. The subsurface fluids are distributed throughout all depths in the crust and respond to the seismogenic processes of earthquakes as well. The influence of the subsurface fluid on gravity variation is, therefore, of equal importance. The fluids, which include the near_surface groundwater and the subsurface fluids distributed throughout all depths in the crust, play a more important role in the gravity variations in terms of the seismogenesis and occurrence of earthquakes than previously realized.\;The abundance of accumulated data shows that the dilatancy instability (IPE) model seems not applicable at least to the seismogenesis and occurrence of earthquakes in the BTTZ region. In order to reflect the physical reality, the earlier proposed combined dilatancy model requires modification. The seismogenic area in the BTTZ region may be modelled as a large pre_stressed volume of a fluid_filled poroelastic medium, including not only the pre_stressed volume surrounding the impending rupture zone but also the volume containing the rupture of the fault zone itself. The pre_stressed volume outside the impending rupture zone is under a state of relatively small change of the pre_existing regional tectonic stress, while the volume containing the impending rupture zone is an induced region of very high local stress concentration, and/or pore over_pressure.\;The calculated gravity variations based on the modified combined dilatancy model (MCDM) with the known physical parameters of the region resemble the observed residual gravity variations. Apparently the residual gravity variations, in addition to responding to the deep_seated seismogenesis and occurrence of earthquakes, predominantly respond to the near_surface groundwater, and the subsurface fluids, which themselves also respond to the seismogenesis and occurrence of earthquakes. On the basis of comparison between the calculated MCDM gravity variations and the observed residual gravity variations, the change of the regional tectonic stress field for the earthquakes of magnitude 4-5 in the BTTZ region could be approximately estimated to be in the neighbourhood of 5%-7%.\;It is apparent that simultaneously monitoring the temporally continuous variations of the near_surface groundwater, subsurface fluids, and gravity coupled with modelling would provide vital information on the history and evolution of the seismogenic processes about 10 months to 1 year prior to the occurrence of an earthquake of magnitude 4-5 and tens of years prior to that of an earthquake of magnitude 7-8 such as the Haicheng earthquake in 1975 and the Tangshan earthquake in 1976 in the BTTZ region. These earthquakes of magnitude 4-5, which so far have occurred in the BTTZ region, may well be the precursory events to a larger earthquake. | Gongxu Gu John T. Kuo Keren Liu Jinhan Zheng Hongyan Lu Duanfa Liu | 1998 | Chinese Science Bulletin1998，43，1： | 10 |
| 5 | Effects of Dietary Net Energy Density and Standardized Ileal Digestible Lysine: Net Energy Ratio on the Performance and Carcass Characteristic of Growing-Finishing Pigs Fed Low Crude Protein Supplemented with Crystalline Amino Acids Diets显示文摘Two 3×3 factorial design trials with 1080 of Yorkshire×Landrace×Duroc barrows were conducted to investigate the effectsof dietary net energy (NE) density and standardized ileal digestible (SID) lysine:NE ratio on the performance of growing-finishing pigs and carcass characteristic of finishing pigs fed low crude protein (CP) supplemented with crystalline aminoacids (CAA) diets. Low CP corn-soybean meal basal diets (14% for Exp. 1 and 11% for Exp. 2) supplemented withcrystalline lysine, methionine, threonine, and tryptophan were formulated. Nine treatments with increasing NE densityand SID lysine:NE ratiowereused in each trial(Exp. 1: 9.66, 9.87, and 10.08 MJ kg-1 NE, 0.89, 0.96,and 1.03 g MJ-1 SID lysine:NE; Exp. 2: 9.83, 10.04, and 10.25 MJ kg-1 NE, 0.69, 0.76, and 0.83 g MJ-1 SID lysine:NE). In Exp. 1, we observed that theaverage daily gain (ADG) for barrows that received the diet containing 9.87 MJ kg-1 NE was significantly higher than thatof barrows fed a 9.66 MJ kg-1 NE diet (P<0.05), but no difference was observed when compared with barrows that receiveda diet containing 10.08 MJ kg-1 NE (P>0.05). TheADG was affected both linearly (P<0.05) and quadratically(P<0.05) as theSID lysine:NE ratio increased. The NE density or SID lysine:NE ratio and their interaction had no effect on the averagedaily feed intake (ADFI) and serum urea nitrogen (SUN) (P>0.05). The feed to gain ratio (F:G) decreased (linearly, P<0.05;quadratically, P<0.05) as the NE density or SID lysine:NE ratio increased, but no interaction of NE density and SID lysine:NE ratio on the F:G. In Exp. 2, the dietary NE density both linearly (P<0.05) and quadratically (P<0.05) affected the ADGand F:G. Barrows that received a diet containing 10.04 MJ kg-1 NE had a greater ADG (P<0.05) than barrows that receiveda 9.83 MJ kg-1 diet, but there was no difference (P>0.05) as compared with barrows that received a diet containing 10.25 MJkg-1 NE. F:G was significantly higher (P<0.05) for barrows that received a 9.83 MJ kg-1 diet when compared with barrowsthat received the other two diets. The ADG was significantly decreased (P<0.05) for pigs that received a diet containing0.69 g MJ-1 SID lysine:NE ratio when compared with pigs fed a diet containing 0.76 or 0.83 g MJ-1 SID lysine:NE ratio. TheNE density or SID lysine:NE ratio and their interaction had no effect on the average daily feed intake, SUN, and carcasscharacteristic for finishing barrows (P>0.05). The overall results of the two experiments indicated that barrows thatreceived the diet with the dietary CP level reduced 4 percentage units compared the NRC (1998) recommendations.Maximized the best performance with NE density and SID lysine:NE ratio were 9.87 MJ kg-1, 1.03 g MJ-1 NE for 20-50 kgpigs, and 10.04 MJ kg-1, 0.76 g MJ-1 NE for 60-100 kg pigs, respectively. | ZHANG Gui-jie YI Xue-wu CHU Li-cui LU Ning Htoo John QIAO Shi-yan | 2011 | Agricultural Sciences in China2011，10，4： | 8 |
| 6 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 7 | Global signatures of protein binding on structured RNAs in Saccharomyces cerevisiae显示文摘Protein binding is essential to the transport,decay and regulation of almost all RNA molecules.However,the structural preference of protein binding on RNAs and their cellular functions and dynamics upon changing environmental conditions are poorly understood.Here,we integrated various high-throughput data and introduced a computational framework to describe the global interactions between RNA binding proteins(RBPs)and structured RNAs in yeast at single-nucleotide resolution.We found that on average,in terms of percent total lengths,~15%of mRNA untranslated regions(UTRs),~37%of canonical non-coding RNAs(ncRNAs)and^11%of long ncRNAs(lncRNAs)are bound by proteins.The RBP binding sites,in general,tend to occur at single-stranded loops,with evolutionarily conserved signatures,and often facilitate a specific RNA structure conformation in vivo.We found that four nucleotide modifications of tRNA are significantly associated with RBP binding.We also identified various structural motifs bound by RBPs in the UTRs of mRNAs,associated with localization,degradation and stress responses.Moreover,we identified>200 novel lncRNAs bound by RBPs,and about half of them contain conserved secondary structures.We present the first ensemble pattern of RBP binding sites in the structured non-coding regions of a eukaryotic genome,emphasizing their structural context and cellular functions. | YANG YuCheng UMETSU Jumpei LU Zhi John | 2014 | Science China(Life Sciences)2014，57，1： | 7 |
| 8 | A new phylogenetic tribal classification of the grape family (Vitaceae)显示文摘Vitaceae (葡萄家庭) 由 16 个类和 ca 组成。首先在热带区域散布的 950 种类。家庭为葡萄的经济重要性是著名的,并且作为热带、适度的森林里的主导的登山者与许多种类也是生态地重要的。最近种系发生并且从所有三个染色体的顺序数据的 phylogenomic 分析在 Vitaceae 以内支持了五主要 clades:(i) 白蔹属, Nekemias, Rhoicissus,和 Clematicissus 的 clade;(ii ) Cissus clade;(iii ) Cayratia, Causonis, Cyphostemma, Pseudocayratia, Tetrastigma,和 undescribed 类 Afrocayratia 的 clade;(iv ) Parthenocissus 和 Yua 的 clade;并且(v) 葡萄类 Vitis 和它的近热带的亲戚 Ampelocissus, Pterisanthes 和 Nothocissus,与在 Ampelocissus 以内嵌套的 Nothocissus 和 Pterisanthes。基于种系发生、词法(主要开花期,花并且种子人物) 证据,新分类把 950 种类和 16 个类放进五个部落:(i) 部落 Ampelopsideae J.Wen 与 Z.L.Nie, trib。nov。(在四个类的 47 种类;白蔹属, Nekemias, Rhoicissus 和 Clematicissus ) ;(ii ) 部落 Cisseae Rchb。(在一个类的 300 种类;Cissus ) ;(iii ) 部落 Cayratieae J.Wen 与 L.M.Lu, trib。nov。(在七个类的 370 种类;Cayratia, Causonis, Afrocayratia, Pseudocayratia, Acareosperma, Cyphostemma 和 Tetrastigma ) ;(iv ) 部落 Parthenocisseae J.Wen 与 Z.D.Chen, trib。nov。( ca。16 spp。在二个类;Parthenocissus 和 Yua ) ;并且(v) 部落 Viteae Dumort。( ca。在二个类的 190 种类;Ampelocissus 和 Vitis ) 。 | JunWen Li-Min Lu Ze-Long Nie Xiu-Qun Liu Ning Zhang Stefanie Ickert-Bond Jean Gerrath Steven R. Manchester John Boggan Zhi-Duan Chen | 2018 | Journal of Systematics and Evolution2018，56，4： | 6 |
| 9 | National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants显示文摘 | Goodarz Danaei Mariel M Finucane Yuan Lu Gitanjali M Singh Melanie J Cowan Christopher J Paciorek John K Lin Farshad Farzadfar Young-Ho Khang Gretchen A Stevens Mayuree Rao Mohammed K Ali Leanne M Riley Carolyn A Robinson Majid Ezzati | 2011 | The Lancet2011，，9785： | 6 |
| 10 | Directly accessing octave-spanning dissipative Kerr soliton frequency combs in an AlN microresonator显示文摘Self-referenced dissipative Kerr solitons (DKSs) based on optical microresonators offer prominent characteristics allowing for various applications from precision measurement to astronomical spectrometer calibration. To date,direct octave-spanning DKS generation has been achieved only in ultrahigh-Q silicon nitride microresonators under optimized laser tuning speed or bi-directional tuning. Here we propose a simple method to easily access the octave-spanning DKS in an aluminum nitride (AlN) microresonator. In the design,two modes that belong to different families but with the same polarization are nearly degenerate and act as a pump and an auxiliary resonance,respectively. The presence of the auxiliary resonance can balance the thermal dragging effect,crucially simplifying the DKS generation with a single pump and leading to an enhanced soliton access window. We experimentally demonstrate the long-lived DKS operation with a record single-soliton step (10.4 GHz or83 pm) and an octave-spanning bandwidth (1100–2300 nm) through adiabatic pump tuning. Our scheme also allows for direct creation of the DKS state with high probability and without elaborate wavelength or power schemes being required to stabilize the soliton behavior. | HAIZHONG WENG JIA LIU ADNAN ALI AFRIDI JING LI JIANGNAN DAI XIANG MA YI ZHANG QIAOYIN LU JOHN F.DONEGAN WEIHUA GUO | 2021 | Photonics Research2021，9，7： | 6 |
| 11 | 基于速度一致性的高速公路出口安全评价显示文摘速度差与安全性有着直接的关系.传统方法以集计的运行速度差ΔV85作为速度一致性指标,容易陷入生态学谬论的误区,并且会高估道路的安全性能.本文比较了几种常用速度一致性评价方法的优劣,采用85位单车速度差85ΔV作为出口匝道速度一致性指标,解析了85ΔV≥ΔV85的关系.通过雷达对沪宁高速和南京绕城高速出口减速车道、匝道上半部以及匝道下半部单车速度的调查,得出连续路段的运行速度差ΔV85、85位单车速度差85ΔV以及85位速度变化率85ΔVR,验证了85ΔV约为ΔV85的1.42~2.02倍,表明使用85ΔV或者85ΔVR作为速度一致性评价指标是更加可靠合理的.最后通过速度差以及速度差变化率大小分级,用三种方法综合判定了37个出口匝道的安全等级. | 郭唐仪 邓卫 LU John | 2010 | 交通运输系统工程与信息2010，10，6： | 5 |
| 12 | Perfluoroalkyl substances and organochlorine pesticides in sediments from Huaihe watershed in China显示文摘Twelve perfluoroalkyl substances(PFASs) and nine organochlorine pesticides(OCPs) were quantified in surface sediments from the Huaihe River, China, along which there are intensive industrial and agricultural activities. Concentrations of PFASs ranged from 0.06 to 0.46 ng/g dry weight(dw), and concentrations of OCPs ranged from 1.48 to 32.65 ng/g dw. Compared with other areas in China, concentrations of PFASs were lesser than the national mean value, while concentrations of OCPs were moderate. Concentrations of perfluorooctanoic acid(PFOA) and perfluorooctane sulfonate(PFOS) ranged from n.d.(not detected) to 0.03 and n.d. to 0.10 ng/g dw,respectively. Among the three groups of OCPs, mean concentrations of hexachlorocyclohexane and its isomers(HCHs), dichlorodiphenyltrichloroethane and its metabolites(DDTs) and hexachlorobenzene(HCB) were 5.62 ± 4.35, 2.43 ± 3.12 and 1.55 ± 4.17 ng/g dw, respectively.Concentrations of HCHs and DDTs decreased from upstream to downstream along the mainstream of the Huaihe River. When compared to sediment quality guidelines(SQGs),concentrations of HCHs, DDTs and HCB would pose adverse biological effects. In general,contamination by PFASs in the upstream of the Huaihe River was more severe than that in the downstream, which was mainly caused by interception from dams, locks and industrial emissions. And OCPs from tributaries, especially the Yinghe River and Wohe River, were higher than those from Huaihe mainstream, and primarily came from historical inputs. | Jing Meng Tieyu Wang Pei Wang John P.Giesy Yonglong Lu | 2014 | Journal of Environmental Sciences2014，26，11： | 5 |
| 13 | The Seismogenic Structure of the 2010 Suining Ms 5.0 Earthquake and its Geometry,Kinematics and Dynamics Analysis显示文摘在 2010 年 1 月, Suining Ms5.0 地震发生在中央四川盆,与在 Moxi-Longnvsi 结构的带和 10 km 的焦点的深度的震中。在这个区域基于地震侧面的结构的解释,我们认出了在 910 km 的深度位于 Suining 区域的 Presinian 地下室的一个地区性的分开差错,转移它从 NW 滑倒到 SE 取向。从 NW 滑动到 SE,并且经历了几的这个分开差错砍并且弯曲,它引起了地下室被卷在并且覆盖阶层褶层变丑。它在 Moxi 区域形成了差错拐弯褶层与一近似 4 km 滑倒。相应地, Moxi 背斜的形成与分开差错有关。与地震分开差错的斜面上的震中,有一个新观点, Suining 地震被这个地下室分开差错的复活引起。自从迟了的侏罗记时期,在地区性的构造应力的影响下面,分开差错从 Longmen 山( LMS )戳带把它的slip 转移了到四川盆的内地,并且最后到西南 Huayingshan ( HYS )的山麓地区,它显示 HYS 可能是 LMS 戳带的最后的前面区域。 | LU Renqi HE Dengfa JOHN Suppe MA Yongsheng GUAN Shuwei SUN Yanpeng GAO Jinwei | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 5 |
| 14 | Non-genetic photoacoustic stimulation of single neurons by a tapered fiber optoacoustic emitter显示文摘Neuromodulation at high spatial resolution poses great significance in advancing fundamental knowledge in the field of neuroscience and offering novel clinical treatments.Here,we developed a tapered fiber optoacoustic emitter(TFOE)generating an ultrasound field with a high spatial precision of 39.6 pm,enabling optoacoustic activation of single neurons or subcellular structures,such as axons and dendrites.Temporally,a single acoustic pulse of sub-microsecond converted by the TFOE from a single laser pulse of 3 ns is shown as the shortest acoustic stimuli so far for successful neuron activation.The precise ultrasound generated by the TFOE enabled the integration of the optoacoustic stimulation with highly stable patch-clamp recording on single neurons.Direct measurements of the electrical response of single neurons to acoustic stimulation,which is difficult for conventional ultrasound stimulation,have been demonstrated.By coupling TFOE with ex vivo brain slice electrophysiology,we unveil cell-type-specific responses of excitatory and inhibitory neurons to acoustic stimulation.These results demonstrate that TFOE is a non-genetic single-cell and sub-cellular modulation technology,which could shed new insights into the mechanism of ultrasound neurostimulation. | Linli Shi Ying Jiang Fernando R.Fernandez Guo Chen Lu Lan Heng-Ye Man John A.White Ji-Xin Cheng Chen Yang | 2021 | Light(Science & Applications)2021，10，8： | 4 |
| 15 | Morphological control of SnTe nanostructures by tuning catalyst composition显示文摘A method of controlling the morphology of SnTe nanostructures produced by a simple chemical vapor deposition is presented, in which Au-containing catalysts with different Au concentrations are used to induce specific growth behavior. Triangular SnTe nanoplates with a {100} dominated surface and {100}, {111} and {120} side facets were induced by AuSn catalysts, whereas 〈010〉 SnTe nanowires with four nonpolar {100} side-facets were produced using AusSn catalysts. Through detailed structural and chemical characterization, coupled with surface energy calculations, it is found that nanowire growth is thermodynamically controlled via a vapor-solid-solid growth mechanism, whereas nanoplate growth is kinetically controlled via a vapor-liquid-solid growth mechanism. Therefore, this study provides a fundamental understanding of the catalyst's role in the growth of IV-VI compound nanostructures. | Yichao Zou Zhigang Chen Jing Lin Xiaohao Zhou Wei Lu John Drennan Jin Zou | 2015 | Nano Research2015，8，9： | 4 |
| 16 | Pseudocayratia, a new genus of Vitaceae from China and 3apan with two new species and three new combinations显示文摘 | Jun wen Li-Min Lu Tsai-Wen Hsu Viet-Cuong Dang Sadaf Habibt John K. Boggan Hiroshi Okada I-Ju Chen Zhi-Duan Chen | 2018 | Journal of Systematics and Evolution2018，56，4： | 4 |
| 17 | Simplified full-depth precast concrete deck panel systems for accelerated bridge construction显示文摘A simplified full-depth precast concrete deck panel system for accelerating bridge construction(ABC) is introduced and a finite element analysis(FEA) is conducted to investigate the static and dynamic responses of this conceptual deck system. The FEA results are compared to those of the traditional full-depth precast concrete deck panel system. The comparison results show that the mechanical behavior of the new deck system is different from that of the traditional deck system. The concrete decks in the new system act as two-way slabs, instead of the one-way slab in the traditional system. Meanwhile, the connections in both the longitudinal and transverse directions may need to accommodate the negative moments.Compared to those in the traditional system, the longitudinal nominal stress at middle span increases a lot in the new deck system and the effective flange width varies significantly. In addition, the dynamic results show that the impact factor is influenced by the spacing of connections.Finally, some design concerns of the new deck system are proposed. | Zhongguo John Ma Yulin Zhan Lin Xiao Lungui Li Weiwei Lu | 2016 | Journal of Modern Transportation2016，24，4： | 4 |
| 18 | Strategies to reduce nutrient pollution from manure management in China显示文摘As the demand for livestock products continues to increase in China,so too does the challenge of managing increasing quantities of manure.Urgent action is needed to control point source(housing,storage and processing)and diffuse(field application)pollution and improve the utilization of manure nutrients and organic matter.Here,we review strategies to improve management at each stage of the manure management chain and at different scales.Many strategies require infrastructure investment,e.g.,for containment of all manure fractions.Engineering solutions are needed to develop advanced composting systems with lower environmental footprints and design more efficient nutrient stripping technologies.At the field-scale,there is an urgent need to develop a manure nutrient recommendation system that accounts for the range of manure types,cropping systems,soils and climates throughout China.At the regional scale,coordinated planning is necessary to promote recoupling of livestock and cropping systems,and reduce nutrient accumulation in regions with little available landbank,while minimizing the risk of pollution swapping from one region to another.A range of stakeholders are needed to support the step change and innovation required to improve manure management,reduce reliance on inorganic fertilizers,and generate new business opportunities. | David R.CHADWICK John R.WILLIAMS Yuelai LU Lin MA Zhaohai BAI Yong HOU Xinping CHEN Thomas H.MISSELBROOK | 2020 | Frontiers of Agricultural Science and Engineering2020，7，1： | 4 |
| 19 | 高速公路前置指路标志设置距离及其安全影响(英文)显示文摘为弥补我国现行规范和美国MUTCD2009关于高速公路前置指路标志设置距离经验主义的缺陷,首先分析了驾驶员驶离主线驾驶行为及前置指路标志设置距离的影响因素.车道数、车道宽度、车道变换时间、驾驶员的视觉特性、标志牌的架设方式以及主线和匝道上的运行速度对出口匝道安全性有显著影响.介绍了前置指路标志的3种架设方式,即路边直立式、路上横跨数和中央架设式,并给出了各自的适用条件.然后建模计算了不同道路几何条件和交通条件下各安装方式的设置距离,3种安装方式具有相同的模型结构.最后以路上横跨式为例,TSIS-CORSIM模拟结果表明,所给模型计算的设置距离在分流鼻上游500m范围内产生的车道变换数较少,比我国的现行规范少58.93%,比MUTCD推荐值少27.35%,因而具有更好的安全性能. | 郭唐仪 邓卫 侯建生 Lu John | 2010 | Journal of Southeast University(English Edition)2010，26，4： | 3 |
| 20 | Cost-efficient Thermal Management for a 48V Li-ion Battery in a Mild Hybrid Electric Vehicle显示文摘The 48V mild hybrid system is a cost-efficient solution for original equipment manufacturers to meet increasingly stringent fuel consumption requirements.However,hybrid functions such as auto-stop/start and brake regeneration are unavailablewhen a 48V battery is at very low temperature because of its limited charge and discharge capability.Therefore,it is important to develop cost-efficient thermal management to warm-up the battery of a 48V mild hybrid electric vehicle(HEV)to recover hybrid functions quickly in cold climate.Following the model-based“V”process,we first define the requirements and then design different mechanisms to heat a 48V battery.Afterward,we build a 48V battery model in LMS AMESim and conduct co-simulation with simplified battery management system and hybrid control unit algorithms in MATLAB Simulink for analysis.Finally,we carry out a series of vehicle experiments at low temperature and observe the effect of heating to validate the design.Both simulation results and experimental data show that a cold 48V battery placed in a cabin with hot air can be heated effectively in the developed“Enhanced Generator Mode with 48V Battery”mode.The entire design is in a newly developed software that cyclically charges and discharges a 48V battery for quick warm-up in cold temperature without needing any additional hardware such as a heater,making it a cost-efficient solution for HEVs. | Chao Yu Guangji Ji Chao Zhang John Abbott Mingshen Xu Pieter Ramaekers Jianxiang Lu | 2018 | Automotive Innovation2018，1，4： | 3 |
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