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| 1 | Appendiceal mucocoeles and pseudomyxoma peritonei显示文摘Mucocoele of the appendix occurs when obstruction of the appendiceal lumen results in mucus accumulation and consequent abnormal dilatation. The most impor- tant aetiology, from a surgical perspective, is either mucinous cystadenoma or cystadenocarcinoma. In the latter, a spontaneous or iatrogenic rupture of the mucocoele can lead to mucinous intraperitoneal ascites, a syndrome known as pseudomyxoma peritonei. Optimal management of mucoceles is achieved through accurate preoperative identification and subsequent careful resection. We report two cases and subsequently discuss the clinical presentation of mucocoeles, their association with pseudomyxoma peritonei and an optimal management of both conditions. | Anupam Dixit John HP Robertson Satvinder S Mudan Charles Akle | 2007 | World Journal of Gastroenterology2007，13，16： | 14 |
| 2 | 肌萎缩性侧索硬化蛋白激活小胶质细胞NLRP3炎性小体显示文摘小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS)的SOD1G93A模型中,半胱天冬酶-1和IL-1β均促进疾病进展,提示小胶质NLRP3在该进程中发挥作用。然而先前的研究表明,SOD1G93A小鼠小胶质细胞不表达NLRP3,SOD1G93A蛋白在小胶质细胞中产生独立于NLRP3的IL-1β。本研究论证了使用Nlrp3-GFP基因敲入小鼠,在SOD1G93A小鼠中小胶质细胞表达NLRP3。本研究显示聚集和可溶性SOD1G93A均可激活小鼠原代小胶质细胞中的炎性小体,导致半胱天冬酶-1和IL-1β裂解,ASC斑点形成以及呈剂量和时间依赖性的IL-1β分泌。重要的是,SOD1G93A无法从缺乏Nlrp3的小胶质细胞或者用特异性NLRP3抑制剂MCC950预处理的小胶质细胞中诱导IL-1β分泌,从而证实NLRP3是介导SOD1诱导的小胶质细胞IL-1β分泌的关键炎症小体复合物。在TDP-43Q331K ALS小鼠模型中也观察到小胶质NLRP3上调,TDP-43野生型和突变蛋白亦可以NLRP3依赖性的方式激活小胶质炎性小体。从机制上讲,本研究确定了活性氧簇和ATP的生成是SOD1G93A介导的NLRP3激活所需的关键事件。总之,本研究的数据表明ALS小胶质细胞表达NLRP3,而病理ALS蛋白激活小胶质NLRP3炎性小体。因此,NLRP3抑制可能是阻止小胶质细胞神经炎症和ALS疾病进展的潜在治疗方法。 | Vandana Deora John D Lee Eduardo AAlbornoz Luke McAlary Cyril J Jagaraj Avril A B Robertson Julie D Atkin Matthew A Cooper Kate Schroder Justin J Yerbury Richard Gordon Trent MWoodruff 杜一星(编译) | 2020 | 神经损伤与功能重建2020，15，9： | 13 |
| 3 | ERODIBILITY CRITERION FOR AUXILIARY SPILLWAYS OF DAMS显示文摘The ability to reliably design auxiliary spillways has become a pressing requirement because of the very large number of dams involved. An empirical classification index representing the erosional resistance of the overall range of particulate, jointed, and intact earth materials is presented and correlated for a number of practical cases from Arkansas and Kansas in the United States of America and from South Africa with the specific stream power of flows observed to be associated with various degrees of erosion. The United States Department of Agriculture data base and the format in which the dare were prepared for the purposes herein, are deseribed in detail. The modes of erosion that occur in spillways are defined.Guidelines are provided for evaluating the failure status of an erosion damaged spillway that enables determination of whether the incident specific stream power exceeded, equalled, or fell below the erosional resistance of various sections of the ground profile affected. The correlation function between specific stream power and erodibility index provides the required design criterion. | Hendrik A. D. Kirsten (Steffen, Robertson, and Kirsten, Ine., Box 55291 Northlands 2116, S. Africa)John S. Moore(Natural Resources Conservation Service, USDA, Box 2890, Washington, DC 20013)Louis H. Kirsten(Civil & Structural Engineering Dept., Iscor Mini | 2000 | International Journal of Sediment Research2000，15，1： | 4 |
| 4 | Upper gastrointestinal bleeding in Scotland 2000-2010: Improved outcomes but a significant weekend effect显示文摘AIM: To assess numbers and case fatality of patients with upper gastrointestinal bleeding(UGIB),effects of deprivation and whether weekend presentation affected outcomes.METHODS: Data was obtained from Information Services Division(ISD) Scotland and National Records of Scotland(NRS) death records for a ten year period between 2000-2001 and 2009-2010. We obtained data from the ISD Scottish Morbidity Records(SMR01) database which holds data on inpatient and daycase hospital discharges from non-obstetric and nonpsychiatric hospitals in Scotland. The mortality data was obtained from NRS and linked with the ISD SMR01 database to obtain 30-d case fatality. We used 23 ICD-10(International Classification of diseases) codes which identify UGIB to interrogate database. We analysed these data for trends in number of hospital admissions with UGIB,30-d mortality over time and assessed effects of social deprivation. We compared weekend and weekday admissions for differences in 30-d mortality and length of hospital stay. We determined comorbidities for each admission to establish if comorbidities contributed to patient outcome. RESULTS: A total of 60643 Scottish residents were admitted with UGIH during January,2000 and October,2009. There was no significant change in annual number of admissions over time,but there was a statistically significant reduction in 30-d case fatality from 10.3% to 8.8%(P < 0.001) over these 10 years. Number of admissions with UGIB was higher for the patients from most deprived category(P < 0.05),although case fatality was higher for the patients from the least deprived category(P < 0.05). There was no statistically significant change in this trend between 2000/01-2009/10. Patients admitted with UGIB at weekends had higher 30-d case fatality compared with those admitted on weekdays(P < 0.001). Thirty day mortality remained significantly higher for patients admitted with UGIB at weekends after adjusting for comorbidities. Length of hospital stay was also higher overall for patients admitted at the weekend when compared to weekdays,although only reached statistical significance for the last year of study 2009/10(P < 0.0005). CONCLUSION: Despite reduction in mortality for UGIB in Scotland during 2000-2010,weekend admissions show a consistently higher mortality and greater lengths of stay compared with weekdays. | Asma Ahmed Matthew Armstrong Ishbel Robertson Allan John Morris Oliver Blatchford Adrian J Stanley | 2015 | World Journal of Gastroenterology2015，21，38： | 4 |
| 5 | A Pooled Analysis of Advanced Colorectal Neoplasia Diagnoses After Colonoscopic Polypectomy显示文摘 | María Elena Martínez John A. Baron David A. Lieberman Arthur Schatzkin Elaine Lanza Sidney J. Winawer Ann G. Zauber Ruiyun Jiang Dennis J. Ahnen John H. Bond Timothy R. Church Douglas J. Robertson Stephanie A. Smith–Warner Elizabeth T. Jacobs David S. Alb | 2009 | Gastroenterology2009，，3： | 2 |
| 6 | Metals emitted from heavy-duty diesel vehicles equipped with advanced PM and NO X emission controls显示文摘 | Shaohua Hu Jorn D. Herner Martin Shafer William Robertson James J. Schauer Harry Dwyer John Collins Tao Huai Alberto Ayala | 2009 | Atmospheric Environment2009，，18： | 2 |
| 7 | Colorectal Cancer in Patients Under Close Colonoscopic Surveillance显示文摘 | Douglas J. Robertson E. Robert Greenberg Michael Beach Robert S. Sandler Dennis Ahnen Robert W. Haile Carol A. Burke Dale C. Snover Robert S. Bresalier Gail McKeown-Eyssen Jack S. Mandel John H. Bond Rosalind U. van Stolk Robert W. Summers Richard Rothste | 2005 | Gastroenterology2005，，1： | 2 |
| 8 | Adjutant therapy in pancreatic cancer: phase Ⅰ trial of radiation dose escalation with concurrent full-dose gemcitabine显示文摘 | Aaron M Allen Mark M Zalupski John M Robertson | 2004 | Int J Radiat Oncol Biol Phys2004，59，5： | 1 |
| 9 | Airports and economic regeneration 显示文摘 | Robertson John A W | 1995 | Journal of Air Transportation Management1995，，2： | 1 |
| 10 | Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery显示文摘 | Jane W. Newburger Richard A. Jonas Janet Soul Barry D. Kussman David C. Bellinger Peter C. Laussen Richard Robertson John E. Mayer Pedro J. del Nido Emile A. Bacha Joseph M. Forbess Frank Pigula Stephen J. Roth Karen J. Visconti Adre J. du Plessis David M | 2007 | The Journal of Thoracic and Cardiovascular Surger2007，，2： | 1 |
| 11 | A Slowly Progressive and Reproducible Animal Model of Intervertebral Disc Degeneration Characterized by MRI, X-Ray, and Histology显示文摘 | Satoshi Sobajima John F. Kompel Joseph S. Kim Corey J. Wallach Douglas D. Robertson Molly T. Vogt James D. Kang Lars G. Gilbertson | 2005 | Spine2005，，： | 1 |
| 12 | Prospective study of peripheral arterial catheter infection and comparison with concurrently sited central venous catheters显示文摘 | David Boon Chai Koh John R. Gowardman Claire M. Rickard Iain K. Robertson Andrew Brown | 2008 | Critical Care Medicine2008，，2： | 1 |
| 13 | Influence of insertion site on central venous catheter colonization and bloodstream infection rates显示文摘 | John R. Gowardman Iain K. Robertson Scott Parkes Claire M. Rickard | 2008 | Intensive Care Medicine2008，，6： | 1 |
| 14 | Raman spectroscopy of amorphous, nanostructured, diamond–like carbon, and nanodiamond显示文摘 | Ferrari Andrea Carlo Robertson John | 2004 | 2004 (1824)2004，，1824： | 1 |
| 15 | Establishment and operation of a Good Manufacturing Practice‐compliant allogeneic Epstein‐Barr virus ( EBV )‐specific cytotoxic cell bank for the treatment of EBV ‐associated lymphoproliferative disease显示文摘 | Mark A. Vickers Gwen M. Wilkie Nicolas Robinson Nadja Rivera Tanzina Haque Dorothy H. Crawford Jacqueline Barry Neil Fraser David M. Turner Victoria Robertson Phil Dyer Peter Flanagan Helen R. Newlands John Campbell Marc L. Turner | 2014 | Br J Haematol2014，，： | 1 |
| 16 | Blindness after Reduction of Facial Fractures显示文摘 | John A. Girotto William Bryan Gamble Bradley Robertson Rick Redett Thomas Muehlberger Mike Mayer James Zinreich Nicholas Iliff Neil Miller Paul N. Manson | 1998 | Plastic & Reconstructive Surgery1998，，6： | 1 |
| 17 | Review: nuclear events in apoptosis显示文摘 | Robertson J D John D R Orrenius S B | 2000 | J Struct Biol2000，129，23： | 1 |
| 18 | Lessons Learned From More Than 1,000 Pancreas Transplants at a Single Institution显示文摘 | David E. R. Sutherland Rainer W. G. Gruessner David L. Dunn Arthur J. Matas Abhinav Humar Raja Kandaswamy S. Michael Mauer William R. Kennedy Frederick C. Goetz R. Paul Robertson Angelika C. Gruessner John S. Najarian | 2001 | Annals of Surgery2001，，4： | 1 |
| 19 | Properties and prospects for non-crystalline carbons显示文摘 | John Robertson | 2002 | Journal of Non-Crystalline Solids2002，，： | 1 |
| 20 | Neither Long-Term Statin Use nor Atherosclerotic Disease Is Associated With Risk of Colorectal Cancer显示文摘 | Douglas J. Robertson Anders Hammerich Riis S?ren Friis Lars Pedersen John A. Baron Henrik Toft S?rensen | 2010 | Clinical Gastroenterology and Hepatology2010，，12： | 1 |
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