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| 1 | Hepatic steatosis is associated with an increased risk of carotid atherosclerosis显示文摘AIM: Although an association between helatic steatosis and vascular risk factors has been described, direct relationships between fatty liver and atherosclerosis have not yet been investigated. The aim of the present study has been to investigate those relationships.METHODS: The Study of Health in Pomerania examined a random population sample aged between 20 and 79 years.A study population of 4 222 subjects without hepatitis B and C infections and without liver cirrhosis was available for the present analysis. Hepatic steatosis was defined sonographically and intima-media thickness (IMT) as well as plaque prevalence were estimated by carotid ultrasound.RESULTS: The prevalence rate of hepatic steatosis was 29.9%. Among subjects aged ≥45 years, an association between hepatic steatosis and IMT of the carotid arteries was found in bivariate analysis, but not after adjustment for atherosclerotic risk factors. Individuals with fatty liver had more often carotid plaques than persons without fatty liver (plaque prevalence rate 76.8% vs 66.6%; P<0.001).This association persisted after adjustment for confounding factors and was predominantly present in subjects with no to mild alcohol consumption.CONCLUSION: There is an independent association between hepatic steatosis and carotid atherosclerotic plaques. Metabolic changes due to nonalcoholic fatty liver disease may explain this relationship. | Henry V(o|¨)lzke Daniel M.Robinson Volker Kleine Roland Deutscher Wolfgang Hoffmann Jan Lüdemann Ulf Schminke Christof Kessler Ulrich John | 2005 | World Journal of Gastroenterology2005，11，12： | 29 |
| 2 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 3 | 提高母猪妊娠后期和哺乳期日粮能量浓度对其生产性能、仔猪活力和后代终生生长的影响(下)显示文摘人们对高产母猪的选育,导致每窝活产仔数显著增加,但是随之而来的仔猪活力和生长性能会因此降低。为了增强仔猪活力和提高生长性能,提高母猪哺乳期能量摄入越来越重要。研究旨在探索提高哺乳期母猪日粮能量(DE)浓度对母猪体重、背膘厚、乳成分及其后代仔猪活力和生长的影响。在妊娠108 d时将妊娠母猪(N=100;大白×长白)随机分配饲喂4种能量浓度日粮(消化能,DE,MJ/kg)直到再次配种:13.8(LL)、14.5(L)、15.2(H)、15.9(HH)。所有日粮均含有1.2%总赖氨酸。妊娠108 d和断奶(哺乳期第26天)时采集血样,哺乳期采集初乳(0 d)和常乳(14 d)。每天记录母猪哺乳期采食量。仔猪出生时记录每窝(总活)产仔数、仔猪初生重、宫内生长受限(IUGR)特征和肌张力。在出生时和出生后24 h记录仔猪鼓膜耳温(TEMP)。在后代猪第1、6、14、26、33、40、54、75和141日龄时称重。后代猪于断奶后(PW)饲喂标准谷物基础日粮。后代猪屠宰时(141日龄)记录胴体数据。HH母猪的哺乳期消化能摄入高于其他处理组(P<0.01)。初乳和常乳成分以及哺乳期采食量不受日粮处理影响。各处理组间的每窝产仔猪数和仔猪初生重相近。与其他处理组相比,LL母猪的后代表现出更多的IUGR特征(P<0.01),而HH母猪的后代表现出更好的肌张力(P<0.01)。与HH母猪的后代仔猪相比,LL母猪(P<0.01)和H母猪(P<0.01)的后代具有更高的24 h TEMP。H母猪断奶仔猪数高于L母猪(P<0.05)和HH母猪(P<0.01),而L母猪断奶仔猪窝重低于H母猪(P<0.05)和LL母猪(P<0.05)。断奶后仔猪生长不受日粮各处理影响。高DE日粮提高母猪能量摄入水平,但并不抑制食欲。饲喂HH日粮提高了仔猪出生时肌张力,而饲喂H日粮提高每窝断奶仔猪数。此次研究观察到仔猪活力的其他特征和断奶前窝生长性能结果互相矛盾。 | 何颖(编译) Rooney H B O’driscoll Keelin O’doherty John V | 2020 | 猪业科学2020，37，9： | 5 |
| 4 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 5 | COX-derived prostanoid pathways in gastrointestinal cancer development and progression: novel targets for prevention and intervention 显示文摘 | Mary C C Kenneth J O John V R | 2012 | Biochim Biophys Acta2012，1825，1： | 1 |
| 6 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 7 | In vitro analysis of cotton pollen germination显示文摘 | John J B Jeff V Mekvub J O | 2004 | Agron J2004，96，： | 1 |
| 8 | A dog' s got personality:Across-species comparative approach to personality judgments in dogs and humans显示文摘 | Gosling S D Kwan V S John O P | | 0，，06： | 1 |
| 9 | Contracting processes and structures for systems of-systems acquisition显示文摘 | Rene G R Thomas V H John S O | 2012 | Systems Engi- neering2012，15，4： | 1 |
| 10 | In vitro analysis of cotton pollen germination显示文摘 | John J B Jeff V Melvin J O | 2004 | Agron J2004，96，： | 1 |
| 11 | In vitro analysis of cotton pollen germination 显示文摘 | John J B Jeff V Melvin J O | 2004 | Agronomy Journal2004，96，： | 1 |
| 12 | Essential iris atrophy, pigment dispersion, and glaucoma in DBA/J mice显示文摘 | John S W Smith R S Savinora O V | 1998 | Invest Ophthalmol Vis Sci1998，39，6： | 1 |
| 13 | Conceptu- alizing and Assessing Self-Enhancement Bias:A Compo- nential Approach 显示文摘 | V S Y Kwan O P John R W Robins L L Kuang | 2008 | Journal of Personality and Social Psy- chology2008，94，6： | 1 |
| 14 | In vitro analysis of cotton pollen germination 显示文摘 | John J B Jeff V Melvin J O | 2004 | Agronomy Journal2004，96，： | 1 |
| 15 | Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group(RCWG)显示文摘 | Matthijnssens J Ciarlet M McDonald S M Attoui H Banyai K Brister J R Buesa J Esona M D Estes M K Gentsch J R Iturriza-Gomara M Johne R Kirkwood C D Martella V Mertens P P Nakagomi O Parre ? o V Rahman M Ruggeri F M Saif L J Santos N Steyer A Taniguchi K Patton J T Desselherger U Van Ranst M | 2011 | Arch Virol2011，156，8： | 1 |
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| 17 | ACC/AHA 2002 guideline update for the management of patients with chronic stable angina—summary article显示文摘 | Raymond J Gibbons Jonathan Abrams Kanu Chatterjee Jennifer Daley Prakash C Deedwania John S Douglas T.Bruce Ferguson Stephan D Fihn Theodore D Fraker Julius M Gardin Robert A O’Rourke Richard C Pasternak Sankey V Williams Raymond J Gibbons Joseph S Alpert | 2003 | Journal of the American College of Cardiology2003，，1： | 1 |
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