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| 1 | Irsogladine maleate and rabeprazole in non-erosive reflux disease: A double-blind, placebo-controlled study显示文摘AIM:To evaluate the efficacy of adding irsogladine maleate(IM) to proton-pump inhibitor(PPI) therapy in non-erosive reflux disease(NERD) treatment.METHODS:One hundred patients with NERD were recruited and randomized to receive rabeprazole plus IM(group I) or rabeprazole plus placebo(group P).The efficacy of the treatment was assessed using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease(FSSG) and the short form(SF)-36 quality of life questionnaires after four weeks of treatment.We also assessed whether patients with NERD with minimal changes(grade M) had different responses to the therapies compared with patients who did not have minimal changes(grade N).RESULTS:Group I and group P showed significant improvements in their FSSG scores after the treatment(from 17.9 ± 7.9 to 9.0 ± 7.6, and from 17.7 ± 7.3 to 11.2 ± 7.9, respectively, P = 0.0001), but there was no statistically significant difference between the FSSG scores in group I and those in group P.Subgroup analysis showed that significant improvements in the FSSG scores occurred in the patients in group I who had NERD grade N(modified Los Angeles classification)(7.8 ± 7.4 vs 12.5 ± 9.8, P = 0.041).The SF-36 scores for patients with NERD grade N who had received IM and rabeprazole were significantly improved in relation to their vitality and mental health scores.CONCLUSION:The addition of IM to rabeprazole significantly improves gastroesophageal reflux diseasesymptoms and the quality of the lives of patients with NERD grade N. | Takayoshi Suzuki Masashi Matsushima Aya Masui Shingo Tsuda Jin Imai Jun Nakamura Yoko Tsukune Tetsufumi Uchida Hiroki Yuhara Muneki Igarashi Jun Koike Tetsuya Mine | 2015 | World Journal of Gastroenterology2015，21，16： | 8 |
| 2 | Advanced start up of UASB reactors by adding of water absorbing polymer 显示文摘 | IMAI T UKITA M LIU Jun | 1997 | Water Science Technol1997，36，67： | 1 |
| 3 | Advanted start up of UASB reactors by adding of water absorbing polymer显示文摘 | Imai Tsuyashi Ukita Masac Liu Jun | 1997 | Water Science and Technology1997，36，67： | 1 |
| 4 | Agent Based Material Transfer Scheduling in SteelWorks 显示文摘 | Junji Kikuchi Masarni Konishi Jun Imai | 2007 | IEEE2007，，： | 1 |
| 5 | Pyrethroid insecticide exposure and semen quality of young Japanese men显示文摘 | Kanako Imai Jun Yoshinaga Mitsuha Yoshikane Hiroaki Shiraishi Makiko Naka Mieno Miki Yoshiike Shiari Nozawa Teruaki Iwamoto | 2014 | Reproductive Toxicology2014，，： | 1 |
| 6 | Advanted start up of UASB reactors by adding of water absorbing polymer显示文摘 | Imai Tsuyoshi Ukita Masao Liu Jun | 1997 | Water Science and Technology1997，36，67： | 1 |
| 7 | Effect of gas pressure on tribological properties and tribochemical reactions of alumina sliding against zirconia in HFC-134a显示文摘 | CONG Peihong IMAI Jun SHIGEYUKI Mori | 2001 | Wear2001，249，： | 1 |
| 8 | Advanted start up of UASB reactors by adding of water absorbing polymer显示文摘 | Imai Tsuyoshi Ukita Masao Liu Jun | 1997 | Water Science and Technology1997，36，67： | 1 |
| 9 | XPS analysis of p-type Cu-doped CdS thin films显示文摘 | Takashi Abe Yasube Kashiwaba Mamoru Baba Jun Imai Hideyuki Sasaki | 2001 | Applied Surface Science2001，，： | 1 |
| 10 | Probably cor- rect k - nearest neighbor search in high dimensions 显示文摘 | Jun Toyama Mineichi Kudo Hideyuki Imai | 2010 | PatternRecognition2010，43，： | 1 |
| 11 | Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance显示文摘 | Jun Yoshino Caterina Conte Luigi Fontana Bettina Mittendorfer Shin-ichiro Imai Kenneth B. Schechtman Charles Gu Iris Kunz Filippo Rossi Fanelli Bruce W. Patterson Samuel Klein | 2012 | Cell Metabolism2012，，5： | 1 |
| 12 | Tomoki Yano Characterization of immunoglobulin light chain isotypes in the common carp显示文摘 | Mitsura Tomana Jun Ishikawa Etsuou Imai Tadaaki Moritomo Mike Nakao | 2002 | Immunogenetics2002，，54： | 1 |
| 13 | Nicotinamide Mononucleotide, a Key NAD + Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice显示文摘 | Jun Yoshino Kathryn F. Mills Myeong Jin Yoon Shin-ichiro Imai | 2011 | Cell Metabolism2011，，4： | 1 |
| 14 | Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts显示文摘 | Takashi Nakamura Yuuki Imai Takahiro Matsumoto Shingo Sato Kazusane Takeuchi Katsuhide Igarashi Yoshifumi Harada Yoshiaki Azuma Andree Krust Yoko Yamamoto Hiroshi Nishina Shu Takeda Hiroshi Takayanagi Daniel Metzger Jun Kanno Kunio Takaoka T. John Martin | 2007 | Cell2007，，5： | 1 |
| 15 | Nicotinamide Mononucleotide, a Key NAD + Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice显示文摘 | Jun Yoshino Kathryn F. Mills Myeong Jin Yoon Shin-ichiro Imai | 2011 | Cell Metabolism2011，，4： | 1 |
| 16 | Mouse-Musashi-1, a Neural RNA-Binding Protein Highly Enriched in the Mammalian CNS Stem Cell显示文摘 | Shin-ichi Sakakibara Takao Imai Kayoko Hamaguchi Masataka Okabe Jun Aruga Kazunori Nakajima Daisuke Yasutomi Takashi Nagata Yasuyuki Kurihara Seiichi Uesugi Takaki Miyata Masaharu Ogawa Katsuhiko Mikoshiba Hideyuki Okano | 1996 | Developmental Biology1996，，2： | 1 |
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