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| 1 | Branched-chain amino acid treatment before transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘AIM:To examine the significance of branched-chain amino acid (BCAA) treatment before transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).METHODS:This study included 99 patients who underwent TACE therapy for HCC at our hospital and were followed up without treatment for at least 6 mo between January 2004 and January 2010.They were divided into 2 groups:those receiving BCAA granules (n=40) or regular diet (n=59,control).Data obtained were retrospectively analyzed (prior to TACE,and 1 wk,1,3,and 6 mo after TACE) in terms of nutritional condition and clinical laboratory parameters (serum albumin level and Child-Pugh score),both of which are determinants of hepatic functional reserve.RESULTS:The BCAA group comprised 27 males and 13 females with a mean age of 69.9 ± 8.8 years.The patients of the BCAA group were classified as follows:Child-Pugh A/B/C in 22/15/3 patients,and Stage Ⅱ/Ⅲ /ⅣA HCC in 12/23/5 patients,respectively.The controlgroup comprised 32 males and 27 females with a mean age of 73.2 ± 10.1 years.In the control group,9 patients had chronic hepatitis,Child-Pugh A/B/C in 39/10/1 patients,and StageⅠ/Ⅱ/Ⅲ/ⅣA HCC in 1/11/35/12 patients,respectively.Overall,both serum albumin level and Child-Pugh score improved significantly in the BCAA group as compared with the control 3 and 6 mo after TACE (P < 0.05).Further analysis was performed by the following categorization:(1) child-Pugh classification;(2) liver cirrhosis subgroup with a serum albumin level > 3.5 g/dL;and (3) epirubicin dose.A similar trend indicating a significant improvement of all variables in the BCAA group was noted (P < 0.05).CONCLUSION:Treatment with BCAA granules in patients who have undergone TACE for HCC is considered useful to maintain their hepatic functional reserve. | Hiroki Nishikawa Yukio Osaki Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Shinichiro Henmi Azusa Sakamoto Tetsuro Ishikawa Sumio Saito Ryuichi Kita Toru Kimura | 2012 | World Journal of Gastroenterology2012，18，12： | 16 |
| 2 | Long-term prognostic impact of circulating tumour cells in gastric cancer patients显示文摘AIM To analyse the long-term prognostic impact of circulating tumour cells(CTCs) in gastric cancer patients who underwent surgery. METHODS A 7.5-m L peripheral vein blood sample was obtained from each patient with treatment-negative gastric adenocarcinoma before surgery. OBP-401, a telomerasespecific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein gene, was used to label CTCs. Correlations between the number of CTCs and clinical end points were evaluated. RESULTS The median follow-up period of the surviving patients with gastric cancer was 60 mo. The CTC number tended to increase concomitantly with disease progression. The overall survival of patients with more than five CTCs in 7.5-m L of peripheral blood was lower than that of patients with five or less CTCs, although the difference was not significant(P = 0.183). A significant difference in relapse-free survival was found between patients with more than five and those with five or less CTCs(P = 0.034).CONCLUSION A lower number of CTCs was correlated with higher relapse-free survival rates in patients. Detection of CTCs using OBP-401 may be useful for predicting prognosis in gastric cancer. | Hiroaki Ito Jun Sato Yukio Tsujino Noriko Yamaguchi Satoshi Kimura Keigo Gohda Katsuhiro Murakami Manabu Onimaru Tohru Ohmori Fumihiro Ishikawa Haruhiro Inoue | 2016 | World Journal of Gastroenterology2016，22，46： | 8 |
| 3 | CO_2 insufflation for potentially diffi cult colonoscopies: Effi cacy when used by less experienced colonoscopists显示文摘AIM: To clarify the effectiveness of CO2 insufflation in potentially difficult colonoscopy cases, particularly in relation to the experience level of colonoscopists.METHODS: One hundred twenty potentially difficult cases were included in this study, which involved females with a low body mass index and patients with earlier abdominal and/or pelvic open surgery or previously diagnosed left-side colon diverticulosis. Patients receiving colonoscopy examinations without sedation using a pediatric variable-stiffness colonoscope were divided into two groups based on either CO2 or standard air insufflation. Both insufflation procedures were also evaluated according to the experience level of the respective colonoscopists who were divided into an experienced colonoscopist (EC) group and a less experienced colonoscopist (LEC) group. Study measurements included a 100-mm visual analogue scale (VAS) for patient pain during and after colonoscopyexaminations, in addition to insertion to the cecum and withdrawal times.RESULTS: Examination times did not differ, however, VAS scores in the CO2 group were signifi cantly better than in the air group (P < 0.001, two-way ANOVA) from immediately after the procedure and up to 2 h later. There were no significant differences between either insufflation method in the EC group (P = 0.29), however, VAS scores for CO2 insufflation were significantly better than air insufflation in the LEC group (P = 0.023) immediately after colonoscopies and up to 4 h afterwards.CONCLUSION: CO2 insufflation reduced patient pain after colonoscopy in potentially difficult cases when performed by LECs. | Toshio Uraoka Jun Kato Motoaki Kuriyama Keisuke Hori Shin Ishikawa Keita Harada Koji Takemoto Sakiko Hiraoka Hideyuki Fujita Joichiro Horii Yutaka Saito Kazuhide Yamamoto | 2009 | World Journal of Gastroenterology2009，15，41： | 5 |
| 4 | Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis显示文摘 | Mitsuhiro Yokoyama Hideki Origasa Masunori Matsuzaki Yuji Matsuzawa Yasushi Saito Yuichi Ishikawa Shinichi Oikawa Jun Sasaki Hitoshi Hishida Hiroshige Itakura Toru Kita Akira Kitabatake Noriaki Nakaya Toshiie Sakata Kazuyuki Shimada Kunio Shirato | 2007 | The Lancet2007，，9567： | 2 |
| 5 | Axillary lymph node dissection can be avoided in women with breast cancer with intraoperative, false-negative sentinel lymph node biopsies显示文摘 | Hiroyuki Takei Masafumi Kurosumi Takashi Yoshida Yuko Ishikawa Yuji Hayashi Jun Ninomiya Katsunori Tozuka Hanako Oba Kenichi Inoue Shigenori Nagai Yoshihiro Saito Tomoko Kazumoto Jun-ichi Saitoh Toshio Tabei | 2010 | Breast Cancer2010，，1： | 2 |
| 6 | Correlation of 18F-FLT and 18F-FDG uptake on PET with Ki-67 immunohistochemistry in non-small cell lung cancer显示文摘 | Yuka Yamamoto Yoshihiro Nishiyama Shinya Ishikawa Jun Nakano Sung Soo Chang Shuji Bandoh Nobuhiro Kanaji Reiji Haba Yoshio Kushida Motoomi Ohkawa | 2007 | European Journal of Nuclear Medicine and Molecular Imaging2007，，10： | 1 |
| 7 | Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensa-Lisms 显示文摘 | KENJI Ueda ATSUSHI Yamashita JUN Ishikawa | 2004 | Nucleic Acids Research2004，32，16： | 1 |
| 8 | Ajimi and Shigeo Toya Abnormal muscle response (lateral spread) and F-wave in patients with hemifacial spasm显示文摘 | Mami Ishikawa Takayuki Ohira Jun Namiki | | 0，，： | 1 |
| 9 | Usefulness of PCR-restriction fragment length polymorphism typing of the coagulase gene to discriminate Arbekacin-resistant methicillin- resistant Staphylococcus aureus strains 显示文摘 | Keiko Ishino Naofumi Tsuchizaki Jun Ishikawa | 2007 | Journal of Clinical Microbiology2007，45，2： | 1 |
| 10 | Simple and Accurate Electrocardiographic Criteria to Differentiate Takotsubo Cardiomyopathy From Anterior Acute Myocardial Infarction显示文摘 | Masami Kosuge Toshiaki Ebina Kiyoshi Hibi Satoshi Morita Jun Okuda Noriaki Iwahashi Kengo Tsukahara Tatsuya Nakachi Masayoshi Kiyokuni Toshiyuki Ishikawa Satoshi Umemura Kazuo Kimura | 2010 | Journal of the American College of Cardiology2010，，： | 1 |
| 11 | Health‐related quality of life after carbon‐ion radiotherapy for prostate cancer: A 3‐year prospective study显示文摘 | Hiroyuki Katoh Hiroshi Tsuji Hitoshi Ishikawa Tadashi Kamada Masaru Wakatsuki Naoki Hirasawa Hiroyoshi Suzuki Koichiro Akakura Takashi Nakano Jun Shimazaki Hirohiko Tsujii | 2014 | Int J Urol2014，，： | 1 |
| 12 | The Effect of Long-term Supplementation With Branched-chain Amino Acid Granules in Patients With Hepatitis C Virus-related Hepatocellular Carcinoma After Radiofrequency Thermal Ablation显示文摘 | Hiroki Nishikawa Yukio Osaki Eriko Iguchi Yorimitsu Koshikawa Soichiro Ako Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Azusa Sakamoto Shinichiro Henmi Keiichi Hatamaru Tetsuro Ishikawa Sumio Saito Akihiro Nasu Ryuichi Kita Toru Kimura | 2013 | Journal of Clinical Gastroenterology2013，，4： | 1 |
| 13 | Seamounts, New Moon and eel Spawning: The Search for the Spawning Site of the Japanese eel显示文摘 | Katsumi Tsukamoto Tsuguo Otake Noritaka Mochioka Tae-Won Lee Hans Fricke Tadashi Inagaki Jun Aoyama Satoshi Ishikawa Shingo Kimura Michael J. Miller Hiroshi Hasumoto Machiko Oya Yuzuru Suzuki | 2003 | Environmental Biology of Fishes2003，，3： | 1 |
| 14 | Leadership and Performance in Japanese R&D Teams 显示文摘 | Jun Ishikawa | 2012 | Asia Pacific Business Review2012，18，2： | 1 |
| 15 | Simple and Accurate Electrocardiographic Criteria to Differentiate Takotsubo Cardiomyopathy From Anterior Acute Myocardial Infarction显示文摘 | Masami Kosuge Toshiaki Ebina Kiyoshi Hibi Satoshi Morita Jun Okuda Noriaki Iwahashi Kengo Tsukahara Tatsuya Nakachi Masayoshi Kiyokuni Toshiyuki Ishikawa Satoshi Umemura Kazuo Kimura | 2010 | Journal of the American College of Cardiology2010，，22： | 1 |
| 16 | Utility of EUS: Elastography in the Diagnosis of Pancreatic Diseases显示文摘 | Yoshiki Hirooka Akihiro Itoh Senju Hashimoto Hiroki Kawashima Kazuo Hara Akira Kanamori Hiroki Uchida Jun Goto Shigeto Ishikawa Naoki Ohmiya Yasumasa Niwa Hidemi Goto | 2005 | Gastrointestinal Endoscopy2005，，5： | 1 |
| 17 | A Phase I/II study of nilotinib in Japanese patients with imatinib-resistant or -intolerant Ph+ CML or relapsed/refractory Ph+ ALL显示文摘 | Arinobu Tojo Kensuke Usuki Akio Urabe Yasuhiro Maeda Yukio Kobayashi Itsuro Jinnai Kazuma Ohyashiki Miki Nishimura Tatsuya Kawaguchi Hideo Tanaka Koichi Miyamura Yasushi Miyazaki Timothy Hughes Susan Branford Shinichiro Okamoto Jun Ishikawa Masaya Okada N | 2009 | International Journal of Hematology2009，，5： | 1 |
| 18 | A Mobile Robot for Inspection of Power Transmission Lines显示文摘 | Jun Sawada Kazuyuki Kusumoto Tadashi Munakata Yasuhisa Maikawa Yoshinobu Ishikawa | 1991 | IEEE Transactions on Power Delivery1991，6，1： | 1 |
| 19 | Frequency Control System with Digital Signal Processing Techniques显示文摘 | Iku Hirano Jun Ishikawa | 2012 | Journal of Energy and Power Engineering2012，6，2： | 1 |
| 20 | Enhanced expression of naofen in kidney of streptozotocin-induced diabetic rats: possible correlation to apoptosis of tubular epithelial cells显示文摘 | Yuko Sato Guo-Gang Feng Lei Huang Jun-Hua Fan Chang Li Jun An Koji Tsunekawa Shuji Kurokawa Yoshihiro Fujiwara Toru Komatsu Fumio Kondo Naohisa Ishikawa | 2010 | Clinical and Experimental Nephrology2010，，3： | 1 |
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