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| 1 | A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone显示文摘Transforming growth factor-β(TGF-β)and bone morphogenetic protein(BMP)play important roles in bone metabolism.Smad ubiquitination regulatory factors(Smurfs)regulate TGF-β/BMP signaling via ubiquitination,resulting in degradation of signaling molecules to prevent excessive activation of TGF-β/BMP signaling.Though Smurf2 has been shown to negatively regulate TGF-β/Smad signaling,its involvement in BMP/Smad signaling in bone metabolism has not been thoroughly investigated.In the present study,we sought to evaluate the role of Smurf2 in BMP/Smad signaling in bone metabolism.Absorbable collagen sponges containing 3μg of recombinant human BMP2(rhBMP2)were implanted in the dorsal muscle pouches of wild type(WT)and Smurf2−/−mice.The rhBMP2-induced ectopic bone in Smurf2−/−mice showed greater bone mass,higher mineral apposition and bone formation rates,and greater osteoblast numbers than the ectopic bone in WT mice.In WT mice,the ectopic bone consisted of a thin discontinuous outer cortical shell and scant inner trabecular bone.In contrast,in Smurf2−/−mice,the induced bone consisted of a thick,continuous outer cortical shell and abundant inner trabecular bone.Additionally,rhBMP2-stimulated bone marrow stromal cells(BMSCs)from Smurf2−/−mice showed increased osteogenic differentiation.Smurf2 induced the ubiquitination of Smad1/5.BMP/Smad signaling was enhanced in Smurf2−/−BMSCs stimulated with rhBMP2,and the inhibition of BMP/Smad signaling suppressed osteogenic differentiation of these BMSCs.These findings demonstrate that Smurf2 negatively regulates BMP/Smad signaling,thereby identifying a new regulatory mechanism in bone metabolism. | Junichi Kushioka Takashi Kaito Rintaro Okada Hiroyuki Ishiguro Zeynep Bal Joe Kodama Ryota Chijimatsu Melanie Pye Masahiro Narimatsu Jeffrey LWrana Yasumichi Inoue Hiroko Ninomiya Shin Yamamoto Takashi Saitou Hideki Yoshikawa Takeshi Imamura | 2020 | Bone Research2020，8，4： | 6 |
| 2 | Risk factors of post‐operative recurrence and adequate surgical approach to improve long‐term outcomes of hepatocellular carcinoma显示文摘 | Junichi Shindoh Kiyoshi Hasegawa Yosuke Inoue Takeaki Ishizawa Rihito Nagata Taku Aoki Yoshihiro Sakamoto Yasuhiko Sugawara Masatoshi Makuuchi Norihiro Kokudo | 2012 | HPB2012，，1： | 2 |
| 3 | Novel hexagonal structure and ultrahigh strength of magnesium solid solution in the Mg–Zn–Y system显示文摘 | Akihisa Inoue Yoshihito Kawamura Mitsuhide Matsushita Kentaro Hayashi Junichi Koike | 2001 | Journal of Materials Research2001，，7： | 2 |
| 4 | Targeted gene expression using the GAL4/UAS system in the silkworm Bombyx mori显示文摘 | MORIKAZU IMAMURA JUNICHI NAKAI SATOSHI INOUE | 2003 | Genetics2003，165，： | 1 |
| 5 | Usefulness of Contrast-Enhanced Intraoperative Ultrasound in Identifying Disappearing Liver Metastases from Colorectal Carcinoma After Chemotherapy显示文摘 | Junichi Arita Yoshihiro Ono Michiro Takahashi Yosuke Inoue Yu Takahashi Akio Saiura | 2014 | Annals of Surgical Oncology2014，，3： | 1 |
| 6 | Innovations in ERW mechanical steel pipe design with automobile applications显示文摘 | Junichi Tamaki Saburo Inoue Miyuki Yamamoto | 1996 | The Sumitomo Seach1996，，58： | 1 |
| 7 | Intra-operative freehand real-time elastography for small focal liver lesions: “Visual palpation” for non-palpable tumors显示文摘 | Yosuke Inoue Michiro Takahashi Junichi Arita Taku Aoki Kiyoshi Hasegawa Yoshifumi Beck Masatoshi Makuuchi Norihiro Kokudo | 2010 | Surgery2010，，5： | 1 |
| 8 | Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats显示文摘 | Nao Inoue Koji Nagao Junichi Hirata | 2004 | Biochemical and Biophysical Communications2004，323，： | 1 |
| 9 | Fabrication and mechanical properties of carbon nanotube yarns spun from ultra-long multi-walled carbon nanotube arrays显示文摘 | Adrian Ghemes Yoshitaka Minami Junichi Muramatsu Morihiro Okada Hidenori Mimura Yoku Inoue | 2012 | Carbon2012，，12： | 1 |
| 10 | Decreasing trends of suspended particulate matter and PM2.5 concentrations in Tokyo, 1990–2010显示文摘 | Kunio Hara Junichi Homma Kenji Tamura Mariko Inoue Kanae Karita Eiji Yano | 2013 | Journal of the Air & Waste Management Association2013，，6： | 1 |
| 11 | Assessment of Gait in a Rat Model of Myofascial Inflammation Using the CatWalk System显示文摘 | Masayuki Miyagi Tetsuhiro Ishikawa Hiroto Kamoda Sumihisa Orita Kazuki Kuniyoshi Nobuyasu Ochiai Shunji Kishida Junichi Nakamura Yawara Eguchi Gen Arai Miyako Suzuki Yasuchika Aoki Tomoaki Toyone Kazuhisa Takahashi Gen Inoue Seiji Ohtori | 2011 | Spine2011，，21： | 1 |
| 12 | Expression of Lewis-related antigen and prognosis in stag I non-small cell lung cancer显示文摘 | Junichi O Sano A Inoue H | 1995 | Ann Thorac Surg1995，59，2： | 1 |
| 13 | Low-fire microwave dielectric ceramics and multilayer devices with silver internal electrode显示文摘 | TATSUYA Inoue JUNICHI Kato | 1993 | Ceram Trans1993，32，： | 1 |
| 14 | Degeneration and recovery of the neuromuscular junction after application of extracorporeal shock wave therapy显示文摘 | Tomonori Kenmoku Nobuyasu Ochiai Seiji Ohtori Takashi Saisu Takahisa Sasho Koichi Nakagawa Nahoko Iwakura Masayuki Miyagi Tetsuhiro Ishikawa Hodumi Tatsuoka Gen Inoue Junichi Nakamura Shunji Kishida Atsushi Saito Kazuhisa Takahashi | 2012 | J. Orthop. Res2012，，10： | 1 |
| 15 | Operative Results of Canal-Expansive Laminoplasty for Cervical Spondylotic Myelopathy in Elderly Patients显示文摘 | Junichi Tanaka Naoki Seki Fumiaki Tokimura Koichi Doi Shigeru Inoue | 1999 | Spine1999，，22： | 1 |
| 16 | Computed Tomographic Angiography Characteristics of Atherosclerotic Plaques Subsequently Resulting in Acute Coronary Syndrome显示文摘 | Sadako Motoyama Masayoshi Sarai Hiroto Harigaya Hirofumi Anno Kaori Inoue Tomonori Hara Hiroyuki Naruse Junichi Ishii Hitoshi Hishida Nathan D. Wong Renu Virmani Takeshi Kondo Yukio Ozaki Jagat Narula | 2009 | Journal of the American College of Cardiology2009，，1： | 1 |
| 17 | Risk factors of post‐operative recurrence and adequate surgical approach to improve long‐term outcomes of hepatocellular carcinoma显示文摘 | Junichi Shindoh Kiyoshi Hasegawa Yosuke Inoue Takeaki Ishizawa Rihito Nagata Taku Aoki Yoshihiro Sakamoto Yasuhiko Sugawara Masatoshi Makuuchi Norihiro Kokudo | 2012 | HPB2012，，1： | 1 |
| 18 | Multislice Computed Tomographic Characteristics of Coronary Lesions in Acute Coronary Syndromes显示文摘 | Sadako Motoyama Takeshi Kondo Masayoshi Sarai Atsushi Sugiura Hiroto Harigaya Takahisa Sato Kaori Inoue Masanori Okumura Junichi Ishii Hirofumi Anno Renu Virmani Yukio Ozaki Hitoshi Hishida Jagat Narula | 2007 | Journal of the American College of Cardiology2007，，4： | 1 |
| 19 | Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats显示文摘 | Nao Inoue Koji Nagao Junichi Hirata | 2004 | Biochemical and Biophysical Communications2004，323，： | 1 |
| 20 | Usefulness of 123I-metaiodobenzylguanidine myocardial scintigraphy for predicting the effectiveness of β-blockers in patients with dilated cardiomyopathy from the standpoint of long-term prognosis显示文摘 | Shinichiro Fujimoto Aritomo Inoue Shinji Hisatake Shohei Yamashina Hisayo Yamashina Hajime Nakano Junichi Yamazaki | 2004 | European Journal of Nuclear Medicine and Molecular Imaging2004，，10： | 1 |
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