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| 1 | Macrophage-derived IL-1α promotes sterile inflammation in a mouse model of acetaminophen hepatotoxicity显示文摘The metabolic intermediate of acetaminophen(APAP)can cause severe hepatocyte necrosis,which triggers aberrant immune activation of liver non-parenchymal cells(NPC).Overzealous hepatic inflammation determines the morbidity and mortality of APAP-induced liver injury(AILI).Interleukin-1 receptor(IL-1R)signaling has been shown to play a critical role in various inflammatory conditions,but its precise role and underlying mechanism in AILI remain debatable.Herein,we show that NLRP3 inflammasome activation of IL-1βis dispensable to AILI,whereas IL-1α,the other ligand of IL-1R1,accounts for hepatic injury by a lethal dose of APAP.Furthermore,Kupffer cells function as a major source of activated IL-1αin the liver,which is activated by damaged hepatocytes through TLR4/MyD88 signaling.Finally,IL-1αis able to chemoattract and activate CD11b^(+)Gr-1^(+) myeloid cells,mostly neutrophils and inflammatory monocytes,to amplify deteriorated inflammation in the lesion.Therefore,this work identifies that MyD88-dependent activation of IL-1αin Kupffer cells plays a central role in the immunopathogenesis of AILI and implicates that IL-1αis a promising therapeutic target for AILI treatment. | Chao Zhang Jin Feng Jun Du Zhiyong Zhuo Shuo Yang Weihong Zhang Weihong Wang Shengyuan Zhang Yoichiro Iwakura Guangxun Meng Yang-Xin Fu Baidong Hou Hong Tang | 2018 | Cellular & Molecular Immunology2018，15，11： | 7 |
| 2 | Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis显示文摘 | Ana Izcue Sophie Hue Sofia Buonocore Carolina V. Arancibia-Cárcamo Philip P. Ahern Yoichiro Iwakura Kevin J. Maloy Fiona Powrie | 2008 | Immunity2008，，4： | 3 |
| 3 | Radiation doses to the tissues of rat from tritiated thymidine administered by three different routes显示文摘 | Takada H Iwakura T Mabechi Y | 1984 | J radiat Res1984，25，3： | 2 |
| 4 | Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice显示文摘 | Fumitake Usui Hiroaki Kimura Taichi Ohshiro Kazuki Tatsumi Akira Kawashima Akiyo Nishiyama Yo-ichiro Iwakura Shun Ishibashi Masafumi Takahashi | 2012 | Biochemical and Biophysical Research Communications2012，，1： | 2 |
| 5 | Myocardial ischemia enhances the expression of acidic fibroblast growth factor in human pericardial fluid显示文摘 | Iwakura A Fujita M Ikemoto M | 2000 | Heart Vessels2000，15，： | 2 |
| 6 | Intravenous nicorandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction显示文摘 | Hiroshi Ito Yoshiaki Taniyama Katsuomi Iwakura Nagahiro Nishikawa Tohru Masuyama Tsunehiko Kuzuya Masatsugu Hori Yorihiko Higashino Kenshi Fujii Takazo Minamino | 1999 | Journal of the American College of Cardiology1999，，3： | 2 |
| 7 | Association between hyperglycemia and the no-reflow phenomenon inpatients with acute myocardial infarction显示文摘 | Katsuomi Iwakura Hiroshi Ito Masashi Ikushima Shigeo Kawano Atsushi Okamura Katsuaki Asano Tadashi Kuroda Koji Tanaka Tohru Masuyama Masatsugu Hori Kenshi Fujii | 2003 | Journal of the American College of Cardiology2003，，1： | 2 |
| 8 | Solvent effect for ruthenium porphyrin显示文摘Relaxation of electronic excited-state and vibrational dynamics in the electronic excited state in Ru II(TPP)(CO) [TPP=tetraphenylporphyrin] dissolved in N2 bubbled benzene,O2 bubbled benzene,N2 bubbled chloroform and N2 bubbled acetone were clarified using a sub-5fs laser pulse. The result showed that the transition energy from the 1Q x states,consisting of the 1Q x(1,0)(π,π*) state(existing at 18800 cm-1 ) and 1Q x(0,0)(π,π*) state(existing at 17800 cm-1 ),to the 1M state of six-coordinated ruthenium complex is lower than that of the five-coordinated ruthenium complex. The intersystem crossing 1Q x(0,0)(π,π*)→ 3(d,π*) in the five-coordinate Ru II(TPP)(CO) in the solution was found to take place in about 1 ps. | IWAKURA Izumi YABUSHITA Atshi KOBAYASHI Takayoshi | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，6： | 2 |
| 9 | Oral treatment with nicorandil at discharge is associated with reduced mortality after acute myocardial infarction显示文摘 | Yasuhiko Sakata Daisaku Nakatani Masahiko Shimizu Shinichiro Suna Masaya Usami Sen Matsumoto Masahiko Hara Satoru Sumitsuji Shigeo Kawano Katsuomi Iwakura Toshimitsu Hamasaki Hiroshi Sato Shinsuke Nanto Masatsugu Hori Issei Komuro | 2011 | Journal of Cardiology2011，，： | 2 |
| 10 | Immunohistochemical localization of transforming growth factor beta, basic fibroblast growth factor and heparan sulphate glyeosaminoglycan in gingival hyperplasia induced by nifedipine and phenytoin 显示文摘 | Saito K Mori S Iwakura M | 1996 | J Periodontal Res1996，31，8： | 1 |
| 11 | Electrochemical properties of Ni/( Ni + RuO2 ) active cathodes for hydrogen evolution in ehlor-alkali electrolysis 显示文摘 | Chiaki Iwakura Masashi Tanaka Shuji Nakamatsu | 1995 | Eleetrochimiea Aeta1995，40，8： | 1 |
| 12 | Association between hyperglycemia and the no-reflow phenomenon in patients with acute myocardial infarction显示文摘 | Iwakura K Ito H Ikushima M | 2003 | J Am Coll Cardiol2003，41，： | 1 |
| 13 | Estradiol enhances recovery after myocardial i~tfarction by augmenting incorporation of bone marrow-derived endothelial progenitor ceils into sites of ischemia-Induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9 显示文摘 | Atsushi Iwakura Shubha Shastry Corinne Luedemann | 2006 | Circulation2006，113，12： | 1 |
| 14 | The IL23/IL17 axis in in- flammation 显示文摘 | Iwakura Y Ishigame H | 2006 | J Clin Invest2006，116，5： | 1 |
| 15 | Automated assessment of myocardial viability after acute myocardial infarction by global longitudinal peak strain on low-dose dobutamine stress echocardiography显示文摘 | Iwakura K Okamura A Koyama Y | | 0，，10： | 1 |
| 16 | Therapeutic effects of interleukin-6 blockade in a murine model of polymyositis that does not require interleukin-17A显示文摘 | Okiyama N Sugihara T Iwakura Y | 2009 | Arthritis Rheum2009，60，8： | 1 |
| 17 | The roles of IL-17A in in- flammatory immune responses and host defense against pathogens 显示文摘 | Iwakura Y Nakae S Saijo S | 2008 | Immunol Rev2008，226，1： | 1 |
| 18 | Myocardial perfusion patterns related to thrombolysis in myocardial infarction peffusion grades after coronary angioplasty in patients with acute anterior wall myocardial infarction显示文摘 | OKAMURA A IWAKURA K | 1996 | Circulation1996，93，11： | 1 |
| 19 | Alterationin the coronary blood flow velocity pattern in patients with no reflow and reperfusedacute myocardial infarction显示文摘 | Iwakura K Ito H Takiuchi S Taniyama Y Nakatsuchi Y Negoro S | 1996 | Circulation1996，94，： | 1 |
| 20 | Functional specialization of interleukin-17 family members显示文摘 | Iwakura Y Ishigame H Saijo S | 2011 | Immunity2011，34，2： | 1 |
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