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85篇 您的检索式:作者名="Junjie Lin"
    题名 作者 年代 出处 被引量
1Emissions of polycyclic aromatic hydrocarbons from coking industries in China显示文摘这研究开始估计多不的芳香的烃的特征(哼) 从 coking 工业的排放,与在四典型焦炭植物进行的领域采样。为每选择植物,栈烟道气体样品在包括的进程期间是镇定的控告煤进炉(CC ) ,推焦炭(PC ) 和焦炭炉气体(CG ) 的燃烧。十六个个人在 US EPA 优先级表上哼被煤气的层析 / 团 spectrometry (GC/MS ) 分析。结果证明总数哼在烟道气体的集中从 45.776 ~ 414.874 g/m3 ,与为 CC (359.545 g/m3 ) 的最高的排放水平。集中哼在 CP1 (收费的邮票) 从 CC 过程射出从 CP3 和 CP4 (收费的顶) 是比那低的。Low-molecular-weight 哼(即,二 -- 到三戒指哼) 到总数的占优势的贡献者哼内容,和小睡, AcPy,流感, PhA,和蚂蚁被发现是最丰富的。为 CC (2.248 g/m3 ) 的全部的 BaPeq 集中比为 PC (1.838 g/m3 ) 的那些高, CG (1.082 g/m3 ) ,和 DbA 作为在从 coking 过程的排出物的 BaP 是到 carcinogenic 风险的一个重要贡献者。微粒哼比对总数的相应贡献哼的占了超过 20% 全部的 BaPeq 集中,它显著地高集体集中(5%) 。微粒并且气体哼当时,应该被考虑潜在的毒性风险哼污染在 coking 期间,过程被估计。吝啬的总数 -- 哼排放因素分别地是为 CC 和 PC 的 346.132 和 93.173 g/kg。Ling Mu Lin Peng Junji Cao Qiusheng He Fan Li Jianqiang Zhang Xiaofeng Liu Huiling Bai 2013Particuology2013,11,1:17
2Growth and nutrient dynamics of Betula alnoides seedlings under exponential fertilization显示文摘Betula alnoides is a fast-growing hardwood species grown in large plantations in Southeast Asia and South China.Nitrogen requirements for producing robus seedlings,growth and nutrient dynamics were investigated using exponential fertilization treatments.Root collar diameter,height,dry mass and nutrient contents of seedlings increased exponentially in all fertilization treatments as time progressed.Moreover,with water soluble fertilizer(Plant Products plus microelements N–P_2O_5–K_2O:20–20–20),300 mg N seedling^(-1)was adequate.Vector analysis revealed that P was the most responsive nutrient element followed by N and K.Dilutions of N and K were evident in the plants without N addition,which induced initial P sufficiency and then luxury consumption probably due to the antagonistic interaction between N and P.However deficiencies of N,P and K were mostly observed in al exponential regimes during the experiment because seedling growth rate exceeded nutrient uptake rate,inferring that further study on improving the nutrient uptake efficiency is needed.Analysis of relationships among nutrient supply,dry mass,N content and N concentration demonstrated that 100–400 mg N seedling^(-1)induced sufficiency to luxury consumption of nitrogen without significant change in dry mass,and 400 mg N seedling^(-1)is recommended to apply for nutrient loading of seedlings before outplanting.The findings will help improve seedling quality and enhance the production of robust seedlings for plantation forestry of this species.Lin Chen Chunsheng Wang Bernard Dell Zhigang Zhao Junjie Guo Daping Xu Jie Zeng 2018Journal of Forestry Research2018,29,1:14
3Quasi-solid-state nanocrystalline TiO2 solar cells using gel network polymer electrolytes based on polysiloxanes显示文摘A quasi-solid-state dye-sensitized nanocrystal-line porous TiO2 film solar cell was fabricated using a novel gel network polymer electrolyte based on polysiloxanes with both polyethylene oxide internal plasticized side chains and quaternary ammonium groups. The cell exhibited better photoelectrical conversion performance under 60 mW/cm2 irradiation. The short photocurrent (Isc) of 5.0 mA/cm2 and open voltage (Voc) of 0.68 V were achieved, and the energy conversion efficiency (h ) and fill factor (ff) were 3.4% and 0.60, respectively.LI Weiying, KANG Junjie, LI Xueping, FANG Shibi, LIN Yuan, WANG Guiqiang & XIAO Xurui Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China 2003Chinese Science Bulletin2003,48,7:11
4Exosomes: roles and therapeutic potential in osteoarthritis显示文摘Exosomes participate in many physiological and pathological processes by regulating cell–cell communication, which are involved in numerous diseases, including osteoarthritis(OA). Exosomes are detectable in the human articular cavity and were observed to change with OA progression. Several joint cells, including chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and secrete exosomes that influence the biological effects of targeted cells. In addition, exosomes from stem cells can protect the OA joint from damage by promoting cartilage repair, inhibiting synovitis, and mediating subchondral bone remodeling.This review summarizes the roles and therapeutic potential of exosomes in OA and discusses the perspectives and challenges related to exosome-based treatment for OA patients in the future.Zhenhong Ni Siru Zhou Song Li Liang Kuang Hangang Chen Xiaoqing Luo Junjie Ouyang Mei He Xiaolan Du Lin Chen 2020Bone Research2020,8,2:10
5Noninvasive Ultrasound Deep Brain Stimulation for the Treatment of Parkinson’s Disease Model Mouse显示文摘Modulating basal ganglia circuitry is of great signifcance in the improvement of motor function in Parkinson’s disease(PD).Here,for the frst time,we demonstrate that noninvasive ultrasound deep brain stimulation(UDBS)of the subthalamic nucleus(STN)or the globus pallidus(GP)improves motor behavior in a subacute mouse model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP).Immunohistochemical c-Fos protein expression confrms that there is a relatively high level of c-Fos expression in the STN-UDBS and GP-UDBS group compared with sham group(both p<0.05).Furthermore,STN-UDBS or GPUDBS signifcantly increases the latency to fall in the rotarod test on day 9(p<0.05)and decreases the time spent climbing down a vertical rod in the pole test on day 12(p<0.05).Moreover,our results reveal that STN-UDBS or GP-UDBS protects the dopamine(DA)neurons from MPTP neurotoxicity by downregulating Bax(p<0.001),upregulating Bcl-2(p<0.01),blocking cytochrome c(Cyt C)release from mitochondria(p<0.05),and reducing cleaved-caspase 3 activity(p<0.01)in the ipsilateral substantia nigra(SN).Additionally,the safety of ultrasound stimulation is characterized by hematoxylin and eosin(HE)and Nissl staining;no hemorrhage or tissue damage is detected.Tese data demonstrate that UDBS enables modulation of STN or GP neural activity and leads to neuroprotection in PD mice,potentially serving as a noninvasive strategy for the clinical treatment of PD.Hui Zhou Lili Niu Long Meng Zhengrong Lin Junjie Zou Xiangxiang Xia Xiaowei Huang Wei Zhou Tianyuan Bian Hairong Zheng 2019Research2019,,1:9
6Carbon Capture and Storage:History and the Road Ahead显示文摘The large-scale deployment of carbon capture and storage(CCS)is becoming increasingly urgent in the global path toward net zero emissions;however,global CCS deployment is significantly lagging behind its expected contribution to greenhouse gas emission reduction.Reviewing and learning from the examples and history of successful CCS practices in advanced countries will help other countries,including China,to promote and deploy CCS projects using scientific methods.This paper shows that the establishment of major science and technology CCS infrastructures in advanced countries has become the main source of CCS technological innovation,cost reduction,risk reduction,commercial promotion,and talent training in the development and demonstration of key CCS technologies.Sound development of CCS requires a transition from pilot-scale science and technology infrastructures to large-scale commercial infrastructures,in addition to incentive policies;otherwise,it will be difficult to overcome the technical barriers between small-scale demonstrations and the implementation of million-tonne-scale CCS and ten-million-tonne-scale CCS hubs.Geological CO_(2) storage is the ultimate goal of CCS projects and the driving force of CO_(2) capture.Further improving the accuracy of technologies for the measurement,monitoring,and verification(MMV)of CO_(2) storage capacity,emission reduction,and safety remains a problem for geological storage.CO_(2) storage in saline aquifers can better couple multiple carbon emission sources and is currently a priority direction for development.Reducing the energy consumption of lowconcentration CO_(2) capture and the depletion of chemical absorbents and improving the operational efficiency and stability of post-combustion CO_(2) capture systems have become the key constraints to largescale CCS deployment.Enhanced oil recovery(EOR)is also important in order for countries to maximize fossil fuel extraction instead of importing oil from less environmentally friendly oil-producing countries.Jinfeng Ma Lin Li Haofan Wang Yi Du Junjie Ma Xiaoli Zhang Zhenliang Wang 2022Engineering2022,8,7:9
7Variability of SO_2 in an intensive fog in North China Plain:Evidence of high solubility of SO_2显示文摘一个地实验在在 11 月 5 日和 2009 年 11 月 8 日之间的一个集中的雾事件被进行,在在诺思中国平原(NCP ) 的一个重重地弄脏 SO2 的区域,到措施 SO2 和其它空气污染物质,雾微滴的液体水内容(LWC ) ,和另外的基本气象学的参数。在雾时期期间, SO2 的集中在雾微滴与 LWC 有关仔细显示出大可变性,它是。, SO2 的平均集中在雾时期期间在非雾时期期间是大约 25 ppbv,它很快归结为大约 47 ppbv。SO2 的如此的大减小建议由于 SO2 的高溶解度, SO2 (大约 70%80%) 的一个多数在雾微滴在水里从气体回复了到水的阶段。然而,到水的阶段变换的计算气体被仅仅使用亨利 SO2 的法律常数大部分低估,因此在雾微滴建议 SO2 的那水的反应可能在提高 SO2 的溶解度起某重要作用。简化现象,一个有效溶解度系数在这研究被建议。SO2 测量的这可变性在 NCP 在雾微滴,为在云的酸味的更好的理解的因此提供的重要含意,猛冲,和雾在广泛的雾事件期间提供 SO2 的氧化的直接证据,现在在中国的一个中央环境焦点由于它的快速的经济发展。Qiang Zhang Xuexi Tie Weili Lin Junji Cao Jiannong Quan Liang Ran Wanyun Xu 2013Particuology2013,11,1:8
8Genomic Analyses Yield Markers for Identifying Agronomically Important Genes in Potato显示文摘野土豆种类有实质的 phenotypic 和生理的差异。这里,我们基于茄属节 Petota 的 201 就职的 genomic 分析报导对野、栽培的土豆种类的一个全面评价。我们定序这 201 就职的染色体并且识别了 6 ? 487 ? 从在 clade 的 167 就职的 006 高质量的单个核苷酸多型性(SNP ) 4 茄属节 Petota,包括 146 野并且有宽广地理分布的 21 栽培双土豆就职。染色体宽的基因变化分析比栽培土豆,和在农学地重要的疾病抵抗的高得多的基因差异,基因在野土豆被观察的证明野土豆的差异高。由关于已知的量的特点 loci (QTL ) 利用信息,而且,我们在选择下面识别了 609 基因,包括那些在 tubers 与痛苦的损失相关,那些在 tuberization 包含了,土豆的二个主要驯养的特点。种系发生的分析在 clade 揭示了所有种类的一个纵贯的部门 4,不是就那些在 S.? brevicaule 建筑群,和进一步支持的 S。是的 candolleanum 栽培土豆和在南部的秘鲁的栽培土豆的 monophyletic 起源的祖先。另外,我们分析了 S. 的染色体 ? candolleanum 并且鉴别 529 基因在栽培土豆输了。一起,在这研究产生的分子的标记为为土豆繁殖有用的农学地重要的基因的鉴定提供一个珍贵资源。Yangping Li Christophe Colleoni Junjie Zhang Qiqi Liang Yufeng Hu Holly Ruess Reinhard Simon Yinghong Liu Hanmei Liu Guowu Yu Eric Schmitt Ghloe Ponitzki Guangjian Liu Huanhuan Huang Feilong Zhan Lin Chen Yubi Huang David Spooner Binquan Huang 2018Molecular Plant2018,11,3:8
9Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients显示文摘Dear Editor,In 2019,a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was identified as the causative agent of Coronavirus Disease 2019(COVID-19).As of 8 June 2020,the World Health Organization(WHO)has reported 6,912,751 globally confirmed cases with 400,469 deaths.Although generally causes mild disease,SARS-CoV-2 infection can result in serious outcomes,including acute lung injury(ALI)and acute respiratory distress syndrome(ARDS),the leading cause of mortality in patients with comorbidities.Recent autopsy studies of COVID-19 patients revealed mononuclear infiltration and excessive production of mucus in the infected lung,especially in the damaged small airways and alveoli(Bian and Team,2020;Liu et al.,2020).Jiangping He Shuijiang Cai Huijian Feng Baomei Cai Lihui Lin Yuanbang Mai Yinqiang Fan Airu Zhu Huang Huang Junjie Shi Dingxin Li' Yuanjie Wei Yueping Li Yingying Zhao’ Yuejun Pan He Liu Xiaoneng Mo Xi He Shangtao Cao FengYu Hu Jincun Zhao Jie Wang Nanshan Zhong Xinwen Chen Xilong Deng Jiekai Chen 2020Protein & Cell2020,11,9:7
10CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1显示文摘Sorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma(HCC).However,sorafenib resistance significantly limits its therapeutic efficacy,and the mechanisms underlying resistance have not been fully clarified.Here we report that a circular RNA,circRNA-SORE(a circular RNA upregulated in sorafenib-resistant HCC cells),plays a significant role in sorafenib resistance in HCC.We found that circRNA-SORE is upregulated in sorafenib-resistant HCC cells and depletion of circRNA-SORE substantially increases the cell-killing ability of sorafenib.Further studies revealed that circRNA-SORE binds the master oncogenic protein YBX1 in the cytoplasm,which prevents YBX1 nuclear interaction with the E3 ubiquitin ligase PRP19 and thus blocks PRP19-mediated YBX1 degradation.Moreover,our in vitro and in vivo results suggest that circRNA-SORE is transported by exosomes to spread sorafenib resistance among HCC cells.Using different HCC mouse models,we demonstrated that silencing circRNA-SORE by injection of siRNA could substantially overcome sorafenib resistance.Our study provides a proof-of-concept demonstration for a potential strategy to overcome sorafenib resistance in HCC patients by targeting circRNA-SORE or YBX1.Junjie Xu Lin Ji Yuelong Liang Zhe Wan Wei Zheng Xiaomin Song Kirill Gorshkov Qiming Sun Hui Lin Xueyong Zheng Jiang Chen Ren-an Jin Xiao Liang Xiujun Cai 2020Signal Transduction and Targeted Therapy2020,5,1:5
11Diffusion mechanism simulation of cloud manufacturing complex network based on cooperative game theory显示文摘Cloud manufacturing is a specific implementation form of the 'Internet + manufacturing' strategy. Why and how to develop cloud manufacturing platform(CMP), however, remains the key concern of both platform operators and users. A microscopic model is proposed to investigate advantages and diffusion forces of CMP through exploration of its diffusion process and mechanism. Specifically, a three-stage basic evolution process of CMP is innovatively proposed. Then, based on this basic process, a more complex CMP evolution model has been established in virtue of complex network theory, with five diffusion forces identified. Thereafter, simulations on CMP diffusion have been conducted. The results indicate that, CMP possesses better resource utilization,user satisfaction, and enterprise utility. Results of simulation on impacts of different diffusion forces show that both the time required for CMP to reach an equilibrium state and the final network size are affected simultaneously by the five diffusion forces. All these analyses indicate that CMP could create an open online cooperation environment and turns out to be an effective implementation of the 'Internet + manufacturing' strategy.GENG Chao QU Shiyou XIAO Yingying WANG Mei SHI Guoqiang LIN Tingyu XUE Junjie JIA Zhengxuan 2018Journal of Systems Engineering and Electronics2018,29,2:4
12Cloning and Characterization of Largemouth Bass(Micropterus salmoides) Myostatin Encoding Gene and Its Promoter显示文摘Myostatin or GDF-8,a member of the transforming growth factor-β(TGF-β) superfamily,has been demonstrated to be a negative regulator of skeletal muscle mass in mammals. In the present study,we obtained a 5.64 kb sequence of myostatin encoding gene and its promoter from largemouth bass(Micropterus salmoides) . The myostatin encoding gene consisted of three exons(488 bp,371 bp and 1779 bp,respectively) and two introns(390 bp and 855 bp,respectively) . The intron-exon boundaries were conservative in comparison with those of mammalian myostatin encoding genes,whereas the size of introns was smaller than that of mammals. Sequence analysis of 1.569 kb of the largemouth bass myostatin gene promoter region revealed that it contained two TATA boxes,one CAAT box and nine putative E-boxes. Putative muscle growth response elements for myocyte enhancer factor 2(MEF2) ,serum response factor(SRF) ,activator protein 1(AP1) ,etc.,and muscle-specific Mt binding site(MTBF) were also detected. Some of the transcription factor binding sites were conserved among five teleost species. This information will be useful for studying the transcriptional regulation of myostatin in fish.LI Shengjie BAI Junjie WANG Lin 2008Journal of Ocean University of China2008,7,3:4
13Spatiotemporal rotational dynamics of laser-driven molecules显示文摘Molecular alignment and orientation by laser fields has attracted significant attention in recent years,mostly due to new capabilities to manipulate the molecular spatial arrangement.Molecules can now be efficiently prepared for ionization,structural imaging,orbital tomography,and more,enabling,for example,shooting of dynamic molecular movies.Furthermore,molecular alignment and orientation processes give rise to fundamental quantum and classical phenomena like quantum revivals,Anderson localization,and rotational echoes,just to mention a few.We review recent progress on the visualization,coherent control,and applications of the rich dynamics of molecular rotational wave packets driven by laser pulses of various intensities,durations,and polarizations.In particular,we focus on the molecular unidirectional rotation and its visualization,the orientation of chiral molecules,and the three-dimensional orientation of asymmetric-top molecules.Rotational echoes are discussed as an example of nontrivial dynamics and detection of prepared molecular states.Kang Lin Ilia Tutunnikov Junyang Ma Junjie Qiang Lianrong Zhou Olivier Faucher Yehiam Prior Ilya Sh.Averbukh Jian Wu 2020Advanced Photonics2020,2,2:4
14Endothelial PDGF-BB/PDGFR-βsignaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation显示文摘The mechanisms that coordinate the shift from joint homeostasis to osteoarthritis(OA)remain unknown.No pharmacological intervention can currently prevent the progression of osteoarthritis.Accumulating evidence has shown that subchondral bone deterioration is a primary trigger for overlying cartilage degeneration.We previously found that H-type vessels modulate aberrant subchondral bone formation during the pathogenesis of OA.However,the mechanism responsible for the elevation of H-type vessels in OA is still unclear.Here,we found that PDGFR-βexpression,predominantly in the CD31^(hi)Emcn^(hi) endothelium,was substantially elevated in subchondral bones from OA patients and rodent OA models.A mouse model of OA with deletion of PDGFR-βin endothelial cells(ECs)exhibited fewer H-type vessels,ameliorated subchondral bone deterioration and alleviated overlying cartilage degeneration.Endothelial PDGFR-βpromotes angiogenesis through the formation of the PDGFR-β/talin1/FAK complex.Notably,endothelium-specific inhibition of PDGFR-βby local injection of AAV9 in subchondral bone effectively attenuated the pathogenesis of OA compared with that of the vehicle-treated controls.Based on the results from this study,targeting PDGFR-βis a novel and promising approach for the prevention or early treatment of OA.Zhuang Cui Hangtian Wu Ye Xiao Ting Xu Junjie Jia Hancheng Lin Rongmin Lin Kun Chen Yihuang Lin Kaiqun Li Xiaohu Wu Changjun Li Bin Yu 2022Bone Research2022,10,4:4
15Heteroepitaxial Growth and Characterization of 3C-SiC Films on Si Substrates Using LPVCVD显示文摘3C-SiC films have been deposited on Si (111) substrates by the Iow-pressure vertical chemical vapor deposition (LPVCVD) with gas mixtures of SiH4, C3H8 and Ha. The growth mechanism of SiC films can be obtained through the observations using field emission scanning electron microscope (FESEM). It is found that the growth process varies from surface control to diffusion control when the deposition temperature increases from 1270 to 1350℃. The X-ray diffraction (XRD) patterns show that the SiC films have good crystallinity and strong preferred orientation.The results of the high resolution transmission electron microscopy (HRTEM) image and the transmission electron diffraction (TED) pattern indicate a peculiar superlattice structure of the film. The values of the binding energy in the high resolution X-ray photoelectron spectra (XPS) further confirm the formation of SiC.Haiwu ZHENG Junjie ZHU Zhuxi FU Bixia LIN Xiaoguang LI 2005Journal of Materials Science & Technology2005,21,4:4
16An analytical solution for the population balance equation using a moment method显示文摘Brownian coagulation is the most important inter-particle mechanism affecting the size distribution of aerosols.Analytical solutions to the governing population balance equation(PBE) remain a challenging issue.In this work,we develop an analytical model to solve the PBE under Brownian coagulation based on the Taylor-expansion method of moments.The proposed model has a clear advantage over conventional asymptotic models in both precision and efficiency.We first analyze the geometric standard deviation(GSD) of aerosol size distribution.The new model is then implemented to determine two analytic solutions,one with a varying GSD and the other with a constant GSD.The varying solution traces the evolution of the size distribution,whereas the constant case admits a decoupled solution for the zero and second moments.Both solutions are confirmed to have the same precision as the highly reliable numerical model,implemented by the fourth-order Runge-Kutta algorithm,and the analytic model requires significantly less computational time than the numerical approach.Our results suggest that the proposed model has great potential to replace the existing numerical model,and is thus recommended for the study of physical aerosol characteristics,especially for rapid predictions of haze formation and evolution.Mingzhou Yu Jianzhong Lin Junji Cao Martin Seipenbusch 2015Particuology2015,13,1:4
17Deep eutectic solvents and alkaline extraction of protein from seabuckthorn seed meal: a comparison study显示文摘Seabuckthorn seed meal(SSM) is a waste of oil extraction industry that rich in protein. In order to seek suitable protein extraction method, three different deep eutectic solvents(DESs)(including choline chlorideglycerol, choline chloride-oxalic acid and choline chloride-urea) were developed for extracting protein from SSM and compared with alkaline. Result indicated that alkaline could effectively extract 56.9% protein from SSM and its protein content was 73.1%, higher than DES at 31.0%-41.4% and 64.3%-67.5%, respectively. However, compared to alkali, DES led to a product with less β-sheet, more β-turn, more essential amino acids, higher total amino acid content, especially choline chloride-urea which extracted protein showing an integrated and similar protein weight distribution compared to SSM. Also, this protein extracted chloride-urea showed a highest digestibility in vitro(by pepsin)(54.2%). These results indicated that choline chloride-urea extraction is better than alkaline extraction for SSM.Junjie Lin Huan Xiang Dongxiao Sun-Waterhouse Chun Cui Wei Wang 2022Food Science and Human Wellness2022,11,4:4
18Changes in dendritic cells and dendritic cell subpopulations in peripheral blood of recipients during acute rejection after kidney transplantation显示文摘Ma Linlin Liu Yong Wu Junjie Xu Xiuhong Liu Fen Feng Lang Xie Zelin Tang Yawang Sun Wen Guo Hongbo Zhang Lei Lin Jun Tian Ye 2014Chinese Medical Journal2014,,8:3
19Consolidation and properties of ultrafine binderless cemented carbide by spark plasma sintering显示文摘由于金属文件夹的缺席,无文件夹的 cemented 碳化物更高有穿,腐蚀,和氧化抵抗。有 200 nm 的一种平均粒子尺寸和活跃元素的小数量的 WC-0.3VC- 0.5Cr3C2 粉末被火花血浆 sintering 巩固。sintered 微观结构表明平均 WC 谷物尺寸是 0.24 m,它与起始的好粉末几乎一致。XRD 的结果证明那个 W2C 阶段被形成。极其细小的无文件夹的 cemented 碳化物的将近完全的 densification 被 sintering 在 1400 点完成 ? 鞌 ?LIU Xiangqing LIN Tao Shao Huiping GUO Zhimeng LUO Ji HAO Junjie 2008Rare Metals2008,27,3:2
20Animal exercise studies in cardiovascular research:Current knowledge and optimal design--A position paper of the Committee on Cardiac Rehabilitation,Chinese Medical Doctors’Association显示文摘Growing evidence has demonstrated exercise as an effective way to promote cardiovascular health and protect against cardiovascular diseases However,the underlying mechanisms of the beneficial effects of exercise have yet to be elucidated.Animal exercise studies are widely used to investigate the key mechanisms of exercise-induced cardiovascular protection.However,standardized procedures and well-established evaluation indicators for animal exercise models are needed to guide researchers in carrying out effective,high-quality animal studies using exercise to prevent and treat cardiovascular diseases.In our review,we present the commonly used animal exercise models in cardiovascular research and propose a set of standard procedures for exercise training,emphasizing the appropriate measurements and analysis in these chronic exercise models.We also provide recommendations for optimal design of animal exercise studies in cardiovascular research,including the choice of exercise models,control of exercise protocols,exercise at different stages of disease,and other considerations,such as age,sex,and genetic background.We hope that this position paper will promote basic research on exercise-induced cardiovascular protection and pave the way for successful translation of exercise studies from bench to bedside in the prevention and treatment of cardiovascular diseases.Yihua Bei Lei Wang Rongjing Ding Lin Che Zhiqing Fan Wei Gao Qi Liang Shenghui Lin Suixin Liu Xiao Lu Yuqin Shen Guifu Wu Jian Yang Guolin Zhang Wei Zhao Lan Guo Junjie Xiao 2021Journal of Sport and Health Science2021,10,6:2
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