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| 1 | Phase II clinical trial using camrelizumab combined with apatinib and chemotherapy as the first-line treatment of advanced esophageal squamous cell carcinoma显示文摘Background:Effective therapeutic options are limited for patients with advanced esophageal squamous cell carcinoma(ESCC).The incorporation of an immune checkpoint inhibitor and a molecular anti-angiogenic agent into the commonly adopted chemotherapy may produce synergistic effects.Therefore,we aimed to investigate the efficacy and safety of camrelizumab plus apatinib combined with chemotherapy as the first-line treatment of advanced ESCC.Methods:In this single-arm prospective phase II trial,patients with unresectable locally advanced or recurrent/metastatic ESCC received camrelizumab 200 mg,liposomal paclitaxel 150 mg/m2,and nedaplatin 50 mg/m2 on day 1,and apatinib 250 mg on days 1-14.The treatments were repeated every 14 days for up to 9 cycles,followed by maintenance therapy with camrelizumab and apatinib.The primary endpoint was objective response rate(ORR)according to the Response Evaluation Criteria in Solid Tumors(version 1.1).Secondary endpoints included disease control rate(DCR),progression-free survival(PFS),overall survival(OS),and safety.Results:We enrolled 30 patients between August 7,2018 and February 23,2019.The median follow-up was 24.98 months(95%confidence interval[CI]:23.05-26.16 months).The centrally assessed ORR was 80.0%(95%CI:61.4%-92.3%),with a median duration of response of 9.77 months(range:1.54 to 24.82+months).The DCR reached 96.7%(95%CI:82.8%-99.9%).The median PFS was 6.85 months(95%CI:4.46-14.20 months),and the median OS was 19.43 months(95%CI:9.93 months–not reached).The most common grade 3-4 treatmentrelated adverse events(AEs)were leukopenia(83.3%),neutropenia(60.0%),and increased aspartate aminotransferase level(26.7%).Treatment-related serious AEs included febrile neutropenia,leukopenia,and anorexia in one patient(3.3%),and single cases of increased blood bilirubin level(3.3%)and toxic epidermal necrolysis(3.3%).No treatment-related deaths occurred.Conclusions:Camrelizumab plus apatinib combined with liposomal paclitaxel and nedaplatin as first-line treatment demonstrated feasible anti-tumor activity and manageable safety in patients with advanced ESCC.Randomized trials to evaluate this new combination strategy are warranted.Trial registration:This trial was registered on July 27,2018,at ClinicalTrials.gov(identifier:NCT03603756). | Bo Zhang Ling Qi Xi Wang Jianping Xu Yun Liu Lan Mu Xingyuan Wang Lidan Bai Jing Huang | 2020 | Cancer Communications2020，40，12： | 38 |
| 2 | Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin显示文摘LRP16 以前在乳癌房间作为导致雌激素的基因被识别。到在子宫内膜的癌症(EC ) 的雌激素和它的功能的效果的 LRP16 的应答的海角房间仍然是不清楚的。这里,我们证明 LRP16 基因的信使 rna 水平和倡导者活动被 17beta-estradiol (E2 ) 显著地在雌激素受体高山增加哈(嗯高山哈)-positiveIshikawa 人 EC 房间。尽管 Ishikawa 细胞的生长率没被 LRP16 的宫外的表示显然影响, Transwell 试金的结果显示出 LRP16-overexpressing 细胞的侵略能力的近似 one-thirdincrease。由于分子的屏蔽,我们观察到 E-cadherin 的表示,与肿瘤转移联系的一个必要粘附分子,被 LRP16 镇压。进一步的倡导者分析以一种剂量依赖者方式表明了那 LRP16 inhibitedE-cadherin transactivation。然而,抑制被雌激素剥夺废除,显示由 LRP16requires 的 E-cadherin 抄写的 down 规定嗯高山哈调停。染色质免疫降水分析表明到 E-cadherin 倡导者的 ERalpha 的绑定被 LRP16 反对,建议那 LRP16 能防碍嗯调停 alpha 的抄写。这些结果建议起来由雌激素的 LRP16 的规定能被在人的 EC 调整 E-cadherin 的 down 涉及侵略生长。 | Yuan Guang Meng Wei Dong Han Ya Li Zhao Ke Huang Yi Ling Si Zhi Qiang Wu Yi Ming Mu | 2007 | Cell Research2007，17，10： | 27 |
| 3 | Novel Strategy for Synthesis of High Quality CdTe Nanocrystals in Aqueous Solution显示文摘A novel aqueous route for the synthesis of high-quality CdTe nanocrystals(NCs) is presented in this article. With both glutathione(GSH) and cysteine[n(GSH):n(cysteine)=1:3] as stabilizers, high-quality CdTe NCs with controllable photoluminescence(PL) wavelength from 500 to 630 nm can be prepared within 4 h. As-prepared CdTe NCs show higher photoluminescence quantum yields(PLQY) compared with CdTe NCs prepared via other aqueous methods. When the fluorescent emission peak appeared in orange-red window, the PLQY reaches 70% or above at room temperature without any post-preparative treatment. | YAN Yu-xi MU Ying FENG Guo-dong ZHANG Lei ZHU Lin-lin XU Ling YANG Rui JIN Qin-han | 2008 | Chemical Research in Chinese Universities2008，24，1： | 21 |
| 4 | Late Pleistocene glaciation of the Changbai Mountains in northeastern China显示文摘The Changbai Mountains (2749 m a.s.l.) in northeastern China are one of the typical mountain regions with glaciation since late Pleistocene as evidenced by well-preserved erosive and accumulative landforms at elevations above 2000 m a.s.l. formed by glaciers around the crater lake, Tianchi Lake. Cirque glaciers developed on both the inner and outer sides of the volcanic cone. Well-preserved cirques, glacial trough valleys, glacial threholds, polished surfaces of the glacial erratics and the moraine ridges indicate that several glaciation processes took place during the last glacial period in this region. Results of optically stimulated luminescence (OSL) dating on the moraine sediments, and the K/Ar, ther- mal ionization mass spectrometry (TIMS), electronic spinning resonance (ESR) dating on the volcanic rocks suggest two periods of glacier advances. One is named the Black Wind Mouth glacier advance taking place on the west and north slopes of the volcanic cone at an elevation of 2000―2100 m a.s.l., which is dated to about 20 ka, being the result of the Last Glacial Maximum (LGM). The other is named the Meteorological Station glacier advance at the elevation of 2400―2600 m a.s.l., dated to 11 ka during the late glacial period, and is tentatively correlated to the Younger Dryas stage. The scope of the former glacier advance is larger than that of the latter. Regional comparisons showed that the glacial sequences in the Changbai Mountains are similar to other glaciated areas in eastern Asia during the later part of the last glacial cycle. | ZHANG Wei NIU YunBo YAN Ling CUI ZhiJiu LI ChuanChuan MU KeHua | 2008 | Chinese Science Bulletin2008，53，17： | 18 |
| 5 | Emissions of polycyclic aromatic hydrocarbons from coking industries in China显示文摘这研究开始估计多不的芳香的烃的特征(哼) 从 coking 工业的排放,与在四典型焦炭植物进行的领域采样。为每选择植物,栈烟道气体样品在包括的进程期间是镇定的控告煤进炉(CC ) ,推焦炭(PC ) 和焦炭炉气体(CG ) 的燃烧。十六个个人在 US EPA 优先级表上哼被煤气的层析 / 团 spectrometry (GC/MS ) 分析。结果证明总数哼在烟道气体的集中从 45.776 ~ 414.874 g/m3 ,与为 CC (359.545 g/m3 ) 的最高的排放水平。集中哼在 CP1 (收费的邮票) 从 CC 过程射出从 CP3 和 CP4 (收费的顶) 是比那低的。Low-molecular-weight 哼(即,二 -- 到三戒指哼) 到总数的占优势的贡献者哼内容,和小睡, AcPy,流感, PhA,和蚂蚁被发现是最丰富的。为 CC (2.248 g/m3 ) 的全部的 BaPeq 集中比为 PC (1.838 g/m3 ) 的那些高, CG (1.082 g/m3 ) ,和 DbA 作为在从 coking 过程的排出物的 BaP 是到 carcinogenic 风险的一个重要贡献者。微粒哼比对总数的相应贡献哼的占了超过 20% 全部的 BaPeq 集中,它显著地高集体集中(5%) 。微粒并且气体哼当时,应该被考虑潜在的毒性风险哼污染在 coking 期间,过程被估计。吝啬的总数 -- 哼排放因素分别地是为 CC 和 PC 的 346.132 和 93.173 g/kg。 | Ling Mu Lin Peng Junji Cao Qiusheng He Fan Li Jianqiang Zhang Xiaofeng Liu Huiling Bai | 2013 | Particuology2013，11，1： | 17 |
| 6 | Preliminary results of FeO mapping using Imaging Interferometer data from Chang'E-1显示文摘Information about the variability,and spatial distribution of iron abundance is important to understand lunar geological history and for future resource utilization. In this paper we present a preliminary model to produce an iron abundance map using images taken by an Imaging Interferometer on board the satellite Chang'E-1. Compared with the Clementine UVVIS images,the images from the Chang'E-1 satellite also allowed for the extraction of FeO abundance distributions on the Moon. However,the prelimi-nary model results suggest an underestimation of ~2 wt.% for the FeO content of the mare region and an overestimation of ~3 wt.% for the highland region. | LING ZongCheng ZHANG Jiang LIU JianZhong ZHANG WenXi BIAN Wei REN Xin MU LingLi LIU JianJun LI ChunLai | 2011 | Chinese Science Bulletin2011，56，4： | 15 |
| 7 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 8 | Preliminary results of TiO_2 mapping using Imaging Interferometer data from Chang'E-1显示文摘The distribution of titanium abundance on the lunar surface is important knowledge for lunar geologic studies and future resource utilization.In this paper,we develop a preliminary model based on'ground truths'from Apollo and Luna sample-return sites to produce a titanium abundance map from Chang’E-1 Imaging Interferometer(IIM) images.The derived TiO2 abundances are validated with Clementine UVVIS results in several regions,including lunar highlands neighboring the Apollo 16 landing site,and high-Ti and low-Ti maria near the standard site of Mare Serenitatis(MS2) .The validation results show that TiO2 abundances modeled with Chang’E-1 IIM data are overestimated for highlands(~0.7 wt.%) and low-Ti maria(~1.5 wt.%) and underestimated for high-Ti maria(~0.8 wt.%). | LING ZongCheng ZHANG Jiang LIU JianZhong ZHANG WenXi ZHANG GuangLiang LIU Bin REN Xin MU LingLi LIU JianJun LI ChunLai | 2011 | Chinese Science Bulletin2011，56，20： | 10 |
| 9 | Analysis of In-hospital Neonatal Death in the Tertiary Neonatal Intensive Care Unit in China: A Multicenter Retrospective Study显示文摘 | Chen-Hong Wang Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Xiao-Mei Tong Hong Liu Guo-Fang Ding Bin Yi Xin-Nian Pan Dan-Ni Zhong Ling Liu Mei Li Cui-Qing Li Shi-Wen Xia Hong-Yun Wang Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Ruo-Bing Shan De-Zhi Mu Xiao-Hong Liu Si-Qi Zhuang Jing Guo Li Liu Jia-Jun Zhu Hong Xiong | 2016 | Chinese Medical Journal2016，，22： | 8 |
| 10 | 一项在欧洲和中国进行的新型胃泌素释放肽前体(ProGRP)免疫检测多中心评估研究显示文摘背景在欧洲和中国进行Elecsys?胃泌素释放肽前体(ProGRP)免疫检测的多中心评估研究。方法在欧洲的3个中心和中国的2个中心,在肺癌中,通过不精密度、稳定性、方法学比较和鉴别诊断能力来评价该检测法。结果 5个分析物浓度的中间不精密度范围为变异系数:2.2%-6.0%。在不同储存条件下,血浆和血清样本均显示出良好的稳定性。在血浆中Elecsys?和ARCHITECT检测(斜率1.02,截距-2.72 pg/m L)之间表现出良好的相关性。同时,Elecsys?检测在血清和血浆样本之间表现出良好的相关性(斜率0.93,截距2.35 pg/m L;相关系数0.97)。ProGRP作为不受种族、年龄、性别或吸烟史相关影响的检测手段,可鉴别小细胞和非小细胞肺癌(NSCLC);截断值为84pg/m L时,曲线下面积为0.90,95%CI:0.87-0.93;敏感性为78.3%,特异性为95%。ProGRP浓度中位数在良性病变(38pg/m L)、其他恶性肿瘤(40 pg/m L)或NSCLC(39 pg/m L)中较低,而在3期以上慢性肾脏疾病中浓度较高(>100pg/m L)。结论 Elecsys?ProGRP检测在血清和血浆中稳定性增加,较现有检测法明显更具优势。ProGRP检测在中国的首次评价在不同种族中显示出相当的鉴别能力。 | Catharina M.KORSE Stefan HOLDENRIEDER Xiuyi ZHI Xiaotong ZAHNG Ling QIU Andrea GEISTANGER Marcus-Rene LISY Birgit WEHNL Daan van den BROEK José M.ESCUDERO Jens STANDOP Mu HU Rafael MOLINA | 2017 | 中国肺癌杂志2017，20，8： | 7 |
| 11 | Initiating Characteristics of Early-onset Type 2 Diabetes Mellitus in Chinese Patients显示文摘 | Hui Yu Li-Fang Xie Kang Chen Gang-Yi Yang Xiao-Yan Xing Jia-Jun Zhao Tian-pei Hong Zhong-Yan Shan Hong-Mei Li Bing Chen Xu-Lei Tang Ling Qi Jing Yang Yuan Fang Ting Li Shuang-ShuangWang Ya-Qi Yin Yi-Ming Mu | 2016 | Chinese Medical Journal2016，，7： | 7 |
| 12 | The Relationship between Polymorphisms at 17 Gene Sites and Hypertension among the Aboriginal Tibetan People显示文摘Objective The incidence of hypertension in Tibet ranks highest among all Chinese provinces. This may be due to genetic changes caused by Tibet's unique natural environment and agrarian lifestyle, prompting us to investigated the relationship between gene polymorphisms and hypertension. Methods Blood samples were collected from 229 hypertensive participants and 372 healthy (control) participants from five Tibetan counties. Seventeen single nucleotide polymorphisms were investigated for their connection to hypertension. Results The C allele at rs2070744 of the NOS3 gene was shown to be significantly associated with hypertension (P=0.0443; OR=1.636). Additionally, the T allele of rs4961 of the ADD gene was correlated with hypertension in women (P=0.03124; OR=1.584). Conclusion In this study we found that the NOS3 and ADD genes were related to a high incidence of hypertension among Tibetans. NOS3 gene plays a role in regulating vascular tone and blood vessel diameter, which may be altered by the low-oxygen environment of Tibet. ADD is involved in water and salt metabolism, which is consistent with the high-salt diet of Tibetans. The correlations elucidated by our study were different from those of other ethnic groups, indicating that these findings may be specific to the Tibetan people. | LI Kui LIANG Yu SUN Yin ZHANG Ling Xia YI Xin CHEN Yong GU SANG LA MU WANG Jian | 2012 | Biomedical and Environmental Sciences2012，25，5： | 6 |
| 13 | Malnutrition Increases the Risk of Mortality in Hospitalized Lung Cancer Patients显示文摘Background The Global Leadership Initiative on Malnutrition(GLIM)recently developed a new set of diagnostic criteria for identifying patients with malnutrition.Because the GLIM criteria were only introduced a little over 3 years ago,additional validation and reliability testing are needed in a variety of populations.Methods We performed an observational,multicenter cohort study.From July 2013 to October 2018,lung cancer patients were recruited from the Daping Hospital of Army Medical University and the First Hospital of Jilin University as part of the INSCOC project.Previously-established cut-off values for the calf circumference(CC,male<30 cm,female<29.5 cm)were applied as the reduced muscal mass of phenotypic criteria to establish the GLIM diagnosis.Multivariate Cox regression analyses were performed to analyze the association between the GLIM criteria and survival.Results A total of 1219 patients with lung cancer were studied as subjects.Their age was 58.81±9.92 years old,and 820 were male and 399 were female.According to the GLIM diagnostic criteria using the CC as a muscle mass measurement,303 patients(24.9%)were categorized as malnourished,142 patients(23.1%)in the adult group(18≤age<60)and 161 patients(26.7%)in the older group(age≥60 years).The patients with malnutrition had a higher incidence of anemia than the nourished patients(P=0.012).The QLQ-C30 score and KPS score indicating that the malnourished patients had a consistently worse quality of life compared to the nourished group(all P<0.001).The median survival of the malnutrition group was 42(95%CI:34-50)months,which was much shorter than the 62(95%CI:57-66)months in the nourished group(P<0.001).In the adult group,the median survival decreased from 65(95%CI:55-72)months in nourished group to 34(95%CI:25-48)months in the patients with malnutrition(P<0.001).In the older group,it decreased from 61(95%CI:55-67)months to 48(95%CI:39-59)months(P=0.001).A Cox regression analysis showed that GLIM-diagnosed malnutrition was associated with an increased risk of death among adult group(HR=1.670,95%CI:1.29-2.16),older group(HR=1.332,95%CI:1.05-1.69)and overall(HR=1.453,95%CI:1.22-1.72).Conclusion All of these results demonstrate that GLIM-diagnosed malnutrition is associated with a poorer survival for all lung cancer patients,independent of age. | Fei Fei Chong Liang Yu Yin Jie Liu Na Li Jing Guo Yang Fan Meng Yuan Zhang Ling Zhang Xiu Mei He Hong Mei Zhang Mu Li Shi Wei Li Hong Xia Xu | 2022 | Journal of Nutritional Oncology2022，7，1： | 4 |
| 14 | The carbon isotopic compositions of Non-methane Hydrocarbons in atmosphere显示文摘Carbon isotopic compositions of atmospheric Non-methane Hydrocarbons(NMHCs) in the urban areas of Taiyuan and Lanzhou in summer were reported and the sources of NMHCs are discussed.Carbon isotopic ratios(δ 13C) of vehicle exhaust,coal-combustion exhaust,fuel volatiles and cooking exhaust were also measured with thermal desorption-gas chromatography-isotope ratio-mass spectrometry(TD-GC-IR-MS).δ 13C values of NMHCs in the urban areas of Lanzhou and Taiyuan range from-32.3‰ to-22.3‰ and from-32.8‰ to-18.1‰.δ 13C values of vehicle exhaust,coal-combustion exhaust,fuel volatiles and cooking exhaust are-32.6‰―-21.7‰,-24.5‰―-22.3‰,-32.5‰―-27.4‰ and-31.6‰―-24.5‰,respectively.The data indicate that vehicle exhaust and cooking exhaust make a significant contribution to the atmospheric NMHCs.Therefore,to reduce emissions of vehicle exhaust and cook-ing exhaust is critical for controlling atmospheric NMHCs pollution in summer. | PENG Lin ZHANG HuiMin REN ZhaoFang MU Ling SHI RuiLiang CHANG LiPing LI Fan | 2009 | Chinese Science Bulletin2009，54，8： | 3 |
| 15 | High electrocatalytic hydrogen evolution activity on a coupled Ru and CoO hybrid electrocatalyst显示文摘Hydrogen evolution reaction (HER) is an essential step in converting renewable energy to clean hydrogen fuel. Exploring highly efficient, stable and cost-effective electrocatalysts is of crucial significance for sustainable HER. Here, we report the design of a coupled ruthenium/cobalt oxide (Ru/CoO) hybrid electrocatalyst for alkaline HER. In this hybrid metal/oxide system, the complicated alkaline HER pathways are overall facilitated;oxygen (O)-vacancy-abundant oxide enhances water splitting and Ru promotes successive hydrogen intermediates to generate hydrogen. The resulting Ru/CoO hybrid electrocatalyst exhibits significantly promoted catalytic activity compared with benchmark Ru catalyst, displaying an overpotential of 55 mV to generate a HER current density of 10 mA cm^-2, comparable with the state-of-the-art Pt/C catalyst and the most efficient alkaline HER electrocatalysts. Furthermore, the strong interaction of Ru nanoparticles with oxide support and the in-situ growth of oxide support on conductive substrate guarantee the long-term stability of as-fabricated Ru/CoO hybrid electrocatalyst. This newly designed hybrid catalyst with abundant metal/oxide interfaces may pave a new pathway for exploring efficient and stable HER electrocatalysts. | Jia-Xin Guo Dong-Yang Yan Kang-Wen Qiu Chuan Mu Dian Jiao Jing Mao Hui Wang Tao Ling | 2019 | Journal of Energy Chemistry2019，28，10： | 3 |
| 16 | Modified Tire-Slip-Angle Model for Chaotic Vehicle Steering Motion显示文摘The 5-DOF vehicle model employs the classical tire-slip-angle model to elicit the stability characteristics in vehicle handling during chaotic motion.However,the energy is not conserved,and the simulation results do not match actual behavior in that the vehicle should stop having lost balance.We have analyzed the limitations of the classical tire-slip-angle equation,and developed another model,which can be applied to all conditions.To ensure the correct use of the Pacejka’s magic formula for vehicle dynamics,we discuss the differences in tire axis systems between the ISO and adapted SAE(Pacejka),and propose a transformation method relating the two different tire axis systems.Finally,simulations are described that are performed in accordance with the established 5-DOF vehicle system dynamics model.The simulation results show that all states returned to the stable region after the vehicle had lost balance.The process involved energy dissipation,and approaches the response actually experienced.The limitations of the classical tire-slip-angle model are fully displayed and the effectiveness of the proposed slip angle model is demonstrated in unsteady vehicle states. | Yu Mu Ling Li Shuming Shi | 2018 | Automotive Innovation2018，1，2： | 3 |
| 17 | Experimental repetitive quantum channel simulation显示文摘Universal control of quantum systems is a major goal to be achieved for quantum information processing,which demands thorough understanding of fundamental quantum mechanics and promises applications of quantum technologies. So far, most studies concentrate on ideally isolated quantum systems governed by unitary evolutions, while practical quantum systems are open and described by quantum channels due to their inevitable coupling to environment. Here, we experimentally simulate arbitrary quantum channels for an open quantum system, i.e. a single photonic qubit in a superconducting quantum circuit.The arbitrary channel simulation is achieved with minimum resource of only one ancilla qubit and measurement-based adaptive control. By repetitively implementing the quantum channel simulation,we realize an arbitrary Liouvillian for a continuous evolution of an open quantum system for the first time. Our experiment provides not only a testbed for understanding quantum noise and decoherence,but also a powerful tool for full control of practical open quantum systems. | Ling Hu Xianghao Mu Weizhou Cai Yuwei Ma Yuan Xu Haiyan Wang Yipu Song Chang-Ling Zou Luyan Sun | 2018 | Science Bulletin2018，63，23： | 2 |
| 18 | Positorn annihilation study on point defects in lead tungstate显示文摘A study on point defects in lead tungstate (PbWO4) by using positron annihilation lifetime method is presented. The measurement was carried out for the cases of untreated, vacuum-annealed, oxygen- annealed and La-doped PbWO4 crystals.It was found that the components τ2, which reflect the positron annihilation in point defects, are different from each other for each case. Some tentative models for the defects are discussed. | GU Mu TANG Xue-Feng TONG Hong-Yong LIANG Ling YAO Ming-Zhen CHEN Ling-Yan(Department of Physics, Tongji University, Shanghai 200092)LIAO Jing-Ying SHEN Ding-Zhong YIN Zhi-Wen(Laboratory of Functional Inorganic Materials, the Chinese Academy of Scien | 2000 | Nuclear Science and Techniques2000，11，2： | 2 |
| 19 | Quantitative Trait Loci for Mercury Tolerance in Rice Seedlings显示文摘Mercury (Hg) is one of the most toxic heavy metals to living organisms and its conspicuous effect is the inhibition of root growth.However,little is known about the molecular genetic basis for root growth under excess Hg2+ stress.To map quantitative trait loci (QTLs) in rice for Hg2+ tolerance,a population of 120 recombinant inbred lines derived from a cross between two japonica cultivars Yuefu and IRAT109 was grown in 0.5 mmol/L CaCl2 solution.Relative root length (RRL),percentage of the seminal root length in +HgCl2 to-HgCl2,was used for assessing Hg2+ tolerance.In a dose-response experiment,Yuefu had a higher RRL than IRAT109 and showed the most significant difference at the Hg2+ concentration of 1.5 μmol/L.Three putative QTLs for RRL were detected on chromosomes 1,2 and 5,and totally explained about 35.7% of the phenotypic variance in Hg2+ tolerance.The identified QTLs for RRL might be useful for improving Hg2+ tolerance of rice by molecular marker-assisted selection. | WANG Chong-qing WANG Tao MU Ping LI Zi-chao YANG Ling | 2013 | Rice science2013，20，3： | 2 |
| 20 | Vimentin significantly promoted gallbladder carcinoma metastasis显示文摘背景位于转移一直不是的胆囊癌( GBC )下面的精确分子的机制充分在现在的学习的 elucidated.Methods ,联系转移的蛋白质被候选人蛋白质 vimentin 的功能的学习是的比较 proteomic analysis.The 识别进一步的 investigated.First ,一双更高、更低的变形 sublines (称为的 GBC-SD/M3 和 GBC-SD ,分别地),从一样的父母房间线发源,被自发的 tumorigenicity 和 metast | DONG Ping HE Xiao-wei GU Jun WU Wen-guang LI Mao-lan YANG Jia-hua ZHANG Ling DING Qi-chen LU Jian-hua MU Jia-sheng CHEN Lei LI Song-gan DING Liang-fu WANG Jian-wei LIU Ying-bin | 2011 | Chinese Medical Journal2011，，24： | 2 |
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