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| 1 | Effect of TiO_2 on Crystallization of the Glass Ceramics Prepared from Granite Tailings显示文摘The effect of TiO2 on the crystallization behaviors of the glass ceramics prepared from granite tailings was investigated by differential scanning calorimetry(DSC), X-ray diffraction(XRD), and field emission scanning electron microscopy(FESEM). The results showed that the crystallization peak temperature decreased firstly, and then increased with the increase of TiO2 content. The optimum addition amount of TiO2 was 8 wt%. With a single-step heat treatment at 924 ℃ for 1 h, augite precipitated as the only crystalline phase both on the surface and in the interior. The avrami parameter of the sample was 3.25, suggesting a twodimensional crystallization mechanism. The activation energies for phase separation and crystallization of augite were 321.75 and 698.83 k J/mol, respectively. | 程金树 KANG Junfeng LOU Xianchun ZHANG Xiaoman LIU Kai WANG Wentian HUAI Xuguang | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，1： | 9 |
| 2 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 3 | Enhanced tribological properties of aligned graphene-epoxy composites显示文摘The random distribution of graphene in epoxy matrix hinders the further applications of grapheneepoxy composites in the field of tribology.Hence,in order to fully utilize the anisotropic properties of graphene,highly aligned graphene-epoxy composites(AGEC)with horizontally oriented structure have been fabricated via an improved vacuum filtration freeze-drying method.The frictional tests results indicated that the wear rate of AGEC slowly increased from 5.19x10^(-6)mm^(3)/(N-m)to 2.87x10^(-5)mm^(3)/(N-m)with the increasing of the normal load from 2 to 10 N,whereas the friction coefficient(COF)remained a constant of 0.109.Compared to the neat epoxy and random graphene-epoxy composites(RGEC),the COF of AGEC was reduced by 87.5%and 71.2%,and the reduction of wear rate was 86.6%and 85.4%at most,respectively.Scanning electron microscope(SEM)observations illustrated that a compact graphene self-lubricant film was formed on the worn surface of AGEC,which enables AGEC to possess excellent tribological performance.Finally,in light of the excellent tribological properties of AGEC,this study highlights a pathway to expand the tribological applications of graphene-epoxy composites. | Yuefeng DU Zhenyu ZHANG Dong WANG Lezhen ZHANG Junfeng CUI Yapeng CHEN Mingliang WU Ruiyang KANG Yunxiang LU Jinhong YU Nan JIANG | 2022 | Friction2022，10，6： | 2 |
| 4 | Hydrothermal synthesis of S-doped TiO2 nanoparticles and their photocatalytic ability for degradationof methyl orange显示文摘 | Tian Hua Ma Junfeng Li Kang | 2009 | Ceram Int2009，35，3： | 1 |
| 5 | Lanthanum-dopedα-Ni(OH)_(2)1D-2D-3D hierarchical nanostructures for robust bifunctional electro-oxidation显示文摘The development of advanced electrocatalysts for electro-oxidation reactions has attracted much attention because of the critical role of such electrocatalysts in improving the overall efficiency of coupled hydrogen production.We have developed an efficient lanthanum-dopedα-Ni(OH)_(2) bifunctional catalyst with a 1D-2D-3D hierarchical nanostructure.It shows superior activity and stability in the anodic oxygen evolution reaction(OER)and urea oxidation reaction(UOR).Enrichment of the edge sites and conducting La doping inα-Ni(OH)_(2) phase enable formation and stabilization of abundant local Ni^(3+)ions.This guarantees ultralow onset potentials in electro-oxidation reactions.The 1D-2D-3D hierarchical nanostructure significantly boosts the in situ generation of high-valence active species,which results in efficient and stable OER and UOR performances,and the synergistic merit of doping-induced facile reaction kinetics.Because of the structural benefits of a large surface area,charge-transfer promotion,good structural stability,and bifunctionality,a 1%La-dopedα-Ni(OH)_(2) hierarchical nanostructure gives superior OER and UOR performances with low overpotentials,large catalytic current densities,and excellent operational stability.It is therefore a promising catalyst for use in simultaneous alkaline wastewater treatment and hydrogen production. | Zimeng Wei Wenbin Sun Shanshan Liu Jindi Qi Luyao Kang jiechen Li Shanshan Lou Junfeng Xie Bo Tanga Yi Xie | 2021 | Particuology2021，19，4： | 1 |
| 6 | A new type of polarographic catalytic wave of organic compound显示文摘 | Xiaofeng Kang Junfeng Song | 1999 | Science in China Series B: Chemistry1999，，5： | 1 |
| 7 | Photocatalytic degradation of methyl orange with W-doped TiOe syn thesized by a hydrothermal method显示文摘 | Tian Hua Ma Junfeng Li Kang | 2008 | Mater Chem Phys2008，112，1： | 1 |
| 8 | Endogenous miRNA Sponge lincRNA-RoR Regulates Oct4, Nanog, and Sox2 in Human Embryonic Stem Cell Self-Renewal显示文摘 | Yue Wang Zhenyu Xu Junfeng Jiang Chen Xu Jiuhong Kang Lei Xiao Minjuan Wu Jun Xiong Xiaocan Guo Houqi Liu | 2013 | Developmental Cell2013，，1： | 1 |
| 9 | Scientific objectives of the Hot Universe Baryon Surveyor(HUBS) mission显示文摘The Hot Universe Baryon Surveyor(HUBS) is a proposed space-based X-ray telescope for detecting X-ray emissions from the hot gas content in our universe. With its unprecedented spatially-resolved high-resolution spectroscopy and large field of view,the HUBS mission will be uniquely qualified to measure the physical and chemical properties of the hot gas in the interstellar medium, the circumgalactic medium, the intergalactic medium, and the intracluster medium. These measurements will be valuable for two key scientific goals of HUBS, namely to unravel the AGN and stellar feedback physics that governs the formation and evolution of galaxies, and to probe the baryon budget and multi-phase states from galactic to cosmological scales. In addition to these two goals, the HUBS mission will also help us solve some problems in the fields of galaxy clusters, AGNs, difuse X-ray backgrounds, supernova remnants, and compact objects. This paper discusses the perspective of advancing these fields using the HUBS telescope. | Joel Bregman Renyue Cen Yang Chen Wei Cui Taotao Fang Fulai Guo Edmund Hodges-Kluck Rui Huang Luis C.Ho Li Ji Suoqing Ji Xi Kang Xiaoyu Lai Hui Li Jiangtao Li Miao Li Xiangdong Li Yuan Li Zhaosheng Li Guiyun Liang Helei Liu Wenhao Liu Fangjun Lu Junjie Mao Gabriele Ponti Zhijie Qu Chenxi Shan Lijing Shao Fangzheng Shi Xinwen Shu Lei Sun Mouyuan Sun Hao Tong Junfeng Wang Junxian Wang Q.Daniel Wang Song Wang Tinggui Wang Weiyang Wang Zhongxiang Wang Dandan Xu Haiguang Xu Heng Xu Renxin Xu Xiaojie Xu Yongquan Xue Hang Yang Feng Yuan Shuinai Zhang Yuning Zhang Zhongli Zhang Yuanyuan Zhao Enping Zhou Ping Zhou | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 1 |
| 10 | Adsorption-parallel catalytic waves of cinnamic acid in hydrogen peroxide-tetra-n-butylammonium bromide-acetate system显示文摘 | Xiaofeng Kang Wei Guo Chuan Zhao Junfeng Song | 2000 | Science in China Series B: Chemistry2000，，3： | 1 |
| 11 | A new type of polarographic catalytic wave of organic compound显示文摘 | Xiaofeng Kang Junfeng Song | 1999 | Science in China Series B: Chemistry1999，，5： | 1 |
| 12 | Rapid and Scalable Synthesis of Prussian Blue Analogue Nanocubes for Electrocatalytic Water Oxidation显示文摘Design and fabrication of earth-abundant electrocatalysts for oxygen evolution reaction(OER)is essential in improving the overall ef-ficiency of water electrolysis.In this work,we proposed a rapid and scalable synthesis route for fabricating Prussian blue analogue(PBA)nano cubes with tun able compositi ons and uniform particle size.With the structural ben efits of abu ndant surface sites,facile charge transfer behavior and favorable Co^(2+)-to-Co^(3+)pre-oxidation reaction,fast generation and accumulation of the catalytically active Co3+sites can be achieved for the CoCo PBA nano cubes,leadi ng to remarkable OER activity with simulta neously achieved low overpotential,large anodic current density,small Tafel slope as well as outstanding intrinsic activity.Of note,by performing Iong-term OER operati on,the CoCo PBA nano cubes exhibit a remarkable 5.5-folds performs nee enhan ceme nt,and obvious surface rec on struc-tion and the accumulation of high-valence Co species can be identified,proving the crucial role of pre-oxidation process in boosting the OER catalysis.This work proposed a un iversal approach for the rapid,scalable and con trollable fabricati on of the PBA-based materials,and the elucidation of the pre-oxidation process in facilitating the OER catalysis may provide useful guidanee for designing and optimizing advanced catalysts for energy-related electro-oxidation reactions in the future. | Wenbin Sun Zimeng Wei Jindi Qi Luyao Kang Jiechen Li Junfeng Xie Bo Tang Yi Xie | 2021 | Chinese Journal of Chemistry2021，39，9： | 1 |
| 13 | A New Route for the Rapid Synthesis of Metal–Organic Frameworks at Room Temperature显示文摘Rapid synthesis of metal–organic frameworks(MOFs),especially high-valence MOFs at roomtemperature without external energy,is a challenging topic.In this work,a stable radical solution has been discovered.Various MOFs with versatile metal nodes and ligands were rapidly synthesized at room temperature in the absence of external energy.Especially,MOFs with conjugated ligands achieved instantaneous architecture(in less than 1 s)and quantitative yield.Radicals in the solution play a crucial role in the accelerated kinetics,and the new radical route paves a cyclic pathway for the MOF synthesis.The mechanism has been thoroughly investigated by electron paramagnetic resonance,in situ proton nuclear magnetic resonance,X-ray absorption spectra,in situ small-angle X-ray scattering-wide-angle X-ray scattering,and density functional theory calculations. | Pei Zhang Xinchen Kang Liming Tao Lirong Zheng Junfeng Xiang Ran Duan Jikun Li Peng Chen Xueqing Xing Guang Mo Zhonghua Wu Buxing Han | 2023 | CCS Chemistry2023，5，6： | 0 |
| 14 | Field-effect at electrical contacts to two-dimensional materials显示文摘The inferior electrical contact to two-dimensional(2D)materials is a critical challenge for their application in post-silicon very large-scale integrated circuits.Electrical contacts were generally related to their resistive effect,quantified as contact resistance.With a systematic investigation,this work demonstrates a capacitive metal-insulator-semiconductor(MIS)field-effect at the electrical contacts to 2D materials:The field-effect depletes or accumulates charge carriers,redistributes the voltage potential,and gives rise to abnormal current saturation and nonlinearity.On one hand,the current saturation hinders the devices’driving ability,which can be eliminated with carefully engineered contact configurations.On the other hand,by introducing the nonlinearity to monolithic analog artificial neural network circuits,the circuits’perception ability can be significantly enhanced,as evidenced using a coronavirus disease 2019(COVID-19)critical illness prediction model.This work provides a comprehension of the field-effect at the electrical contacts to 2D materials,which is fundamental to the design,simulation,and fabrication of electronics based on 2D materials. | Yao Guo Yan Sun Alvin Tang Ching-Hua Wang Yanqing Zhao Mengmeng Bai Shuting Xu Zheqi Xu Tao Tang Sheng Wang Chenguang Qiu Kang Xu Xubiao Peng Junfeng Han Eric Pop Yang Chai | 2021 | Nano Research2021，14，12： | 0 |
| 15 | Interactions between H_(2)O_(2)and dissolved organic matter during granular activated carbon-based residual H_(2)O_(2)quenching from the upstream UV/H_(2)O_(2)process显示文摘Granular activated carbon(GAC)filtration can be employed to synchronously quench residual H_(2)O_(2)from the upstream UV/H_(2)O_(2)process and further degrade dissolved organicmatter(DOM).In this study,rapid small-scale column tests(RSSCTs)were performed to clarify the mechanisms underlying the interactions between H_(2)O_(2)and DOM during the GAC-based H_(2)O_(2)quenching process.It was observed that GAC can catalytically decompose H_(2)O_(2),with a long-lasting high efficiency(>80%for approximately 50,000 empty-bed volumes).DOM inhibited GAC-based H_(2)O_(2)quenching via a pore-blocking effect,especially at high concentrations(10 mg/L),with the adsorbed DOM molecules being oxidized by the continuously generated·OH;this further deteriorated the H_(2)O_(2)quenching efficiency.In batch experiments,H_(2)O_(2)could enhance DOM adsorption by GAC;however,in RSSCTs,it deteriorated DOM removal.This observation could be attributed to the different·OH exposure in these two systems.It was also observed that aging with H_(2)O_(2)and DOM altered the morphology,specific surface area,pore volume,and the surface functional groups of GAC,owing to the oxidation effect of H_(2)O_(2)and·OH on the GAC surface as well as the effect of DOM.Addi-tionally,the changes in the content of persistent free radicals in the GAC samples were insignificant following different aging processes.This work contributes to enhancing understanding regarding the UV/H_(2)O_(2)-GAC filtration scheme,and promoting the application in drinking water treatment. | Yaoyao Kang Junfeng Lian Yichun Zhu Zuwen Liu Wentao Li Huiyu Dong Yuanyue Wang Jinfeng Zeng Zhimin Qiang | 2023 | Journal of Environmental Sciences2023，，6： | 0 |
| 16 | Three-terminal germanium-on-silicon avalanche photodiode with extended p-charge layer for dark current reduction显示文摘Germanium-on-silicon(Ge-on-Si) avalanche photodiodes(APDs) are widely used in near-infrared detection, laser ranging, free space communication, quantum communication, and other fields. However, the existence of lattice defects at the Ge/Si interface causes a high dark current in the Ge-on-Si APD, degrading the device sensitivity and also increasing energy consumption in integrated circuits. In this work, we propose a novel surface illuminated Ge-on-Si APD architecture with three terminals. Besides two electrodes on Si substrates, a third electrode is designed for Ge to regulate the control current and bandwidth, achieving multiple outputs of a single device and reducing the dark current of the device. When the voltage on Ge is -27.5 V, the proposed device achieves a dark current of 100 n A, responsivity of 9.97 A/W at -40 d Bm input laser power at 1550 nm, and optimal bandwidth of 142 MHz. The low dark current and improved responsivity can meet the requirements of autonomous driving and other applications demanding weak light detection. | XIAOBIN LIU XUETONG LI YUXUAN LI YINGZHI LI ZIHAO ZHI MIN TAO BAISONG CHEN LANXUAN ZHANG PENGFEI GUO GUOQIANG LO XUEYAN LI FENGLI GAO BONAN KANG JUNFENG SONG | 2022 | Photonics Research2022，10，8： | 0 |
| 17 | Microenvironment-responsive chemotherapeutic nanogels for enhancing tumor therapy via DNA damage and glutathione consumption显示文摘Although targeted therapy and immunotherapy are now shining in the treatment of some cancers,chemotherapy is still the cornerstone of drug treatment for many cancer patients.The emergence of chemotherapy prodrugs can improve the drug activity and reduce the side effects of chemotherapy.When used,the tumor microenvironment has characteristics different from normal tissues,and the existence of the microenvironment provided a more convenient way to design responsive nanodrugs.Herein,we designed a glutathione(GSH)-responsive prodrug nanogels for enhancing tumor chemotherapy.In the nanogels of HHNP,10-hydroxycamptothecin(HCPT)played an essential role in killing cancer cells.HCPT was jointed with a cross-linker agent with disulfide bond and was further coated with polyethylene glycol,which not only prolonged the half-life of the drug,but also made HCPT accurate transport to the tumor fractions and achieved precise and controllable release.The proposal of HHNP effectively retained the biological activity of the drug,and introduced functions such as targeting,selective release and biodegradation,which greatly improved the medical efficiency of the drug and effectively reduced the toxic and side effects.This chemotherapeutic prodrug nanogel offers a new window for constructing efficient drug delivery platform. | Mengjie Ye Yuan Gao Mengyun Liang Wei Qiu Xian bin Ma Jiming Xu Junfeng Hu Peng Xue Yuejun Kang Zhigang Xu | 2022 | Chinese Chemical Letters2022，33，9： | 0 |
| 18 | An Importance Assessment Model of Open-Source Community Java Projects Based on Domain Knowledge Graph显示文摘With the rise of open-source software,the social development paradigm occupies an indispensable position in the current software development process.This paper puts forward a variant of the PageRank algorithm to build the importance assessment model,which provides quantifiable importance assessment metrics for new Java projects based on Java open-source projects or components.The critical point of the model is to use crawlers to obtain relevant information about Java open-source projects in the GitHub open-source community to build a domain knowledge graph.According to the three dimensions of the Java open-source project’s project influence,project activity and project popularity,the project is measured.A modified PageRank algorithm is proposed to construct the importance evaluation model.Thereby providing quantifiable importance evaluation indicators for new Java projects based on or components of Java open-source projects.This article evaluates the importance of 4512 Java open-source projects obtained on GitHub and has a good effect. | Chengrong Yang Rongjing Bu Yan Kang Yachuan Zhang Hao Li Tao Li Junfeng Li | 2020 | Journal on Big Data2020，2，4： | 0 |
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