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| 1 | Cardiac autonomic nerve fiber regeneration in chronic heart failure Do Akt gene-transduced mesenchymal stem cells promote repair?显示文摘BACKGROUND: Transplantation of Akt-over-expressing mesenchymal stem cells (Akt-MSCs) has been shown to repair infarcted myocardium and improve cardiac function. However, little is known about the therapeutic effects of Akt-MSCs on cardiac autonomic neuropathy in chronic heart failure (CHF). OBJECTIVE: The present study used adriamycin-induced CHF rat models to observe the effect of Akt-MSCs on cardiac autonomic nervous regeneration and the factors mediating this effect. DESIGN, TIME AND SETTING: A randomized, controlled animal experiment was performed at the Central Laboratory of Basic Medical College, China Medical University, between September 2008 and April 2009. MATERIALS: Rabbit anti-choline acetyltransferase (ChAT), growth associated protein-43 (GAP-43), synaptophysin (SYN) polyclonal antibodies and the secondary antibody (goat anti-rabbit IgG) were purchased from Boster, China. Cat-A-Kit assay system was provided by Amersham, USA. METHODS: (1) Adult rat MSCs were isolated and cultured for the preparation of Akt-MSCs. (2) Forty male Wistar rats were intramyocardially administered adriamycin at 2 mg/kg over 3 days for a total of five times and once a week for additional five times thereafter to establish CHF models. At 2 weeks after final adriamycin treatment, 34 successful CHF rat models were randomized to three groups: Akt-MSCs (n = 11), simple MSCs (s-MSCs, n =11), and control (n = 12). Each group was intravenously administered Akt-MSCs (2×106 cells in 100 μL PBS), s-MSCs (2×106 cells in 100 μL PBS) or equal volume of phosphate buffered saline, once a day for a total of three times. MAIN OUTCOME MEASURES: At 4 weeks after final adriamycin treatment, myocardial norepi- nephrine (NE) content was detected using a Cat-A-Kit assay system. Myocardial ChAT, SYN and GAP-43 were performed by immunohistochemistry and Western blot analysis. Prior to, 2 and 4 weeks after adriamycin treatment, echocardiographic examination was performed and left ventricular ejection fraction (LVEF) was determined. RESULTS: Myocardial NE content, as well as SYN-positive and GAP-43-positive nerve fiber density and expression, and LVEF, was the greatest in the Akt-MSCs group, followed by the s-MSCs group, and lastly the control group (P < 0.05 or P < 0.01). ChAT expression was similar between Akt-MSCs and s-MSCs groups, but it was higher compared with the control group (P < 0.05). NE contents were negatively correlated to LVEF (r = -0.64, P = 0.015). CONCLUSION: Transplantation of MSCs, in particular Akt-MSCs, promotes cardiac nervous regeneration in failing heart, which might be mediated by GAP-43. | Hongliang Kong Zhanquan Li Shumei Zhao Li Zhu Yingjun Zhao Weiwei Zhang GuipingXu Wenjun Hao Huijun Li Guoxian Qi | 2010 | Neural Regeneration Research2010，5，1： | 13 |
| 2 | Hierarchical space–time block codes signals classification using higher order cumulants显示文摘An efficient method for blind classification of space–time block codes(STBCs) based on fourth-order cumulants is proposed for a single receiver antenna.This paper presents a model of received STBCs signals in multiple input single output(MISO) communication systems and applies the characteristics of coding matrices to derive analytical expressions for the fourth-order cumulants to be used as the basis of an algorithm.The fourth-order cumulants at various delay vectors present non-null values that depend on the transmitted STBCs.Tests of nullity are accomplished by hypothesis testing.The proposed algorithm avoids the need for a priori information of modulation scheme,channel coefficients,and noise power.Consequently,it is well suited for non-cooperative scenarios.Simulations show that this method performs well even at low signal-to-noise ratios(SNRs). | Ling Qing Zhang Limin Yan Wenjun Kong Dongming | 2016 | Chinese Journal of Aeronautics2016，29，3： | 9 |
| 3 | Park7 interacts with p47phox to direct NADPH oxidase- dependent ROS production and protect against sepsis显示文摘 | Wenjun Liu Hailong Wu Lili Chen Yankai Wen Xiaoni Kong Wei-Qiang Gao | 2015 | Cell Research2015，25，6： | 5 |
| 4 | Spirolindemers A and B,Lindenane Sesquiterpenoid Oligomers Equipped with Oxaspiro[4.5]decane from Chloranthus henryi显示文摘Spirolindemers A and B,unprecedented lindenane sesquiterpenoid dimer(1)and trimer(2)equipped with oxaspiro[4.5]decane unit,were discovered from the medicinal plant Chloranthus henryi.Their structures including absolute configurations were achieved by HRMS,NMR,ECD,X-ray diffraction analyses,and quantum chemical calculations.Biogenetically,hetero-and homo-Diels-Alder additions may dominate the formation of oxaspiro[4.5]decane and spiro[4.5]decane skeletons,respectively.Compound 1 showed anti-inflammatory activity by inhibiting the expression of iNOS and COX-2. | Jixin Li Jun Chi Pengfei Tang Yunpeng Sun Weijia Lu Wenjun Xu Yongyue Wang Jun Luo Lingyi Kong | 2022 | Chinese Journal of Chemistry2022，40，5： | 4 |
| 5 | MS1 is essential for male fertility by regulating the microsporocyte cell plate expansion in soybean显示文摘Male sterility is an essential trait in hybrid seed production,especially for monoclinous and autogamous food crops.Soybean male-sterile ms1 mutant has been known for more than 50 years and could be instrumental in making hybrid seeds.However,the gene responsible for the male-sterile phenotype has remained unknown.Here,we report the map-based cloning and characterization of the MS1 gene in soybean.MS1 encodes a kinesin protein and localizes to the nucleus,where it is required for the male meiotic cytokinesis after telophase Ⅱ.We further substantiated that MS1 colocalizes with microtubules and is essential for cell plate formation in soybean male gametogenesis through immunostaining.Both ms1 and CRISPR/Cas9 knockout mutants show complete male sterility but are otherwise phenotypically normal,making them perfect tools for producing hybrid seeds.The identification of MS1 has the practical potential for assembling the sterility system and speeding up hybrid soybean breeding. | Xiaolong Fang Xiaoyuan Sun Xiangdong Yang Qing Li Chunjing Lin Jie Xu Wenjun Gong Yifan Wang Lu Liu Limei Zhao Baohui Liu Jun Qin Mengchen Zhang Chunbao Zhang Fanjiang Kong Meina Li | 2021 | Science China(Life Sciences)2021，64，9： | 4 |
| 6 | Study on the pre-ignition characteristics of wire insulation in the narrow channel setup显示文摘A narrow channel setup was established and experiments were conducted to study the pre-ignition characteristics of wire insulation under overload conditions in weak buoyancy environment.The pre-ignition temperature variation trend of both the wire insulation and its nearby temperature monitoring points,the movement characteristics of smoke produced from the wire insulation and the ignition delay time of wire insulation were investigated.The results indicated that the narrow channel setup with a height of 10-15 mm was effective to suppress the effect of buoyancy,and the pre-ignition characteristics of wire insulation in microgravity could be predicted well by the narrow channel method. | WANG Kai WANG BaoRui AI YuHua KONG WenJun | 2012 | Science China(Technological Sciences)2012，55，8： | 2 |
| 7 | Positioning taxonomic research for the future显示文摘Why do taxonomists matter? The work of taxonomists is often understated if not completely misunderstood. Without taxonomists, organisms cannot be accurately identified, neither can these organisms be given universally accepted names, and reliably positioned in the phylogenetic tree of life. Thanks to the work of taxonomists over the last 269 years since Carl Linnaeus established the binomial system, we can now measure the health and wealth of our biodiversity in a refined, science-based inventory prescribed by stringent nomenclatural rules. | Deyuan Hong Wenying Zhuang Min Zhu Keping Ma Xiaoquan Wang Dawei Huang Yalin Zhang Guodong Ren Wenjun Bu Wanzhi Cai Dong Ren Ding Yang Aiping Liang Fengyan Bai Runzhi Zhang Fumin Lei Shuqiang Li Hongzhi Kong Lei Cai Yucheng Dai Chaodong Zhu Qisen Yang Jun Chen Zhongli Sha Jianping Jiang Jing Che Donghui Wu Jiatang Li Qiang Wang Xinli Wei Ming Bai Xingyue Liu Xuexin Chen Gexia Qiao | 2022 | Zoological Systematics2022，47，3： | 2 |
| 8 | Fabrication of large-area uniform carbon nanotube foams as near-critical-density targets for laser–plasma experiments显示文摘Carbon nanotube foams(CNFs)have been successfully used as near-critical-density targets in the laser-driven acceleration of high-energy ions and electrons.Here we report the recent advances in the fabrication technique of such targets.With the further developed floating catalyst chemical vapor deposition(FCCVD)method,large-area(>25 cm^(2))and highly uniform CNFs are successfully deposited on nanometer-thin metal or plastic foils as double-layer targets.The density and thickness of the CNF can be controlled in the range of 1−13 mg/cm^(3)and 10−200µm,respectively,by varying the synthesis parameters.The dependence of the target properties on the synthesis parameters and the details of the target characterization methods are presented for the first time. | Pengjie Wang Guijun Qi Zhuo Pan Defeng Kong Yinren Shou Jianbo Liu Zhengxuan Cao Zhusong Mei Shirui Xu Zhipeng Liu Shiyou Chen Ying Gao Jiarui Zhao Wenjun Ma | 2021 | High Power Laser Science and Engineering2021，9，2： | 1 |
| 9 | Study on Prefire Phenomena of Wire Insulation in Microgravity 显示文摘 | KONG Wenjun WANG Baorui ZHANG Weikuo | 2008 | Microgravity Science and Technology2008，20，： | 1 |
| 10 | Study on the Pre~ignition Temperature Variations of Wire Insulaqtion Under Overload Conditions in Microgravity by the Functional Simulation Method 显示文摘 | WANG Kai WANG Baorui KONG Wenjun | 2014 | Journal of Fire Sci- ences2014，32，25： | 1 |
| 11 | Numerical study of the effects of gravity on soot formation in laminar coflowmethane/air diffusion flames under different air stream velocities显示文摘 | Kong Wenjun Liu Fengshan | 2009 | Combustion Theory and Modelling2009，13，6： | 1 |
| 12 | Recursive Dictionary-Based Simultaneous Orthogonal Matching Pursuit for Sparse Unmixing of Hyperspectral Data显示文摘The sparse unmixing problem of greedy algorithms still remains a great challenge at finding an optimal subset of endmembers for the observed data from the spectral library,due to the usually high correlation of the spectral library.Under such circumstances,a novel greedy algorithm for sparse unmixing of hyperspectral data is presented,termed the recursive dictionary-based simultaneous orthogonal matching pursuit(RD-SOMP).The algorithm adopts a block-processing strategy to divide the whole hyperspectral image into several blocks.At each iteration of the block,the spectral library is projected into the orthogonal subspace and renormalized,which can reduce the correlation of the spectral library.Then RD-SOMP selects a new endmember with the maximum correlation between the current residual and the orthogonal subspace of the spectral library.The endmembers picked in all the blocks are associated as the endmember sets of the whole hyperspectral data.Finally,the abundances are estimated using the whole hyperspectral data with the obtained endmember sets.It can be proved that RD-SOMP can recover the optimal endmembers from the spectral library under certain conditions.Experimental results demonstrate that the RD-SOMP algorithm outperforms the other algorithms,with a better spectral unmixing accuracy. | Kong Fanqiang Guo Wenjun Shen Qiu Wang Dandan | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，4： | 1 |
| 13 | Effects of fuel properties on the combustion behavior of different types of porous beds soaked with combustible liquid显示文摘 | Christopher Y H Chao J H Wang and Wenjun Kong | 2004 | International Journal of Heat and Mass Transfer2004，24，47： | 1 |
| 14 | Behavior of non spread diffusion flames of combustible liquid soaked in porous beds显示文摘 | Wenjun Kong Christopher Y H Chaoa | 2002 | Proceedings of the Combustion Institute2002，29，1： | 1 |
| 15 | High-energy-density plasma in femtosecond-laser-irradiated nanowire-array targets for nuclear reactions显示文摘In this work,the high-energy-density plasmas(HEDP)evolved from joule-class-femtosecond-laser-irradiated nanowire-array(NWA)targets were numerically and experimentally studied.The results of particle-in-cell simulations indicate that ions accelerated in the sheath field around the surfaces of the nanowires are eventually confined in a plasma,contributing most to the high energy densities.The protons emitted from the front surfaces of the NWA targets provide rich information about the interactions that occur.We give the electron and ion energy densities for broad target parameter ranges.The ion energy densities from NWA targets were found to be an order of magnitude higher than those from planar targets,and the volume of the HEDP was several-fold greater.At optimal target parameters,8%of the laser energy can be converted to confined protons,and this results in ion energy densities at the GJ/cm^(3) level.In the experiments,the measured energy of the emitted protons reached 4 MeV,and the changes in energy with the NWA’s parameters were found to fit the simulation results well.Experimental measurements of neutrons from 2H(d,n)3He fusion with a yield of(24±18)×10^(6)/J from deuterated polyethylene NWA targets also confirmed these results. | Defeng Kong Guoqiang Zhang Yinren Shou Shirui Xu Zhusong Mei Zhengxuan Cao Zhuo Pan Pengjie Wang Guijun Qi Yao Lou Zhiguo Ma Haoyang Lan Wenzhao Wang Yunhui Li Peter Rubovic Martin Veselsky Aldo Bonasera Jiarui Zhao Yixing Geng Yanying Zhao Changbo Fu Wen Luo Yugang Ma Xueqing Yan Wenjun Ma | 2022 | Matter and Radiation at Extremes2022，7，6： | 1 |
| 16 | Allelic variation in the coumarate 3-hydroxylase gene associated with wood properties of Catalpa fargesii Bur.显示文摘Coumarate 3-hydroxylase(C3h)genes participate in the synthesis of lignin and may affect the properties of wood that are important for its commercial value.A better understanding of the natural variation in C3h genes and their associations to wood properties is required to effectively improve wood quality.We used a candidate gene-based association mapping approach to identify CfC3h allelic variants associated with traits that affect the wood properties of Catalpa fargesii.We first isolated the full-length CfC3h cDNA(1825 bp),which was expressed at relatively high levels in xylem according to real time-polymerase chain reaction.In totally,17 common single-nucleotide polymorphisms(minor allele frequency>5%)were identified through cloning and sequencing the CfC3h locus from a mapping population(including 88 unrelated natural C.fargesii individuals collected from main distribution area).Nucleotide diversity and linkage disequilibrium(LD)in CfC3h indicate that CfC3h has low nucleotide diversity(π_(t)=0.0031 andθ_(w)=0.0103)and relatively low LD(within 1800 bp;r^(2)≥0.1).An association analysis identified eight common single-nucleotide polymorphisms(SNPs)(false discovery rate,Q<0.10)and ten haplotypes(Q<0.10)associated with wood properties,explaining 4.92-12.09%of the phenotypic variance in an association population consisted of 125 unrelated natural individuals(The 88 individuals from the mapping population were comprised in the association population).Our study would provide new insight into C3h gene affecting wood quality,and the SNP markers identified would have potential applications in marker-assisted breeding in the future. | Nan Lu Fang Mei Zhi Wang Nan Wang Yao Xiao Lisheng Kong Guanzheng Qu Wenjun Ma Junhui Wang | 2021 | Journal of Forestry Research2021，32，6： | 1 |
| 17 | Elodexanthones A—J, Isoprenylated Xanthone Derivatives with Diverse Skeletons and Bioactivities from Hypericum elodeoides显示文摘Elodexanthones A—J (1—10), two pairs of rearranged isoprenylated xanthone enantiomers with an unprecedent 6/6/5/6 tetracyclic core (1—2) along with seven new isoprenylated xanthones (3—9) and a pair of phenylpropanoid xanthones (10), were purified and enantio-separated from the whole plant of Hypericum elodeoides. Their structures including absolute configurations were characterized by the comprehensive analysis of NMR, HRESIMS, NMR calculations, and ECD calculations. Through Bayer-Villiger oxidation, Claisen condensation and electrophilic addition, the rearranged skeletons of elodexanthones A—B (1—2) were generated from isoprenylated xanthone precursors. The bioactivities evaluation exhibited that compounds 3, 5, 8—10 showed anti-inflammatory activity with the IC_(50) values in the range of 9.53—34.39 μmol/L, and compounds 3—7, and 9 showed notable α-glucosidase inhibitory activity (IC_(50): 6.02—257.11 μmol/L). | Yanbing Mu Yaqi Li Qiji Li Wenjun Xu Yunpeng Sun Siyuan Wang Letian Cui Lingyi Kong Jun Luo | 2022 | Chinese Journal of Chemistry2022，40，24： | 1 |
| 18 | Experimental and Numerical Studies of a Microscale Internal Combustion Swing Engine(MICSE)显示文摘In this paper,the operation characteristics of a microscale internal combustion swing engine(MICSE)were investigated experimentally and numerically.The energy flow path of MICSE was comprehensively analyzed based on the first law of thermodynamics.The accuracy of zero-dimensional model was verified by experiments.The indicative thermal efficiency of the engine increases first and then decreases with the increase of equivalent ratio or ignition advance angle.The results show that there exists an optimum equivalent ratio and ignition advance angle during operation.The maximum efficiency of the engine reaches 12.5%when the equivalent ratio and ignition advance angle are 0.8 and−0.553,respectively.MICSE can operate normally when the equivalent ratio is greater than 0.6.The peak value of net heat release rate lags behind that of pressure change,which is different from the conventional crank engine.Experimental and simulation results show that the leakage of MICSE is serious,and it is the main loss of MICSE.The order of energy terms is as follows:leakage loss>exhaust loss>heat loss>indicative work. | DU Ning KONG Wenjun | 2021 | Journal of Thermal Science2021，30，5： | 1 |
| 19 | Effects of Diluents on the Ignition of Premixed H2/Air Mixtures 显示文摘 | ZHANC Weikuo CHEN Zheng KONG Wenjun | 2012 | Combustion and Flame2012，159，： | 1 |
| 20 | Boosting in-plane anisotropy by periodic phase engineering in two-dimensional VO_(2) single crystals显示文摘In-plane anisotropy(IPA)due to asymmetry in lattice structures provides an additional parameter for the precise tuning of characteristic polarization-dependent properties in two-dimensional(2D)materials,but the narrow range within which such method can modulate properties hinders significant development of related devices.Herein we present a novel periodic phase engineering strategy that can remarkably enhance the intrinsic IPA obtainable from minor variations in asymmetric structures.By introducing alternant monoclinic and rutile phases in 2D VO_(2)single crystals through the regulation of interfacial thermal strain,the IPA in electrical conductivity can be reversibly modulated in a range spanning two orders of magnitude,reaching an unprecedented IPA of 113.Such an intriguing local phase engineering in 2D materials can be well depicted and predicted by a theoretical model consisting of phase transformation,thermal expansion,and friction force at the interface,creating a frame-work applicable to other 2D materials.Ultimately,the considerable adjustability and reversibility of the presented strategy provide opportunities for future polarization-dependent photoelectric and optoelectronic devices. | Meng Ran Chao Zhao Xiang Xu Xiao Kong Younghee Lee Wenjun Cui Zhi-Yi Hu Alexander Roxas Zhengtang Luo Huiqiao Li Feng Ding Lin Gan Tianyou Zhai | 2022 | Fundamental Research2022，2，3： | 0 |
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