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| 1 | Oxidative stress and lipid peroxidation products:effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis显示文摘BACKGROUND:Melatonin (N-acetyl-5-methoxytripta-mine) is a free radical scavenger and a strong antioxidant,secreted by the pineal gland.In this study,we evaluated the effects of decreasing and increasing serum melatonin levels on malonyldialdehyde (MDA),superoxide dismutase (SOD),and reduced glutathione (GSH) levels in pancreatic tissue from rats with experimental acute pancreatitis.METHODS:Experimental acute pancreatitis was induced in three groups of Wistar albino rats (10 animals per group) by pancreatic ductal ligation.The first group had only acute pancreatitis and served as the control.Surgical pinealectomy was added to acute pancreatitis in the second group,removing the source of endogenous melatonin (low melatonin levels group).The third group was given 0.1 ml daily intraperitoneal injections of 20 mg/ml melatonin solution for one week (high melatonin levels group).The effects of melatonin levels were evaluated by comparison of the levels of MDA,SOD,and GS in pancreatic tissue.RESULT:We found that intraperitoneal melatonin injections decreased the levels of MDA and increased the levels of SOD and GSH in pancreatic tissue.CONCLUSION:Exogenous melatonin has a preventive effect on lipid peroxidation and oxidative damage in acute pancreatitis. | Cavit l Kahraman Dinler O■uz Hasdemir Oktay Büyüka■ik Güler Bu■dayci | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 7 |
| 2 | Quantification of gliclazide by semi-micro high-performance liquid chromatography:application to a bioequivalence study of two formulations in healthy subjects显示文摘 | PARK J Y KIM KA KIM S L | 2004 | J Pharm Biomed Anal2004，35，4： | 1 |
| 3 | Comparison and evaluation of methods for liver segmentation from CT datasets显示文摘 | Heimann T van Ginneken B Styner MA Arzhaeva Y Aurich V Bauer C Beck A Becket C Beichel R Bekes G Bello F Binnig G Bischof H Bornik A Cashman PM Chi Y Cordova A Dawant BM Fidrich M Furst JD Furukawa D Grenacher L Hornegger J Kainmuller D Kitney RI Kobatake H Lamecker H Lange T Lee J Lennon B Li R Li S Meinzer HP Nemeth G Raicu DS Rau AM van Rikxoort EM Rousson M Rusko L Saddi KA Schmidt G Seghers D Shimizu A Slagmolen P Sorantin E Soza G Susomboon R Waite JM Wimmer A Wolf I | 2009 | IEEE Transactions on Medical Imaging2009，28，8： | 1 |
| 4 | Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration显示文摘 | Wan C Gilbert SR Wang Y Cao X Shen X Ramaswamy G Jacobsen KA Alaql ZS Eberhardt AW Gerstenfeld LC Einhorn TA Deng L Clemens TL | | 0，，： | 1 |
| 5 | Alterations in fecal Lactobacillus and Bifidobacterium species in type 2 diabetic patients in Southern China population显示文摘 | L& KA Li Y Xu X | 2012 | Front Physio2012，3，： | 1 |
| 6 | Using the Roy Adaptation Model to develop an antenatal assessment instrument显示文摘 | Linda L Alan Y Ka Fai W | 2011 | Nursing Science Quarterly2011，24，4： | 1 |
| 7 | Facile synthesis of 2H-indazole derivatives starting from the Baylis-Hill- man adducts of 2-cyclohexen-1-one 显示文摘 | Ka Y L Saravanan G and Jae N K | 2005 | Tetrahedron Lett2005，46，： | 1 |
| 8 | Development of single-transistor-control LDO based on flipped voltage follower for SOC显示文摘 | Man T Y Ka Nang L Chi Yat L | 2008 | Circuits and Systems I:Regular Papers IEEE Transactions on2008，55，5： | 1 |
| 9 | Evaluation of vaccines in the EUTB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis显示文摘 | Williams A Hatch GJ Clark SO Gooch KE Hatch KA Hall GA Huygen K Ottenhoff TH Franken KL Andersen P Doherty TM Kaufmann SH Grode L Seiler P Martin C Gicquel B Cole ST Brodin P Pym AS Dalemans W Cohen J Lobet Y Goonetilleke N McShane H Hill A Parish T Smith D Stoker NG Lowrie DB Kallenius G Svenson S Pawlowski A Blake K Marsh PD | 2005 | Tuberculosis (Edinb)2005，85，12： | 1 |
| 10 | Alterations in fecal Lactobacillus and Bifidobacterium species in type 2 diabetic patients in Southern China population显示文摘 | L(e) KA Li Y Xu X | 2012 | Front Physiol2012，3，： | 1 |
| 11 | Exosomal pMHC-I complex targets T cell-based vaccine to directly stimulate CTL responses leading to antitumor immunity in transgenic FVBneuN and HLA-A2/HER2 mice and eradicating trastuzumab-resistant tumor in athymic nude mice显示文摘 | Wang L Xie Y Ahmed KA | 2013 | Breast Cancer Res Treat2013，140，2： | 1 |
| 12 | HTLV-1 bZIP factor induces T-cell lymphoma and systemic inlamination in vivo 显示文摘 | Satou Y Yasunaga J Zhao T Yoshida M Miyazato P Takai K Shimizu K Ohshima K Green P L Oh-kura N Yamaguchi T Ono M Sakaguchi S Matsuo- ka M | 2011 | PLoS Patho gens2011，7，10： | 1 |
| 13 | Comparative analysis of bat genomes provides insight into the evolution of flight and immunity 显示文摘 | Zhang G Cowled C Shi Z Huang Z Bishop-Lilly KA Fang X Wynne JW Xiong Z Baker ML Zhao W Tachedjian M Zhu Y Zhou P Jiang X Ng J Yang L Wu L Xiao J Feng Y Chen Y Sun X Zhang Y Marsh GA Crameri G Broder CC Frey KG Wang LF Wang J | 2013 | Science2013，339，6118： | 1 |
| 14 | Neuropeptide Y2 receptors are involved in enhanced neurogenic vasoconstriction in spontaneously hypertensive rats显示文摘 | Gradin KA Buus C L Li J Y | 2006 | Br J Pharmacol2006，148，5： | 1 |
| 15 | Alterations in fecal Lactobacillus and Bifidobacterium species in type 2 diabetic patients in Southern China population显示文摘 | LêKA Li Y Xu X | 2012 | Front Physio2012，3，： | 1 |
| 16 | Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus 显示文摘 | Liao HX Lynch R Zhou T Gao F Alam SM Boyd SD Fire AZ Roskin KM Schramm CA Zhang Z ZhuJ Sha- piro L NISC Comparative Sequencing Program Mullikin JC Gnanakaran S Hraber P Wiehe K Kelsoe G Yang G Xia SM Montefiori DC Parks R Lloyd KE Scearce RM Soderberg KA Cohen M Kamanga G Louder MK Tran LM Chen Y Cai F Chen S Moquin S Du X Joyce MG Srivatsan S Zhang B Zheng A Shaw GM Hahn BH Kepler TB Korber BT Kwong PD Mascola JR Haynes BF | 2013 | Nature2013，496，7446： | 1 |
| 17 | Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives [Beta]-catenin/T cell factor-dependent hepatocarcinogenesis显示文摘 | Feng Hai Cheng Alfred S L Tsang Daisy P Li May S Go Minnie Y Cheung Yue S Zhao Gui-jun Ng Samuel S Lin Marie C Yu Jun Lai Paul B To Ka F Sung Joseph J Y | 2011 | Journal of Clinical Investigation2011，，8： | 1 |
| 18 | Exogenous melatonin treatment reduces hepatocyte damage in rats with experimental acute pancreatitis显示文摘 | Cavit ??l Kahraman Dinler O?uz Hasdemir Oktay Büyüka??k Güler Bu?dayc? Hakan Terzi | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，5： | 1 |
| 19 | Synthesis of 4b,5,10a,11-tetrahydroindeno-quinolin-10-ones from Baylis-Hillman adducts显示文摘 | Chang G L Ka Y L Saravanan G S | 2004 | Tetrahedron Let2004，45，： | 1 |
| 20 | Discrimination of homologous chromosomes of maize with Giemsa staining显示文摘 | Hadlaczky G Y Ka'lma'n L | 1975 | Heredity1975，35，： | 1 |
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