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| 1 | 关于6A02铝合金板热成型-整体淬火工艺的实验研究显示文摘作为重要的轻质结构材料,铝合金已广泛用于汽车和航空工业。主要用来制造具有高强度,精确尺寸的零件。本文中开发了一种特殊装置,用来研究冷轧6A02铝合金板热成型-整体淬火工艺。用测维氏硬度和拉伸试验来反映强化效果。用扫描电镜(SEM)透射电镜(TEM)、和电子背散射衍射进行显微检测来阐明强化机理。结果表明,随着固溶时间(<50 min)延长维氏硬度增大,强化效应越大。成型零件的维氏硬度能从冷轧态的73 HV或热成型-整体淬火工艺(在520℃固溶50 min,以50°C/s冷却,以160°C/10 h时效)加热后的40 HV增加到106.5 HV。相应的拉伸强度和屈服强度分别是315.6 MPa和253.6 MPa。强化相是未成形的弥散的GP区,约5 nm大小。轧制态的可热处理的铝合金板通常直接用热成型-整体淬火工艺不作任何前处理。 | Fan Xiaobo He Zhubin Yuan Shijian Zheng Kailun | 2013 | 热处理技术与装备2013,34,6: | 19 |
| 2 | Surface energy budget diagnosis reveals possible mechanism for the different warming rate among Earth’s three poles in recent decades显示文摘With the introduction of the‘‘Third Pole'[1],the Arctic,Antarctic,and Tibetan Plateau(TP)can be collectively referred to as the‘‘three poles of the Earth'.The cryosphere is an important component of the climate system because of its effect on Earth’s surface albedo and its role in reducing the amount of heat exchanged between the atmosphere and ocean or land(2)As the dominant parts of the cryosphere,the Arctic,Antarctic,and TP are pivotal and sensitive areas of global climate change.Global warming will weaken the inherent stability of the cryosphere,such as its ice shelves,glaciers and permafrost[3,4]. | Kailun Gao Anmin Duan Deliang Chen Guoxiong Wu | 2019 | Science Bulletin2019,64,16: | 16 |
| 3 | CVD growth of fingerprint-like patterned 3D graphene film for an ultrasensitive pressure sensor显示文摘与便携设备的快速的发展,有高敏感和宽可使用的范围的灵活压力传感器高度被需要。在自然,有许多改编得好的结构,通过自然选择开发,它为 biomimetic 材料或设备的设计鼓舞了我们。特别地,在许多表皮的山脉放大外部刺激的地方,人的指尖皮肤可能是一个好例子为高度敏感的传感器模仿。在这个工作,基于唯一的化学蒸汽免职( CVD )种模仿指尖皮肤的形态学的 3D graphene 电影,我们制作了察觉到膜的灵活压力,它同时显示出 110 的高敏感( kPa )为 0-0.2 kPa 和宽可使用的压力范围(多达 75 kPa )的1。从自然叶子塑造的层次结构化的 PDMS 电影为 graphene 电影被用作支持的有弹性的电影,它也贡献压力传感器的优异表演。压力传感器显示出低察觉限制(0.2 Pa ) ,快反应(< 30 ms ) ,并且为超过 10,000 的优秀稳定性装载 / 卸掉周期。把特征基于这些,我们在检测微小的对象,声音,和人的生理的信号演示了它的应用程序,为监视的健康和人 / 机器在便携电子学显示出它的潜力连接。 | Kailun Xia Chunya Wang Muqiang Jian Qi Wang Yingying Zhang | 2018 | Nano Research2018,11,2: | 13 |
| 4 | Antibacterial effects of platelet-rich fibrin produced by horizontal centrifugation显示文摘Platelet-rich fibrin(PRF)has been widely used owing to its ability to stimulate tissue regeneration.To date,few studies have described the antibacterial properties of PRF.Previously,PRF prepared by horizontal centrifugation(H-PRF)was shown to contain more immune cells than leukocyte-and platelet-rich fibrin(L-PRF).This study aimed to compare the antimicrobial effects of PRFs against Staphylococcus aureus and Escherichia coli in vitro and to determine whether the antibacterial effects correlated with the number of immune cells.Blood samples were obtained from eight healthy donors to prepare L-PRF and H-PRF.The sizes and weights of L-PRF and H-PRF were first evaluated,and their antibacterial effects against S.aureus and E.coli were then tested in vitro using the inhibition ring and plate-counting test methods.Flow-cytometric analysis of the cell components of L-PRF and H-PRF was also performed.No significant differences in size or weight were observed between the L-PRF and H-PRF groups.The H-PRF group contained more leukocytes than the L-PRF group.While both PRFs had notable antimicrobial activity against S.aureus and E.coli,H-PRF demonstrated a significantly better antibacterial effect than L-PRF.Furthermore,the antimicrobial ability of the PRF solid was less efficient than that of wet PRF.In conclusion,H-PRF exhibited better antibacterial activity than L-PRF,which might have been attributed to having more immune cells. | Mengge Feng Yulan Wang Peng Zhang Qin Zhao Shimin Yu Kailun Shen Richard J.Miron Yufeng Zhang | 2020 | International Journal of Oral Science2020,12,4: | 12 |
| 5 | High-efficiency forming processes for complex thin-walled titanium alloys components: state-of-the-art and perspectives显示文摘Complex thin-walled titanium alloy components play a key role in the aircraft,aerospace and marine industries,offering the advantages of reduced weight and increased thermal resistance.The geometrical complexity,dimensional accuracy and in-service properties are essential to fulfill the high-performance standards required in new transportation systems,which brings new challenges to titanium alloy forming technologies.Traditional forming processes,such as superplastic forming or hot pressing,cannot meet all demands of modern applications due to their limited properties,low productivity and high cost.This has encouraged industry and research groups to develop novel high-efficiency forming processes.Hot gas pressure forming and hot stamping-quenching technologies have been developed for the manufacture of tubular and panel components,and are believed to be the cut-edge processes guaranteeing dimensional accuracy,microstructure and mechanical properties.This article intends to provide a critical review of high-efficiency titanium alloy forming processes,concentrating on latest investigations of controlling dimensional accuracy,microstructure and properties.The advantages and limitations of individual forming process are comprehensively analyzed,through which,future research trends of high-efficiency forming are identified including trends in process integration,processing window design,full cycle and multi-objective optimization.This review aims to provide a guide for researchers and process designers on the manufacture of thin-walled titanium alloy components whilst achieving high dimensional accuracy and satisfying performance properties with high efficiency and low cost. | Kehuan Wang Liliang Wang Kailun Zheng Zhubin He Denis J Politis Gang Liu Shijian Yuan | 2020 | International Journal of Extreme Manufacturing2020,2,3: | 10 |
| 6 | Atmospheric heat source/sink dataset over the Tibetan Plateau based on satellite and routine meteorological observations显示文摘The Tibetan Plateau(TP),acting as a large elevated land surface and atmospheric heat source during spring and summer,has a substantial impact on regional and global weather and climate.To explore the multi-scale temporal variation in the thermal forcing effect of the TP,here we calculated the surface sensible heat and latent heat release based on 6-h routine observations at 80(32)meteorological stations during the period 1979–2016(1960–2016).Meanwhile,in situ air-column net radiation cooling during the period 1984–2015 was derived from satellite data.This new data-set provides continuous,robust,and the longest observational atmospheric heat source/sink data over the third pole,which will be helpful to better understand the spatial-temporal structure and multi-scale variation in TP diabatic heating and its influence on the earth’s climatic system. | Anmin Duan Senfeng Liu Yu Zhao Kailun Gao Wenting Hu | 2018 | Big Earth Data2018,2,2: | 7 |
| 7 | Superelastic wire-shaped supercapacitor sustaining 850% tensile strain based on carbon nanotube@graphene fiber显示文摘 | Huimin Wang Chunya Wang Muqiang Jian Qi Wang Kailun Xia Zhe Yin Mingchao Zhang Xiaoping Liang Yingying Zhang | 2018 | Nano Research2018,11,5: | 6 |
| 8 | Physical sensors for skin-inspired electronics显示文摘Skin,the largest organ in the human body,is sensitive to external stimuli.In recent years,an increasing number of skin-inspired electronics,including wearable electronics,implantable electronics,and electronic skin,have been developed because of their broad applications in healthcare and robotics.Physical sensors are one of the key building blocks of skin-inspired electronics.Typical physical sensors include mechanical sensors,temperature sensors,humidity sensors,electrophysiological sensors,and so on.In this review,we systematically review the latest advances of skin-inspired mechanical sensors,temperature sensors,and humidity sensors.The working mechanisms,key materials,device structures,and performance of various physical sensors are summarized and discussed in detail.Their applications in health monitoring,human disease diagnosis and treatment,and intelligent robots are reviewed.In addition,several novel properties of skin-inspired physical sensors such as versatility,self-healability,and implantability are introduced.Finally,the existing challenges and future perspectives of physical sensors for practical applications are discussed and proposed. | Shuo Li Yong Zhang Yiliang Wang Kailun Xia Zhe Yin Huimin Wang Mingchao Zhang Xiaoping Liang Haojie Lu Mengjia Zhu Haomin Wang Xinyi Shen Yingying Zhang | 2020 | InfoMat2020,2,1: | 5 |
| 9 | Expansion of pathogen recognition specificity in plants using pattern recognition receptors and artificially designed decoys显示文摘Pathogen/microbe-associated molecular patterns(PAMPs/MAMPs) are recognized by plant pattern recognition receptors(PRRs)localized on the cell surface to activate immune responses.This PAMP-triggered immunity(PTI) confers resistance to a broad range of pathogenic microbes and,therefore,has a great potential for genetically engineering broad-spectrum resistance by transferring PRRs across plant families.Pathogenic effectors secreted by phytopathogens often directly target and inhibit key components of PTI signaling pathways via diverse biochemical mechanisms.In some cases,plants have evolved to produce decoy proteins that mimic the direct virulence target,which senses the biochemical activities of pathogenic effectors.This kind of perception traps the effectors of erroneous targeting and results in the activation of effector-triggered immunity(ETI) instead of suppressing PTI.This mechanism suggests that artificially designed decoy proteins could be used to generate new recognition specificities in a particular plant.In this review,we summarize recent advances in research investigating PAMP recognition by PRRs and virulence effector surveillance by decoy proteins.Successful expansion of recognition specificities,conferred by the transgenic expression of EF-Tu receptor(EFR) and AvrPphB susceptible 1(PBS1) decoys,has highlighted the considerable potential of PRRs and artificially designed decoys to expand plant resistance spectra and the need to further identify novel PRRs and decoys. | Lifan Sun Jun Qin Kailun Wang Jie Zhang | 2017 | Science China(Life Sciences)2017,60,8: | 5 |
| 10 | Bioaccumulation, subcellular distribution and chemical forms of yttrium in rice seedling显示文摘Yttrium(Y) accumulation in soil is a serious environment problem in China. To understand the mechanisms involved in Y tolerance and detoxification in rice seedling, the bioaccumulation, subcellular distribution, and chemical forms of Y was investigated in the present study. The results show that the content of Y both in roots and shoots increases with the increasing concentration of Y, and a large amount of Y is stored in roots. Subcellular distribution of Y in rice indicates that the majority of Y is bound to cell wall. Meanwhile, various chemical forms of Y is absorbed by rice. The greatest amount of Y is extracted by 2% hydrate acetic acid(HAc) and 0.6 mol/L HCl(particularly 2% HAc), which indicates that most of Y is combined with un-dissolved phosphate and oxalate(particularly phosphate). Cluster analysis, based on Y abundance levels, reveals the relationship between Y distribution patterns and chemical forms. Our results imply that Y forming of precipitates with phosphate(and/or oxalate) and depositing in the cell wall may be a key strategy for Y detoxicity and tolerance in rice. | Shengnan Zheng Caiyun Zhang Kailun Shi Jinxiao Wang Guanjun Sun Qiaochu Hu Fengyun Zhao Xue Wang | 2018 | Journal of Rare Earths2018,36,3: | 4 |
| 11 | Fractal Nature of Capillary and Viscous Fingering in Two-Dimensional Porous Media显示文摘A computer model of capillary and viscous fingering in a porous media is presented,which treats the media as a square lattice connected with randomly chosen radius.The fractal properties of the model are studied for shell-shell aggregation method by Monte Carlo simulation.The simulation results show that the dimension D increases along with increasing of M and decreasing ofμ,where M andμare the ratios of the viscosity of the two fluids and the most probable radius of the throat in porous media respectively.It is found that there exist four regions for fluid. | TIAN Juping YU Boming YAO Kailun | 1995 | Chinese Physics Letters1995,12,12: | 3 |
| 12 | Application of exosomes as liquid biopsy in clinical diagnosis显示文摘Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating tumor cells,extracellular vesicles,nucleic acids,and so forth.Exosomes are small extracellular vesicles with sizes between 30–150 nm.They are secreted by multivesicular bodies through exocytosis in live cells and can participate in intercellular communication due to their contents,including nucleic acids,proteins,and lipids.Herein,we investigate publication frequencies on exosomes over the past 10 years,and review recent clinical studies on liquid biopsy of exosomes in the fields of oncology,pregnancy disorders,cardiovascular diseases,and organ transplantation.We also describe the advantages of exosomes as an effective liquid biopsy tool and the progression of exosome extraction methods.Finally,we depict the commercial development of exosome research and discuss the future role of exosomes in liquid biopsy. | Biting Zhou Kailun Xu Xi Zheng Ting Chen Jian Wang Yongmao Song Yingkuan Shao Shu Zheng | 2020 | Signal Transduction and Targeted Therapy2020,5,1: | 2 |
| 13 | The detection of HBV DNA with gold nanoparticle gene probes显示文摘Objective: Gold nanoparticle Hepatitis B virus (HBV) DNA probes were prepared, and their application for HBV DNA mea-surement was studied. Methods: Alkanethiol modified oligonucleotide was bound with self-made Au nanoparticles to formnanoparticle HBV DNA gene probes, through covalent binding of Au-S. By using a fluorescence-based method, the number ofthiol-derivatized, single-stranded oligonucleotides and their hybridization efficiency with complementary oligonucleotides in solutionwas determined. With the aid of Au nanoparticle-supported mercapto-modified oligonucleotides serving as detection probes, andoligonucleotides immobilized on a nylon membrane surface acting as capturing probes, HBV DNA was detected visually by sand-wich hybridization based on highly sensitive aggregation and silver staining. The modified nanoparticle HBV DNA gene probeswere also used to detect the HBV DNA extracted from serum in patients with hepatitis B. Results: Compared with bare Aunanoparticles, oligonucleotide modified nanoparticles had a higher stability in NaCl solution or under high temperature environ-ment and the absorbance peak of modified Au nanoparticles shifted from 520nm to 524nm. For Au nanoparticles, the maximaloligonucleotide surface coverage of hexaethiol 30-mer oligonucleotide was (132 ±10) oligonucleotides per nanoparticle, and thepercentage of hybridization strands on nanoparticles was (22 ±3%). Based on a two-probe sandwich hybridization/nanoparticleamplification /silver staining enhancement method, Au nanoparticle gene probes could detect as low as 10-11 mol/L composite HBVDNA molecules on a nylon membrane and the PCR products of HBV DNA visually. As made evident by transmission electron mi-croscopy, the nanoparticles assembled into large network aggregates when nanoparticle HBV DNA gene probes were applied to de-tect HBV DNA molecules in liquid. Conclusion:Our results showed that successfully prepared Au nanoparticle HBV DNA geneprobes could be used to detect HBV DNA directly. The detection-visuallized method has many advantages, including high sensitivity,simple operation and low cost. This technique has potential applications in many fields, especially in multi-gene detection chips. | Dong Xia Xiaoping Luo Qin Ning Qianghua Lu Kailun Yao Zuli Liu | 2007 | Journal of Nanjing Medical University2007,21,4: | 2 |
| 14 | Dynamic simulation of a space gas-cooled reactor power system with a closed Brayton cycle显示文摘Space nuclear reactor power(SNRP)using a gas-cooled reactor(GCR)and a closed Brayton cycle(CBC)is the ideal choice for future high-power space missions.To investigate the safety characteristics and develop the control strategies for gas-cooled SNRP,transient models for GCR,energy conversion unit,pipes,heat exchangers,pump and heat pipe radiator are established and a system analysis code is developed in this paper.Then,analyses of several operation conditions are performed using this code.In full-power steady-state operation,the core hot spot of 1293 K occurs near the upper part of the core.If 0.4$reactivity is introduced into the core,the maximum temperature that the fuel can reach is 2059 K,which is 914 K lower than the fuel melting point.The system finally has the ability to achieve a new steady-state with a higher reactor power.When the GCR is shut down in an emergency,the residual heat of the reactor can be removed through the conduction of the core and radiation heat transfer.The results indicate that the designed GCR is inherently safe owing to its negative reactivity feedback and passive decay heat removal.This paper may provide valuable references for safety design and analysis of the gas-cooled SNRP coupled with CBC. | Chenglong WANG Ran ZHANG Kailun GUO Dalin ZHANG Wenxi TIAN Suizheng QIU Guanghui SU | 2021 | Frontiers in Energy2021,15,4: | 2 |
| 15 | Silkworm Silk Fibers with Multiple Reinforced Properties Obtained through Feeding Ag Nanowires显示文摘Silkworm silk fbers have been woven into textiles for thousands of years,because of their attractive luster,good mechanical properties,excellent biocompatibility,and large-scale production.With the development of human society,preparation of silk fbers with modifed or enhanced properties are highly desirable for potential applications in structural materials and smart textiles.Herein,we realized the reinforcement of multiple properties of silk fbers by feeding silkworms with Ag nanowire(Ag NW)modifed diets.The obtained silk fbers show obviously enhanced comprehensive mechanical properties,including improved tensile strength,elongation at break,tensile modulus,and toughness,which are increased by 37.2%,37.6%,68.3%,and 69.8%,respectively.Furthermore,compared with unmodifed silk,the electrical conductivity and thermal conductivity of modifed silk fbers are improved by 246.4%and 32.1%,respectively.The analysis on the components and structure shows that the incorporated Ag NWs lead to increased content of random coil/α-helix,improved orientation of crystallites,and increased content of Ag compared to pristine silk fbers,which may contribute to the enhanced mechanical,electrical,and thermal properties. | Haojie Lu Muqiang Jian Zhe Yin Kailun Xia Shaoyi Shi Mingchao Zhang Huimin Wang Xiaoping Liang Weigang Ma Xing Zhang Yingying Zhang | 2022 | Advanced Fiber Materials2022,4,3: | 2 |
| 16 | Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future directions显示文摘With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expanding the targeted therapeutic options improved the survival and safety. However, responses to these agents are commonly temporary and incomplete. Moreover, even patients with the same oncogenic driver gene can respond diversely to the same agent. Furthermore, the therapeutic role of immune-checkpoint inhibitors (ICIs) in oncogene-driven NSCLC remains unclear. Therefore, this review aimed to classify the management of NSCLC with driver mutations based on the gene subtype, concomitant mutation, and dynamic alternation. Then, we provide an overview of the resistant mechanism of target therapy occurring in targeted alternations (“target-dependent resistance”) and in the parallel and downstream pathways (“target-independent resistance”). Thirdly, we discuss the effectiveness of ICIs for NSCLC with driver mutations and the combined therapeutic approaches that might reverse the immunosuppressive tumor immune microenvironment. Finally, we listed the emerging treatment strategies for the new oncogenic alternations, and proposed the perspective of NSCLC with driver mutations. This review will guide clinicians to design tailored treatments for NSCLC with driver mutations. | Jia Zhong Hua Bai Zhijie Wang Jianchun Duan Wei Zhuang Di Wang Rui Wan Jiachen Xu Kailun Fei Zixiao Ma Xue Zhang Jie Wang | 2023 | Frontiers of Medicine2023,17,1: | 2 |
| 17 | Air plasma-sprayed high-entropy (Y_(0.2)Yb_(0.2)Lu_(0.2)Eu_(0.2)Er_(0.2))_(3)Al_(5)O_(12) coating with high thermal protection performance显示文摘High-entropy rare-earth aluminate(Y_(0.2)Yb_(0.2)Lu_(0.2)Eu_(0.2)Er_(0.2))_(3)Al_(5)O_(12)(HE-RE_(3)Al_(5)O_(12))has been considered as a promising thermal protection coating(TPC)material based on its low thermal conductivity and close thermal expansion coefficient to that of Al2O3.However,such a coating has not been experimentally prepared,and its thermal protection performance has not been evaluated.To prove the feasibility of utilizing HE-RE_(3)Al_(5)O_(12) as a TPC,HE-RE_(3)Al_(5)O_(12) coating was deposited on a nickelbased superalloy for the first time using the atmospheric plasma spraying technique.The stability,surface,and cross-sectional morphologies,as well as the fracture surface of the HE-RE_(3)Al_(5)O_(12) coating were investigated,and the thermal shock resistance was evaluated using the oxyacetylene flame test.The results show that the HE-RE_(3)Al_(5)O_(12) coating can remain intact after 50 cycles at 1200℃ for 200 s,while the edge peeling phenomenon occurs after 10 cycles at 1400℃ for 200 s.This study clearly demonstrates that HE-RE_(3)Al_(5)O_(12) coating is effective for protecting the nickel-based superalloy,and the atmospheric plasma spraying is a suitable method for preparing this kind of coatings. | Kailun WANG Jinpeng ZHU Hailong WANG Kaijun YANG Yameng ZHU Yubin QING Zhuang MA Lihong GAO Yanbo LIU Sihao WEI Yongchun SHU Yanchun ZHOU Jilin HE | 2022 | Journal of Advanced Ceramics2022,11,10: | 2 |
| 18 | Growth of large-area aligned pentagonal graphene domains on high-index copper surfaces显示文摘化学蒸汽免职(CVD ) 内在地种的单个水晶的 graphene 领域趋于有六倍的对称;然而,几个因素能影响生长动力学,它能接着与不同形状导致 graphene 的形成。这里,我们由 CVD 在 Cu 陪衬上报导面向的大区域的五角的单个水晶的 graphene 领域的生长。我们发现那飞机有选择地贡献了到五角的 graphene 的形成的高索引的 Cu。我们的结果显示在内在的 Cu 的水晶的表面上在场的格子步在对步垂直的方向支持了 graphene 生长并且最后导致了形成一个五边形的边之一的消失。另外,氢支持了五角的领域的形成。这个工作提供新卓见进 graphene 生长的机制。 | Kailun Xia Vasilii I. Artyukhov Lifei Sun Jingying Zheng Liying Jiao Boris I. Yakobson Yingying Zhang | 2016 | Nano Research2016,9,7: | 2 |
| 19 | Hausdorff dimension and scaling nature of anisotropy diffusion DLA cluster显示文摘 | Tian Juping Yao Kailun | 1998 | Indian Journal of Pure & Applied Physics1998,36,: | 1 |
| 20 | Electrochemically triggered decoupled transport behaviors in intercalated graphite:From energy storage to enhanced electromagnetic applications显示文摘Pyrolytic graphite (PG) with highly aligned graphene layers,present anisotropic electrical and thermal transport behavior,which is attractive in electronic,electrocatalyst and energy storage.Such pristine PG could meeting the limit of electrical conductivity (~2.5×10^(4) S·cm^(−1)),although efforts have been made for achieving high-purity sp^(2) hybridized carbon.For manipulating the electrical conductivity of PG,a facile and efficient electrochemical strategy is demonstrated to enhance electrical transport ability via reversible intercalation/de-intercalation of AlCl_(4)^(-)into the graphitic interlayers.With the stage evolution at different voltages,variable electrical and thermal transport behaviors could be achieved via controlling AlCl_(4)^(-)concentrations in the PG because of substantial variation in the electronic density of states.Such evolution leads to decoupled electrical and thermal transport (opposite variation trend) in the in-plane and out-of-plane directions,and the in-plane electrical conductivity of the pristine PG (1.25×10^(4) S·cm^(−1)) could be massively promoted to 4.09×10^(4) S·cm(AlCl_(4)^(-)intercalated PG),much better than the pristine bulk graphitic papers used for the electrical transport and electromagnetic shielding.The fundamental mechanism of decoupled transport feature and electrochemical strategy here could be extended into other anisotropic conductive bulks for achieving unusual behaviors. | Ya Chen Kailun Zhang Na Li Wei Guan Zhiyuan Li Haosen Chen Shuqiang Jiao Weili Song | 2023 | International Journal of Minerals,Metallurgy and Materials2023,30,1: | 1 |