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| 1 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 2 | Pathways of China's PM;air quality 2015–2060 in the context of carbon neutrality显示文摘Clean air policies in China have substantially reduced particulate matter(PM;) air pollution in recent years,primarily by curbing end-of-pipe emissions.However,reaching the level of the World Health Organization(WHO) guidelines may instead depend upon the air quality co-benefits of ambitious climate action.Here,we assess pathways of Chinese PM;air quality from 2015 to 2060 under a combination of scenarios that link global and Chinese climate mitigation pathways(i.e.global 2℃-and 1.5℃-pathways,National Determined Contributions(NDC) pledges and carbon neutrality goals) to local clean air policies.We find that China can achieve both its near-term climate goals(peak emissions) and PM;air quality annual standard(35 μg/m;) by 2030 by fulfilling its NDC pledges and continuing air pollution control policies.However,the benefits of end-of-pipe control reductions are mostly exhausted by 2030,and reducing PM;exposure of the majority of the Chinese population to below 10 μg/m;by 2060 will likely require more ambitious climate mitigation efforts such as China’ s carbon neutrality goals and global1.5℃-pathways.Our results thus highlight that China’s carbon neutrality goals will play a critical role in reducing air pollution exposure to the level of the WHO guidelines and protecting public health. | Jing Cheng Dan Tong Qiang Zhang Yang Liu Yu Lei Gang Yan Liu Yan Sha Yu Ryna Yiyun Cui Leon Clarke Guannan Geng Bo Zheng Xiaoye Zhang Steven JDavis Kebin He | 2021 | National Science Review2021，8，12： | 23 |
| 3 | A generative model of identifying informative proteins from dynamic PPI networks显示文摘Informative proteins are the proteins that play critical functional roles inside cells.They are the fundamental knowledge of translating bioinformatics into clinical practices.Many methods of identifying informative biomarkers have been developed which are heuristic and arbitrary,without considering the dynamics characteristics of biological processes.In this paper,we present a generative model of identifying the informative proteins by systematically analyzing the topological variety of dynamic protein-protein interaction networks(PPINs).In this model,the common representation of multiple PPINs is learned using a deep feature generation model,based on which the original PPINs are rebuilt and the reconstruction errors are analyzed to locate the informative proteins.Experiments were implemented on data of yeast cell cycles and different prostate cancer stages.We analyze the effectiveness of reconstruction by comparing different methods,and the ranking results of informative proteins were also compared with the results from the baseline methods.Our method is able to reveal the critical members in the dynamic progresses which can be further studied to testify the possibilities for biomarker research. | ZHANG Yuan CHENG Yue JIA KeBin ZHANG AiDong | 2014 | Science China(Life Sciences)2014，57，11： | 2 |
| 4 | Improved measurement of carbonaceous aerosol:evaluation of the sampling artifacts and inter-comparison of the thermal-optical analysis methods显示文摘 | CHENG Yuan HE Kebin DUAN Fengkui | 2010 | Atmospheric Chemistry and Physics2010，10，17： | 1 |
| 5 | Sampling artifacts of organic and inorganic aerosol:Implications for the speciation measurement of particulate matter显示文摘 | CHENG Yuan DUAN Fengkui HE Kebin | 2012 | Atmospheric Environment2012，55，8： | 1 |
| 6 | A yearlong study of water-soluble organic carbon in Beijing II: Light absorption properties显示文摘 | Zhenyu Du Kebin He Yuan Cheng Fengkui Duan Yongliang Ma Jiumeng Liu Xiaolu Zhang Mei Zheng Rodney Weber | 2014 | Atmospheric Environment2014，，： | 1 |
| 7 | Measurement of semivolatile carbonaceous aerosols and its implications:a review显示文摘 | CHENG Yuan HE Kebin DUAN Fengkui | 2009 | Environment International2009，35，3： | 1 |
| 8 | Positive sampling artifact of carbonaceous aerosols and its influence on the thermal-optical split of OC/EC显示文摘 | CHENG Yuan HE Kebin DUAN Fengkui | 2009 | Atmospheric Chemistry and Physics2009，9，18： | 1 |
| 9 | Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation显示文摘Interleukin-33(IL-33)is a crucial nuclear cytokine that induces the type 2 immune response and maintains immune homeostasis.The fine-tuned regulation of IL-33 in tissue cells is critical to control of the type 2 immune response in airway inflammation,but the mechanism is still unclear.Here,we found that healthy individuals had higher phosphate-pyridoxal(PLP,an active form of vitamin B6)concentrations in the serum than asthma patients.Lower serum PLP concentrations in asthma patients were strongly associated with worse lung function and inflammation.In a mouse model of lung inflammation,we revealed that PLP alleviated the type 2 immune response and that this inhibitory effect relied on the activity of IL-33.A mechanistic study showed that in vivo,pyridoxal(PL)needed to be converted into PLP,which inhibited the type 2 response by regulating IL-33 stability.In mice heterozygous for pyridoxal kinase(PDXK),the conversion of PL to PLP was limited,and IL-33 levels were increased in the lungs,aggravating type 2 inflammation.Furthermore,we found that the mouse double minute 2 homolog(MDM2)protein,an E3 ubiquitin-protein ligase,could ubiquitinate the N-terminus of IL-33 and sustain IL-33 stability in epithelial cells.PLP reduced MDM2-mediated IL-33 polyubiquitination and decreased the level of IL-33 through the proteasome pathway.In addition,inhalation of PLP alleviated asthma-related effects in mouse models.In summary,our data indicate that vitamin B6 regulates MDM2-mediated IL-33 stability to constrain the type 2 response,which might help develop a potential preventive and therapeutic agent for allergy-related diseases. | Songling Zhu Shufen Zhong Kebin Cheng Li-Sha Zhang Jiu-wu Bai Zu Cao Su Wang Wen Chen Shipeng Cheng Liyan Ma Zhiyang Ling Yuying Huang Wangpeng Gu Xiaoyu Sun Chunyan Yi Meng Zhao Shuo Liang Jin-Fu Xu Bing Sun Yaguang Zhang | 2023 | Cellular & Molecular Immunology2023，20，7： | 1 |
| 10 | A yearlong study of water-soluble organic carbon in Beijing II: Light absorption properties显示文摘 | Zhenyu Du Kebin He Yuan Cheng Fengkui Duan Yongliang Ma Jiumeng Liu Xiaolu Zhang Mei Zheng Rodney Weber | 2014 | Atmospheric Environment2014，，： | 1 |
| 11 | The character-istics of Beijing aerosol during two distinct episodes : impactsof biomass burning and fireworks 显示文摘 | YUAN Cheng ENGLING G* HE Kebin | 2014 | Environmental Pollu-tion2014，185，4： | 1 |
| 12 | Source apportionment of PM 2.5 nitrate and sulfate in China using a source-oriented chemical transport model显示文摘 | Hongliang Zhang Jingyi Li Qi Ying Jian Zhen Yu Dui Wu Yuan Cheng Kebin He Jingkun Jiang | 2012 | Atmospheric Environment2012，，： | 1 |
| 13 | Sweep coverage with mobile sensors显示文摘 | LI Mo CHENG Weifang LIU Kebin | 2011 | IEEE Transactions on Mobile Computing2011，10，11： | 1 |
| 14 | Evaluation of fungal spore characteristics in Beijing, China, based on molecular tracer measurements显示文摘 | Linlin Liang Guenter Engling Kebin He Zhenyu Du Yuan Cheng Fengkui Duan | 2013 | Environmental Research Letters2013，，1： | 1 |
| 15 | Characteristics of 2-methyltetrols in ambient aerosol in Beijing, China显示文摘 | Linlin Liang Guenter Engling Fengkui Duan Yuan Cheng Kebin He | 2012 | Atmospheric Environment2012，，： | 1 |
| 16 | Mass absorption efficiency of elemental carbon and water-soluble organic carbon in Beijing, China 显示文摘 | CHENG Yuan HE Kebin ZHENG Mei | 2011 | Atmospheric Chemistry and Physics2011，11，11： | 1 |
| 17 | Air pollution health burden embodied in China's supply chains显示文摘Product trade plays an increasing role in relocating production and the associated air pollution impact among sectors and regions.While a comprehensive depiction of atmospheric pollution redistribution through trade chains is missing,which may hinder targeted clean air cooperation among sectors and regions.Here,we combined five state-of-the-art models from physics,economy,and epidemiology to track the anthropogenic fine particle matters(PM_(2.5))related premature mortality along the supply chains within China in 2017.Our results highlight the key sectors that affect PM_(2.5)-related mortality from both production and consumption perspectives.The consumption-based effects from food,light industry,equipment,construction,and services sectors,caused 2e22 times higher deaths than those from a production perspective and totally contributed 63%of the national total.From a cross-boundary perspective,25.7%of China's PM_(2.5)-related deaths were caused by interprovincial trade,with the largest transfer occurring from the central and northern regions to well-developed east coast provinces.Capital investment dominated the cross-boundary effect(56%of the total)by involving substantial equipment and construction products,which greatly rely on product exports from regions with specific resources.This supply chain-based analysis provides a comprehensive quantification and may inform more effective joint-control efforts among associated regions and sectors from a health risk perspective. | Hongyan Zhao Ruili Wu Yang Liu Jing Cheng Guannan Geng Yixuan Zheng Hezhong Tian Kebin He Qiang Zhang | 2023 | Environmental Science and Ecotechnology2023，，4： | 0 |
| 18 | Opportunities for Computational Techniques for Multi-Omics Integrated Personalized Medicine显示文摘Personalized medicine is defined as 'a model of healthcare that is predictive, personalized, preventive,and participator' and has very broad content. With the rapid development of high-throughput technologies, an explosive accumulation of biological information is collected from multiple layers of biological processes, including genomics, transcriptomics, proteomics, metabonomics, and interactomics(omics). Implementing integrative analysis of these multiple omics data is the best way of deriving systematical and comprehensive views of living organisms, achieving better understanding of disease mechanisms, and finding operable personalized health treatments. With the help of computational methods, research in the field of biology and biomedicine has gained tremendous benefits over the past few decades. In the new era of personalized medicine, we will rely more on the assistance of computational analysis. In this paper, we briefly review the generation of multiple omics and their basic characteristics. And then the challenges and opportunities for computational analysis are discussed and some state-of-art analysis methods that were recently proposed by peers for integrative analysis of multiple omics data are reviewed. We foresee that further integrated omics data platform and computational tools would help to translate the biological knowledge to clinical usage and accelerate development of personalized medicine. | Yuan Zhang Yue Cheng Kebin Jia Aidong Zhang | 2014 | Tsinghua Science and Technology2014，19，6： | 0 |
| 19 | Formation of secondary inorganic aerosol in a frigid urban atmosphere显示文摘Formation of secondary inorganic aerosol(SIA)was investigated during a six-month long heating season in Harbin,China.Enhanced sulfate formation was observed at high relative humidity(RH),with the same threshold RH(80%)for both colder and warmer measurement periods.Compared to wintertime results from Beijing,the threshold RH was considerably higher in Harbin,whereas the RH-dependent enhancement of sulfur oxidation ratio(SOR)was less significant.In addition,the high RH events were rarely encountered,and for other periods,the SOR were typically as low as~0.1.Therefore,the sulfate formation was considered inefficient in this study.After excluding the several cases with high RH,both SOR and the nitrogen oxidation ratio(NOR)exhibited increasing trends as the temperature increased,with the increase of NOR being sharper.The nitrate to sulfate ratio tended to increase with increasing temperature as well.Based on a semi-quantitative approach,this trend was attributed primarily to the temperature-dependent variations of precursors including SO_(2) and NO_(2).The influence of biomass burning emissions on SIA formation was also evident.With stronger impact of biomass burning,an enhancement in NOR was observed whereas SOR was largely unchanged.The different patterns were identified as the dominant driver of the larger nitrate to sulfate ratios measured at higher concentrations of fine particulate matter. | Yuan Cheng Qinqin Yu Jiumeng Liu Youwen Sun Linlin Liang Zhenyu Du Guannan Geng Wanli Ma Hong Qi Qiang Zhang Kebin He | 2022 | Frontiers of Environmental Science & Engineering2022，16，2： | 0 |
| 20 | MEIC-global-CO_(2):A new global CO_(2)emission inventory with highly-resolved source category and sub-country information显示文摘CO_(2)emission inventory provides fundamental data for climate research and emission mitigation.Currently,most global CO_(2)emission inventories were developed with energy statistics from International Energy Agency(IEA)and were available at country level with limited source categories.Here,as the first step toward a high-resolution and dynamic updated global CO_(2)emission database,we developed a data-driven approach to construct seamless and highly-resolved energy consumption data cubes for 208 countries/territories,797 sub-country administrative divisions in 29 countries,42 fuel types,and 52 sectors,with the fusion of activity data from 24 international statistics and 65 regional/local statistics.Global CO_(2)emissions from fossil fuel combustion and cement production in 1970–2021 were then estimated with highly-resolved source category(1,484 of total)and sub-country information(797 of total).Specifically,73%of global CO_(2)emissions in 2021 were estimated with sub-country information,providing considerably improved spatial resolution for global CO_(2)emission accounting.With the support of detailed information,the dynamics of global CO_(2)emissions across sectors and fuel types were presented,representing the evolution of global economy and progress of climate mitigation.Remarkable differences of sectoral contribution were found across sub-country administrative divisions within a given country,revealing the uneven distribution of energy and economic structure among different regions.Our estimates were generally consistent with existing databases at aggregated level for global total or large emitters,while large discrepancies were observed for middle and small emitters.Our database,named the Multiresolution Emission Inventory model for Climate and air pollution research(MEIC)is publicly available through http://gffzz6c575fb1d0a54d36hownkunw5puxo6nwf.ffgz.tsg.suse.edu.cn with highly-resolved information and timely update,which provides an independent carbon emission accounting data source for climate research. | Ruochong XU Dan TONG Qingyang XIAO Xinying QIN Cuihong CHEN Liu YAN Jing CHENG Can CUI Hanwen HU Wenyu LIU Xizhe YAN Huaxuan WANG Xiaodong LIU Guannan GENG Yu LEI Dabo GUAN Kebin HE Qiang ZHANG | 2024 | Science China Earth Sciences2024，67，2： | 0 |
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