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| 1 | Micro/nano-structured TiO2 surface with dual-functional antibacterial effects for biomedical applications显示文摘Implant-associated infections are generally difficult to cure owing to the bacterial antibiotic resistance which is attributed to the widespread usage of antibiotics.Given the global threat and increasing influence of antibiotic resistance,there is an urgent demand to explore novel antibacterial strategies other than using antibiotics.Recently,using a certain surface topography to provide a more persistent antibacterial solution attracts more and more attention.However,the clinical application of biomimetic nano-pillar array is not satisfactory,mainly because its antibacterial ability against Gram-positive strain is not good enough.Thus,the pillar array should be equipped with other antibacterial agents to fulfill the bacteriostatic and bactericidal requirements of clinical application.Here,we designed a novel model substrate which was a combination of periodic micro/nano-pillar array and TiO2 for basically understanding the topographical bacteriostatic effects of periodic micro/nano-pillar array and the photocatalytic bactericidal activity of TiO2.Such innovation may potentially exert the synergistic effects by integrating the persistent topographical antibacterial activity and the non-invasive X-ray induced photocatalytic antibacterial property of TiO2 to combat against antibiotic-resistant implant-associated infections.First,to separately verify the topographical antibacterial activity of TiO2 periodic micro/nano-pillar array,we systematically investigated its effects on bacterial adhesion,growth,proliferation,and viability in the dark without involving the photocatalysis of TiO2.The pillar array with sub-micron motif size can significantly inhibit the adhesion,growth,and proliferation of Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli).Such antibacterial ability is mainly attributed to a spatial confinement size-effect and limited contact area availability generated by the special topography of pillar array.Moreover,the pillar array is not lethal to S.aureus and E.coli in 24 h.Then,the X-ray induced photocatalytic antibacterial property of TiO2 periodic micro/nano-pillar array in vitro and in vivo will be systematically studied in a future work.This study could shed light on the direction of surface topography design for future medical implants to combat against antibiotic-resistant implant-associated infections without using antibiotics. | Xiang Ge Chengzu Ren Yonghui Ding Guang Chen Xiong Lu Kefeng Wang Fuzeng Ren Meng Yang Zhuochen Wang Junlan Li Xinxin An Bao Qian Yang Leng | 2019 | Bioactive Materials2019，4，1： | 8 |
| 2 | Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics显示文摘Adhesive hydrogels have broad applications ranging from tissue engineering to bioelectronics;however,fabricating adhesive hydrogels with multiple functions remains a challenge.In this study,a mussel-inspired tannic acid chelated-Ag(TA-Ag)nanozyme with peroxidase(POD)-like activity was designed by the in situ reduction of ultrasmall Ag nanoparticles(NPs)with TA.The ultrasmall TA-Ag nanozyme exhibited high catalytic activity to induce hydrogel self-setting without external aid.The nanozyme retained abundant phenolic hydroxyl groups and maintained the dynamic redox balance of phenol-quinone,providing the hydrogels with long-term and repeatable adhesiveness,similar to the adhesion of mussels.The phenolic hydroxyl groups also afforded uniform distribution of the nanozyme in the hydrogel network,thereby improving its mechanical properties and conductivity.Furthermore,the nanozyme endowed the hydrogel with antibacterial activity through synergistic effects of the reactive oxygen species generated via POD-like catalytic reactions and the intrinsic bactericidal activity of Ag.Owing to these advantages,the ultrasmall TA-Ag nanozyme-catalyzed hydrogel could be effectively used as an adhesive,antibacterial,and implantable bioelectrode to detect bio-signals,and as a wound dressing to accelerate tissue regeneration while preventing infection.Therefore,this study provides a promising approach for the fabrication of adhesive hydrogel bioelectronics with multiple functions via mussel-inspired nanozyme catalysis. | Zhanrong Jia Xuanhan Lv Yue Hou Kefeng Wang Fuzeng Ren Dingguo Xu Qun Wang Kelong Fan Chaoming Xie Xiong Lu | 2021 | Bioactive Materials2021，6，9： | 7 |
| 3 | Mussel‑Inspired Redox‑Active and Hydrophilic Conductive Polymer Nanoparticles for Adhesive Hydrogel Bioelectronics显示文摘Conductive polymers(CPs)are generally insoluble,and developing hydrophilic CPs is significant to broaden the applications of CPs.In this work,a mussel-inspired strategy was proposed to construct hydrophilic CP nanoparticles(CP NPs),while endowing the CP NPs with redox activity and biocompatibility.This is a universal strategy applicable for a series of CPs,including polyaniline,polypyrrole,and poly(3,4-ethylenedioxythiophene).The catechol/quinone contained sulfonated lignin(LS)was doped into various CPs to form CP/LS NPs with hydrophilicity,conductivity,and redox activity.These CP/LS NPs were used as versatile nanofillers to prepare the conductive hydrogels with long-term adhesiveness.The CP/LS NPs-incorporated hydrogels have a good conductivity because of the uniform distribution of the hydrophilic NPs in the hydrogel network,forming a well-connected electric path.The hydrogel exhibits long-term adhesiveness,which is attributed to the mussel-inspired dynamic redox balance of catechol/quinone groups on the CP/LS NPs.This conductive and adhesive hydrogel shows good electroactivity and biocompatibility and therefore has broad applications in electrostimulation of tissue regeneration and implantable bioelectronics. | Donglin Gan Tao Shuai Xiao Wang Ziqiang Huang Fuzeng Ren Liming Fang Kefeng Wang Chaoming Xie Xiong Lu | 2020 | Nano-Micro Letters2020，12，12： | 4 |
| 4 | Delivery of surface-mediated non-viral gene nanoparticles from ultrathin layer-by-layer multilayers显示文摘An efficient and safe gene delivery system remains a challenge in the development of gene therapy.Polycation-based gene nanoparticles are a typical non-viral gene delivery system,which are able to transfect cells in vitro and in vivo.This paper reported a facile method for constructing biodegradable multilayers via layer-by-layer self-assembly,in which the polycation-based gene nanoparticles were loaded.Through this surface-mediated delivery system,adherent cells on the multilayer could be transfected in situ.Gene nanoparticles-loaded multilayers transfect cells with higher efficiency than naked DNA-loaded multilayers because of the complex configuration of the DNA.DNA nanoparticles/PGA multilayers constructed on the scaffold surface could also realize in situ transfection on the adherent cells.The well-structured,easy-processed multilayers may provide a novel approach to precisely controlled delivery of gene nanoparticles,which may have potential applications for gene therapy in tissue engineering and medical implants. | WANG XueFei,REN KeFeng,LIN QuanKui & JI Jian Key Laboratory of Macromolecule Synthesis and Functionalization,Ministry of Education Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China | 2010 | Science China Chemistry2010，53，3： | 4 |
| 5 | Risk Assessment of Marine Environments Along the South China Sea and North Indian Ocean on the Basis of a Weighted Bayesian Network显示文摘Marine environments have a considerable influence on the construction of the Chinese 21st Century Maritime Silk Road.Thus,an objective and quantitative risk assessment of marine environments has become a key problem that must be solved urgently.To deal with the uncertainty in marine environmental risks caused by complex factors and fuzzy mechanisms,a new assessment technique based on a weighted Bayesian network(BN)is proposed.Through risk factor analysis,node selection,structure construc-tion,and parameter learning,we apply the proposed weighted BN-based assessment model for the risk assessment and zonation of marine environments along the Maritime Silk Road.Results show that the model effectively fuses multisource and uncertain envi-ronmental information and provides reasonable risk assessment results,thereby offering technical support for risk prevention and disaster mitigation along the Maritime Silk Road. | LI Ming ZHANG Ren LIU Kefeng | 2021 | Journal of Ocean University of China2021，20，3： | 3 |
| 6 | Poly (d,l-lactide)/nano-hydroxyapatite composite scaffolds for bone tissue engineering and biocompatibility evaluation显示文摘 | Jie Ren Peng Zhao Tianbin Ren Shuying Gu Kefeng Pan | 2008 | Journal of Materials Science: Materials in Medicine2008，，3： | 1 |
| 7 | Measurement and influencing factors of urban traffic ecological resilience in developing countries: A case study of 31 Chinese cities显示文摘An urban traffic ecosystem is a spatial structure composed of air,population,vehicles,roads,green spaces,and regions.Traffic ecological resilience is a critical issue in high-quality urban development.From the perspective of system optimization,it is important to study the level of urban traffic ecological resilience and analyze its influencing factors.In this study,we evaluated traffic ecological resilience,characterized its spatio-temporal differentiation,and explored its influencing factors by constructing a system of urban traffic ecological resilience and by analyzing the environmental protection and urban construction data in 31 Chinese cities during 2011-2018.By conducting Kernel density analysis,standard deviation ellipse,comprehensive weight determination,panel data regression analysis,andχ2test,we found that traffic ecological resilience was low on the whole and exhibited the temporal trend of“decreasing first and then increasing”and the spatial characteristic of“high in the east,second in the middle,and low in the west”.The cities with high traffic ecological resilience density values were located in Southeast China and tended to move from northwest to southeast.Governance capability,market activity,technological innovation capability,opening degree,and financial resources had significant effects on urban traffic ecological resilience.Finally,we gave some suggestions for improving the urban traffic ecological resilience in Chinese cities as well as other developing countries in the world. | HU Xiwu SU Yunqing REN Kefeng SONG Fang XUE Ruixiang | 2021 | Regional Sustainability2021，2，3： | 1 |
| 8 | Construction of redox-active multilayer film for electrochemically con- trolled release 显示文摘 | SUN Yixin REN Kefeng ZHAO Yixiu | 2013 | Langmuir2013，29，11： | 1 |
| 9 | Cell culture medium as an alternative to conventional simulated body fluid显示文摘 | Juliana T.Y. Lee Yang Leng King L. Chow Fuzeng Ren Xiang Ge Kefeng Wang Xiong Lu | 2011 | Acta Biomaterialia2011，，6： | 1 |
| 10 | Research on the Contents of Chinese Seabucklthorn Fruit Oil and Its Application to Chloasma Treatments显示文摘 | Hanqing Xu Junfeng Ren Huili Xu Kefeng Sun Ailin Lv Jie Fen | 2005 | Journal of US-China Medical Science2005，2，6： | 1 |
| 11 | Hierarchical Capillary Coating to Biofunctionlize Drug-Eluting Stent for Improving Endothelium Regeneration显示文摘The drug-eluting stent(DES)has become one of the most successful and important medical devices for coronary heart disease,but yet suffers from insufficient endothelial cell(EC)growth and intima repair,eventually leading to treatment failure.Although biomacromolecules such as vascular endothelial growth factor(VEGF)would be promising to promote the intima regeneration,combining hydrophilic and vulnerable biomacromolecules with hydrophobic drugs as well as preserving the bioactivity after harsh treatments pose a huge challenge.Here,we report on a design of hierarchical capillary coating,which composes a base solid region and a top microporous region for incorporating rapamycin and VEGF,respectively.The top spongy region can guarantee the efficient,safe,and controllable loading of VEGF up to 1μg/cm^(2) in 1 minute,providing a distinctive real-time loading capacity for saving the bioactivity.Based on this,we demonstrate that our rapamycin-VEGF hierarchical coating impressively promoted the competitive growth of endothelial cells over smooth muscle cells(ratio of EC/SMC~25)while relieving the adverse impact of rapamycin to ECs.We further conducted the real-time loading of VEGF on stents and demonstrate that the hierarchical combination of rapamycin and VEGF showed remarkable endothelium regeneration while maintaining a very low level of in-stent restenosis.This work paves an avenue for the combination of both hydrophobic and hydrophilic functional molecules,which should benefit the next generation of DES and may extend applications to diversified combination medical devices. | Jing Wang Yunfan Xue Jun Liu Mi Hu He Zhang Kefeng Ren Yunbing Wang Jian Ji | 2020 | Research2020，，1： | 1 |
| 12 | A deep-learning-based workflow to deal with the defocusing problem in high-throughput experiments显示文摘The increasing throughput of experiments in biomaterials research makes automatic techniques more and more necessary.Among all the characterization methods,microscopy makes fundamental contributions to biomaterials science where precisely focused images are the basis of related research.Although automatic focusing has been widely applied in all kinds of microscopes,defocused images can still be acquired now and then due to factors including background noises of materials and mechanical errors.Herein,we present a deep-learning-based method for the automatic sorting and reconstruction of defocused cell images.First,the defocusing problem is illustrated on a high-throughput cell microarray.Then,a comprehensive dataset of phase-contrast images captured from varied conditions containing multiple cell types,magnifications,and substrate materials is prepared to establish and test our method.We obtain high accuracy of over 0.993 on the dataset using a simple network architecture that requires less than half of the training time compared with the classical ResNetV2 architecture.Moreover,the subcellular-level reconstruction of heavily defocused cell images is achieved with another architecture.The applicability of the established workflow in practice is finally demonstrated on the high-throughput cell microarray.The intelligent workflow does not require a priori knowledge of focusing algorithms,possessing widespread application value in cell experiments concerning high-throughput or time-lapse imaging. | Yunfan Xue Honglin Qian Xu Li Jing Wang Kefeng Ren Jian Ji | 2022 | Bioactive Materials2022，7，5： | 0 |
| 13 | Corrigendum to“Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics”[Bioact.Mater.6(2021)2676-2687/452]显示文摘The authors regret | Zhanrong Jia Xuanhan Lv Yue Hou Kefeng Wang Fuzeng Ren Dingguo Xu Qun Wang Kelong Fan Chaoming Xie Xiong Lu | 2023 | Bioactive Materials2023，，5： | 0 |
| 14 | Computer Simulation of Ions Doped Hydroxyapatite: A Brief Review显示文摘A brief review of commonly encountered anions,cations and co-doped HA and Ca-deficient HA was given in the DFT studies.First,the charge compensation mechanism,the preference substitution sites and crystal structure changes of doped HA were described and discussed.And then conclusions were drawn and future challenges were discussed.The review is expected to provide theoretical guidance for the development of bioactive HA with special structures and functions. | 王蒙豪 王群 鲁雄 WANG Kefeng REN Fuzeng | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，4： | 0 |
| 15 | Evolving a Bayesian network model with information flow for time series interpolation of multiple ocean variables显示文摘Based on Bayesian network (BN) and information flow (IF),a new machine learning-based model named IFBN is put forward to interpolate missing time series of multiple ocean variables. An improved BN structural learning algorithm with IF is designed to mine causal relationships among ocean variables to build network structure. Nondirectional inference mechanism of BN is applied to achieve the synchronous interpolation of multiple missing time series. With the IFBN,all ocean variables are placed in a causal network visually,making full use of information about related variables to fill missing data. More importantly,the synchronous interpolation of multiple variables can avoid model retraining when interpolative objects change. Interpolation experiments show that IFBN has even better interpolation accuracy,effectiveness and stability than existing methods. | Ming Li Ren Zhang Kefeng Liu | 2021 | Acta Oceanologica Sinica2021，40，7： | 0 |
| 16 | Secrecy Outage Probability for Two-Way Integrated Satellite Unmanned Aerial Vehicle Relay Networks with Hardware Impairments显示文摘In this paper,we investigate the secrecy outage performance for the two-way integrated satellite unmanned aerial vehicle relay networks with hardware impairments.Particularly,the closed-form expression for the secrecy outage probability is obtained.Moreover,to get more information on the secrecy outage probability in a high signalto-noise regime,the asymptotic analysis along with the secrecy diversity order and secrecy coding gain for the secrecy outage probability are also further obtained,which presents a fast method to evaluate the impact of system parameters and hardware impairments on the considered network.Finally,Monte Carlo simulation results are provided to show the efficiency of the theoretical analysis. | Xiaoting Ren Kefeng Guo | 2023 | Computer Modeling in Engineering & Sciences2023，，6： | 0 |
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