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| 1 | Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma显示文摘Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver failure.Liver cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver cancers.Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management.Chronic infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for HCC.Due to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of HCC.Common mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral proteins.DNA integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV infection.The current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC. | Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel | 2020 | World Journal of Gastroenterology2020，26，38： | 25 |
| 2 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study显示文摘 | Shamir R Mehta Salim Yusuf Ron JG Peters Michel E Bertrand Basil S Lewis Madhu K Natarajan Klas Malmberg Hans-Jürgen Rupprecht Feng Zhao Susan Chrolavicius Ingrid Copland Keith AA Fox | 2001 | The Lancet . 2001 (9281)2001，，9281： | 4 |
| 3 | On the role of Mn (IV) vacancies in the photoreductive dissolution of hexagonal birnessite显示文摘 | KIDEOK D K KEITH R GARRISON S | 2009 | Geochimica et Cosmochimica Acta2009，73，： | 1 |
| 4 | Generalizing the partial global planning algorithm 显示文摘 | Decker Keith S Lesser Victor R | 1992 | International Journal of Intelligent and Cooperative Information System1992，1，2： | 1 |
| 5 | Characterization of inclusion complexes of betamethasone - related steroids with cy- clodextrins using high- performance liquid chromatography显示文摘 | Keith G F Eugene R R Nicholas H S | 2000 | Chromatography A2000，903，12： | 1 |
| 6 | Factors controlling prolific gas production from low-permeability sandstone reservoirs= Implica- tions for resource assessment, prospect development, and risk analysis显示文摘 | Keith W S Robert M C John W R | 2004 | AAPG Bulletin2004，88，10： | 1 |
| 7 | Generalizing the partial global planning algorithm 显示文摘 | Keith S Decker Victor R Lesser | 1992 | Intemational Journal of Intelligent and Cooperative Information Systems1992，，2： | 1 |
| 8 | Knowledge sharing between design and manufacture 显示文摘 | COCHRANE S D KEITH C YOUNG R I | 2005 | Lecture Notes in Computer Science2005，3684，： | 1 |
| 9 | Mobilization of PAHs and PCBs from in-place contaminated marine sediments during simulated resuspension events显示文摘 | LATIMER J S DAVIS W R KEITH D J | 1999 | Estuarine Coastal and Shelf Science1999，49，4： | 1 |
| 10 | Dissimilatory nitrate reduction by a strain of Desulfovibrio desulfuricans 显示文摘 | Keith S M Herbert R A | 1983 | FEMS Microbiology Letters1983，18，12： | 1 |
| 11 | Estimationof surface water quality changesin response to land use change:application of the export coefficientmo d e l u s i n g r e mot e s e n s i n gand geographical informationsystem显示文摘 | Nandish M M Keith S R | 1996 | Journal of environmentalmanagement1996，48，： | 1 |
| 12 | Mandatory steroid testing of high school athletes:A synthesis of state ini- tiatives and federal constitutional rights显示文摘 | KENNETH J S KEITH M C SHANTEL R K | 2012 | J Legal Aspects Sport2012，，21： | 1 |
| 13 | Probabilistic assessment of laboratory-Derived acute toxicity data for the triazine herbicides to aquatic organisms显示文摘 | Keith R S Dennis C | 2008 | The Triazine Herbicides2008，，28： | 1 |
| 14 | Gene expression in giant-celltumors显示文摘 | Keith M S Edward Y C Denis R C | 2004 | J Biotechno2004，114，1： | 1 |
| 15 | Neuropatholo- gy of chronic pancreatitis in humans显示文摘 | Keith R G Keshavjee S H Kerenyi N R | 1985 | Can J Surg1985，28，： | 1 |
| 16 | Self -concept disconfir- mation, psychological distress, and marital happiness显示文摘 | Schafer R B Wickrama K A S Keith P M | 1996 | Journal of Marriage and the Family1996，58，1： | 1 |
| 17 | Chromosome 3p tumor-suppressor gene alterations in cervical carcinomas显示文摘 | Christopher R H Keith A C Carol L K S | 2001 | Molecular Carcinogenesis2001，30，： | 1 |
| 18 | How Changing the Focus of Attention Affects Performance, Kinematics, and Electromyography in Dart Throwing 显示文摘 | Keith R L David E S Alice F H | 2010 | Human Movement Science2010，29，： | 1 |
| 19 | Model for pubilc sector designbuild project selection 显示文摘 | Keith R M Anthony D S | 1998 | Journal of Construction Engineering and Management1998，146，6： | 1 |
| 20 | Resource characterization of the McMurray Wabiskaw deposit in the Athabasca South Region of Northeastern Alberta显示文摘 | MacGillivray J R Strobl R S Keith D A W | | 0，，： | 1 |
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