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| 1 | Early Helicobacter pylori Eradication Decreases Risk of Gastric Cancer in Patients With Peptic Ulcer Disease显示文摘 | Chun–Ying Wu Ken N. Kuo Ming–Shiang Wu Yi–Ju Chen Chang–Bi Wang Jaw–Town Lin | 2009 | Gastroenterology2009，，5： | 4 |
| 2 | Biodegradable nanocarriers for small interfering ribonucleic acid (siRNA) co-delivery strategy increase the chemosensitivity of pancreatic cancer cells to gemcitabine显示文摘Ribonucleic acid (RNA) interference (RNAi) therapies are promising cancertreatment modalities that can specifically target abnormal proto-oncogenes, thusimproving the therapeutic effect. For the treatment of pancreatic cancer, targetingone mutant proto-oncogene by RNAi usually does not yield the desired therapeuticefficiency. Both K-ras gene mutations and Notch1 overexpression are commonsymptoms in pancreatic cancer patients, and play a crucial role in pancreaticcancer cell drug resistance. In this study, biodegradable charged polyester-basedvectors (BCPVs) were synthesized for the co-delivery of K-ras and Notch1 smallinterfering ribonucleic acid (siRNA) into MiaPaCa-2 cells (pancreatic cancercell line) to overcome drug resistance to gemcitabine (GEM), a first-line chem-otherapeutic drug used in the clinic. BCPVs could effectively absorb negative siRNAto form a capsule-like structure, prevent siRNA from nuclease digestion in theserum, and promote effective siRNA cell internalization and endosomal escape.Through K-ras and Notch1 gene silencing in MiaPaCa-2 cells, BCPV-siRNAKsiRNAN^tcm nanocomplexes effectively reversed the epithelia-mesenchymaltransition (EMT) in MiaPaCa-2 cells, thereby greatly enhancing the sensitivity ofMiaPaCa-2 cells to GEM. MiaPaCa-2 cell proliferation, migration, and invasionwere effectively inhibited, and cell apoptosis was also significantly enhanced bythe synergistic antitumor effect of BCPV-siRNAK siRNAN^t~l nanocomplexesand GEM. These results suggest that this combination RNAi therapy can be usedto improve cancer cell sensitivity to chemotherapeutic drugs. Specifically, thisnewly develooed strate^v has a great potential for treating pancreatic cancer. | Chengbin Yang Kok Ken Chan Wen-Jen Lin Alana Mauluidy Soehartono Guimiao Lin Huiting Toh Ho Sup Yoon Chih-Kuang Chen Ken-Tye Yong | 2017 | Nano Research2017，10，9： | 3 |
| 3 | Total Ginsenoside Extract from Panax ginseng Enhances Neural Stem Cell Proliferation and Neuronal Differentiation by Inactivating GSK-3β显示文摘Objective:To study the effects of total ginsenosides(TG)extract from Panax ginseng on neural stem cell(NSC)proliferation and differentiation and their underlying mechanisms.Methods:The migration of NSCs after treatment with various concentrations of TG extract(50,100,or 200μg/mL)were monitored.The proliferation of NSCs was examined by a combination of cell counting kit-8 and neurosphere assays.NSC differentiation mediated by TG extract was evaluated by Western blotting and immunofluorescence staining to monitor the expression of nestin and microtubule associated protein 2(MAP2).The GSK-3β/β-catenin pathway in TG-treated NSCs was examined by Western blot assay.The NSCs with constitutively active GSK-3βmutant were made by adenovirus-mediated gene transfection,then the proliferation and differentiation of NSCs mediated by TG were further verified.Results:TG treatment significantly enhanced NSC migration(P<0.01 or P<0.05)and increased the proliferation of NSCs(P<0.01 or P<0.05).TG mediation also significantly upregulated MAP2 expression but downregulated nestin expression(P<0.01 or P<0.05).TG extract also significantly induced GSK-3βphosphorylation at Ser9,leading to GSK-3βinactivation and,consequently,the activation of the GSK-3β/β-catenin pathway(P<0.01 or P<0.05).In addition,constitutive activation of GSK-3βin NSCs by the transfection of GSK-3βS9 A mutant was found to significantly suppress TG-mediated NSC proliferation and differentiation(P<0.01 or P<0.05).Conclusion:TG promoted NSC proliferation and neuronal differentiation by inactivating GSK-3β. | LIN Kai-li ZHANG Ji CHUNG Hau-lam WU Xin-yi LIU Bin ZHAO Bo-xin SZE Stephen Cho-wing ZHOU Ping-zheng YUNG Ken Kin-lam ZHANG Shi-qing | 2022 | Chinese Journal of Integrative Medicine2022，28，3： | 2 |
| 4 | Functional Role of Matrix Metalloproteinase-8 in Stem/Progenitor Cell Migration and Their Recruitment Into Atherosclerotic Lesions显示文摘 | Qingzhong Xiao Feng Zhang Luyang Lin Changcun Fang Guanmei Wen Tsung-Neng Tsai Xiangyuan Pu David Sims Zhongyi Zhang Xiaoke Yin Binia Thomaszewski Boris Schmidt Manuel Mayr Ken Suzuki Qingbo Xu Shu Ye | 2013 | Circulation Research2013，，1： | 2 |
| 5 | ABO blood type, long-standing diabetes, and the risk of pancreatic cancer显示文摘AIM: To retrospectively study pancreatic cancer patients with respect to their ABO blood type and diabetes. METHODS: Our analysis included a cohort of 1017 patients with pancreatic ductal cancer diagnosed at our hospital in Tokyo. They were divided into two groups: 114 patients with long-standing type 2 diabetes (DM group, defined as diabetes lasting for at least three years before the diagnosis of pancreatic cancer) and 903 patients without diabetes (non-DM group). Multivariate analysis was performed to identify factors that are associated with long-standing diabetes. The DM group was further divided into three subgroups according to the duration of diabetes (3-5 years, 5.1-14.9 years, and 15 years or more) and univariate analyses were performed. RESULTS: Of the 883 pancreatic cancer patients with serologically assessed ABO blood type, 217 (24.6%) had blood type O. Compared with the non-DM group, the DM group had a higher frequency of blood type B [odds ratio (OR) = 2.61, 95%CI: 1.24-5.47; reference group: blood type A]. Moreover, male (OR = 3.17, 95%CI: 1.67-6.06), older than 70 years of age (OR = 2.19, 95%CI: 1.20-3.98) and presence of a family history of diabetes (OR = 6.21, 95%CI: 3.38-11.36) were associated with long-standing type 2 diabetes. The mean ages were 64.8 ± 9.2 years, 67.1 ± 9.8 years, and 71.7 ± 7.0 years in the subgroups with the duration of diabetes, 3-5 years, 5.1-14.9 years, and 15 years or more, respectively (P = 0.007). A comparison of ABO blood type distribution among the subgroups also showed a significant difference (P = 0.03). CONCLUSION: The association of pancreatic cancer with blood type and duration of diabetes needs to be further examined in prospective studies. | Naoto Egawa Yingsong Lin Taku Tabata Sawako Kuruma Seiichi Hara Ken Kubota Terumi Kamisawa | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 6 | Characterization of Fish Cu/Zn–Superoxide Dismutase and Its Protection from Oxidative Stress显示文摘 | Chuian-Fu Ken Chi-Tsai Lin Jei-Fu Shaw Jen-Leih Wu | 2003 | Marine Biotechnology2003，，2： | 1 |
| 7 | High-quality genomic DNA extraction from formalin-fixed and paraffin-embedded samples deparaffinized using mineral oil显示文摘 | JIANGHAI LIN STEPHEN H KENNED Y | 2009 | Anal Biochem2009，395，2： | 1 |
| 8 | Molecular cloning of a cDNA coding for copper/zinc super oxide dismutase from zebra fish and its expression in Escherichia coli 显示文摘 | Ken CF Shaw JF Wu JL Lin CT | 1998 | Journal of Agriculture and Food Chemistry1998，46，： | 1 |
| 9 | Characterization of copper/zinc- super oxide dismutase from Pagrus major and enzyme stability显示文摘 | Ken CF Weng DF Duan K J Lin CT | 2002 | Journal of Agriculture and Food Chemistry2002，50，： | 1 |
| 10 | Characterization of Cu, Zn - SuperOxide dismutase from Pagrus major and enzyme stability显示文摘 | Ken CF Weng DF Duan K J Lin CT | 2002 | Journal of Agriculture and Food Chemistry2002，50，： | 1 |
| 11 | Effect of surface coating on antibacterial behavior of magnesium based metals显示文摘 | KEN L LIN X TAN L L YANG K | 2011 | Materials Letters2011，65，： | 1 |
| 12 | Expression of muscatinic receptor subtypes in rat gastric smooth muscle显示文摘 | Sheng lin Masayoshi Ken Takeuehi | | 0，，05： | 1 |
| 13 | Expression of Muscarinic Receptor Subtypes in Rat Gastric Smooth Muscle显示文摘 | Masayoshi Kajimura Ken Takeuchi | 1997 | Digestive Diseases and Sciences1997，42，5： | 1 |
| 14 | Causality assessment of herb-induced liver injury using multidisciplinary approach and Roussel Uclaf Causality Assessment Method (RUCAM)显示文摘 | Tai Nin Chau Wing I. Cheung Teresa Ngan Jieru Lin Ken Wing San Lee Wing Tat Poon Vincent King Sun Leung Tony Mak Man Li Tse | 2011 | Clinical Toxicology2011，，1： | 1 |
| 15 | Diagnostic Accuracy of Real-Time Tissue Elastography for the Staging of Liver Fibrosis: A Meta-Analysis显示文摘 | Kunio Kobayashi Haruhisa Nakao Takeshi Nishiyama Yingsong Lin Shogo Kikuchi Yuji Kobayashi Takaya Yamamoto Norimitsu Ishii Tomohiko Ohashi Ken Satoh Yukiomi Nakade Kiyoaki Ito Masashi Yoneda | 2015 | European Radiology2015，，1： | 1 |
| 16 | Tomoregulin ectodormain shedding by proinflammatory cytokine显示文摘 | Hong Lin Ken W Masakoi Y | 2003 | Life Sciences2003，73，： | 1 |
| 17 | Basic fibroblast growth factor regulates type I collagen and collafenase gene expression in human smooth muscle cells显示文摘 | Kenned y SH Qin H Lin L | 1995 | Am J Pathol1995，146，3： | 1 |
| 18 | Rather than interleukin‐27, interleukin‐6 expresses positive correlation with liver severity in na?ve hepatitis B infection patients显示文摘 | Jung‐Ta Kao Hsueh‐Chou Lai Shu‐Mei Tsai Pei‐Chao Lin Po‐Heng Chuang Cheng‐Ju Yu Ken‐Sheng Cheng Wen‐Pang Su Ping‐Ning Hsu Cheng‐Yuan Peng Yi‐Ying Wu | 2012 | Liver Int2012，，6： | 1 |
| 19 | Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression显示文摘 | Wartman Lukas D Larson David E Xiang Zhifu Ding Li Chen Ken Lin Ling Cahan Patrick Klco Jeffery M Welch John S Li Cheng Payton Jacqueline E Uy Geoffrey L Varghese Nobish Ries Rhonda E Hoock Mieke Koboldt Daniel C McLellan Michael D Schmid | 2011 | Journal of Clinical Investigation2011，，： | 1 |
| 20 | Distance difference error correction by least square for stationary signal-strength- difference-based hyperbolic location in cellular communi- cations 显示文摘 | Liu Bo Chieh Lin Ken Huang | 2008 | IEEE Transactions on Vehicular Technology2008，57，1： | 1 |
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