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| 1 | Feasibility of gastric endoscopic submucosal dissection with continuous low-dose aspirin for patients receiving dual antiplatelet therapy显示文摘BACKGROUND Endoscopic submucosal dissection(ESD) for gastric neoplasms during continuous low-dose aspirin(LDA) administration is generally acceptable according to recent guidelines. This retrospective study aimed to investigate the effect of continuous LDA on the postoperative bleeding after gastric ESD in patients receiving dual antiplatelet therapy(DAPT).AIM To investigate the feasibility of gastric ESD with continuous LDA in patients with DAPT.METHODS A total of 597 patients with gastric neoplasms treated with ESD between January2010 and June 2017 were enrolled. The patients were categorized according to type of antiplatelet therapy(APT).RESULTS The postoperative bleeding rate was 6.9%(41/597) in all patients. Patients were divided into the following two groups: no APT(n = 443) and APT(n = 154). APT included single-LDA(n = 95) and DAPT(LDA plus clopidogrel, n = 59)subgroups. In the single-LDA and DAPT subgroups, 56 and 39 patients were received continuous LDA, respectively. The bleeding rate with continuous singleLDA(10.7%) was similar to that with discontinuous single-LDA(10.3%)(P >0.99). Although the bleeding rate with continuous LDA in patients receiving DAPT(23.1%) was higher than that with discontinuous LDA in patients receiving DAPT(5.0%), no significant difference was observed(P = 0.141).CONCLUSION The bleeding rate with continuous LDA in patients receiving DAPT was not statistically different from that with discontinuous LDA in patients receiving DAPT. Therefore, continuous LDA administration may be acceptable for ESD in patients receiving DAPT, although patients should be carefully monitored for possible bleeding. | Hideaki Harada Satoshi Suehiro Daisuke Murakami Ryotaro Nakahara Takuya Nagasaka Tetsuro Ujihara Ryota Sagami Yasushi Katsuyama Kenji Hayasaka Yuji Amano | 2019 | World Journal of Gastroenterology2019，25，4： | 6 |
| 2 | Endoscopic submucosal dissection for small submucosal tumors of the rectum compared with endoscopic submucosal resection with a ligation device显示文摘AIM To evaluate the efficacy and safety of endoscopic submucosal dissection(ESD) for small rectal submucosal tumors(SMTs).METHODS Between August 2008 and March 2016, 39 patients were treated with endoscopic submucosal resection with a ligation device(ESMR-L)(n = 21) or ESD(n = 18) for small rectal SMTs in this study. Twenty-five lesions were confirmed by histological evaluation of endoscopic biopsy prior to the procedure, and 14 lesions were not evaluated by endoscopic biopsy. The results for the ESMR-L group and the ESD group were retrospectively compared, including baseline characteristics and therapeutic outcomes.RESULTS The rate of en bloc resection was 100% in both groups. Although the rate of complete endoscopic resectionwas higher in the ESD group than in the ESMR-L group(100% vs 95.2%), there were no significant differences between the two groups(P = 0.462). In one patient in the ESMR-L group with a previously biopsied tumor, histological complete resection with a vertical margin involvement of carcinoid tumor could not be achieved, whereas there was no incomplete resection in the ESD group. The mean length of the procedure was significantly greater in the ESD group than in the ESMR-L group(14.7 ± 6.4 min vs 5.4 ± 1.7 min, P < 0.05). The mean period of the hospitalization was also significantly longer in the ESD group than in the ESMR-L group(3.7 ± 0.9 d vs 2.8 ± 1.5 d, P < 0.05). Postoperative bleeding was occurred in one patient in the ESMR-L group.CONCLUSION Both ESMR-L and ESD were effective for treatment of small rectal SMTs. ESMR-L was simpler to perform than ESD and took less time. | Hideaki Harada Satoshi Suehiro Daisuke Murakami Ryotaro Nakahara Takanori Shimizu Yasushi Katsuyama Yasunaga Miyama Kenji Hayasaka Shigetaka Tounou | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 5 |
| 3 | Dual therapy for third-line Helicobacter pylori eradication and urea breath test prediction显示文摘We evaluated the efficacy and tolerability of a dual therapy with rabeprazole and amoxicillin (AMX) as an empiric third-line rescue therapy. In patients with failure of first-line treatment with a proton pump inhibitor (PPI)- AMX-clarithromycin regimen and second-line treatment with the PPI-AMX-metronidazole regimen, a third-line eradication regimen with rabeprazole (10 mg q.i.d.) and AMX (500 mg q.i.d.) was prescribed for 2 wk. Eradication was confirmed by the results of the 13C-urea breath test (UBT) at 12 wk after the therapy. A total of 46 patients were included; however, two were lost to followup. The eradication rates as determined by per-protocol and intention-to-treat analyses were 65.9% and 63.0%,respectively. The pretreatment UBT results in the subjects showing eradication failure; those patients showing successful eradication comprised 32.9 ± 28.8 permil and 14.8 ± 12.8 permil, respectively. The pretreatment UBT results in the subjects with eradication failure were significantly higher than those in the patients with successful eradication (P = 0.019). A low pretreatment UBT result (≤ 28.5 permil) predicted the success of the eradication therapy with a positive predictive value of 81.3% and a sensitivity of 89.7%. Adverse effects were reported in 18.2% of the patients, mainly diarrhea and stomatitis. Dual therapy with rabeprazole and AMX appears to serve as a potential empirical third-line strategy for patients with low values on pretreatment UBT. | Toshihiro Nishizawa Hidekazu Suzuki Takama Maekawa Naohiko Harada Tatsuya Toyokawa Toshio Kuwai Masanori Ohara Takahiro Suzuki Masahiro Kawanishi Kenji Noguchi Toshiyuki Yoshio Shinji Katsushima Hideo Tsuruta Eiji Masuda Munehiro Tanaka Shunsuke Katayama Norio Kawamura Yuko Nishizawa Toshifumi Hibi Masahiko Takahashi | 2012 | World Journal of Gastroenterology2012，18，21： | 4 |
| 4 | Comprehensive review of post-liver resection surgical complications and a new universal classification and grading system显示文摘Liver resection is the gold standard treatment for certain liver tumors such as hepatocellular carcinoma and metastatic liver tumors. Some patients with such tumors already have reduced liver function due to chronic hepatitis, liver cirrhosis, or chemotherapy-associated steatohepatitis before surgery. Therefore, complications due to poor liver function are inevitable after liver resection. Although the mortality rate of liver resection has been reduced to a few percent in recent case series, its overall morbidity rate is reported to range from 4.1% to 47.7%. The large degree of variation in the post-liver resection morbidity rates reported in previous studies might be due to the lack of consen-sus regarding the definitions and classification of postliver resection complications. The Clavien-Dindo(CD) classification of post-operative complications is widely accepted internationally. However, it is hard to apply to some major post-liver resection complications because the consensus definitions and grading systems for posthepatectomy liver failure and bile leakage established by the International Study Group of Liver Surgery are incompatible with the CD classification. Therefore, a unified classification of post-liver resection complications has to be established to allow comparisons between academic reports. | Masayuki Ishii Toru Mizuguchi Kohei Harada Shigenori Ota Makoto Meguro Tomomi Ueki Toshihiko Nishidate Kenji Okita Koichi Hirata | 2014 | World Journal of Hepatology2014，6，10： | 3 |
| 5 | Serum Folate and Homocysteine Levels Are Associated With Colon Tumorigenesis in End-Stage Renal Disease Patients显示文摘 | Eisuke Kaji Jun Kato Shunsuke Saito Keita Harada Kenji Kuwaki Masashi Tatsukawa Tamiya Morikawa Sakiko Hiraoka Hiroshi Matsushima Kazuhide Yamamoto | 2011 | Nutrition and Cancer2011，，2： | 1 |
| 6 | Correlation between right ventrieular Tei index by tissue Doppler imaging and pulsed Doppler imaging in fetuses 显示文摘 | Duan YQ Harada Kenji Wu W | 2008 | Pediat Cardiol2008，29，4： | 1 |
| 7 | Pulmonary varices: A case report and review of the literature显示文摘 | Tadashi Uyama MD Yasumasa Monden Kunihiko Harada Hiroshi Tamaki Kazumasa Miura Toshikatsu Taniki Suguru Kimura Kohnosuke Hashioka Kenji Nobuhara | 1988 | The Japanese Journal of Surgery1988，，3： | 1 |
| 8 | Effect of topical application of raspberry ketone on dermal production of insulin - like growth factor - I in mice and on hair growth and skin elasticity in humans 显示文摘 | Harada Naoaki Okajima Kenji Narimatsu Noriko | 2008 | Growth Hormone & IGF Research2008，18，： | 1 |
| 9 | Complementary roles of pro-gastrin-releasing peptide (ProGRP) and neuron specific enolase (NSE) in diagnosis and prognosis of small-cell lung cancer (SCLC)显示文摘 | Takuo Shibayama Hiroshi Ueoka Kenji Nishii Katsuyuki Kiura Masahiro Tabata Kazuyo Miyatake Takuji Kitajima Mine Harada | 2001 | Lung Cancer2001，，： | 1 |
| 10 | Assessment of Global Left Ventricular Function by Tissue Doppler Imaging显示文摘 | Kenji Harada Masamichi Tamura Manatomo Toyono | 2001 | Am J Cardiology2001，88，： | 1 |
| 11 | In vitro sequence-dependent interaction between nedaplatin and paclitaxel in human cancer cell lines显示文摘 | Risa Tanaka Yasushi Takii Yoshihiro Shibata Hiroshi Ariyama Baoli Qin Eishi Baba Hitoshi Kusaba Kenji Mitsugi Mine Harada Shuji Nakano | 2005 | Cancer Chemotherapy and Pharmacology2005，，3： | 1 |
| 12 | Photocatagtil degradation of organophosphorous insecticides in aqueous inaqueous semiconductor显示文摘 | Harada Kenji Hisanaga Temaki | 1990 | Water Res1990，24，11： | 1 |
| 13 | Circulating p53 Antibody in Patients with Colorectal Cancer显示文摘 | Goshi Shiota Masato Ishida Naoya Noguchi Kenji Oyama Yuji Takano Michiko Okubo Shunsuke Katayama Yasushi Tomie Kenichi Harada Kotaro Hori Kumiyo Ashida Yosuke Kishimoto Akihide Hosoda Takeaki Suou Takamasa Kanbe Kiwamu Tanaka Kimiyasu Nosaka Osamu Tanida | 2000 | Digestive Diseases and Sciences2000，，1： | 1 |
| 14 | Onboard Spectral Calibration for the Japanese Hyper-spectral Sen- sor显示文摘 | Kenji Tatsumi NagamitsuOhgi Hisashi Harada | 2010 | SPIE2010，7826，78： | 1 |
| 15 | Doppler Echocardiographic Findings of Indomethacin-Induced Occlusion of the Fetal Ductus Arteriosus显示文摘 | Yasushi Takahashi Kenji Harada Akira Ishida Toshinobu Tanaka Akira Tsuda Goro Takada | 1996 | Amer J Perinatol1996，，01： | 1 |
| 16 | Sustained-re-lease adrenomedullin ointment accelerates wound healing of pres-sure ulcers显示文摘 | Kazuhiko Harada Kenichi Yamahara Shunsuke Ohnishi KentaroOtani Hirohisa Kanoh Hatsue Ishibashi-Ueda Naoto Minamino Kenji Kangawa Noritoshi Nagaya Tomoaki Ikeda | 2011 | Regulatory Peptides2011，9，1： | 1 |
| 17 | Effect of magnesium sulfate pretreatment and dignifieanee of matrix metalloproteinase - 1 and interleukin - 6 levels in coronary reperfusion therapy for patients with acute myocardial infarction 显示文摘 | Masashi Shibata Kenji Ueshima Masako Harada | 1999 | Angiology1999，50，： | 1 |
| 18 | Prediction model of hepatocarcinogenesis for patients with hepatitis C virus-related cirrhosis. Validation with internal and external cohorts显示文摘 | Kenji Ikeda Yasuji Arase Satoshi Saitoh Masahiro Kobayashi Takashi Someya Tetsuya Hosaka Norio Akuta Yoshiyuki Suzuki Fumitaka Suzuki Hitomi Sezaki Hiromitsu Kumada Akihisa Tanaka Hideharu Harada | 2006 | Journal of Hepatology2006，，6： | 1 |
| 19 | Prevention of Alveolar Air Leakage after Video-Assisted Thoracic Surgery: Comparison of the Efficacy of Methods Involving the Use of Fibrin Glue显示文摘 | Hideki Kawai Kenji Harada Hideki Ohta Takeshi Tokushima Shiro Oka | 2012 | Thorac cardiovasc Surg2012，，05： | 1 |
| 20 | Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy显示文摘 | Shinji Yasuno Koichiro Kuwahara Hideyuki Kinoshita Chinatsu Yamada Yasuaki Nakagawa Satoru Usami Yoshihiro Kuwabara Kenji Ueshima Masaki Harada Toshio Nishikimi Kazuwa Nakao | 2013 | Br J Pharmacol2013，，： | 1 |
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