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| 1 | Pit-and trench-forming osteoclasts:a distinction that matters显示文摘Osteoclasts(OCs)seeded on bone slices either drill round pits or dig long trenches.Whereas pits correspond to intermittent resorption,trenches correspond to continuous and faster resorption and require a distinct assembly of the resorption apparatus.It is unknown whether the distinction between pits and trenches has any biological relevance.Using OCs prepared from different blood donors,we found that female OCs achieved increased resorption mainly through pit formation,whereas male OCs did so through trench formation.Trench formation went along with high collagenolytic activity and high cathepsin K(CatK)expression,thereby allowing deeper demineralization.A specific CatK inhibitor abrogated the generation of trenches,while still allowing the generation of pits.OCs obtained from bone marrow were more prone to generate trenches than those obtained from blood.Scanning electron microscopy of bone surfaces eroded in vivo showed trenches and pits of similar size as those made by OCs in culture.We conclude that the distinction between trench-and pit-forming OCs is relevant to the differences among OCs from different skeletal sites,different individuals,including gender,and results from differences in colIagenolytic power.This indicates a biological relevance and highlights the importance of discriminating between pits and trenches when assessing resorption. | Ditte MH Merrild Dinisha C Pirapaharan Christina M Andreasen Per Kjxrsgaard-Andersen Anas MJ Mùller Ming Ding Jean-Marie Delaissé Kent Sùe | 2015 | Bone Research2015，3，4： | 2 |
| 2 | Meat tenderness and muscle growth: is there any relationship? 显示文摘 | Koohmaraie M Kent M P Shackelford S D Veiseth E Wheeler T L | 2002 | Meat Science2002，62，： | 1 |
| 3 | Tissue distribution and clearance of tritium-labeled dihydro microcystin-LR epimers administered to Atlantic salmon via intraperitoneal injention显示文摘 | Williams D E Kent M L Andersen R J | 1995 | Toxicon1995，33，： | 1 |
| 4 | The ac- curacy of wind observations from ships显示文摘 | TAYLOR P K KENT E C YELLAND M J | 1995 | Advances in the Applications of Marine Climatology1995，2，2： | 1 |
| 5 | Knowledge acquisition from foreign parents in international joint ventures: An empirical study in Vietnam显示文摘 | PHAN T A BAUGHN C C NGO T M H KENT E N | 2006 | International Business Review2006，，15： | 1 |
| 6 | Geochemical and isotopic constraints on the petrogenesis of the Noril' sk Talnakh ore-forming system 显示文摘 | Czamanske G K Wooden J L Zientek M L Fedorenko V A Zen' ko T E Kent J King B-S W Knight R J Siems D F | 1994 | Proceedings of the Sudbury Noril'' sk Symposium Ontario Geological Surrey Special Publication1994，5，： | 1 |
| 7 | The patient with hormone refractory protate cancer: determining who, when and how to treat显示文摘 | Kent E C Hussain M H A | 2003 | Urology2003，62，： | 1 |
| 8 | BioMagResBank显示文摘 | Ulrich E L Akutsu H Doreleijers J F Harano Y Ioannidis Y E Lin J Livny M Mading S Maziuk D Miller Z Nakatani E Schulte C F Tolmie D E Kent Wenger R Yao H Markley J L | | 0，，1： | 1 |
| 9 | Neural basis for the genesis and control of arrhythmias associated with myocardial infarction显示文摘 | KENT K M EPSTEIN S E | 1976 | Cardiology1976，61，1： | 1 |
| 10 | Oxidative stress and NFκB activation in the lungs of rats: a synergistic interaction between soot and iron particles显示文摘 | Ya-Mei Zhou Cai-Yun Zhong Ian M Kennedy Valerie J Leppert Kent E Pinkerton | 2003 | Toxicology and Applied Pharmacology2003，，2： | 1 |
| 11 | Performance of primocane-fruiting raspberries grown in the greenhouse显示文摘 | Dale A Gilley A Kent E M | 2001 | Journal American Pomological Society2001，55，1： | 1 |
| 12 | Quantitative RT-PCR: Pitfall and Potential显示文摘 | Willard M F Stephen J W Kent E V | 1999 | Bio Techniques1999，26，1： | 1 |
| 13 | Bioaccumulation and clearance of microcystins from salt water mussels, Mytilus edulis, and in vivo evidence for covalently bound microcystins in mussel tissues 显示文摘 | Williams D E Dawe S C Kent M L | 1997 | Toxicon1997，35，： | 1 |
| 14 | Growth and or- ganized development of cultured cells显示文摘 | Steward F C Mapes M O Kent A E | 1958 | American Journal of Botany1958，45，： | 1 |
| 15 | Ascent of dinosaurs linked to an iridium anomaly at the Triassic-Jurassic boundary显示文摘 | Olsen P E Kent D V Sues H D Koeberl C Huber H Monlanari A Rainforth E C Fowell S J Szajna M J Hartline B W | 2002 | Science2002，296，5571： | 1 |
| 16 | Deep hypothermic circulatory arrest: I. Effects of cooling on electroencephalogram and evoked potentials显示文摘 | Mark M Stecker Albert T Cheung Alberto Pochettino Glenn P Kent Terry Patterson Stuart J Weiss Joseph E Bavaria | 2001 | The Annals of Thoracic Surgery2001，，1： | 1 |
| 17 | Pleiotropic locus for emotion recognition and amygdala volume identified using univariate and bivariate linkage显示文摘 | Knowles E E M D Reese M Kent J W | 2015 | American Journal of Psy- chiatry2015，172，2： | 1 |
| 18 | Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity显示文摘 | Hoet R M Cohen E H Kent R B | | 0，，： | 1 |
| 19 | Accuracy of the EORTC risk tables and of the CUETO scoring model to predict out comes in non-muscle invasive urothelial carcinoma of the bladder显示文摘 | Xylinas E Kent M Kluth L | 2013 | Br J Cancer2013，109，6： | 1 |
| 20 | Quantitative RT-PCR : pitfall and potential 显示文摘 | WILLARD M F STEPHEN J W KENT E V | 1999 | Bio Techniques1999，26，1： | 1 |
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