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| 1 | Interpretation of breast cancer screening guideline for Chinese women显示文摘Breast cancer is the most common malignant tumor in Chinese women.Early screening is the best way to improve the rates of early diagnosis and survival of breast cancer patients.The peak onset age for breast cancer in Chinese women is considerably younger than those in European and American women.It is imperative to develop breast cancer screening guideline that is suitable for Chinese women.By summarizing the current evidence on breast cancer screening in Chinese women,and referring to the latest guidelines and consensus on breast cancer screening in Europe,the United States,and East Asia,the China Anti-Cancer Association and National Clinical Research Center for Cancer(Tianjin Medical University Cancer Institute and Hospital)have formulated population-based guideline for breast cancer screening in Chinese women.The guideline provides recommendations on breast cancer screening for Chinese women at average or high risk of breast cancer according to the following three aspects:age of screening,screening methods,and screening interval.This article provides more detailed information to support the recommendations in this guideline and to provide more direction for current breast cancer screening practices in China. | Yubei Huang Zhongsheng Tong Kexin Chen Ying Wang Peifang Liu Lin Gu Juntian Liu Jinpu Yu Fengju Song Wenhua Zhao Yehui Shi Hui Li Huaiyuan Xiao Xishan Hao | 2019 | Cancer Biology & Medicine2019，16，4： | 10 |
| 2 | Detrital Zircon U-Pb Geochronology from Greywackes in the Niujuanzi Ophiolitic Mélange, Beishan Area, NW China: Provenance and Tectonic Implications显示文摘The Niujuanzi ophiolitic mélange represents the remnant of oceanic crust between the Dunhuang massif and Mingshui-Hanshan massif. Greywacke from different tectonic slices in the Niujuanzi ophiolitic mélange were analyzed for detrital zircon U-Pb geochronology, trace elements and whole-rock trace elements to infer their provenance and the evolution of the Niujuanzi Ocean. Sample N-76 s containing Carboniferous spores has the youngest zircon age of 323 Ma, while sample N-85 s without fossils has the youngest zircon age of 449 Ma. The two samples were deposited no earlier than 323 and 449 Ma, respectively. The greywackes are depleted in large ion lithophile elements, and are relatively enriched in high field strength elements. The age spectra and trace element concentrations indicate that the sediments may have been deposited near the trench. The Hf, U, and Yb contents of zircons from sample N-76 s vary widely, whereas those from sample N-85 s have a narrow range. Sample N-76 s contains both continental and oceanic zircons, while sample N-85 s contains only continental zircons. The sediments were derived from the continental arc and accretionary wedge. The Paleozoic oceanic crust zircons have ages of 430–500 Ma, indicating the timing of the expansion of the HongliuheNiujuanzi-Xichangjing Ocean expansion. The oldest Paleozoic continental zircon has an age of 470 Ma, suggesting that the northward subduction of the oceanic crust may have started at that time. | Shengdong Wang Kexin Zhang Bowen Song Shucai Li Jianxing Li Jiyuan Yu Jianjun Bu | 2018 | Journal of Earth Science2018，29，1： | 8 |
| 3 | Application of deep learning in ecological resource research:Theories, methods, and challenges显示文摘Ecological resources are an important material foundation for the survival,development,and self-realization of human beings.In-depth and comprehensive research and understanding of ecological resources are beneficial for the sustainable development of human society.Advances in observation technology have improved the ability to acquire long-term,cross-scale,massive,heterogeneous,and multi-source data.Ecological resource research is entering a new era driven by big data.Traditional statistical learning and machine learning algorithms have problems with saturation in dealing with big data.Deep learning is a method for automatically extracting complex high-dimensional nonlinear features,which is increasingly used for scientific and industrial data processing because of its ability to avoid saturation with big data.To promote the application of deep learning in the field of ecological resource research,here,we first introduce the relationship between deep learning theory and research on ecological resources,common tools,and datasets.Second,applications of deep learning in classification and recognition,detection and localization,semantic segmentation,instance segmentation,and graph neural network in typical spatial discrete data are presented through three cases:species classification,crop breeding,and vegetation mapping.Finally,challenges and opportunities for the application of deep learning in ecological resource research in the era of big data are summarized by considering the characteristics of ecological resource data and the development status of deep learning.It is anticipated that the cooperation and training of cross-disciplinary talents may promote the standardization and sharing of ecological resource data,improve the universality and interpretability of algorithms,and enrich applications with the development of hardware. | Qinghua GUO Shichao JIN Min LI Qiuli YANG Kexin XU Yuanzhen JU Jing ZHANG Jing XUAN Jin LIU Yanjun SU Qiang XU Yu LIU | 2020 | Science China Earth Sciences2020，63，10： | 7 |
| 4 | Genomic selection: A breakthrough technology in rice breeding显示文摘Rice(Oryza sativa)provides a staple food source for more than half the world population.However,the current pace of rice breeding in yield growth is insufficient to meet the food demand of the everincreasing global population.Genomic selection(GS)holds a great potential to accelerate breeding progress and is cost-effective via early selection before phenotypes are measured.Previous simulation and experimental studies have demonstrated the usefulness of GS in rice breeding.However,several affecting factors and limitations require careful consideration when performing GS.In this review,we summarize the major genetics and statistical factors affecting predictive performance as well as current progress in the application of GS to rice breeding.We also highlight effective strategies to increase the predictive ability of various models,including GS models incorporating functional markers,genotype by environment interactions,multiple traits,selection index,and multiple omic data.Finally,we envision that integrating GS with other advanced breeding technologies such as unmanned aerial vehicles and open-source breeding platforms will further improve the efficiency and reduce the cost of breeding. | Yang Xu Kexin Ma Yue Zhao Xin Wang Kai Zhou Guangning Yu Cheng Li Pengcheng Li Zefeng Yang Chenwu Xu Shizhong Xu | 2021 | The Crop Journal2021，9，3： | 7 |
| 5 | Early Paleozoic Ocean Plate Stratigraphy of the Beishan Orogenic Zone, NW China: Implications for Regional Tectonic Evolution显示文摘The Beishan orogenic zone is a key area to understand evolution of the Central Asian Orogenic Belt that is an accretionary factory well-enough preserved in the Paleozoic. In early Paleozoic, the tectonic mélange zone containing the coherent unit and mélange unit is triggered by the complicated accretionary process of the Beishan area. The early Paleozoic tectonic evolution of the Beishan orogenic zone is investigated in this study using sedimentology and stratigraphic correlations of the lowe Paleozoic deposits. From the Cambrian to the middle Ordovician, this region was characterized by geographically extensive, flat-bedded siliceous mudstone, indicating the existence of a large ocean basin. The oceanic plate entered the convergence phase in terms of the Wilson Circle during the Middle Ordovician, when numerous magmatic arcs formed along two opposite sides of the ocean. The magmatic arcs became the widest during the Silurian, suggesting that the Hongliuhe-Niujuanzi-Xichangjing Ocean(HNX;a southern branch of the Paleo Asian Ocean) was reduced to a small residual ocean in the central Beishan region by that time, and probably lasted till the Carboniferous or later by newly published data. | WANG Jiaxuan ZHANG Kexin JIN Jisuo SONG Bowen YU Yang WANG Lijun WANG Shengdong SUN Shuo | 2020 | Acta Geologica Sinica(English Edition)2020，94，4： | 3 |
| 6 | High-throughput sequencing analysis of the regulation of intestinal flora in giant pandas with indigestion using a probiotic agent LyPB显示文摘This study aimed to investigate the eff ect of LyPB on the intestinal microfl ora of giant pandas with indigestion,using high-throughput sequencing(HTS)technology.The species distribution and microfl oral density and diversity before and after administration of the LyPB probiotic agent were analyzed.LyPB evidently has the ability to adjust the fl oral imbalance in the panda’s intestine.To test the eff ects of LyPB on the microfl ora of the panda gut,fecal samples were taken from a healthy giant panda(Anan)without administration of LyPB and from a dyspeptic giant panda Yangyang before and after LyPB administration.Compared with the sample obtained from healthy Anan(anan-c)and that obtained from dyspeptic Yangyang before LyPB administration(yangyang1),the sample taken from Yangyang(yangyang2)after LyPB administration displayed a signifi cant increase in the operational taxonomic unit index.An increase in the Chao index indicated an increase in the microfl oral richness,while an increase in the Shannon index indicated an increase in microfl oral diversity.At phylum and genus levels,a signifi cant increase was observed in the density of probiotic bacteria of phylum fi rmicutes,genus Streptococcus,while a drastic reduction in the density of Escherichia coli/Escherichia coli Shigella/bacteria of genus Shigella was observed.Data obtained in this study shows that LyPB preparations successfully improve the microbial structure within the panda’s intestinal canal by signifi cantly increasing the eff ective microbial community and decreasing the number of pathogenic microbes. | Yu Zhang Zhi Zhang Jianzhang Ma Bo Luo Guiquan Zhang Guocai Zhang Kexin Yang Gang Wei | 2020 | Journal of Forestry Research2020，31，6： | 3 |
| 7 | Transmission line fault-cause identification method for large-scale new energy grid connection scenarios显示文摘The accurate fault-cause identification for overhead transmission lines supports the operation and maintenance personnel in formulating targeted maintenance strategies and shortening the time of inspecting faulty lines.With the goal of achieving“carbon peak and carbon neutrality”,the schemes for clean energy generation have rapidly developed.Moreover,new energy-consuming equipment has been widely connected to the power grid,and the operating characteristics of the power system have significantly changed.Consequently,these have impacted traditional fault identification methods.Based on the time-frequency characteristics of the fault waveform,new energy-related parameters,and deep learning model,this study proposes a fault identification method suitable for scenarios where a high proportion of new energy is connected to the power grid.Ten parameters related to the causes of transmission line fault and new energy connection scenarios are selected as model characteristic parameters.Further,a fault identification model based on adaptive deep belief networks was constructed,and its effect was verified by field data. | Hanqing Liang Xiaonan Han Haoyang Yu Fan Li Zhongjian Liu Kexin Zhang | 2022 | Global Energy Interconnection2022，5，4： | 3 |
| 8 | Review of minimally invasive continuous glucose monitoring technology & instruments显示文摘Continuous blood glucose monitoring is important for the diagnosis,treatment,and study of diabetes. many organizations have been working on this subject in recent two decades. Glucose concentration in interstitial fluid is closely related to the blood glucose levels. Minimally invasive continuous blood glucose monitoring technology based on the glucose detection in interstitial fluid develops rapidly and gets more and more attentions from the patients and the doctors,due to its instantaneous real-time display of glucose level,'24/7'coverage,and the ability to characterize glycemic variability. According to the different detection methods,most of the continuous glucose monitoring technology could be divided into two kinds: subcutaneous implantation method and transdermal extraction method. This paper review s the recent development of minimally invasive blood glucose monitoring technology and instruments. The mainly remained challenges and related research directions are presented as well. | YU Haixia LI Dachao XU Kexin | 2016 | Instrumentation2016，3，4： | 2 |
| 9 | MOFs fertilized transition-metallic single-atom electrocatalysts for highly-efficient oxygen reduction: Spreading the synthesis strategies and advanced identification显示文摘Metal-organic frameworks(MOFs) have been widely used in oxygen reduction reaction(ORR) of fuel cells and metal-air batteries, attributed to their unique structures and compositions. Recently, the preparation of transition-metallic single-atom electrocatalysts(TM-SACs) using MOFs as precursors or templates has made great progress. Herein, the development history of SACs prepared based on MOFs and their characterization are overviewed firstly, and then several strategies are summarized for preparing TM-SACs using MOFs and further modification. Finally, the challenges and opportunities confronted by TM-SACs are fully discussed. Consequently, our work can guide the realization of TM-SACs abundant with high activity, high loading and high stability. | Kexin Song Yu Feng Wei Zhang Weitao Zheng | 2022 | Journal of Energy Chemistry2022，31，4： | 2 |
| 10 | Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk显示文摘 | Biyun Qian Huan Zhang Lina Zhang Xiaoying Zhou Herbert Yu Kexin Chen | 2010 | Lung Cancer2010，，2： | 2 |
| 11 | Recent Progress of Counter Electrodes in Nanocrystalline Dye-sensitized Solar Cells显示文摘敏化染料的太阳能电池(DSC ) 在于有 nanoparticulated 半导体, sensitizers,电解质和相反的电极(CE ) 的几 differentmaterials:photoanodes 的联合。每材料为 CE 的主要功能是把电子转移到氧化还原作用电解质和 regenerate 碘化物离子的太阳能 intoelectricity.The 的变换执行特定的任务。GE 的工作主要集中于运动表演的研究和传统的 CE 的稳定性改进 DSC 的全面效率,寻求新奇设计概念或新材料。在这评论,发展和研究不同 CE 材料和他们的电气化学的表演进行,并且这些问题被讨论。 | Kexin LI Zhexun YU Yanhong LUO Dongmei LI Qingbo MENG | 2007 | Journal of Materials Science & Technology2007，23，5： | 2 |
| 12 | Towards Converged Millimeter-Wave/Terahertz Wireless Communication and Radar Sensing显示文摘Converged communication and radar sensing systems have attained increasing attention in recent years.The development of converged radar-data systems is reviewed,with a special focus on millimeter/terahertz systems as a promising trend.Firstly,we present historical development and convergence technology concept for communication-radar systems,and highlight some emerging technologies in this area.We then provide an updated and comprehensive survey of several converged systems operating in different microwave and millimeter frequency bands,by providing some selective typical communication and radar sensing systems.In this part,we also summarize and compare the system performance in terms of maximum range/range resolution for radar mode and Bit Error Rate(BER)/wireless distance for communication mode.In the last section,the convergence of millimeter/terahertz communication-radar system is concluded by analyzing the prospect of millimeter-wave/terahertz technologies in providing ultrafast data rates and high resolution for our smart future. | GAO Xiang Saqlain MUHAMMAD CAO Xiaoxiao WANG Shiwei LIU Kexin ZHANG Hangkai YU Xianbin | 2020 | ZTE Communications2020，18，1： | 2 |
| 13 | Catalytic synthesis of diphenolic acid from levulinic acid over cesium partly substituted Wells-Dawson type heteropolyacid显示文摘 | Yu Xiaodan Guo Yihang Li Kexin | | Journal of Molecular Catalysis A:Chemical0，，： | 1 |
| 14 | Astrocyte elevated gene-1: a novel independent prognostic biomarker for metastatic ovarian tumors显示文摘 | Cong Li Kexin Chen Jianping Cai Qing-Tao Shi Yinghong Li Lejing Li Hongtao Song Huilei Qiu Yu Qin Jing-Shu Geng | 2014 | Tumor Biology2014，，4： | 1 |
| 15 | A high-concentrated and nonflammable electrolyte for potassium ion-based dual-graphite batteries显示文摘Potassium ion-based dual-graphite batteries(KDGBs)emerge as promising devices for large-scale applications due to their high voltage,low cost,environmental friendliness.However,conventional KPF6/carbonate-based electrolytes suffer from severe oxidation decomposition,low concentration,flammability,which limit the capacity and cyclability of KDGBs.Herein,a nonflammable potassium bis(fluorosulfonyl)imide/triethyl phosphate(KFSI/TEP)electrolyte was designed for KDGBs.When the salt-to-solvent molar ratio increases to 1:1.3,graphite cathode operated at the cut-off potential of 5.2 V exhibits much enhanced capacity,excellent rate capability(26.4 mAh∙g^(−1) at 1.0 A∙g^(−1)),superior cyclability with 98%capacity retention after 350 cycles.Inorganic compounds-rich electrode/electrolyte interphase layers derived from the preferential decomposition of FSI−anions ensure good compatibility of the 1:1.3 KFSI/TEP electrolyte with K metal and graphite anodes.Based on this electrolyte,asassembled KDGBs show high operation voltage of 4.3 V and good cycling performance.This work provides feasibility for developing long-life and safe-operation DGBs. | Kexin Li Guiyou Ma Dandan Yu Wen Luo Jiaxin Li Laishun Qin Yuexiang Huang Da Chen | 2023 | Nano Research2023，16，5： | 1 |
| 16 | Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation显示文摘 | Hao Yu Lingli Zheng Lianhong Yin Lina Xu Yan Qi Xu Han Youwei Xu Kexin Liu Jinyong Peng | 2014 | International Immunopharmacology2014，，： | 1 |
| 17 | Novel ladder patch monopole antenna for UWB application显示文摘A novel printed microstrip-fed ladder patch monopole antenna is presented for ultrawide band(UWB) application. The antenna consists of rectangular patch elements ladder arrayed at the both sides of the microstrip-fed line on a printed circuit board(PCB) and a rectangular ground plane. The antenna parameters of ladder number N, the rectangular patches geometry of ladder elements, the ladder step length and the length of ground plane are studied to obtain optimized antenna performances. The successfully designed, implemented and measured antenna has a compact size of 12 mm×12 mm and operation frequency band from 3.1 GHz to 10.6 GHz with voltage standing wave ratio(VSWR) less than 2. Using the ladder patch array in microstrip monopole antenna design makes antennas flexible in terms of controlling resonances, bandwidth, stable radiation patterns, and constant group delay. | Han Yu'nan Ma Tao Zhang Hongxin Zhang Kexin Dai Lin Zhao Pengfei | 2015 | The Journal of China Universities of Posts and Telecommunications2015，22，6： | 1 |
| 18 | Cr^(3+)/Y^(3+)co-doped persistent luminescence nanoparticles with biological window activation for in vivo repeatable imaging显示文摘The near-infrared(NIR)persistent luminescence materials(PLMs)can remain long-lasting luminescence after removal of the excitation light,which permits bioimaging with high sensitivity owing to the absence of background fluorescence interference from in situ excitation.Recently,the NIR PLMs have aroused intensive research interest in bioimaging.However,the optimal excitation wavelength of current NIR PLMs is located in the ultraviolet region with shallow tissue penetration,making it difficult to activate effectively in vivo,and seriously hindering their further application in bioimaging.Herein,we report a novel kind of Cr^(3+)ions and Y^(3+)ions co-doped NIR PLM,Zn_(1.3)Ga_(1.4)Sn_(0.3)O_(4):Cr^(3+),Y^(3+)(ZGSCY),which emits NIR persistent luminescence at 696 nm.Compared with Zn_(1.3)Ga_(1.4)Sn_(0.3)O_(4):Cr^(3+)(ZGSC)excited by the light with a wavelength in the biological window(>650 nm),after being co-doped with Y^(3+)ions,the NIR persistent luminescence performance of ZGSCY is significantly improved because of the increase of trap concentration in the matrix.In addition,we synthesized ZGSCY nanoparticles(NPs)by the combustion method,which exhibit excellent optical properties after being excited by the light with a wavelength in the biological window.After surface modification with PEG,the ZGSCY NPs present low cytotoxicity.Notably,due to the co-doping of Y^(3+)ions,the signal-to-noise ratio(SNR)of ZGSCY NPs in vivo imaging is about 1.8 times higher than that of the ZGSC NPs.Furthermore,the rechargeable in vivo imaging and passive tumor-targeted imaging are successfully achieved by activating with a lightemitting diode(LED,659 nm)after intravenous injection of ZGSCY.Thus,this kind of NIR PLM with high excitation efficiency performance in the biological window is expected to promote its biomedical application in deep tissues. | Huimin Jiang Lin Liu Kexin Yu Xianggui Yin Shenghui Zheng Liang Song Junpeng Shi Yun Zhang | 2022 | Journal of Rare Earths2022，40，9： | 1 |
| 19 | A novel Gd-based phosphor NaGdGeO_(4):Bi^(3+),Li^(+)with super-long ultraviolet-A persistent luminescence显示文摘In very recent years,ultraviolet(UV)persistent luminescent materials(PLMs)have attracted widespread attention due to their potential biological applications.However,owing to the lack of suitable emitters and hosts,the design and development of excellent UV PLMs remain challenging.Here,we report a new Gd-based PLM NaGdGeO_(4):Bi^(3+)with super-long UVA persistent luminescence(PersL).By further codoping Li^(+)ions to increase the concentration of traps,the UVA PersL intensity of NaGdGeO_(4):Bi^(3+)is increased by 5.5 times.The optimal NaGdGeO_(4):Bi^(3+),Li^(+)exhibits excellent UVA PersL and can persist for more than 200 h.Moreover,the phosphor NaGdGeO_(4):Bi^(3+),Li^(+)also exhibits photostimulated property with a red LED or NIR laser excitation after the long-term decay,and can be activated by X-ray.This promising Gd-based UVA PLM is expected to have potential applications in biomedicine through triggering photocatalysts or photosensitizers by its UVA PersL to achieve photodynamic therapy and its potential ability of magnetic resonance(MR)imaging due to Gd^(3+)ions as MR imaging probe contained in the host NaGdGeO_(4). | Lin Liu Kexin Yu Liyan Ming Yangyang Sheng Shenghui Zheng Liang Song Junpeng Shi Yun Zhang | 2022 | Journal of Rare Earths2022，40，9： | 1 |
| 20 | Developmental toxicity and programming alterations of multiple organs in offspring induced by medication during pregnancy显示文摘Medication during pregnancy is widespread,but there are few reports on its fetal safety.Recent studies suggest that medication during pregnancy can affect fetal morphological and functional development through multiple pathways,multiple organs,and multiple targets.Its mechanisms involve direct ways such as oxidative stress,epigenetic modification,and metabolic activation,and it may also be indirectly caused by placental dysfunction.Further studies have found that medication during pregnancy may also indirectly lead to multi-organ developmental programming,functional homeostasis changes,and susceptibility to related diseases in offspring by inducing fetal intrauterine exposure to too high or too low levels of maternal-derived glucocorticoids.The organ developmental toxicity and programming alterations caused by medication during pregnancy may also have gender differences and multi-generational genetic effects mediated by abnormal epigenetic modification.Combined with the latest research results of our laboratory,this paper reviews the latest research progress on the developmental toxicity and functional programming alterations of multiple organs in offspring induced by medication during pregnancy,which can provide a theoretical and experimental basis for rational medication during pregnancy and effective prevention and treatment of drug-related multiple fetal-originated diseases. | Zhengjie Lu Yu Guo Dan Xu Hao Xiao Yongguo Dai Kexin Liu Liaobin Chen Hui Wang | 2023 | Acta Pharmaceutica Sinica B2023，13，2： | 1 |
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