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| 1 | Analysis of genetic architecture and favorable allele usage of agronomic traits in a large collection of Chinese rice accessions显示文摘Genotyping and phenotyping large natural populations provide opportunities for population genomic analysis and genome-wide association studies(GWAS). Several rice populations have been re-sequenced in the past decade;however, many major Chinese rice cultivars were not included in these studies. Here, we report large-scale genomic and phenotypic datasets for a collection mainly comprised of 1,275 rice accessions of widely planted cultivars and parental hybrid rice lines from China. The population was divided into three indica/Xian and three japonica/Geng phylogenetic subgroups that correlate strongly with their geographic or breeding origins. We acquired a total of 146 phenotypic datasets for 29 agronomic traits under multi-environments for different subpopulations. With GWAS, we identified a total of 143 significant association loci, including three newly identified candidate genes or alleles that control heading date or amylose content. Our genotypic analysis of agronomically important genes in the population revealed that many favorable alleles are underused in elite accessions, suggesting they may be used to provide improvements in future breeding efforts. Our study provides useful resources for rice genetics research and breeding. | Xiuxiu Li Zhuo Chen Guomin Zhang Hongwei Lu Peng Qin Ming Qi Ying Yu Bingke Jiao Xianfeng Zhao Qiang Gao Hao Wang Yunyu Wu Juntao Ma Liyan Zhang Yongli Wang Lingwei Deng Shanguo Yao Zhukuang Cheng Diqiu Yu Lihuang Zhu Yongbiao Xue Chengcai Chu Aihong Li Shigui Li Chengzhi Liang | 2020 | Science China(Life Sciences)2020，63，11： | 8 |
| 2 | Characterization of a Novel Anti-DR5 Monoclonal Antibody WD1 with the Potential to Induce Tumor Cell Apoptosis显示文摘TNF-related apoptosis-inducing ligand (TRAIL) is a TNF family member capable of inducing apoptosis. Death receptor 5 (DR 5) is a key receptor of TRAIL and plays an important role in TRAIL-induced apoptosis. To prepare monoclonal antibodies (mAbs) against DR5,cDNA encoding soluble DR5 (sDR5) was firstly amplified by reverse transcriptase-polymerase chain reaction (RT-PCR) with specific primers,and then inserted into a prokaryotic expression vector pET-30a. The recombinant plasmid was expressed in Escherichia coli strain BL21 (DE3),and sDR5 was purified by nickel affinity chromatography. As an antigen,sDR5 was used to immunize mice. Hybridomas secreting antibodies against sDR5 were identified. One positive clone was selected to produce antibody,WD1. ELISA and immunofluorescence demonstrated that WD1 could bind recombinant sDR5 and membrane-bound DR5 (mDR5) on Jurkat and Molt-4 cells. ATPLite assays showed that Jurkat and Molt-4 cells were sensitive to the antibody in a dose dependent manner. The Annexin V/PI assays and Giemsa's staining both showed that WD1 could induce Jurkat cell apoptosis efficiently. Transient transfection of 293T cells and indirect immunofluorescence assay demonstrated that mAb (WD1) couldn't cross-react with DR4. Our findings indicated that the novel antibody,WD1 could act as a direct agonist,bind DR5 characteristically,and initiate efficient apoptotic signaling and tumor regression. Thus,WD1 would be a leading candidate for potential cancer therapeutics. | Jing Wang Zhou Lin Chunxia Qiao Ming Lv Ming Yu He Xiao Qingyang Wang Liyan Wang Jiannan Feng Beifen Shen Yuanfang Ma Yan Li | 2008 | Cellular & Molecular Immunology2008，5，1： | 4 |
| 3 | Phase Ⅲ Clinical Trials of the Cell Differentiation Agent-2 (CDA-2): Therapeutic Efficacy on Breast Cancer, Non-Small Cell Lung Cancer and Primary Hepatoma显示文摘 | Fengyi Feng Qing Lu Changquan Ling Yang Zhang Fengzhan Qin Huaqing Wang Wenxia Huang Shunchang Jiao Qiang Chen Mingzhong Li Yunzhong Zhu Meizhen Zhou Jun Ren Yetao Gao Jingpo Zhao Rongsheng Zheng Wenhua Zhao Zhiqiang Meng Fang Li Qizhong Zhang Dongli Zhao Liyan Xu Yongqiang Zhang Yanjun Zhang Zhenjiu Wang Shuonqi Liu Ming C. Liau | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 3 |
| 4 | Comparison of diagnostic value of PET using 18- fluoro-2-deoxyglucose, CT and MR1 in detecting skull base invasion of nasopharyngeal carcinomas显示文摘客观我们用 18-fluoro-2-deoxyglucose ( FDG )比较了正电子排放断层摄影术(宠物),提高的计算断层摄影术( CT )和在检测颅骨的磁性的回声成像( MRI )基于鼻咽的癌( NPC )的侵略并且基于鼻咽的癌的侵略在决定颅骨的存在评估这三个方法的价值。方法提高的 CT, MRI 和 PET-CT 扫描的图象,表现在间隔 ≤
到 2007 年 2 月的从 2004 年 7 月的 57 个 NPC 病人上的 20 天,被选择并且考察。比较的端点是敏感,特性,精确性,积极预兆的价值(PPV ) 和提高的 CT, MRI 和 PET-CT 的否定预兆的价值(NPV ) ,基于为至少 6 个月的组织病理学说的调查结果或临床的成像后续。检测 NPC,提高的 CT 的敏感, MRI 和 PET-CT 的颅骨底侵略的结果是 68.18% , 84.09% , 97.67% 分别地;特性是 76.92% , 69.23% , 57.14% 分别地;精确性是 70.18% , 80.7% , 87.72% 分别地;PPV 是 90.9% , 90.24% , 87.5% 分别地;NPV 是 41.67% , 56.25% , 88.89% 分别地。结论 PET-CT 比 CT 在敏感有明显的优点(P <
0.05 ) 并且 MRI,比在精确性和 NPV 的二个方法好并且可能为在检测 NPC 病人的颅骨底侵略的新病人更珍贵。 | Xiumei Ma Ming Ye Taifu Liu Li Li Liyan Dai | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，8： | 3 |
| 5 | Effects of Bacterial-Feeding Nematodes and Glucose on Phenanthrene Removal by Pseudomonas putida显示文摘Bacterial-feeding nematodes can promote the bacterial activity through feeding.Bacterial abundance and their activity affect the degradation of polycyclic aromatic hydrocarbons(PAH) such as phenanthrene.The effects of bacterial-feeding nematodes,bacteria,and their interactions on the degradation of phenanthrene with or without glucose were studied through a microcosm experiment.The results showed that up to 57.0%of phenanthrene in mineral medium contaminated with phenanthrene was degraded in the control with bacteria alone and bacteria with the presence of nematodes and/or glucose increased the degradation of phenanthrene by 25.6%to 36.6%.Although both nematode and bacteria abundance decreased gradually,catechol 2,3-dioxygenase(C230) activity increased during the incubation period.Compared with bacteria alone,the presence of nematodes significantly increased C230 activity as well as the abundance of bacteria;this effect was more pronounced when glucose was present.The results imply that nematodes might promote the removal of phenanthrene from medium by stimulating bacteria and C230 activities. | JING Yongping LIYan LIU Zhaohui ZHANG Yingpeng LIU Ping SUN Ming Jiafa LUO | 2017 | Pedosphere2017，27，1： | 2 |
| 6 | Reduced MTA1 Expression by RNAi Inhibits in Vitro Invasion and Migration of Esophageal Squamous Cell Carcinoma Cell Line显示文摘 | Haili Qian Ning Lu Liyan Xue Xiao Liang Xueyan Zhang Ming Fu Yongqiang Xie Qimin Zhan Zhihua Liu Chen Lin | 2005 | Clinical & Experimental Metastasis2005，，8： | 1 |
| 7 | AC impedance characteristics of a 2kW PEM fuel cell stack under different operating conditions and load changes显示文摘 | Xiqiang Yan Ming Hou Liyan Sun Dong Liang Qiang Shen Hongfei Xu Pingwen Ming Baolian Yi | 2007 | International Journal of Hydrogen Energy2007，，17： | 1 |
| 8 | AC impedance characteristics of a 2kW PEM fuel cell stack under different operating conditions and load changes显示文摘 | Yan Xiqiang Hou Ming Sun Liyan | 2007 | International Journal of Hydrogen Energy2007，32，17： | 1 |
| 9 | The Study on Transient Characteristics of Proton Exchange Membrane Fuel Cell Stack During Dynamic Loading显示文摘 | Yang Xiqian Hou Ming Sun Liyan | 2007 | Joumal of Power Sources2007，163，2： | 1 |
| 10 | The study on transient characteristic of proton exchange membrane fuel cell stack during dynamic loading显示文摘 | YAN Xiqiang HOU Ming SUN Liyan | 2007 | Journal of Power Sources2007，163，2： | 1 |
| 11 | A novel Gd-based phosphor NaGdGeO_(4):Bi^(3+),Li^(+)with super-long ultraviolet-A persistent luminescence显示文摘In very recent years,ultraviolet(UV)persistent luminescent materials(PLMs)have attracted widespread attention due to their potential biological applications.However,owing to the lack of suitable emitters and hosts,the design and development of excellent UV PLMs remain challenging.Here,we report a new Gd-based PLM NaGdGeO_(4):Bi^(3+)with super-long UVA persistent luminescence(PersL).By further codoping Li^(+)ions to increase the concentration of traps,the UVA PersL intensity of NaGdGeO_(4):Bi^(3+)is increased by 5.5 times.The optimal NaGdGeO_(4):Bi^(3+),Li^(+)exhibits excellent UVA PersL and can persist for more than 200 h.Moreover,the phosphor NaGdGeO_(4):Bi^(3+),Li^(+)also exhibits photostimulated property with a red LED or NIR laser excitation after the long-term decay,and can be activated by X-ray.This promising Gd-based UVA PLM is expected to have potential applications in biomedicine through triggering photocatalysts or photosensitizers by its UVA PersL to achieve photodynamic therapy and its potential ability of magnetic resonance(MR)imaging due to Gd^(3+)ions as MR imaging probe contained in the host NaGdGeO_(4). | Lin Liu Kexin Yu Liyan Ming Yangyang Sheng Shenghui Zheng Liang Song Junpeng Shi Yun Zhang | 2022 | Journal of Rare Earths2022，40，9： | 1 |
| 12 | Bioactive Pregnanes from Nerium oleander显示文摘 | Liming Bai Liyan Wang Ming Zhao | 2007 | Journal of Natural Products2007，70，1： | 1 |
| 13 | Construction, photoelectric response and phase transition for new hybrid double perovskites showing narrow band gaps显示文摘To explore the lead-free key scientific issue in perovskite, double perovskite based on Ag Bi and Cu Bi was naturally selected as a competitive candidate due to its fascinating functional features, such as self-powered circularly polarized light detection, X-ray detection, photoluminescence and so on. However, the most challenging point is to simulate the structure and function of traditional lead-based perovskite in new double perovskite. At the same time, there are few suitable double perovskite systems with optical and electrical potential. The above two points greatly limit the competitiveness of double perovskite. In order to solve this problem, firstly, by analyzing and comparing previous studies,we used 2,2-dimethylpropan-1-aminium(abbreviated as 2,2-DPA) as the organic template to assemble materials. Solid-to-solid phase transition materials(2,2-DPA)3Bi2I91 and(2,2-DPA)3Pb2I72 were constructed. Along the path of lead-free and two-dimensional maintenance, we successfully synthesized(2,2-DPA)4AgBiI8.H_(2)O 3 and(2,2-DPA)_(4)CuBiI8.H_(2)O 4. As two typical semiconductors, 3 and 4 with narrower optical band gaps of 1.98 and 1.76 e V show obvious photo-response when the xenon lamp with intensity of 20 m W/cm^(2)is on or off, implying that they may be applied to light-harvesting and light-detecting devices. By referring to the phase transition mechanism of 1 and 2, 3 may be caused by ordered-disordered transition of the organic part, which was proven to be the first solid-to-solid phase transition material with <100>-oriented layered double perovskites with n = 1 by systematic characterization methods after dehydration for all we know. We believed that this work can provide meaningful guidance for the development of lead-free double perovskites. | Changyuan Su Zhixu Zhang Jie Yao Ming Chen Peizhi Huang Yi Zhang Dawei Fu Liyan Xie | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
| 14 | Multi-Omics-Guided Discovery of Omicsynins Produced by Streptomyces sp.1647:Pseudo-Tetrapeptides Active Against Influenza A Viruses and Coronavirus HCoV-229E显示文摘Many microorganisms have mechanisms that protect cells against attack from viruses.The fermentation components of Streptomyces sp.1647 exhibit potent anti-influenza A virus(IAV)activity.This strain was isolated from soil in southern China in the 1970s,but the chemical nature of its antiviral substance(s)has remained unknown until now.We used an integrated multi-omics strategy to identify the antiviral agents from this streptomycete.The antibiotics and Secondary Metabolite Analysis Shell(antiSMASH)analysis of its genome sequence revealed 38 biosynthetic gene clusters(BGCs)for secondary metabolites,and the target BGCs possibly responsible for the production of antiviral components were narrowed down to three BGCs by bioactivity-guided comparative transcriptomics analysis.Through bioinformatics analysis and genetic manipulation of the regulators and a biosynthetic gene,cluster 36 was identified as the BGC responsible for the biosynthesis of the antiviral compounds.Bioactivity-based molecular networking analysis of mass spectrometric data from different recombinant strains illustrated that the antiviral compounds were a class of structural analogues.Finally,18 pseudo-tetrapeptides with an internal ureido linkage,omicsynins A1–A6,B1–B6,and C1–C6,were identified and/or isolated from fermentation broth.Among them,11 compounds(omicsynins A1,A2,A6,B1–B3,B5,B6,C1,C2,and C6)are new compounds.Omicsynins B1–B4 exhibited potent antiviral activity against IAV with the 50%inhibitory concentration(IC_(50))of approximately 1μmol·L^(-1)and a selectivity index(SI)ranging from 100 to 300.Omicsynins B1–B4 also showed significant antiviral activity against human coronavirus HCoV-229E.By integrating multi-omics data,we discovered a number of novel antiviral pseudo-tetrapeptides produced by Streptomyces sp.1647,indicating that the secondary metabolites of microorganisms are a valuable source of novel antivirals. | Hongmin Sun Xingxing Li Minghua Chen Ming Zhong Yihua Li Kun Wang Yu Du Xin Zhen Rongmei Gao Yexiang Wu Yuanyuan Shi Liyan Yu Yongsheng Che Yuhuan Li Jian-Dong Jiang Bin Hong Shuyi Si | 2022 | Engineering2022，，9： | 0 |
| 15 | A novel Li^(+)-doped MgLuGaO_(4)phosphor with stable white-light emission and long persistent luminescence显示文摘In recent years,white persistent luminescence materials have received extensive attention due to the potential application of white light in the field of plant growth lighting.The white persistent luminescence materials synthesized by traditional methods either have strict requirements on the concentration of doped ions or cannot produce white light continuously and stably due to different decay rates of various emission centers,which limits their further application.In our work,we successfully synthesized a novel Li^(+)-doped MgLuGaO_(4)phosphor with stable white-light emission and long persistent luminescence.The broadband emission of MgLuGaO_(4):Li^(+)is mainly located at 350-650 nm,which has no change at different decay time,showing stable white-light emission.The persistent luminescence intensity is increased by 3.8 times and the persistent luminescence time is extended from 24 h to more than 36 h by doping Li+ions.Stable white-light and long persistent luminescence emission make it promising to be used in plant growth lighting. | Yangyang Sheng Liyan Ming Lin Liu Peng Lin Junpeng Shi Liang Song Yun Zhang | 2022 | Journal of Rare Earths2022，40，9： | 0 |
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