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	题名	作者	年代	出处	被引量
1	Early apoptosis and cell death induced by ATX-S10Na(Ⅱ)-mediated photodynamic therapy are Bax- and p53-dependent in human colon cancer cells显示文摘AIM: To investigate the roles of Bax and p53 proteins in photosensitivity of human colon cancer cells by using lysosome-localizing photosensitizer, ATX-S10Na (Ⅱ).METHODS: HCT116 human colon cancer cells and Bax-null or p53-null isogenic derivatives were irradiated with a diode laser. Early apoptosis and cell death in response to photodynamic therapy were determined by MTT assays, annexin V assays, transmission electron microscopy assays, caspase assays and western blotting.RESULTS: Induction of early apoptosis and cell death was Bax- and p53-dependent. Bax and p53 were required for caspase-dependent apoptosis. The levels of anti-apoptotic Bcl-2 family proteins, Bcl-2 and Bcl-xL, were decreased in Bax- and p53-independent manner.CONCLUSION: Our results indicate that early apoptosis and cell death of human colon cancer cells induced by photodynamic therapy with lysosome-localizing photosensitizer ATX-S10Na (Ⅱ) are mediated by p53-Bax network and low levels of Bcl-2 and Bcl-xL proteins. Our results might help in formulating new therapeutic approaches in photodynamic therapy.	Makoto Mitsunaga Akihito Tsubota Kohichi Nariai Yoshihisa Namiki Makoto Sumi Tetsuya Yoshikawa Kiyotaka Fujise	2007	World Journal of Gastroenterology2007，13，5：	3
2	The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells显示文摘	Kaoru Mitsui Yoshimi Tokuzawa Hiroaki Itoh Kohichi Segawa Mirei Murakami Kazutoshi Takahashi Masayoshi Maruyama Mitsuyo Maeda Shinya Yamanaka	2003	Cell2003，，5：	3
3	The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells显示文摘	Kaoru Mitsui Yoshimi Tokuzawa Hiroaki Itoh Kohichi Segawa Mirei Murakami Kazutoshi Takahashi Masayoshi Maruyama Mitsuyo Maeda Shinya Yamanaka	2003	Cell2003，，5：	2
4	Excitatory synaptie transmission mediated by NMDA receptors is more sensitive to isoflurine than are Non - NMDA receptor mediated responses 显示文摘	KOHICHI NISHIKAWA M BRUCE MACLVER	2000	Anesthesiology2000，92，：	1
5	Production of ultra fine SiC powder from SiC bulk by arc-plasma irradiation under different atmospheres and its application to photocatalysis 显示文摘	Nariki Yasufumi Inoue Yasunobu Tanaka Kohichi	1990	Journal of Materials Science1990，25，7：	1
6	Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1 G93A mice显示文摘	Andrea C. Pardo Victor Wong Leah M. Benson Margaret Dykes Kohichi Tanaka Jeffrey D. Rothstein Nicholas J. Maragakis	2006	Experimental Neurology2006，，1：	1
7	Development of a differential optical-fiber displacement sensor 显示文摘	Fukuo Suganuma Atsushi Shimamoto Kohichi Tanaka	1999	Applied Optics1999，38，7：	1
8	Analysis of the sensible heat flux from the exterior surface of buildings using time sequential thermography显示文摘	Akira Hoyano Kohichi Asano Takehisa Kanamaru	1999	Atmospheric Environment1999，，24：	1
9	Effect of grinding on bending fracture strength of WC-Co alloy 显示文摘	Shuichi Goto Yukinari Kanda Kohichi Sugimoto	1995	Nippon Kikai Gakkai Ronbunshu A Hen/Transactions of the Japan Society of Mechanical Engineers Part A1995，61，9：	1
10	Functional and binding studies of insurmountable antagonism of 606A, a novel AT1-receptor antagonism in rabbit tissues 显示文摘	Yukie K Kohichi M Yeshihiro H	1999	J Cardiovasc Pharmacol1999，34，1：	1
11	A Novel Type of EWS-CHOP Fusion Gene in Two Cases of Myxoid Liposarcoma显示文摘	Taisuke Hosaka Yasuaki Nakashima Katsuyuki Kusuzaki Hiroaki Murata Tomitaka Nakayama Takeharu Nakamata Tomoki Aoyama Takeshi Okamoto Kohichi Nishijo Nobuhito Araki Tadao Tsuboyama Takashi Nakamura Junya Toguchida	2002	The Journal of Molecular Diagnostics2002，，3：	1
12	Peroxisome proliferator-activated receptor α and its response element are required but not sufficient for transcriptional activation of the mouse heart-type fatty acid binding protein gene显示文摘	Kowhei Kawabe Hirokazu Saegusa Kohichi Seto Hiroaki Urabe Kiyoto Motojima	2005	International Journal of Biochemistry and Cell Biology2005，，7：	1
13	Phase I study of the combination of nedaplatin and weekly paclitaxel in patients with advanced non-small cell lung cancer显示文摘	Kentaro Okuda Takashi Hirose Hiroo Ishida Sojiro Kusumoto Tomohide Sugiyama Kohichi Ando Takao Shirai Tsukasa Ohnishi Naoya Horichi Tohru Ohmori Mitsuru Adachi	2008	Cancer Chemotherapy and Pharmacology2008，，5：	1
14	Structure and properties of epoxy resins modified with acrylic particles显示文摘	Tadshi Ashida Atsushi Katoh Kohichi Handa	1999	J Appl Poly Sci1999，74，：	1
15	Preparation of ultrafine RuO2-TiO2 binary oxide particles by a Sol-Gel process, 显示文摘		1993	J Electrochem Soc1993，140，4：	1
16	Light-Harvesting and energy-transfer system based on self-assembling perylene diimide-appended hexaazatriphenylene显示文摘	Tsutomu I Kohichi M Yusuke I	2005	Organic Letters2005，7，15：	1
17	Evaluation of ceramics composed of different hydroxyapatite to tricalcium phosphate ratios as carriers for rhBMP-2显示文摘	IMRANUL Alam M D IZUMI Asahina KOHICHI Ohmamiuda	2001	Biomaterials2001，22，：	1
18	Nanoindentation of a 10 nm thick thin film显示文摘	Takeshi Sawa Yasushi Akiyama Atsushi Shimamoto and Kohichi Tanaka	1999	J Mater Res1999，14，6：	1
19	Preparation of ultrafine RuO2-TiO2 binary oxide particles by a sol-gel process 显示文摘	Kohichi Kameyama Shigeru Shohiji Satoshi Onoue	1993	J Electrochem Soc1993，140，5：	1
20	Fourier Domain Decoding Algorithm of Non-Binary LDPC codes for Parallel Implementation 显示文摘	KASAI Kenta SAKANIWA Kohichi	2011	IEEE International Con- ference2011，93，10：	1

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