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| 1 | Endoscopic diagnosis of cervical esophageal heterotopic gastric mucosa with conventional and narrow-band images显示文摘AIM:To compare the diagnostic yield of heterotopic gastric mucosa(HGM)in the cervical esophagus with conventional imaging(CI)and narrow-band imaging(NBI).METHODS:A prospective study with a total of 760patients receiving a CI examination(mean age 51.6years;47.8%male)and 760 patients undergoing NBI examination(mean age 51.2 years;45.9%male).The size of HGM was classified as small(1-5 mm),medium(6-10 mm),or large(>1 cm).A standardized questionnaire was used to obtain demographic characteristics,social habits,and symptoms likely to be related to cervical esophageal HGM,including throat symptoms(globus sensation,hoarseness,sore throat,and cough)and upper esophageal symptoms(dysphagia and odynophagia)at least 3 mo in duration.The clinicopathological classification of cervical esophageal HGM was performed using the proposal by von Rahden et al.RESULTS:Cervical esophageal HGM was found in 36of 760(4.7%)and 63 of 760(8.3%)patients in the CI and NBI groups,respectively(P=0.007).The NBI mode discovered significantly more small-sized HGM than CI(55%vs 17%;P<0.0001).For the 99 patients with cervical esophageal HGM,biopsies were performed in 56 patients;37(66%)had fundic-type gastric mucosa,and 19 had antral-type mucosa.For the clinicopathological classification,77 patients(78%)were classified as HGMⅠ(asymptomatic carriers);21 as HGMⅡ(symptomatic without morphologic changes);and one as HGMⅢ(symptomatic with morphologic change).No intraepithelial neoplasia or adenocarcinoma was found.CONCLUSION:NBI endoscopy detects more cervical esophageal HGM than CI does.Fundic-type gastric mucosa constitutes the most common histology.One-fifth of patients have throat or dysphagic symptoms. | Chi-Liang Cheng Cheng-Hui Lin Nai-Jen Liu Jui-Hsiang Tang Yen-Lin Kuo Yi-Ning Tsui | 2014 | World Journal of Gastroenterology2014，20，1： | 13 |
| 2 | Optimum design of hierarchical stiffened shells for low imperfection sensitivity显示文摘A concept of hierarchical stiffened shell is proposed in this study,aiming at reducing the imperfection sensitivity without adding additional weight.Hierarchical stiffened shell is composed of major stiffeners and minor stiffeners,and the minor stiffeners are generally distributed between adjacent major stiffeners.For various types of geometric imperfections,e.g.,eigenmode-shape imperfections,hierarchical stiffened shell shows significantly low imperfection sensitivity compared to traditional stiffened shell.Furthermore,a surrogate-based optimization framework is proposed to search for the hierarchical optimum design.Then,two optimum designs based on two different optimization objectives(including the critical buckling load and the weighted sum of collapse loads of geometrically imperfect shells with small-and large-amplitude imperfections)are compared and discussed in detail.The illustrative example demonstrates the inherent superiority of hierarchical stiffened shells in resisting imperfections and the effectiveness of the proposed framework.Moreover,the decrease of imperfection sensitivity can finally be converted into a decrease of structural weight,which is particularly important in the development of large-diameter launch vehicles. | Bo Wang Peng Hao Gang Li Jia-Xin Zhang Kai-Fan Du Kuo Tian Xiao-Jun Wang Xiao-Han Tang | 2014 | Acta Mechanica Sinica2014，30，3： | 12 |
| 3 | Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium显示文摘 | Hui Zhang Xiuzhen Huang Kuo Liu Juan Tang Lingjuan He Wenjuan pu Qiaozhen Liu Yan Li Xueying Tian Yue Wang Libo Zhang Ying Yu Hongyan Wang Ronggui Hu Fengchao Wang Ting Chen Qing-Dong Wang Zengyong Qiao Li Zhang Kathy O Lui Bin Zhou | 2017 | Cell Research2017，27，9： | 6 |
| 4 | Role of body mass index in colon cancer patients in Taiwan显示文摘AIM:To determine the effect of body mass index(BMI) on the characteristics and overall outcome of colon cancer in Taiwan.METHODS:From January 1995 to July 2003,2138 patients with colon cancer were enrolled in this study.BMI categories(in kg/m 2) were established according to the classification of the Department of Health of Taiwan.Postoperative morbidities and mortality,and survival analysis including overall survival(OS),diseasefree survival(DFS),and cancer-specific survival(CSS) were compared across the BMI categories.RESULTS:There were 164(7.7%) underweight(BMI < 18.5 kg/m 2),1109(51.9%) normal-weight(BMI = 18.5-23.9 kg/m 2),550(25.7%) overweight(BMI = 24.0-26.9 kg/m 2),and 315(14.7%) obese(BMI ≥27 kg/m 2) patients.Being female,apparently anemic,hypoalbuminemic,and having body weight loss was more likely among underweight patients than among the other patients(P < 0.001).Underweight patients had higher mortality rate(P = 0.007) and lower OS(P < 0.001) and DFS(P = 0.002) than the other patients.OS and DFS did not differ significantly between normal-weight,overweight,and obese patients,while CSS did not differ significantly with the BMI category.CONCLUSION:In Taiwan,BMI does not significantly affect colon-CSS.Underweight patients had a higher rate of surgical mortality and a worse OS and DFS than the other patients.Obesity does not predict a worse survival. | Chih-Chien Chin Yi-Hung Kuo Chien-Yuh Yeh Jinn-Shiun Chen Reiping Tang Chung-Rong Changchien Jeng-Yi Wang Wen-Shih Huang | 2012 | World Journal of Gastroenterology2012，18，31： | 4 |
| 5 | Advances in the Coenzyme Q10 Biosynthesis Pathway in Rhodobacter sphaeroides and the Enhancement of Coenzyme Q10 Production Based on Metabolic Engineering显示文摘Coenzyme Q10 is widely used in food,cosmetics and pharmaceuticals,possessing a broad market.Rhodobacter sphaeroides is enriched in natural coenzyme Q10 and is becoming an important microorganism for producing natural coenzyme Q10.The paper reviewed the biosynthesis pathways of coenzyme Q10 in R.sphaeroides and the advances in enhancement of coenzyme Q10 production in R.sphaeroides based on metabolic engineering. | Kuo TANG Zhiping ZHAO | 2019 | Agricultural Biotechnology2019，8，4： | 4 |
| 6 | CDH13 Genetic Polymorphisms, Adiponectin and Ischemic Stroke: a Chinese Family-based Sib-pair Study显示文摘Objective To understand the relationships between CDH13(T-cadherin) genetic polymorphisms, adiponectin levels and ischemic stroke, and possible interactions between CDH13 polymorphisms and other risk factors. Methods We recruited 342 Chinese ischemic stroke sib pairs. We genotyped rs4783244 and rs7193788 on CDH13 using time-of-flight mass spectrometry genotyping technology and measured total and high-molecular weight(HMW) adiponectin levels. We investigated associations between SNPs and ischemic stroke, and interactions between SNPs and other risk factors using multi-level mixed-effects regression model. Results In individuals without ischemic stroke, CDH13 rs4783244 was associated with total adiponectin levels(per T: Coef =-0.257, P = 0.001). CDH13 rs7193788 was associated with total adiponectin levels(per A: Coef =-0.221, P = 0.001) and HMW adiponectin levels(per A: Coef =-0.163, P = 0.003). rs7193788 was significantly associated with ischemic stroke(GA/AA vs. GG: OR = 1.55, 95% CI: 1.07 to 2.24, P = 0.020) after Bonferroni correction(α = 0.025). There was an interaction between rs7193788 and diabetes(P = 0.036). Compared to diabetes-free individuals with rs7193788 GG genotype, diabetes patients with rs7193788 GA/AA genotypes had higher risks for ischemic stroke(OR = 2.64, 95% CI: 1.58-4.40, P < 0.001). Conclusion CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke. An interaction is found between CDH13 SNP and diabetes for ischemic stroke. | CHEN Li SUN Ke Xin JUAN Juan FANG Kai LIU Kuo WANG Xue Yin WANG Ling YANG Chao LIU Xiao Qiang LI Jing TANG Xun WU Yi Qun QIN Xue Ying WU Tao CHEN Da Fang HU Yong Hua | 2017 | Biomedical and Environmental Sciences2017，30，1： | 4 |
| 7 | Assessment of causal association between thyroid function and lipid metabolism:a Mendelian randomization study显示文摘Background:Thyroid dysfunction is associated with cardiovascular diseases.However,the role of thyroid function in lipid metabolism remains partly unknown.The present study aimed to investigate the causal association between thyroid function and serum lipid metabolism via a genetic analysis termed Mendelian randomization(MR).Methods:The MR approach uses a genetic variant as the instrumental variable in epidemiological studies to mimic a randomized controlled trial.A two-sample MR was performed to assess the causal association,using summary statistics from the Atrial Fibrillation Genetics Consortium(n=537,409)and the Global Lipids Genetics Consortium(n=188,577).The clinical measures of thyroid function include thyrotropin(TSH),free triiodothyronine(FT3)and free thyroxine(FT4)levels,FT3:FT4 ratio and concentration of thyroid peroxidase antibodies(TPOAb).The serum lipid metabolism traits include total cholesterol(TC)and triglycerides,high-density lipoprotein,and low-density lipoprotein(LDL)levels.The MR estimate and MR inverse variance-weighted method were used to assess the association between thyroid function and serum lipid metabolism.Results:The results demonstrated that increased TSH levels were significantly associated with higher TC(β=0.052,P=0.002)and LDL(β=0.041,P=0.018)levels.In addition,the FT3:FT4 ratio was significantly associated with TC(β=0.240,P=0.033)and LDL(β=0.025,P=0.027)levels.However,no significant differences were observed between genetically predicted FT4 and TPOAb and serum lipids.Conclusion:Taken together,the results of the present study suggest an association between thyroid function and serum lipid metabolism,highlighting the importance of the pituitary-thyroid-cardiac axis in dyslipidemia susceptibility. | Jing-Jia Wang Zhen-Huang Zhuang Chun-Li Shao Can-Qing Yu Wen-Yao Wang Kuo Zhang Xiang-Bin Meng Jun Gao Jian Tian Ji-Lin Zheng Tao Huang Yi-Da Tang | 2021 | Chinese Medical Journal2021，，9： | 3 |
| 8 | Intraductal papillary neoplasia of the liver associated with hepatolithiasis显示文摘 | Tse-Ching Chen Yasuni Nakanuma Yoh Zen Miin-Fu Chen Yi-Yin Jan Ta-Sen Yeh Cheng Tang Chiu Tseng-Tong Kuo Jun-ichi Kamiya Koji Oda Michinari Hamaguchi Yoshiyuki Ohno Ling-Ling Hsieh Yuji Nimura | 2001 | Hepatology2001，，4： | 2 |
| 9 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，6： | 2 |
| 10 | Free triiodothyronine level correlates with statin responsiveness in acute myocardial infarction显示文摘BackgroundAlthough 甲状腺荷尔蒙(TH ) 在类脂化合物新陈代谢上有重要效果,在 TH 和 statin 应答之间的关系从来没被调查过。我们假设那 TH 与尖锐心肌的梗塞(AMI ) 在病人在 statin 应答起一个重要作用 .MethodsConsecutive Fuwai 医院(中国北京) 里的 1091 个就医的 AMI 病人被注册进这当前的研究。学习人口基于 statin 治疗的紧张被划分成三个组:低紧张(n = 221 ) ,中等紧张(n = 712 ) 并且高紧张(n = 158 ) 。类脂化合物层次在 statin 治疗持续 10-14 天以后被测量。在 TH ,类脂化合物侧面层次和降低目标的低密度的脂蛋白胆固醇( LDL-C )的成就之间的协会在 statin therapy.ResultsBy 上与 AMI 在病人被探索一般线性分析,在免费 triiodothyronine ( FT3 )和 LDL-C 水平之间的一个重要线性趋势(线性系数 r =-0.082, P = 0.001 )并且 FT3 和全部的胆固醇( TC )铺平( r =-0.105, P = 0.031 )在中等紧张的 statin 组被观察。一个更明显的线性趋势在高紧张的 statin 组被检测(为 LDL-C:r =-0.113, P = 0.005;为 TC:r =-0.172, P = 0.029,分别地) 。然而,没有重要关联在低紧张的 statin 组被观察。与 low-FT3 组相比(定义为 FT3 < 1.79 pg/mL ) ,为达到 LDL-C 的 OR (95% CI )< 3.0mmol/L 被发现是 2.217 (1.001-4.839 ) 在更高的 FT3 组织(> 2.95 pg/mL ) 。为达到更集中的目标的 OR (95% CI )(LDL-C < 1.8mmol/L ) 是 2.836 (1.014-5.182 ).ConclusionsOur 学习表明在 FT3 层次的那个变化与在 AMI 病人的 statins 的胆固醇阴沉的应答有关。这些调查结果建议低 FT3 可以是因缺乏 LDL-C 目标成就和病人穷人应答负责的一个因素到 statin 治疗。 | Wen-Yao WANG Kuo ZHANG Wei ZHAO A. Martin Gerdes Giorgio Iervasi Yi-Da TANG | 2018 | Journal of Geriatric Cardiology2018，15，4： | 2 |
| 11 | Glycosidically Bound Aroma Compounds in Ginger( Zingiber Officinale Roscoe) 显示文摘 | Ping Wu May - Chien Kuo Chi - Tang Ho | 1990 | J Agric Food Chem1990，，38： | 1 |
| 12 | Clinical implications of the SETBP1 mutation in patients with primary myelodysplastic syndrome and its stability during disease progression 显示文摘 | Hou HA Kuo YY Tang JL | 2014 | Am J Hematnl2014，89，2： | 1 |
| 13 | Prevalence of psychiatric disorders among bereaved survivors of a disastrous earthquake in taiwan显示文摘 | Kuo CJ Tang HS Tsay CJ | 2003 | Psychiatr Serv2003，54，2： | 1 |
| 14 | Prevalence,interference,and risk factors for chronic pain among Taiwanese community older people显示文摘 | Yu HY Tang FI Kuo BI | 2006 | Pain Manag Nurs2006，7，1： | 1 |
| 15 | Antioxidant activities of natural phenolic compounds from Acacia Confusa bark显示文摘 | Tung Yu - tang Wu Jyh - homg Kuo Yueh - hsiung | 2007 | Biores ouree technology2007，98，： | 1 |
| 16 | Discovering recency, frequency, and monetary ( RFM ) sequential patterns from customers' purchasing data 显示文摘 | Chen Y L Kuo M H Wu S Y Tang K | 2009 | Elec- tronic Commerce Research and Applications2009，8，5： | 1 |
| 17 | Human glucose- 6- phosphate dehy- drogenase (G6PD) gene transforms NIH 3T3 cells and induces tumors in nude mice显示文摘 | Kuo W Lin J Tang TK | 2000 | Int J Cancer2000，85，6： | 1 |
| 18 | High pH cause disintegration of the root surface in Lupinus angustifolius L显示文摘 | Tang C X Kuo J Longnecker NE | 1993 | Ann Bot1993，71，： | 1 |
| 19 | Optimization of Coenzyme Q10Production Procedure from Rhodobacter sphaeroides Overexpressing UbiE显示文摘In the present study,single factors including inoculation amount,fermentation temperature,fermentation duration and ratio of fermentation medium volume to total flask volume were optimized for enhancing the production of coenzyme Q10 from genetic engineered Rhodobacter sphaeroides overexpressing UbiE.The experimental results suggested that optimal single factors were: inoculation amount 2%,fermentation temperature 30 ℃,fermentation duration 48 h,and fermentation medium volume to total flask volume 80%.The present study will promote the large scale production of CoQ10 from microorganisms. | Kuo TANG Zhiping ZHAO Li ZHANG Zhenhui KANG | 2019 | Agricultural Biotechnology2019，8，5： | 1 |
| 20 | Prevalence of psychiatric disorders among bereaved survivors of a disastrous earthquake in Taiwan显示文摘 | Kuo C J Tang H S Tasy C J | 2003 | Psychiatr Serv2003，54，： | 1 |
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