|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Neoatherosclerosis:Coronary stents seal atherosclerotic lesions but result in making a new problem of atherosclerosis显示文摘Chronic inflammation of the native vessel wall with infiltration of lipid-laden foamy macrophages through impaired endothelium results in atherosclerosis. Percutaneous coronary intervention, including metallic stent implantation, is now widely utilized for the treatment of atherosclerotic lesions of the coronary artery. Baremetal stents and the subsequently developed drugeluting stents seal the atherosclerosis and resolve lumen stenosis or obstruction of the epicardial coronary artery and myocardial ischemia. After stent implantation, neointima proliferates within the stented segment. Chronic inflammation caused by a foreign body reaction to the implanted stent and subsequent neovascularization, which is characterized by the continuous recruitment of macrophages into the vessel, result in the transformation of the usual neointima into an atheromatous neointima. Neointima with an atherosclerotic appearance, such as that caused by thin-cap fibroatheromas, is now recognized as neoatherosclerosis, which can sometimes cause in-stent restenosis and acute thrombotic occlusion originating from the stent segment following disruption of the atheroma. Neoatherosclerosis is emerging as a new coronary stent-associated problem that has not yet been resolved. In this review article, we will discuss possible mechanisms, clinical challenges, and the future outlook of neoatherosclerosis. | Hidenori Komiyama Masamichi Takano Noritake Hata Yoshihiko Seino Wataru Shimizu Kyoichi Mizuno | 2015 | World Journal of Cardiology2015，7，11： | 7 |
| 2 | Diagnostic utility of narrow-band imaging endoscopy for pharyngeal superfi cial carcinoma显示文摘AIM: To investigate the endoscopic features of pharyngeal superfi cial carcinoma and evaluate the utility of narrow-band imaging (NBI) for this disease. METHODS: In the present prospective study, 335 patients underwent conventional white light (CWL) en-doscopy and non-magnifi ed/magnifi ed NBI endoscopy, followed by an endoscopic biopsy, for 445 superfi cial lesions in the oropharynx and hypopharynx. The macroscopic appearance of superfi cial lesions was categorized as either elevated (< 5 mm in height), flat, or depressed (not ulcerous). Superficial carcinoma (SC) was defi ned as a superfi cial lesion showing high-grade dysplasia or squamous cell carcinoma on histology. The color, delineation, and macroscopic appearances of the lesions were evaluated by CWL endoscopy. The ratio of the brownish area/intervascular brownish epithelium (IBE), as well as microvascular proliferation, dilation, and irregularities, was determined by non-magnifi ed/ magnifi ed NBI endoscopy. An experienced pathologist who was unaware of the endoscopic fi ndings made the histological diagnoses. By comparing endoscopic fi ndings with histology, we determined the endoscopic features of SC and evaluated the diagnostic utility of NBI. RESULTS: The 445 lesions were divided histologically into two groups: a non-SC group, including non-neoplasia and low-grade dysplasia cases, and an SC group. Of the 445 lesions examined, 333 were classified as non-SC and 112 were classif ied as SC. There were no significant differences in age, gender, or the location of the lesions between the patients in the two groups. The mean diameter of the SC lesions was signif icantly greater than that of non-SC lesions (11.0 ± 7.6 mm vs 4.6 ± 3.6 mm, respectively, P < 0.001). Comparisons of CWL endoscopy fi ndings for SC and non-SC lesions by univariate analysis revealed that the incidence of redness (72% vs 41%, respectively, P < 0.001) and a flat or depressed type of lesion (58% vs 44%, respectively, P = 0.013) was significantly higher in the SC group. Using non-magnifi ed NBI endoscopy, the incidence of a brownish area was signifi cantly higher for SC lesions (79% vs 57%, respectively, P < 0.001). On magnifi ed NBI endoscopy, the incidence of IBE (68% vs 33%, P < 0.001) and microvascular proliferation (82% vs 51%, P < 0.001), dilation (90% vs 76%, P =0.002), and irregularity (82% vs 31%, P < 0.001) was also signifi cantly higher for the SC compared with the non-SC lesions. Multivariate analysis revealed that the incidence of redness (P = 0.022) on CWL endoscopy and IBE (P < 0.001) and microvascular irregularities (P < 0.001) on magnif ied NBI endoscopy was signif icantly higher in SC than non-SC lesions. Redness alone exhibited signifi cantly higher sensitivity and signifi cantly lower specifi city for the diagnosis of SC compared with redness plus IBE and microvascular irregularities (72% vs 52%, P = 0.002; and 59% vs 92%, P < 0.001, respectively). The accuracy of redness plus IBE and irregularities for the diagnosis of SC was signifi cantly greater than using redness alone (82% vs 62%, respectively, P < 0.001). CONCLUSION: Redness, IBE, and microvascular irregularities appear to be closely related to SC lesions. Magnifi ed NBI endoscopy may increase the diagnostic accuracy of CWL endoscopy for SC. | Noboru Yoshimura Kenichi Goda Hisao Tajiri Yukinaga Yoshida Takakuni Kato Yoichi Seino Masahiro Ikegami Mitsuyoshi Urashima | 2011 | World Journal of Gastroenterology2011，17，45： | 7 |
| 3 | Coronary atherosclerosis is already ongoing in pre-diabetic status: Insight from intravascular imaging modalities显示文摘Diabetes mellitus is a powerful risk factor of coronary artery disease(CAD), leading to death and disability. In recent years, given the accumulating evidence that prediabetes is also related to increasing risk of CAD including cardiovascular events, a new guideline has been proposed for the treatment of blood cholesterolfor primary prevention of cardiovascular events. This guideline recommends aggressive lipid-lowering statin therapy for primary prevention in diabetes and other patients. The ultimate goal of patient management is to inhibit progression of systemic atherosclerosis and prevent fatal cardiovascular events such as acute coronary syndrome(ACS). Because disruption of atherosclerotic coronary plaques is a trigger of ACS, the high-risk atheroma is called a vulnerable plaque. Several types of novel diagnostic imaging technologies have been developed for identifying the characteristics of coronary atherosclerosis before the onset of ACS, especially vulnerable plaques. According to coronary angioscopic evaluation, atherosclerosis severity and plaque vulnerability were more advanced in prediabetic than in nondiabetic patients and comparable to that in diabetic patients. In addition, pharmacological intervention by statin therapy changed plaque color and complexity, and the dynamic changes in plaque features are considered plaque stabilization. In this article, we review the findings of atherosclerosis in prediabetes, detected by intravascular imaging modalities, and the therapeutic implications. | Osamu Kurihara Masamichi Takano Yoshihiko Seino Wataru Shimizu Kyoichi Mizuno | 2015 | World Journal of Diabetes2015，6，1： | 4 |
| 4 | Sulfonylurea and glinide reduce insulin content, functional expression of K ATP channels, and accelerate apoptotic β-cell death in the chronic phase显示文摘 | Akira Takahashi Kazuaki Nagashima Akihiro Hamasaki Naomitsu Kuwamura Yukiko Kawasaki Hiroki Ikeda Yuichiro Yamada Nobuya Inagaki Yutaka Seino | 2007 | Diabetes Research and Clinical Practice2007，，3： | 2 |
| 5 | JNK contributes to temozolomide resistance of stem-like glioblastomacells via regulation of MGMT expression显示文摘 | Masashi Okada Atsushi Sato Keita Shibuya Eriko Watanabe Shizuka Seino Shuhei Suzuki Manabu Seino Yoshitaka Narita Soichiro Shibui Takamasa Kayama Chifumi Kitanaka | 2014 | International Journal of Oncology2014，，2： | 2 |
| 6 | Carbon-supported AuPd bimetallic nanoparticles synthesized by high-energy electron beam irradiation for direct formic acid fuel cell显示文摘 | Yuji Ohkubo Masashi Shibata Satoru Kageyama Satoshi Seino Takashi Nakagawa Junichiro Kugai Hiroaki Nitani Takao A. Yamamoto | 2013 | Journal of Materials Science2013，，5： | 2 |
| 7 | Synthesis of yttrium alumina garnet by the hydrothermal method显示文摘 | Hakuta Yukiya Seino Kezuei Kominami Hiroshi | 1991 | J Am Ceram Soc1991，74，： | 2 |
| 8 | Soluble lectin-like oxidized LDL receptor-1 (sLOX-1) as a valuable diagnostic marker for rupture of thin-cap fibroatheroma: Verification by optical coherence tomography显示文摘 | Nobuaki Kobayashi Masamichi Takano Noritake Hata Noriaki Kume Masanori Yamamoto Shinya Yokoyama Takuro Shinada Kazunori Tomita Akihiro Shirakabe Toshiaki Otsuka Yoshihiko Seino Kyoichi Mizuno | 2013 | International Journal of Cardiology2013，，： | 2 |
| 9 | 显示文摘 | Seino Y Takada K Kim B | 2005 | Solid State Ionics2005，176，3134： | 1 |
| 10 | Cardiac emergency triage and therapeutic decisions using whole blood rapid troponin T test for patients with suspicious acute coronary syndrome显示文摘 | Tanaka K Seino Y Ohbayashi K | 2001 | Jpn Circ J2001，65，： | 1 |
| 11 | Role of Fas/Fas L pathway in the activation of infiltrating cells in murine acute myocarditis caused by Coxsackievirus B3显示文摘 | Seko Y Kayagaki N Seino K | 2002 | J Am Coll Cardiol2002，39，8： | 1 |
| 12 | Eight-hydroxy-2 '-deoxyguanosine in granulose cells is correlated with the quality of oocytes and embryos in an in vitro fertilization-embryo transfer program显示文摘 | Seino T Saito H Kaneko T | 2002 | Fertil and Steril2002，77，6： | 1 |
| 13 | Plasma natriuretic peptide levels and daily physical activity in patients with pacemaker implantation 显示文摘 | Wu X Seino Y Ogura H | 2001 | Jpn Heart J2001，42，4： | 1 |
| 14 | Use of a whole blood rapid panel test for heart-type fatty acid-binding protein in patients with acute chest pain:comparison with rapid troponin T and myoglobin tests显示文摘 | Seino Y Ogata K Takano T | 2003 | Am J Med2003，115，3： | 1 |
| 15 | Requirement for natural killer T(NKT) cells in the induction of allograft tolerance显示文摘 | Seino K Fukao K Muramoto K | 2001 | Pro Natl Acad Sci USA2001，98，： | 1 |
| 16 | An analysis of chattering in coldrolling of ultra thin gauge steel strip 显示文摘 | Yarita I Furukawa K Seino Y | 1979 | Transactions ISU1979，19，1： | 1 |
| 17 | Office cardiologists cooperative study on whole blood rapid panel tests in patients with suspicious acute myocardial infarction:Comparison between heart-type fatty acid-binding protein and troponin T tests 显示文摘 | Seino Y Tomita Y Takano T | 2004 | Circ J2004，68，2： | 1 |
| 18 | Synthesis of fully aliphatic polyimides显示文摘 | Hiroshi Seino Takeshi Sasaki Amane Mochizuki | | 0，，： | 1 |
| 19 | Dipeptidyl peptidase-4 inhibitors and sulfonylureas for type 2 diabetes:Friend or foe显示文摘 | Yabe D Seino Y | 2014 | J Diabetes Investig2014，5，5： | 1 |
| 20 | ATP-sensitive potassium channels: a model of het-ero-multimeric potassium channcl/releptor asembbies 显示文摘 | Seino S | 1999 | Annu Rev Physiol1999，61，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员