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| 1 | Increased Expression of Plasminogen Activator Inhibitor-1 with Fibrin Deposition in a Murine Model of Aging, 'Klotho' Mouse显示文摘 | Kyosuke Takeshita Koji Yamamoto Masafumi Ito Takahisa Kondo Tadashi Matsushita Makoto Hirai Tetsuhito Kojima Masahiko Nishimura Yoichi Nabeshima David Loskutoff Hidehiko Saito Toyoaki Murohara | 2002 | Semin Thromb Hemost2002，，06： | 1 |
| 2 | Phase 1/2 study of concurrent chemoradiotherapy with weekly irinotecan hydrochloride for advanced/recurrence uterine cancer:A multi-institutional study of Kansai Clinical Oncology Group显示文摘Objective:Concurrent chemoradiotherapy using cisplatin was thought to be standard treatment for squamous cell carcinoma of cervix,but it had not been effective for adenocarcinoma.Concurrent chemoradiotherapy using irinotecan hydrochloride(CPT-11)had been effective for colorectal cancer,thus,we chose CPT-11 as a candidate for gynecologic adenocarcinoma.To evaluate the maximum tolerated dose(MTD)of weekly CPT-11 with external pelvic radiotherapy,a phase 1/2 study was conducted according to modified Fibonacci method.Methods:Eligible patients were advanced uterine cancer with measurable diseases[performance score(PS):0-2].Study period was from August 1 st,2002 to December 31 st,2008.The starting dose level(DL)of CPT-11 was 30 mg/m2(DL1)given weekly for 4 weeks.Subsequently,dose escalation was scheduled in 10 mg/m2 increments to 60 mg/m^2(DL4).The fixed radiotherapy consisted of whole pelvic 1.8 Gy/d,once a day in weekday for five weeks and it amounted to 45 Gy(25 fractions)in total.Results:Seventeen patients were enrolled.As for toxicities,one(1/17:5.9%)grade(G)4 neutropenia lasting 7 days had been seen in DL4.G2 diarrhea was identified in 35.3%(6/17)of the patients,and 11.8%(2/17)G3 diarrhea was observed in DL3 and DL4.Thus,the MTD of CPT-11 was defined as dose of 60 mg/m^2.The recommended dose was decided as 50 mg/m^2.The response rate was 88.2%[9 complete response(CR),3 partial response(PR),3 stable disease(SD),2 not evaluable(NE)].Disease control rate at 1 month after treatment completion was 100%but distant metastases were found in 24%(4/17)in longer outcome.Conclusions:MTD was 60 mg/m^2 and recommended dose was set as 50 mg/m2.This concurrent chemoradiation using weekly CPT-11 was feasible at 50 mg/m^2,and it might be effective even in adenocarcinoma of the uterus. | Satoshi Takeuchi Haruo Kuroboshi Taisuke Mori Kimihiko Ito Eiji Kondo Tsutomu Tabata Yoshio Itani Ryuji Kawaguchi Kyosuke Takeuchi Toshinori Soejima Ryohei Sasaki | 2020 | Chinese Journal of Cancer Research2020，32，2： | 1 |
| 3 | Receptor activator of NF-κB ligand induces the expression of carbonic anhydrase II, cathepsin K, and matrix metalloproteinase-9 in osteoclast precursor RAW264.7 cells显示文摘 | Kyosuke Fujisaki Natsuko Tanabe Naoto Suzuki Takayuki Kawato Osamu Takeichi Osamu Tsuzukibashi Masaharu Makimura Koichi Ito Masao Maeno | 2007 | Life Sciences2007，，14： | 1 |
| 4 | Effects of low'energy electron beam irradiation on flexural properties of self-curing acrylic resin 显示文摘 | Kyosuke Ito Akiko Nomum Shttichi Nomttra | 2014 | Journal of Prosthodontic Re- search2014，58，1： | 1 |
| 5 | Differential diagnosis of hepatic nodules using delayed parenchymal phase imaging of levovist contrast ultrasound: comparative study with SPIO-MRI显示文摘 | Shiro Suzuki Hiroko Iijima Fuminori Moriyasu Shunichi Sasaki Kyosuke Yanagisawa Takeo Miyahara Kazutake Oguma Masahiro Yoshida Toshiya Horibe Naoki Ito Dai Kakizaki Kimihiko Abe Kaoru Tsuchiya | 2004 | Hepatology Research2004，，2： | 1 |
| 6 | Effect of terminal locations of pods on biomass production and ^(13)C partitioning in a fasciated stem soybean Shakujo显示文摘This study addresses the hypothesis that stagnation of soybean yield on the farm can be improved by selection of a physiological trait favoring carbon assimilate partitioning to terminally placed pods versus genotypes having axillary pods at close plant spacing.13C was fed to source-sink units comprising a leaf,axillary/terminal pods,and petioles at upper and lower positions of the stem axis in two soybean cultivars,namely Shakujo and Enrei,at different densities of populations.The cultivars differ significantly in architecture,Shakujo bearing a few hundreds of pods in close succession to one another in a terminally placed raceme,in contrast to Enrei having axillary racemes.Pod yield per plant was higher in Enrei than in Shakujo at low density,but Shakujo out-yielded Enrei at close spacing.Population density decreased yield per plant and altered the pattern of assimilate partitioning significantly within the plants for both varieties.At high density more assimilates moved to the upper parts at the cost of the lower parts.The terminally placed pods of Shakujo were advantaged to receive assimilates under density stress.No benefit was accrued to pod filling of Enrei,however,under this condition. | Kyosuke YAMADA Aoi SASAKURA Kiyoshi NISHIWAKI Hany A.EL-SHEMY Pravat K.MOHAPATRA Nguyen T.NGUYEN Hideki KUROSAKI Syunsuke KANAI Junki ITO Kounosuke FUJITA | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，1： | 0 |
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