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| 1 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 2 | Seismic fragility assessment of existing sub-standard low strength reinforced concrete structures显示文摘An analytical seismic fragility assessment framework is presented for the existing low strength reinforced concrete structures more common in the building stock of the developing countries.For realistic modelling of such substandard structures,low strength concrete stress-strain and bond-slip capacity models are included in calibrating material models.Key capacity parameters are generated stochastically to produce building population and cyclic pushover analysis is carried out to capture inelastic behaviour.Secant period values are evaluated corresponding to each displacement step on the capacity curves and used as seismic demand.A modified capacity demand diagram method is adopted for the degrading structures,which is further used to evaluate peak ground acceleration from back analysis considering each point on the capacity curve as performance point.For developing fragility curves,the mean values of peak ground acceleration are evaluated corresponding to each performance point on the series of capacity curves.A suitable probability distribution function is adopted for the secant period scatter at different mean peak ground acceleration values and probability of exceedance of limit states is evaluated.A suitable regression function is used for developing fragility curves and regression coefficients are proposed for different confidence levels.Fragility curves are presented for a low rise pre-seismic code reinforced concrete structure typical of developing countries. | Sohaib Ahmad Nicolas Kyriakides Kypros Pilakoutas Kyriacos Neocleous Qaiser uz Zaman | 2015 | Earthquake Engineering and Engineering Vibration2015，14，3： | 3 |
| 3 | Percutaneous Intraductal Radiofrequency Ablation is a Safe Treatment for Malignant Biliary Obstruction: Feasibility and Early Results显示文摘 | Malkhaz Mizandari Madhava Pai Feng Xi Vlastimil Valek Andrasina Tomas Pietro Quaretti Rita Golfieri Cristina Mosconi Ao Guokun Charis Kyriakides Robert Dickinson Joanna Nicholls Nagy Habib | 2013 | CardioVascular and Interventional Radiology2013，，3： | 3 |
| 4 | On bend-stretch forming of aluminum extruded tubes -Ⅰ:experiments 显示文摘 | MILLER J E KYRIAKIDES S BASTARD A H | 2001 | International J of Mechanical Sciences2001，，43： | 2 |
| 5 | Midgut neuroendocrine tumor presenting with acute intestinal ischemia显示文摘Neuroendocrine tumors represent a heterogeneous group of neoplasms that arise from neuroendocrine cells and secrete various peptides and bioamines. While gastrointestinal neuroendocrine tumors,commonly called carcinoids,account for about 2/3 of all neuroendocrine tumors,they are relatively rare. Small intestine neuroendocrine tumors originate from intestinal enterochromaffin cells and represent about 1/4 of small intestine neoplasms. They can be asymptomatic or cause nonspecific symptoms,which usually leads to a delayed diagnosis. Imaging modalities can aid diagnosis and surgery remains the mainstay of treatment. We present a case of a jejunal neuroendocrine tumor that caused nonspecific symptoms for about 1 year before manifesting with acute mesenteric ischemia. Abdominal X-rays revealed pneumatosis intestinalis and an abdominal ultrasound and computed tomography confirmed the diagnosis. The patient was submitted to segmental enterectomy. Histopathological study demonstrated a neuroendocrine tumor with perineural and arterial infiltration and lymph node metastasis. The postoperative course was uneventful and the patient denied any adjuvant treatment. | Ioannis Mantzoros Natalia Antigoni Savvala Orestis Ioannidis Styliani Parpoudi Lydia Loutzidou Despoina Kyriakidou Angeliki Cheva Vasileios Intzos Konstantinos Tsalis | 2017 | World Journal of Gastroenterology2017，23，45： | 2 |
| 6 | 18F-fluorodeoxyglucose positron emission tomography in management of pancreatic cystic tumors显示文摘 | Yaojun Zhang Adam E. Frampton Jack L. Martin Charis Kyriakides Jan Jin Bong Nagy A. Habib Panagiotis Vlavianos Long R. Jiao | 2012 | Nuclear Medicine and Biology2012，，7： | 2 |
| 7 | 有 laparoscopic Habib 4 × radiofrequency 设备的巨大的 exophytic 肝 haemangioma 的 Laparoscopic 切除术显示文摘 Haemangiomas are the most common solitary benign neoplasm of the liver with an incidence ranging from 5% to 20%. Although usually small and asymptomatic, they may reach considerable proportions and rarely give rise to life-threatening complications. Surgical intervention is required for incapacitating symptoms, established complications, and diagnostic uncertainty. The resection of haemangiomas demands meticulous surgical technique, owing to their high vascularity and the concomitant risk of intra-operative haemorrhage. Laparoscopic resection of giant haemangiomas is even more challenging, and has only been reported twice. We here report the case of a giant 10 cm liver haemangioma which was successfully resected laparoscopically using the laparoscopic HabibTM 4×, a bipolar radiofrequency device, without clamping major vessels and with minimal blood loss. Transfusion of blood or blood products was not required. The patient had an uneventful recovery and was asymptomatic at 7-mo follow-up. | Metesh Acharya Nikolaos Panagiotopoulos Premjithlal Bhaskaran Charis Kyriakides Madhava Pai Nagy Habib | 2012 | World Journal of Gastrointestinal Surgery2012，4，8： | 2 |
| 8 | On the initiation andpropagation of buckles in a beam on a nonlinearfoundation 显示文摘 | Netto A Kyriakides S Ouyang X | 1999 | Journal of Applied Mechanics Transactions of the ASME1999，66，2： | 1 |
| 9 | In-plane biaxial crushing of honeycombs-Part Ⅰ: analysis显示文摘 | Papka S D Kyriakides S | 1999 | International Journal of Solids and Structures1999，36，29： | 1 |
| 10 | Early brain natriureticpeptide increase reflects acute myocardial ischemia in patientswith on-going chest pain显示文摘 | Nikolaou NI Kyriakides ZS Tsaglis EP | 2005 | Int J Cardiol2005，101，2： | 1 |
| 11 | Dynamic performance of integral buckle arrestors for offshore pipelines 显示文摘 | T A Netto S Kyriakides | 2000 | International Journal of Mechanical Sciences2000，，42： | 1 |
| 12 | Bifurcation and localization in- stabilities in cylindrical shells under bending- Ⅱ : predic- tions 显示文摘 | Ju G T Kyriakides S | 1992 | International Journal of Solids and Struc- tures1992，29，9： | 1 |
| 13 | The lack of thrombospondin-1 (TSP1) dictates the course of wound healing in double TSP1/ TSP2-null mice显示文摘 | Agah A Kyriakides TR Lawler J | 2002 | Am J Pathol2002，161，3： | 1 |
| 14 | White-rot fungi and their enzymes for the treatment of industrial dye effluents显示文摘 | Wesenberg D Kyriakides I Agathos S N | 2003 | Biotechnology Advances2003，22，1： | 1 |
| 15 | pH-sensitive polymers that enhance intracellular drug delivery in vivo显示文摘 | Kyriakides T R Cheung C Y Murthy N | 2002 | J Control Release2002，78，13： | 1 |
| 16 | Compressive response of open cell foams Part II: Initiation and evolution of crushing显示文摘 | L. Gong S. Kyriakides | 2004 | International Journal of Solids and Structures2004，，5： | 1 |
| 17 | Early brain natriuetic peptide increase reflects acute myocardial ischemia in patients with ongoing chest pain显示文摘 | Nikolaou NL Kyriakides ZS Tsaglis EF | 2010 | Inter J Card2010，，2： | 1 |
| 18 | Membra- neattack complex of complement and neutrophils me- diate the injury of acid aspiration显示文摘 | Kyriakides C Austen W Jr Wang Y | 1999 | J Appl Physiol1999，87，： | 1 |
| 19 | Inelastic behaviour of an AS4/PEEK composite under combined transverse compression and shear显示文摘 | Vogler T J Kyriakides S | 1999 | International Journal of Plasticity1999，15，8： | 1 |
| 20 | Postoperative recovery of third nerve palsy due to posterior communicating aneurysms 显示文摘 | Kyriakides T Aziz TZ Torrens MJ | 1989 | Br J Neurosurg1989，3，5： | 1 |
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