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| 1 | Radioembolization with Yttrium-90 microspheres in hepatocellular carcinoma:Role and perspectives显示文摘Transarterial radioembolization(TARE) is a form of brachytherapy in which intra-arterially injected yttrium-90-loaded microspheres serve as a source for internal radiation purposes.On the average,it produces disease control rates exceeding 80% and it is a consolidated therapy for hepatocellular carcinoma(HCC);however,current data are all based on retrospective series or non-controlled prospective studies since randomized controlled trials comparing it with the other liver-directed therapies for intermediate and locally advanced stage HCC are still underway.The data available show that TARE provides similar or even better survival rates when compared to transarterial chemoembolization(TACE).First-line TARE is best indicated for both intermediatestage patients(staged according to the barcelona clinic liver cancer staging classification) who have lesions which respond poorly to TACE due to multiple tumors or a large tumor burden,and for locally advanced-stage patients with solitary tumors,and segmental or lobar portal vein tumor thrombosis.In addition,emerging data have suggested the use of TARE in patients who are classified slightly beyond the Milan criteria regarding radical treatment for downstaging purposes.As a secondline treatment,TARE can also be applied in patients progressing to TACE or sorafenib;a large number of phase Ⅱ/Ⅲ trials are ongoing with the purpose of evaluating the best association with systemic therapies.Transarterial radioembolization is very well tolerated and has a low rate of complications which are mainly related to unintended non-target tissue irradiation,including the surrounding liver parenchyma.The complications can be additionally reduced by accurate patient selection and a strict pre-treatment evaluation including dosimetry and assessment of the vascular anatomy.Since a correct treatment algorithm for potential TARE candidates is not clear and standardized,this comprehensive review analyzes the best selection criteria for patients who really benefit from TARE and also the new advances of this therapy,which can be a very important weapon against HCC. | Cristina Mosconi Alberta Cappelli Cinzia Pettinato Rita Golfieri | 2015 | World Journal of Hepatology2015，7，5： | 10 |
| 2 | Large regenerative nodules in a patient with Budd-Chiari syndrome after TIPS positioning while on the liver transplantation list diagnosed by Gd-EOB-DTPA MRI显示文摘BACKGROUND:Large regenerative nodules (LRNs) are hyperplastic benign nodules most commonly associated with Budd-Chiari syndrome (BCS),caused by outflow obstruction of the hepatic veins or vena cava.To our knowledge,no cases of LRNs arising in BCS after transjugular intrahepatic portosystemic shunt (TIPS) positioning and detected by GdEOB-DTPA MRI have been reported in the literature.METHODS:A 58-year-old woman with BCS,on the liver transplantation (LT) list,underwent a follow-up enhanced MRI.Two years earlier,a TIPS had been placed.In 2008,recurrent hepaticoencephalopathy resistant to medical treatment fulfilled the LT criteria for BCS treated with TIPS and the patient was therefore added to the LT list.CT performed before TIPS had not detected any hepatic lesions.CT performed six months after TIPS showed its complete patency but documented two indeterminate hypervascular liver lesions.RESULTS:MRI performed with Gd-EOB-DTPA revealed additional hypervascular lesions with uptake and retention of the medium in the hepatobiliary phase,thus reflecting a benign behavior of hepatocellular composition.These MRI features were related to LRNs as confirmed by histopathologic analysis.CONCLUSIONS:Gd-EOB-DTPA-enhanced MRI is potentially superior to standard imaging using gadolinium chelates or spiral CT,especially for the differential diagnosis of hypervascular lesions.Gd-EOB-DTPA MRI may become the imaging method of choice for evaluating LT list patients with BCS after TIPS placement. | Matteo Renzulli Vincenzo Lucidi Cristina Mosconi Chiara Quarneti Emanuela Giampalma Rita Golfieri | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 5 |
| 3 | Renal function and physical fitness after 12-mo supervised training in kidney transplant recipients显示文摘AIM To evaluate the effect of a 12-mo supervised aerobic and resistance training, on renal function and exercise capacity compared to usual care recommendations.METHODS Ninety-nine kidney transplant recipients(KTRs) were assigned to interventional exercise(Group A; n = 52) and a usual care cohort(Group B; n = 47). Blood and urine chemistry, exercise capacity, muscular strength, anthropometric measures and health-related quality of life(HRQo L) were assessed at baseline, and after 6 and 12 mo. Group A underwent a supervised training three times per week for 12 mo. Group B received only general recommendations about home-based physical activities.RESULTS Eighty-five KTRs completed the study(Group A, n = 44; Group B, n = 41). After 12 mo, renal function remained stable in both groups. Group A significantly increased maximum workload(+13 W, P = 0.0003), V'O2 peak(+3.1 mL/kg per minute, P = 0.0099), muscular strength in plantar flexor(+12 kg, P = 0.0368), height in the countermovement jump(+1.9 cm, P = 0.0293) and decreased in Body Mass Index(-0.5 kg/m^2, P = 0.0013). HRQo L significantly improved in physical function(P = 0.0019), physical-role limitations(P = 0.0321) and social functioning scales(P = 0.0346). Noimprovements were found in Group B.CONCLUSION Twelve-month of supervised aerobic and resistance training improves the physiological variables related to physical fitness and cardiovascular risks without consequences on renal function. Recommendations alone are not sufficient to induce changes in exercise capacity of KTRs. Our study is an example of collaborative working between transplant centres, sports medicine and exercise facilities. | Giulio Sergio Roi Giovanni Mosconi Valentina Totti Maria Laura Angelini Erica Brugin Patrizio Sarto Laura Merlo Sergio Sgarzi Michele Stancari Paola Todeschini Gaetano La Manna Andrea Ermolao Ferdinando Tripi Lucia Andreoli Gianluigi Sella Alberto Anedda Laura Stefani Giorgio Galanti Rocco Di Michele Franco Merni Manuela Trerotola Daniela Storani Alessandro Nanni Costa | 2018 | World Journal of Transplantation2018，8，1： | 4 |
| 4 | Percutaneous Intraductal Radiofrequency Ablation is a Safe Treatment for Malignant Biliary Obstruction: Feasibility and Early Results显示文摘 | Malkhaz Mizandari Madhava Pai Feng Xi Vlastimil Valek Andrasina Tomas Pietro Quaretti Rita Golfieri Cristina Mosconi Ao Guokun Charis Kyriakides Robert Dickinson Joanna Nicholls Nagy Habib | 2013 | CardioVascular and Interventional Radiology2013，，3： | 3 |
| 5 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 6 | Percutaneous Intraductal Radiofrequency Ablation for Clearance of Occluded Metal Stent in Malignant Biliary Obstruction: Feasibility and Early Results显示文摘 | Madhava Pai Vlastimil Valek Andrasina Tomas Attila Doros Pietro Quaretti Rita Golfieri Cristina Mosconi Nagy Habib | 2014 | CardioVascular and Interventional Radiology2014，，1： | 2 |
| 7 | Oct 4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells显示文摘Neuroblastoma (NB ) 联系了 endothelial microvessels (他们) 可以被导出肿瘤的 endothelial 房间(侦探) 衬里,那是遗传上不稳定的并且 chemoresistant。这里,我们由集中于 Octamer 有约束力的抄写因素 4 在 NB 探讨了侦探祖先的鉴定(Oct-4 ) 作为一个通常认为的标记。Oct-4 + 房间在主要 NB 样品被检测(n = 23 ) ,变形骨头髓把发成送气音(n = 10 ) , NB 房间线(n = 4 ) ,并且 orthotopic 肿瘤(n = 10 ) 在 immunodeficient 老鼠由 HTLA-230 NB 房间线形成了。大多数 Oct-4 + 房间显示出 perivascular 分布,与他们中的 5% 个一起在 perinecrotic 区域的 homing。自从他们与恶意的房间分享了 MYCN oncogene 的扩大,所有 Oct-4 + 房间是导出肿瘤的。表示的 Perivascular Oct-4 + 细胞起源房间相关的、神经祖先相关、 NB 相关的标记包括表面 Tenascin C (TNC ) ,那不在 perinecrotic Oct-4 + 细胞和体积肿瘤细胞。在 vitro 区分进在包含脉管的 endothelial 生长因素(VEGF ) 的媒介在文化之上表示 vascular-endothelial-cadherin,前列腺特定的膜抗原和 CD31 的象 endothelial 一样房间的 TNC + 然而并非 TNC − HTLA-230 房间。TNC + 然而并非 TNC − HTLA-230 房间形成了 neurospheres 什么时候在没有浆液的媒介有教养。房间部分是 tumorigenic,但是仅仅肿瘤由包含的他们由侦探衬里的 TNC + 房间形成了。在结论,我们在 NB 肿瘤识别了包含 Oct-4 + 肿瘤房间的二个通常认为的壁龛。Oct-4 +/TNC+ perivascular NB 房间显示了粘性的高度并且用作侦探的祖先。Oct4 +/TNC+ 祖先的治疗学的指向可以抵抗导出 NB 的 EC 的贡献到肿瘤恶化和 chemoresistance。 | Annalisa Pezzolo Federica Parodi Danilo MarimPietri Lizzia Raffaghello Claudia Cocco Angela Pistorio Manuela Mosconi Claudio Gambini Michele Cilli Silvia Deaglio Fabio Malavasi Vito Pistoia | 2011 | Cell Research2011，21，10： | 2 |
| 8 | Post-transplant renal artery stenosis:the hemodynamic response to revascularization显示文摘 | Mosconi L Bruno S | 2001 | Kidney Int2001，60，1： | 1 |
| 9 | Treatment of femoral diaphyseal non-unions:our experience显示文摘 | Benazzo F Mosconi M Bove F | 2010 | Injury2010，41，11： | 1 |
| 10 | Breast milk immune complexes are potent inducers of oral tolerance in neonates and prevent asthma development显示文摘 | Mosconi E Rekima A Seitz-Polski B | | 0，，05： | 1 |
| 11 | Changes of lysosomal enzyme activities in sea bass Dicentrarchus labrax eggs and developing embryos显示文摘 | Carnevali O Mosconi G Cambi A | 2001 | Aquaculture2001，202，3： | 1 |
| 12 | Brain glucose metabolism in the early and specif?ic diagnosis of Alzheimer's disease 显示文摘 | Mosconi L | 2005 | Eur J Nucl Med2005，32，： | 1 |
| 13 | The pre–mild cognitive impairment, subjective cognitive impairment stage of Alzheimer’s disease显示文摘 | Barry Reisberg Leslie Prichep Lisa Mosconi E. Roy John Lidia Glodzik-Sobanska Istvan Boksay Isabel Monteiro Carol Torossian Alok Vedvyas Nauman Ashraf Imran A. Jamil Mony J. de Leon | 2008 | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2008，，1： | 1 |
| 14 | Epirubicin versus CMF as adjuvant therapy for stage I and II breast cancer: A prospective randomized study显示文摘 | Colozza M Bisagni G Mosconi A | 2002 | Eur J Cancer2002，38，： | 1 |
| 15 | Urinary protein excretion rate is the best independent predictor of ESRF in non-diabetic proteinuric chronic nephropathies显示文摘 | Ruggenenti P Perna A Mosconi L | 1998 | Kidney Int1998，53，5： | 1 |
| 16 | The value of oxaliplatin in combination with continuous infusion +/- bolus 5-fluorouracil and levo-folinic acid in metastatic colorectal cancer progressing after 5FU-based chemotherapy: a GISCAD(Italian Group for the Study of Digestive Tract) cancer phase Ⅱ trial 显示文摘 | Mosconi S Cascinu S Zaniboni A | 2000 | Tumori2000，86，6： | 1 |
| 17 | Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism显示文摘 | Mosconi L Brys M Switalski R | 2007 | Proc Natl Acad Sci U S A2007，104，19： | 1 |
| 18 | Prognosis of untreated patients with idiopathic membranous nephropathy 显示文摘 | Schieppati A Mosconi L Perna A | 1993 | N Engl J Med1993，329，2： | 1 |
| 19 | Gemcitabine as second-line treatment for relapsing or refractory advanced non small cell lung cancer-A phase Ⅱ trial显示文摘 | Crino L Mosconi AM Scagliotti GV | 1998 | Semin Oncol1998，25，4： | 1 |
| 20 | Urnary protein excretion rate is the best independictor of ESRF in nondiabetrc proteinuric chronic nephropathies 显示文摘 | Ruggenenti P Pema A Mosconi L | 1998 | Kidney Int1998，53，： | 1 |
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