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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Use of antibiotics in broiler production:Global impacts and alternatives显示文摘Antibiotics are used to fight bacterial infections.However, a selective pressure gave rise to bacteria resistant to antibiotics.This leaves scientists worried about the danger to human and animal health.Some strategies can be borrowed to reduce the use of antibiotics in chicken farms.Much research has been carried out to look for natural agents with similar beneficial effects of growth promoters.The aim of these alternatives is to maintain a low mortality rate, a good level of animal yield while preserving environment and consumer health.Among these, the most popular are probiotics, prebiotics, enzymes,organic acids, immunostimulants, bacteriocins, bacteriophages, phytogenic feed additives, phytoncides,nanoparticles and essential oils. | Youcef Mehdi Marie-Pierre Létourneau-Montminy Marie-Lou Gaucher Younes Chorfi Gayatri Suresh Tarek Rouissi Satinder Kaur Brar Caroline Cté Antonio Avalos Ramirez Stéphane Godbout | 2018 | Animal Nutrition2018，，2： | 19 |
| 3 | Anterior knee pain after a total knee arthroplasty: What can cause this pain?显示文摘Total Knee Arthroplasty has been shown to be a successful procedure for treating patients with osteoarthritis,and yet approximately 5%-10%of patients experience residual pain,especially in the anterior part of the knee.Many theories have been proposed to explain the etiology of this anterior knee pain(AKP)but,despite improvements having been made,AKP remains a problem.AKP can be described as retropatellar or peripatellar pain,which limits patients in their everyday lives.Patients suffering from AKP experience difficulty in standing up from a chair,walking up and down stairs and riding a bicycle.The question asked was:'How can a‘perfectly’placed total knee arthroplasty(TKA)still be painful:what can cause this pain?'.To prevent AKP after TKA it is important to first identify the different anatomical structures that can cause this pain.Greater attention to and understanding of AKP should lead to significant pain relief and greater overall patient satisfaction after TKA.This article is a review of what pain is,how nerve signalling works and what is thought to cause Anterior Knee Pain after a Total Knee Arthroplasty. | Stéfanus Jacob Martinus Breugem Daniёl Haverkamp | 2014 | World Journal of Orthopedics2014，5，3： | 11 |
| 4 | 青年型开角型青光眼的中国家系的新型Myocilin基因突变显示文摘目的:探讨某中国家系青年型开角型青光眼(JOAG)的致病基因。
方法:在一个青光眼家系中,三代人中患JOAG或高眼压。我们筛查了6位家族成员Myocilin(MYOC)和 optineurin(OPTN)的突变和apolipoprotein E的多态性,2位患有JOAG,2位患有高眼压,2位无症状。正常对照组包括200位与本家系无关联的受试者。用编码野生型或变异性 MYOC 互补 DNA 的表达载体转染cos-7细胞系。细胞内或分泌的MYOC蛋白用Western法进行检测。 | Bao Jian Fan Dexter Y. L Leung Dan Yi Wang Stéphane Vincent Raymond Pancy O. S. Tam Dennis S. C. Lam Chi Pui Pang 王婷(译) | 2006 | 美国医学会眼科杂志(中文版)2006，18，4： | 5 |
| 5 | Stem cell therapy as an emerging paradigm for stroke ( STEPS) Ⅱ显示文摘Cell-based therapies represent a new therapeutic approach for stroke.In 2007,investigators from academia,industry leaders,and members of the National Institutes of Health crafted recommendations to facilitate the | Savitz SI Chopp M Deans R Carmichael ST Phinney D Wechsler L | 2011 | 中华神经外科疾病研究杂志2011，10，3： | 5 |
| 6 | Gamma knife stereotactic radiosurgery for the management of incidentally-identified brain metastasis from non-small cell lung cancer显示文摘 | Marko NF Suh JH Chao ST Barnett GH Vogelbaum MA Toms S Well R J Angelov L | 2011 | 中国神经肿瘤杂志2011，9，1： | 4 |
| 7 | Stereotactic radiosurgery as single-modality treatment of incidentally identified renal cell carcinoma brain metastases显示文摘 | Marko NF Angelov L Toms SA Suh JH Chao ST Vogelbaum MA Barnett GH Weil RJ | 2010 | 中国神经肿瘤杂志2010，8，3： | 4 |
| 8 | Increased Risk for Nonmelanoma Skin Cancers in Patients Who Receive Thiopurines for Inflammatory Bowel Disease显示文摘 | Laurent Peyrin–Biroulet Kiarash Khosrotehrani Fabrice Carrat Anne–Marie Bouvier Jean–Baptiste Chevaux Tabassome Simon Frank Carbonnel Jean–Frédéric Colombel Jean–Louis Dupas Philippe Godeberge Jean–Pierre Hugot Marc Lémann Stéphane Nahon Jean–Marc Sabaté | 2011 | Gastroenterology2011，，5： | 3 |
| 9 | Liver transplantation for alcoholic liver disease: Lessons learned and unresolved issues显示文摘The use of liver transplantation(LT) as a treatment for alcoholic liver disease(ALD) has been highly controversial since the beginning. The ever increasing shortage of organs has accentuated the low priority given to patients suffering from ALD, which is considered a 'self-inflicted' condition. However, by improving the long-term survival rates, making them similar to those from other indications, and recognizing that alcoholism is a primary disease, ALD has become one of the most common indications for LT in Europe and North America, a situation thought unfathomable thirty years ago. Unfortunately, there are still many issues with the use of this procedure for ALD. There are significant relapse rates, and the consequences of excessive drinking after LT range from asymptomatic biochemical and histological abnormalities to graft failure and death. A minimum three-month period of sobriety is required for an improvement in liver function, thus making LT unnecessary, and to demonstrate the patient's commitment to the project, even though a longer abstinence period does not guarantee lower relapse rates after LT. Recent data have shown that LT is also effective for severe alcoholic hepatitis when the patient is unresponsive to corticosteroids therapy, with low relapse rates in highly selected patients, although these results must be confirmed before LT becomes a standard procedure in this setting. Finally, LT for ALD is accompanied by an increased risk of de novo solid organ cancer, skin cancer, and lymphoproliferative disorders, which has a large impact on the survival rates. | José Ursic-Bedoya Stéphanie Faure Hélène Donnadieu-Rigole Georges-Philippe Pageaux | 2015 | World Journal of Gastroenterology2015，21，39： | 3 |
| 10 | Endotoxin-tolerant mice have mutations in Toll-like receptor4 (Tlr4)显示文摘 | Qureshi ST Lariviere L Leveque G | 1999 | J Exp Med1999，189，4： | 2 |
| 11 | Dual Peroxisome Proliferator–Activated Receptor α/δ Agonist GFT505 Improves Hepatic and Peripheral Insulin Sensitivity in Abdominally Obese Subjects显示文摘 | Bertrand Cariou Rémy Hanf Stéphanie Lambert-Porcheron Yassine Za?r Valérie Sauvinet Benoit No?l Laurent Flet Hubert Vidal Bart Staels Martine Laville | 2013 | Diabetes Care2013，，10： | 2 |
| 12 | Wheat bran tissue fractionation using biochemical markers显示文摘 | Carole Antoine Stéphane Peyron Valérie Lullien-Pellerin Jo?l Abecassis Xavier Rouau | 2004 | Journal of Cereal Science2004，，3： | 2 |
| 13 | Co-occurrence of infantile epileptic seizures and childhood paroxysmal choreoathetosis in one family:clinical,EEG,and SPECT characterization of episodic events显示文摘 | Thiriaux A de St Martin A Vercueil L | 2002 | Mov Disord2002，79，1： | 1 |
| 14 | Reconstruction of Current Profile Parameters and Plasma Shapes in Tokamaks显示文摘 | Lao L L St John H | 1985 | Nuclear Fusion1985，25，11： | 1 |
| 15 | Distance sampling显示文摘 | Thomas L Buckland ST Burnham KP | 2002 | Encyclopedia of Environmetrics2002，1，： | 1 |
| 16 | Histopathologic and clinical subtypes of autoimmune pancreatitis: the honolulu consensus document显示文摘 | Chari ST Kloeppel G Zhang L | 2010 | Pancreatology2010，10，6： | 1 |
| 17 | Alternative promoters regulate transcription of the gene that encodes stem cell surface protein AC133显示文摘 | Shmelkov SV Jun L St Clair R | 2004 | Blood2004，103，6： | 1 |
| 18 | A histochemical study of iron,transferrin,and ferritin in Alzheimer’s diseased brains显示文摘 | Connor J R Menzies S L St Martin S M | 1992 | J Neurosci Res1992，31，1： | 1 |
| 19 | Loss of T-cell protein tyrosine phosphatase in the intestinal epithelium promotes local inflammation by increasing colonic stem cell proliferation显示文摘T-cell protein tyrosine phosphatase(TC-PTP)has a critical role in the development of the immune system and has been identified as a negative regulator of inflammation.Single-nucleotide polymorphisms in the TC-PTP locus have been associated with increased susceptibility to inflammatory bowel diseases(IBDs)in patients.To further understand how TC-PTP is related to IBDs,we investigated the role of TC-PTP in maintaining the intestinal epithelial barrier using an in vivo genetic approach.Intestinal epithelial cell(IEC)-specific deletion of TC-PTP was achieved in a mouse model at steady state and in the context of dextran sulphate sodium(DSS)-induced colitis.Knockout(KO)of TC-PTP in IECs did not result in an altered intestinal barrier.However,upon DSS treatment,IECspecific TC-PTP KO mice displayed a more severe colitis phenotype with a corresponding increase in the immune response and inflammatory cytokine profile.The absence of TC-PTP caused an altered turnover of IECs,which is further explained by the role of the tyrosine phosphatase in colonic stem cell(CoSC)proliferation.Our results suggest a novel role for TC-PTP in regulating the homeostasis of CoSC proliferation.This supports the protective function of TC-PTP against IBDs,independently of its previously demonstrated role in intestinal immunity. | Stéphanie Bussières-Marmen Valérie Vinette Jeremy Gungabeesoon Isabelle Aubry Luis Alberto Pérez-Quintero Michel L Tremblay | 2018 | Cellular & Molecular Immunology2018，15，4： | 1 |
| 20 | Incorporating a statistically based shape model into a system for computor-assisted anterior cruciate ligament surgery显示文摘 | Markus F St(e)phane L R(e)mi J | 1999 | Medical Image Analysis1999，3，3： | 1 |
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