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| 1 | Herbal compatibility of Traditional Chinese Medical formulas for acquired immunodeficiency syndrome显示文摘OBJECTIVE:Because herbal compatibility is one of the most important reasons why Traditional Chinese Medcine(TCM) formulas are effective for acquired immunodeficiency syndrome(AIDS),our study aimed to determine the compatibility of herbs based on published AIDS clinical research in Chinese periodicals.To achieve this aim,we designed a new data-mining algorithm according to TCM data characteristics.METHODS:We found 25 clinical AIDS studies,all using Chinese herbs for treatment,in the Traditional Chinese Medicine Database System,and information on diagnosis and treatment was extracted.To find out herbal compatibility,especially the formulae for herbal combinations,we proposed an improved association rule algorithm based on the frequency of combinations.In this algorithm,all the compatibility relationships were displayed in a tree structure,by which the relationship between formulas and their derivation could be clearly inferred.RESULTS:Data analysis showed that approximately 100 herbs have been used for treating AIDS.Based on the whole herb compatibility tree,we calculated a basic formula for AIDS:Huang Qi combined with Ren Shen,Fu Ling,Bai Zhu,Bai Zhu,Dang Gui,and Bai Shao.This formula,deriving from most of clinical prescriptions,and was chosed by most of clinicians for AIDS treatment.From data mining we found that Qi replenishment and detoxification were the main treatment principles,which coincided with the AIDS pathological mechanism in which immune function is destroyed by human immunodeficiency virus(HIV).CONCLUSIONS:Our data-mining results suggest that the core TCM treatment of AIDS is replenishing Qi and detoxification,by which AIDS patients' immune system may be enhanced.Compatibility of Huang Qi with some frequently-used herbs have shown real efficacy in clinical practice,which warrants pharmacological research in the future. | Meng Cui Jinghua Li Haiyan Li Chunxin Song | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 5 |
| 2 | Experimental study on uplift mechanism of pipeline buried in sand using high-resolution fiber optic strain sensing nerves显示文摘Reliable assessment of uplift capacity of buried pipelines against upheaval buckling requires a valid failure mechanism and a reliable real-time monitoring technique.This paper presents a sensing solution for evaluating uplift capacity of pipelines buried in sand using fiber optic strain sensing(FOSS)nerves.Upward pipe-soil interaction(PSI)was investigated through a series of scaled tests,in which the FOSS and image analysis techniques were used to capture the failure patterns.The published prediction models were evaluated and modified according to observations in the present study as well as a database of 41 pipe loading tests assembled from the literature.Axial strain measurements of FOSS nerves horizontally installed above the pipeline were correlated with the failure behavior of the overlying soil.The test results indicate that the previous analytical models could be further improved regarding their estimations in the failure geometry and mobilization distance at the peak uplift resistance.For typical slip plane failure forms,inclined shear bands star from the pipe shoulder,instead of the springline,and have not yet reached the ground surface at the peak resistance.The vertical inclination of curved shear bands decreases with increasing uplift displacements at the post-peak periods.At large displacements,the upward movement is confined to the deeper ground,and the slip plane failure progressively changes to the flow-around.The feasibility of FOSS in pipe uplift resistance prediction was validated through the comparison with image analyses.In addition,the shear band locations can be identified using fiber optic strain measurements.Finally,the advantages and limits of the FOSS system are discussed in terms of different levels in upward PSI assessment,including failure identification,location,and quantification. | Haojie Li Honghu Zhu Yuanhai Li Chunxin Zhang Bin Shi | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，4： | 5 |
| 3 | Characterization,Evolution and Expression of the Calmodulinl Genes from the Amphioxus Branchiostoma belcheri tsingtauense显示文摘二全身的 cDNAs ,命名 CaM1a 和 CaM1b ,编码高度 conservedcalmodulinl ( CaM1 )蛋白质,从文昌鱼 Branchiostoma belcheritsingtauense.There 的 cDNA 图书馆被孤立仅仅是他们之间的二核苷酸差别,生产 CaMl 的氨基酸顺序的 CaMla 和 CaMlb.Comparison 之间的一氨基酸差别表明 theB.belcheri tsingtauense CaMla 与 B.floridae andB.lanceolatum ,果蝇 melanogaster 凸轮,海鞘类动物 Halocynthia roretzi CaMA 和软体动物 Aplysiacalifornica 凸轮,和 CaMlb 的 CaMl 蛋白质是相同的仅仅在一个位置不同( 138 , Asn 到毒蛇)。种系发生的分析显示在所有三文昌鱼种的 CaMl 看起来编码常规凸轮 andCaMl 可能从 CaMl.Southern 污点的基因复制被导出建议有在 B.belcheri tsingtauense.Northern 污点的染色体并且在 situ 杂交分析 hows 的 CaMl 的二个拷贝二个 CaMl mRNA 抄本的存在与在不同成年纸巾的各种各样的表示层次和在文昌鱼 B.belcheri tsingtauense.The 进化和后生动物的凸轮 mRNA 的差异的胚胎的阶段,抄本也被讨论。 | Jing LUAN Zhenhui LIU Shicui ZHANG Hongyan LI Chunxin FAN Lei LI | 2007 | Acta Biochimica et Biophysica Sinica2007，39，4： | 4 |
| 4 | An international multicentric phaseⅢrandomized controlled trial of time-acupoints-space acupuncture for the prevention of chemotherapy-induced fatigue in patients with early stage breast cancer:a study protocol显示文摘OBJECTIVE:To determine the difference in prevention of chemotherapy-induced fatigue between time-acupointsspace acupuncture(ATAS)administered weekly compared to sham acupuncture and non-acupuncture in patients with early breast cancer receiving adjuvant chemotherapy by epirubicine-cyclophosphamide(EC)followed by paclitaxel,as measured by the multidimensional fatigue inventory(MFI)over the previous week and Visual Analogue Scale measuring fatigue(VAS-F),and to evaluate the effects of ATAS on selfreported neuropathy pain,sleep,anxiety and depression.METHODS:In this multicenter clinical trial,we have randomized patients into 3 groups:ATAS,Sham and nonacupuncture with an unequal randomization of 2∶1∶1.A cloud related electronical clinical report form and smartphone platform was established for data entry.Patients with a history of stageⅠ-Ⅲbreast cancer scheduled to receive adjuvant chemotherapy.Acupuncture will be delivered once a week during chemotherapy with VAS-F evaluation.In order to qualify and quantify the mechanism of fatigue induced by chemotherapy with or without acupuncture,an evaluation of immune profiling was incorporate in this study.RESULTS:The presence and seriousness of chemotherapy-induced fatigue should be considered in therapeutic programs for early breast cancer treatment.Fatigue induced by adjuvant chemotherapy in patients with breast cancer remains a major concern affecting the quality of life significantly.Unfortunately,we do not have effective pharmacological interventions yet.And clinical trials of acupuncture in preventing chemotherapyinduced fatigue in patients with early breast cancer have not been reported.CONCLUSION:The findings of the trial will allow us to determine the effects of acupuncture treatment approach.We will also be able to confirm whether ATAS is better than sham acupuncture and non-acupuncture treatments. | Saghachian Mahasti Barry Caroline Asselain Bernard LI Yunfen NIE Jianyun LIU Dequan CHEN Dedian CHEN Chunxin Laura Estevez LI Wenhui Jean-Pierre Armand ZHU Miansheng JU Liya | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 2 |
| 5 | Robust object tracking with adaptive fusion of color and edge strength lo- cal mean features based on oarticle fiber显示文摘 | LI Chunxin Wang Xiaotong Xu Xiaogang | 2009 | IEEE Imer- national Forum on Information Technology and Applica- tions ( S7695 - 3600)2009，10，： | 1 |
| 6 | Executive compensation, supervisory board, and China’s governance reform: a legal approach perspective显示文摘 | Shujun Ding Zhenyu Wu Yuanshun Li Chunxin Jia | 2010 | Review of Quantitative Finance and Accounting2010，，4： | 1 |
| 7 | Analysis on All-Day Operating Solar Absorption Refrigeration System with Heat Pump System显示文摘 | Hui Li Xingjuan Zhang Chunxin Yang | 2015 | Procedia Engineering2015，，： | 1 |
| 8 | Investigation on ergonomics characteristics of protective clothing based on capture of three-dimensional body movements显示文摘 | HU Huimin DING Li YANG Chunxin | | 0，，： | 1 |
| 9 | An algorithm for simulating human ann movement considering the comfort level显示文摘 | FENG Y LI D CHUNXIN Y | 2005 | Simulation Modelling Practice and Theory2005，13，5： | 1 |
| 10 | Effects of cytokines and chemokines on migration of mesenchymal stem cells following spinal cord injury显示文摘We investigated the effects of cytokines and chemokines and their associated signaling pathways on mesenchymal stem cell migration after spinal cord injury, to determine their roles in the curative effects of mesenchymal stem cells. This study reviewed the effects of tumor necrosis factor-α, vascular endothelial growth factor, hepatocyte growth factor, platelet-derived growth factor, basic fibroblast growth factor, insulin like growth factor-1, stromal cell-derived factor and monocyte chemoattractant protein-1, 3 during mesenchymal stem cell migration to damaged sites, and analyzed the signal transduction pathways involved in their effects on mesenchymal stem cell migration. The results confirmed that phosphatidylinositol 3-kinase/serine/threonine protein kinases and nuclear factor-κB play crucial roles in the migration of mesenchymal stem cells induced by cytokines and chemokines. | Longyun Li Maoguang Yang Chunxin Wang Qiheng Zhao Jian Liu Chuanguo Zhan Zhi Liu Xuepeng Li Weihua Wang Xiaoyu Yang | 2012 | Neural Regeneration Research2012，7，14： | 1 |
| 11 | Gas-liquid-liquid extraction in a novel rotating microchannel extractor显示文摘In this work,a novel rotating microchannel extractor(RME)is designed and further used for the extraction of chromium(Ⅲ)from water.Unexpectedly,the micro-extraction had the same effect as carrying out 2.9-stage cross-flow extractions.Various factors,including the gas intake methods,gas intake quantity(Qg),distance between inner rotor and outer wall(D),rotational inner rotor speed(R)and volumetric flow rate(Qa,Qo),were selected to investigate their effect on the extraction efficiency(η)thoroughly.The relation map ofηwith Weaand We(o-g)for RME provides a comprehension for the gas–liquid–liquid extraction process in this RME system. | Rui Ma Chunxin Fan Yubin Wang Jianhong Luo Jun Li Sridhar Komarneni | 2020 | Chinese Journal of Chemical Engineering2020，28，10： | 0 |
| 12 | Cathodic behavior of scandium(Ⅲ) on reactive copper electrodes in LiF-CaF_(2)eutectic molten salt显示文摘The electrochemical formation of Sc-Cu alloy was investigated in LiF-CaF_(2) eutectic molten salt employing various electrochemical methods.Cyclic voltammetry and square wave voltammetry indicate that the reduction of scandium(Ⅲ) on the tungsten electrode is a one-step reduction process with three electrons transfer.And underpotential deposition of scandium on the copper electrode occurs owing to the depolarization effect,i.e.,forming Sc-Cu intermetallic compounds.The thermodynamic properties of the Sc-Cu intermetallic compounds ScCu_(4),ScCu_(2),and ScCu in the temperature range of 1153-1223 K were estimated by open-circuit chronopotentiometry.Moreover,the Sc-Cu alloys were prepared by potentiostatic electrolysis and characterized by optical microscope,X-ray diffraction,scanning electron microscopy,and energy dispersive spectroscopy.The results reveal that only Sc-Cu alloy composed of Cu-ScCu_(4) can be synthesized at low cathodic current density and above eutectic temperature. | Chunxin Wang Jianshe Chen Binchuan Li Hang Zhao Binjun Jin Kuiren Liu Qing Han | 2022 | Journal of Rare Earths2022，40，10： | 0 |
| 13 | Development of diagnostic markers for a wheat leaf rust resistance gene Lr42 using RNA-sequencing显示文摘Wheat leaf rust is a prevalent foliar disease in wheat worldwide. Growing resistant cultivars is an effective strategy to minimize the impact of leaf rust on yield and grain quality. Lr42 is a leaf rust resistance gene identified from Aegilops tauschii and is still effective against current predominant leaf rust races in the United States and many other countries. In this study, we developed diagnostic DNA markers for Lr42 using the sequence polymorphisms of a differentially expressed gene(TaRPM1) encoding a putative NBARC protein in the Lr42 candidate region identified by RNA-sequencing of two near-isogenic lines contrasting in Lr42 alleles. Markers were designed based on a deletion mutation and a single nucleotide polymorphism(SNP) in the gene. Haplotype analyses of the newly developed markers in the three diversity panels demonstrated that they are diagnostic for Lr42, and superior to previously used markers in selection accuracy. These markers have the advantages of low cost and easy assay, and they are suitable for marker-assisted selection in breeding programs with either high-or low-throughput marker screening facilities. | Yang Liu Hui Chen Chunxin Li Lirong Zhang Mingqin Shao Yuhui Pang Xiangyang Xu Guihua Bai | 2021 | The Crop Journal2021，9，6： | 0 |
| 14 | Improved diagnosis of thyroid cancer aided with deep learning applied to sonographic text reports:a retrospective,multi-cohort,diagnostic study显示文摘Objective:Large volume radiological text data have been accumulated since the incorporation of electronic health record(EHR)systems in clinical practice.We aimed to determine whether deep natural language processing algorithms could aid radiologists in improving thyroid cancer diagnosis.Methods:Sonographic EHR data were obtained from the EHR database.Pathological reports were used as the gold standard for diagnosing thyroid cancer.We developed thyroid cancer diagnosis based on natural language processing(THCaDxNLP)to interpret unstructured sonographic text reports for thyroid cancer diagnosis.We used the area under the receiver operating characteristic curve(AUROC)as the primary metric to measure the performance of the THCaDxNLP.We compared the performance of thyroid ultrasound radiologists aided with THCaDxNLP vs.those without THCaDxNLP using 5 independent test sets.Results:We obtained a total number of 788,129 sonographic radiological reports.The number of thyroid sonographic data points was 132,277,18,400 of which were thyroid cancer patients.Among the 5 test sets,the numbers of patients per set were 439,186,82,343,and 171.THCaDxNLP achieved high performance in identifying thyroid cancer patients(the AUROC ranged from 0.857–0.932).Thyroid ultrasound radiologists aided with THCaDxNLP achieved significantly higher performances than those without THCaDxNLP in terms of accuracy(93.8%vs.87.2%;one-sided t-test,adjusted P=0.003),precision(92.5%vs.86.0%;P=0.018),and F1 metric(94.2%vs.86.4%;P=0.007).Conclusions:THCaDxNLP achieved a high AUROC for the identification of thyroid cancer,and improved the accuracy,sensitivity,and precision of thyroid ultrasound radiologists.This warrants further investigation of THCaDxNLP in prospective clinical trials. | Qiang Zhang Sheng Zhang Jianxin Li Yi Pan Jing Zhao Yixing Feng Yanhui Zhao Xiaoqing Wang Zhiming Zheng Xiangming Yang Lixia Liu Chunxin Qin Ke Zhao Xiaonan Liu Caixia Li Liuyang Zhang Chunrui Yang Na Zhuo Hong Zhang Jie Liu Jinglei Gao Xiaoling Di Fanbo Meng Wei Ji Meng Yang Xiaojie Xin Xi Wei Rui Jin Lun Zhang Xudong Wang Fengju Song Xiangqian Zheng Ming Gao Kexin Chen Xiangchun Li | 2022 | Cancer Biology & Medicine2022，19，5： | 0 |
| 15 | Bioinspired Scalable Total Synthesis of Opioids显示文摘As one of the largest and most representative families of natural medicines harvested from plants,the mass production of opioids legitimately occupies large,worldwide farmland cultivation of opium poppies,causing severe regulation limitations and supply uncertainty.Due to their complex structures,the chemical synthesis of opioids has been criticized as infeasible for large-scale production in view of lengthy synthetic steps and overall low efficiency. | Xiaohan Zhou Wenfei Li Ruijie Zhou Xiaoqing Wu Yuan Huang Wenlong Hou Chunxin Li Yifan Zhang Wei Nie Yu Wang Hao Song Xiao-Yu Liu Zhibing Zheng Fei Xie Song Li Wu Zhong Yong Qin | 2021 | CCS Chemistry2021，3，9： | 0 |
| 16 | Characterization, Evolution and Tissue-specific Expression of AmphiCalbin, a Novel Gene Encoding EF-hand Calcium-binding Protein in Amphioxus Branchiostoma belcheri显示文摘一条文昌鱼全身的 cDNA , AmphiCalbin ,编码新奇EF手钙绑定蛋白质( EFCaBP ),从文昌鱼 Branchiostoma belcheri.It 的内脏 cDNA 图书馆被孤立与 636 bp 由 1321 bp 组成与种系发生的分析为二有趣的推论提供的约 24.5 kDa.The 的一个分子的团编码 211 氨基酸的蛋白质的开的读框架。首先,有被区分开来与其它的一组未命名的 EFCaBPs 的 AmphiCalbin 簇识别了 EFCaBPs.Second,在脊椎动物的底的 AmphiCalbin 下降未命名的 EFCaBPs clade,可能代表他们的原型。这被 AmphiCalbin 有与脊椎动物的相同的一个 exon-intron 组织的事实也支持未命名的 EFCaBP 基因。在 situ 杂交的两织物节并且在 situ 杂交整个山证明 AmphiCalbin 的一个织物特定的表达式模式,与在消化系统和性腺的表示的高水平。AmphiCalbin 可能在消化系统和性腺起一个作用,这被建议。这些观察为未命名的 EFCaBPs 的函数的进一步的理解打了基础。 | Jing LUAN Shicui ZHANG Zhenhui LIU Chunxin FAN Guangdong JI Lei LI | 2007 | Acta Biochimica et Biophysica Sinica2007，39，11： | 0 |
| 17 | Flexible radio-frequency micro electro-mechanical switch towards the applications of satellite communications显示文摘This paper presents a flexible radio-frequency microelectromechanical system(RF MEMS)switch integrated on cyclo-olefin polymer(COP)substrate using a modified surface MEMS processing technology,which could be used in the 17-19 GHz frequency band of satellite communication.Through systematic simulation analysis,it is found that flexible RF MEMS switch can achieve certain bending radius by miniaturizing the electronic dimension,without degrading the RF performance.It is demonstrated that the RF characteristics of flexible RF MEMS switch with special anchor structural design,fabricated by modified surface MEMS processing,are not sensitive to bending deformation under the curvature of 0 mm^(-1),0.05 mm^(-1),0.10 mm^(-1).Furthermore,the range of bending curvature which will affect the RF characteristics is given through systematic simulation.The flexible RF MEMS switch with high process compatibility and stable RF performance is believed to be promising candidates for future microwave communications and other consumer electronics. | Yingli Shi Chao Zhou Zibo Cao Yurong He Jingwen Guo Chunxin Li Qianhong Wu Kui Liang Yanzhao Li Yuan Lin | 2022 | npj Flexible Electronics2022，6，1： | 0 |
| 18 | Modeling pipe-soil interaction under vertical downward relative offset using B-spline material point method显示文摘To analyze the pipeline response under permanent ground deformation,the evolution of resistance acting on the pipe during the vertical downward offset is an essential ingredient.However,the efficient simulation of pipe penetration into soil is challenging for the conventional finite element(FE)method due to the large deformation of the surrounding soils.In this study,the B-spline material point method(MPM)is employed to investigate the pipe-soil interaction during the downward movement of rigid pipes buried in medium and dense sand.To describe the density-and stress-dependent behaviors of sand,the J2-deformation type model with state-dependent dilatancy is adopted.The effectiveness of the model is demonstrated by element tests and biaxial compression tests.Afterwards,the pipe penetration process is simulated,and the numerical outcomes are compared with the physical model tests.The effects of pipe size and burial depth are investigated with an emphasis on the mobilization of the soil resistance and the failure mechanisms.The simulation results indicate that the bearing capacity formulas given in the guidelines can provide essentially reasonable estimates for the ultimate force acting on buried pipes,and the recommended value of yield displacement may be underestimated to a certain extent. | Chunxin Zhang Honghu Zhu Haojie Li | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，6： | 0 |
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