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| 1 | Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration显示文摘1. Introduction Drug-induced liver injury (DILI), defined as liver injury caused by a drug and/or its metabolites, is a common clinical adverse drug reaction1–4. This type of injury can cause acute liver failure and even death in severe cases5. | Xiaohe Xiao Jianyuan Tang Yimin Mao Xiuhui Li Jiabo Wang Chenghai Liu Kewei Sun Yong’an Ye Zhengsheng Zou Cheng Peng Ling Yang Yuming Guo Zhaofang Bai Tingting He Jing Jing Fengyi Li Na An | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 22 |
| 2 | Different properties of GaN-based LED grown on Si(111) and transferred onto new substrate显示文摘InGaN MQW LEDs, grown by metal-organic chemical vapor deposition (MOCVD) on Si(111) substrates, were successfully bonded and transferred onto new Si substrate. After chemical etching Si(111) substrate and inductively coupled plasma (ICP) etching the transferred LED film to Si-doped layer, a vertical structure GaN blue LEDs were then fabricated. The characteristics of the lateral structure LED (grown on Si) and the vertical structure LED (bonded on Si) were investigated. It shows the performance of ver- tical structure LEDs had obviously been improved compared to the lateral structure LEDs and the tensile stress in GaN layer of vertical structure LEDs is smaller than that in lateral structure LEDs. | XIONG Chuanbing JIANG Fengyi FANG Wenqing WANG Li LIU Hechu MO Chunnan | 2006 | Science China(Technological Sciences)2006，49，3： | 12 |
| 3 | A Novel Carbon Nanotube-Supported NiP Amorphous Alloy Catalyst and Its Hydrogenation Activity显示文摘碳支持 nanotube 捏非结晶的催化剂(NiP/CNT ) 被导致的减小准备。苯加氢为催化活的学习被用作探查反应。在载体上的催化剂的活动和热稳定性的支持的效果基于各种各样的描述被讨论,包括 XRD, TEM, ICP, XPS, H2-TPD,和 DTA。与 NiP 非结晶的合金比较, NiP/CNT 催化剂上的苯变换更低,但是 NiP/CNT 的比放射性更高,它被归因于支持,捐赠电子的效果,和 CNT 的氢存储能力生产的分散。因为分散和电子效果和 CNT 支持的好热传导能力, NiP/CNT 热稳定性被改进。给词调音:碳 nanotube;催化剂载体;催化性质;镍;P;加氢; | Yan Ju Fengyi Li | 2006 | Journal of Natural Gas Chemistry2006，15，4： | 8 |
| 4 | Developing superior alleles of yield genes in rice by artificial mutagenesis using the CRISPR/Cas9 system显示文摘Rice yield is an important and complex agronomic trait controlled by multiple genes.In recent decades,dozens of yield-associated genes in rice have been cloned,many of which can increase production in the form of loss or degeneration of function.However,mutations occurring randomly under natural conditions have provided very limited genetic resources for yield increases.In this study,potentially yield-increasing alleles of two genes closely associated with yield were edited artificially.The recently developed CRISPR/Cas9system was used to edit two yield genes:Grain number 1a(Gn1a)and DENSE AND ERECT PANICLE1(DEP1).Several mutants were identified by a target sequence analysis.Phenotypic analysis confirmed one mutant allele of Gn1a and three of DEP1 conferring yield superior to that conferred by other natural high-yield alleles.Our results demonstrate that favorable alleles of the Gnla and DEP1 genes,which are considered key factors in rice yield increases,could be developed by artificial mutagenesis using genome editing technology. | Liyu Huang Ru Zhang Guangfu Huang Yanxia Li Getachew Melaku Shilai Zhang Haitao Chen Yanjuan Zhao Jing Zhang Yesheng Zhang Fengyi Hu | 2018 | The Crop Journal2018，6，5： | 8 |
| 5 | Si-substrate vertical-structure InGaN/GaN micro-LED-based photodetector for beyond 10 Gbps visible light communication显示文摘Visible light communication(VLC)has emerged as a promising communication method in 6G.However,the development of receiving devices is much slower than that of transmitting devices,limited by materials,structures,and fabrication.In this paper,we propose and fabricate an InGaN/GaN multiple-quantum-well-based vertical-structure micro-LED-based photodetector(μPD)on a Si substrate.A comprehensive comparison of the photoelectrical performance and communication performance of three sizes ofμPDs,10,50,and 100μm,is presented.The peak responsivity of all threeμPDs is achieved at 400 nm,while the passband full-widths at half maxima are 87,72,and 78 nm for 10,50,and 100μmμPDs,respectively.The−20 dB cutoff bandwidth is up to 822 MHz for 50μmμPD.A data rate of 10.14 Gbps is experimentally demonstrated by bit and power loading discrete multitone modulation and the proposed digital pre-equalizer algorithm over 1 m free space utilizing the self-designed 4×450μmμPD array as a receiver and a 450 nm laser diode as a transmitter.This is the first time a more than 10 Gbps VLC system has been achieved utilizing a GaN-based micro-PD,to the best of our knowledge.The investigation fully demonstrates the superiority of Si substrates and vertical structures in InGaN/GaNμPDs and shows its great potential for high-speed VLC links beyond 10 Gbps. | JIANYANG SHI ZENGYI XU WENQING NIU DONG LI XIAOMING WU ZIWEI LI JUNWEN ZHANG CHAO SHEN GUANGXU WANG XIAOLAN WANG JIANLI ZHANG FENGYI JIANG SHAOHUA YU NAN CHI | 2022 | Photonics Research2022，10，10： | 5 |
| 6 | Performance of microbiological control by a point-of-use filter system for drinking water purification显示文摘Purification capacity of a faucet mounted type water filter for home use was evaluated,particularly with regard to microbiological performance under different running conditions.Biofilms were formed inside the filter,affecting the bacterial quality of the effuent water.Low flow rate,long stagnation period and high filter temperature were found favorable for bacterial growth inside.By commercial analytical profile index(API) kits,ten different bacterial species were identified in drinking water,four of which were probably contributed to the biofilm formation since they were also present in the biofilm.Fluorescence in situ hybridization(FISH) was used to confirm the API identification results,and direct viable count(DVC) method was employed to improve the sensitivity of FISH for the isolated Acinetobacter spp.and Pseudomonas putida as models.Relationship between the filter operating condition and the bacterial community alteration was partly revealed,which could provide the basic knowledge for the filter design and its practical use. | SU Fengyi LUO Mingfang ZHANG Fei LI Peng LOU Kai XING Xinhui | 2009 | Journal of Environmental Sciences2009，21，9： | 4 |
| 7 | A new acyclic peroxide from Aspergillus nidulans SD-531,a fungus obtained from deep-sea sediment of cold spring in the South China Sea显示文摘A new acyclic peroxide derivative asperoxide A(1),along with 13 known compounds,namely,microperfuranone(2),9-hydroxymicroperfuranone(3),gibellulin A(4),lecanoric acid(5),terrequinone A(6),sterigmatocystin(7),isosecosterigmatocystin(8),arugosin C(9),curvularin(10),3,3'-diindolylmethane(11),austinol(12),austin(13),and dehydroaustin(14),were isolated and identified from the culture extract of Aspergillus nidulans SD-531,a fungus obtained from the deep-sea sediment of cold spring in the South China Sea.Their structures were determined based on detailed interpretation of nuclear magnetic resonance(NMR)spectroscopic and mass spectrometry data analysis.All the isolated compounds were evaluated for antimicrobial activities against human and aquatic bacteria as well as plant pathogenic fungi.Compounds 1–8,10,and 11 exhibited antimicrobial activities against some of the tested strains with minimum inhibitory concentration(MIC)values ranging from^2 to 64μg/mL.Compounds 4 and 6 displayed strongest activities among the tested samples and might be used as promising molecules for the development of natural antimicrobial agents. | LÜFengyi LI Xiaoming CHI Luping MENG Linghong WANG Bingui | 2020 | Journal of Oceanology and Limnology2020，38，4： | 4 |
| 8 | Sirtl regulates testosterone biosynthesis in Leydig cells via modulating autophagy显示文摘Dear Editor,Steroid hormones are crucial signal molecules that regulate a large number of physiological and developmental pro-cesses.Testosterone is the key steroid hormone required for the development of male characteristics and also supports the physiology of the male reproductive system(Sinclair et al.,2015).Testosterone is primarily produced by the Leydig cells residing in the testicular interstitium.The cholesterol acts as a substrate for the biosynthesis of testosterone.Since steroidogenic cells are capable of stor-ing only very ltte hormone,rapid synthesis of hormone requires the mobilization of the precursor cholesterol,chiefly stored as intracellular lipid droplets(LDs)(Danielsen et al.,2016).Leydig cells are the major sites to produce testos-terone,there are extremely active autophagy in them,and a decline in steroidogenesis has also been associated with the decline of autophagic flow.Moreover,the disruption of autophagy leads to decreased intracellular LDs,and there-fore affects testosterone synthesis in the Leydig cells(Danielsen et al..2016;Gao et al,2018). | Muhammad Babar Khawar Chao Liu Fengyi Gao Hui Gao Wenwen Liu Tingting Han Lina Wang Guoping Li Hui Jiang Wei Li | 2021 | Protein & Cell2021，12，1： | 3 |
| 9 | Phase Ⅲ Clinical Trials of the Cell Differentiation Agent-2 (CDA-2): Therapeutic Efficacy on Breast Cancer, Non-Small Cell Lung Cancer and Primary Hepatoma显示文摘 | Fengyi Feng Qing Lu Changquan Ling Yang Zhang Fengzhan Qin Huaqing Wang Wenxia Huang Shunchang Jiao Qiang Chen Mingzhong Li Yunzhong Zhu Meizhen Zhou Jun Ren Yetao Gao Jingpo Zhao Rongsheng Zheng Wenhua Zhao Zhiqiang Meng Fang Li Qizhong Zhang Dongli Zhao Liyan Xu Yongqiang Zhang Yanjun Zhang Zhenjiu Wang Shuonqi Liu Ming C. Liau | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 3 |
| 10 | Si-substrate LEDs with multiple superlattice interlayers for beyond 24 Gbps visible light communication显示文摘High-speed visible light communication(VLC)using light-emitting diodes(LEDs)is a potential complementary technology for beyond-5 G wireless communication networks.The speed of VLC systems significantly depends on the quality of LEDs,and thus various novel LEDs with enhanced VLC performance increasingly emerge.Among them,In Ga N/Ga N-based LEDs on a Si-substrate are a promising LED transmitter that has enabled VLC data rates beyond 10 Gbps.The optimization on the period number of superlattice interlayer(SL),which is a stressrelief epitaxial layer in a Si-substrate LED,has been demonstrated to be an effective method to improve Si-substrate LED’s luminescence properties.However,this method to improve LED’s VLC properties is barely investigated.Hence,we for the first time experimentally studied the impact of SL period number on VLC performance.Accordingly,we designed and fabricated an integrated 4×4 multichromatic Si-substrate wavelength-divisionmultiplexing LED array chip with optimal SL period number.This chip allows up to 24.25 Gbps/1.2 m VLC transmission using eight wavelengths,which is the highest VLC data rate for an In Ga N/Ga N LED-based VLC system to the best of our knowledge.Additionally,a record-breaking data rate of 2.02 Gbps over a 20-m VLC link is achieved using a blue Si-substrate LED with the optimal SL period number.These results validate the effectiveness of Si-substrate LEDs for both high-speed and long-distance VLC and pave the way for Si-substrate LED design specially for high-speed VLC applications. | FANGCHEN HU SHOUQING CHEN GUOQIANG LI PENG ZOU JUNWEN ZHANG JIAN HU JIANLI ZHANG ZHIXUE HE SHAOHUA YU FENGYI JIANG NAN CHI | 2021 | Photonics Research2021，9，8： | 3 |
| 11 | Effects of Angelica sinensis extracts on lipid oxidation in fish feeds and growth performance of juvenile Jian carp(Cyprinus carpio var. Jian)显示文摘The study was to explore the effect of the extracts of Angelica sinensis(EAs) on lipid oxidation in fish feeds compared with ethoxyquin(EQ) and the effect of dietary EAs on growth performance of carp(Cyprinus carpio var. Jian). Firstly, fish feeds were respectively added with EQ, and ethyl ether extract ethyl acetate extract(EAE), acetone extract, ethanol extract(EE) and aqueous extract(AQE) of Angelica sinensis, except for the control. The results showed that EAs and EQ inhibited lipid oxidation in fish feed(P < 0.05). Of all of the examined EAs, EAE showed the strongest protective effects against lipid oxidation(P < 0.05). Moreover, EAE at high concentrations showed a stronger effect on lipid oxidation compared with EQ(P < 0.05). Then, 7 experimental diets respectively supplemented with 0.0, 1.0, 2.0, 3.0, 4.0, 5.0 and 6.0 g/kg of EAE were fed to the respective treatment groups for 30 d. Four replicates were performed for each treatment group; 20 carp(mean weight: 12.10 ± 0.13 g) were in each replicate. The result indicated that dietary EAE improved the growth performance in carp(P < 0.05). The appropriate con centration of EAE for carp growth was estimated to be 3.643 g/kg diet. Thus, EAE could be used as a natural antioxidant in feeds for Jian carp. | Huatao Li Dandan Yang Zhihao Li Mingquan He Fengyi Li Jun Jiang Siyi Tang Peiyuan Peng Wenhao Du Yuting Ma Ying Liu | 2019 | Animal Nutrition2019，，1： | 2 |
| 12 | A review of ARGs in WWTPs:Sources,stressors and elimination显示文摘Antibiotic re sistance genes(ARGs)in aquatic enviro nments,which seriously endanger human health and ecological safety,have become a worldwide concern due to their easy diffusion and proliferation.Wastewater treatment plants(WWTPs),which receive resistant bacteria and ARGs from a wide variety of sources(i.e.,livestock farms,hospitals,antibiotic manufactures,and households),are regarded as important emission sources of aquatic ARGs.This review presents a quantitative profile of the majority sources of ARGs in the influent of WWTPs and discusses the potential factors that affect the concentration distribution of ARGs.Specifically,a noteworthy existence of ARGs,which ranged from 1 E+05 to 1 E+11 copies/mL,was detected in livestock breeding wastewater,and household wastewater(caused by the unlimited utilization of antibiotics)was determined to be the predominant contributor of ARGs in WWTPs.We summarized the selective pressure on ARGs and determined the positive correlation of the concentration of ARGs and the existence of many containments,including antibiotics,heavy metals(Zn and Cu were frequently reported),quaternary ammonium compounds,etc.In the last section,physical,chemical,and biological treatments for the removal of ARGs and their effluent in WWTPs are discussed and prospective future studies are summarized. | Kena Qin Liangliang Wei Jianju Li Bo Lai Fengyi Zhu Hang Yu Qingliang Zhao Kun Wang | 2020 | Chinese Chemical Letters2020，31，10： | 2 |
| 13 | The oral microbiome of pregnant women facilitates gestational diabetes discrimination显示文摘The oral microbiota plays an important role in the development of various diseases,whereas its association with gestational diabetes mellitus (GDM) remains largely unclear.The aim of this study is to identify biomarkers from the oral microbiota of GDM patients by analyzing the microbiome of the saliva and dental plaque samples of 111 pregnant women.We find that the microbiota of both types of oral samples in GDM patients exhibits differences and significantly varies from that of patients with periodontitis or dental caries.Using bacterial biomarkers from the oral microbiota,GDM classification models based on support vector machine and random forest algorithms are constructed.The area under curve (AUC) value of the classification model constructed by combination of Lautropia and Neisseria in dental plaque and Streptococcus in saliva reaches 0.83,and the value achieves a maximum value of 0.89 by adding clinical features.These findings suggest that certain bacteria in either saliva or dental plaque can effectively distinguish women with GDM from healthy pregnant women,which provides evidence of oral microbiome as an informative source for developing noninvasive biomarkers of GDM. | Xiaoqing Li Jiayong Zheng Xiuling Ma Bing Zhang Jinyang Zhang Wenhuan Wang Congcong Sun Yeping Wang Jianqiong Zheng Haiying Chen Jiejing Tao Hai Wang Fengyi Zhang Jinfeng Wang Hongping Zhang | 2021 | Journal of Genetics and Genomics2021，48，1： | 2 |
| 14 | Genome and Comparative Transcriptomics of African Wild Rice Oryza Iongistaminata Provide Insights into Molecular Mechanism of Rhizomatousness and Self-Incompatibility显示文摘Dear Editor, Oryza Iongistaminata is an African wild rice species with AA genome type possessing special traits that are highly valued for improving cultivated rice,such as strong resistance to biotic and abiotic stresses (Song et al.,1995) for improving resistance of cultivars,rhizomatousness for perennial breeding (Glover et al.,2010),and self-incompatibility (SI) for new ways to produce hybrid seeds (Ghesquiere,1986).Deciphering the genome of O.longistaminata will be the key to uncovering the mechanism of these hallmark traits and improving cultivated rice. | Yesheng Zhang Shilai Zhang Hui Liu Binying Fu Lijuan Li Min Xie Yue Song Xin Li Jing Cai Wenting Wan Ling Kui Hui Huang Jun Lyu Yang Dong Wensheng Wang Liyu Fluang Jing Zhang Qinzhong Yang Qinfi Shan Qiong Li Wangqi Huang Dayun Tao Muhua Wang Mingsheng Chen Yeisoo Yu Rod A. Wing Wen Wang Fengyi Hu | 2015 | Molecular Plant2015，8，11： | 1 |
| 15 | Effect of rare earth element europium on amaranthin synthesis in Amarathus caudatus seedlings显示文摘 | Fuli Zeng Hong Er Tian Zhipeng Wang Yi An Fengyi Gao Lijing Zhang Fengmin Li Lun Shan | 2003 | Biological Trace Element Research (-)2003，，1： | 1 |
| 16 | Benzene hydrogenation over amorphous NiB/bentonite catalyst and promoting effect of Nd 显示文摘 | ZHANG Rongbin LI Fengyi SHI Qiujie | 2003 | Applied Catalysis A2003，239，： | 1 |
| 17 | Inheritance and mapping of male sterility restoration gene in upland japonica restorer lines显示文摘 | Dayun Tao Peng Xu Jing Li Fengyi Hu Youqiong Yang Jiawu Zhou XueLing Tan Monty P. Jones | 2004 | Euphytica2004，，3： | 1 |
| 18 | Preparation of Carbon Nanotubes from Methane on Ni/Cu/Al Catalyst显示文摘A series of Ni/Cu/Al catalyst samples were prepared by the co-precipitation method. Carbon nanotubes with large inner diameters are successfully synthesized from methane on Ni/Cu/Al catalyst by adding sodium carbonate. The effects of the copper content and amounts of sodium carbonate on the morphology and microstructures of carbon nanotubes were investigated by CO adsorption and TEM technique. The experimental results showed that copper can influence both the catalytic activity and catalyst life. Best result was obtained when the copper content was 15%. Addition of sodium carbonate favors the formation of carbon nanotubes with large inner diameters. The growth mechanism of carbon nanotubes with large inner diameter is discussed. | Renzhong Wei Fengyi Li YaH Ju | 2005 | Journal of Natural Gas Chemistry2005，14，3： | 1 |
| 19 | Selective Synthesis of Dimethylamine Over Rare Earth Modified Mordenites显示文摘 | QIU ZUMIN LI FENGYI JIANG BOQUAN | 1998 | Journal of Natural Gas Chemistry1998，7，4： | 1 |
| 20 | The effects of rare earths on supported amorphous Ni-B/Al2O3catalysts显示文摘 | Rongbin Zhang Fengyi Li Qiujie Shi | 2001 | Applied Catalysis A:General2001，205，： | 1 |
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