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| 1 | Predicting lifetime risk for developing atherosclerotic cardiovascular disease in Chinese population:the China-PAR project显示文摘Evidence on the lifetime risk for atherosclerotic cardiovascular disease(ASCVD) is insufficient;yet,estimating an individual's lifetime risk allows for a comprehensive assessment of ASCVD burden.We developed and validated lifetime risk prediction equations for ASCVD using four large and ongoing prospective cohorts of Chinese,the China-PAR project(Prediction for ASCVD Risk in China).Sexspecific equations were developed using two cohorts(as the derivation cohort) of 21,320 participants.Two other independent cohorts with 14,123 and 70,838 participants were used for their external validation,respectively.We evaluated both calibration and discrimination measures for model performance.Furthermore,we estimated ASCVD-free years lost or excess absolute risk attributable to high 10-year risk(!10.0%) and/or high lifetime risk(!32.8%).After 12.3 years' follow-up of the derivation cohort,1048 ASCVD events and 1304 non-ASCVD deaths were identified.Our sex-specific equations had good internal validation,with discriminant C statistics of 0.776(95% confidence interval [CI]:0.757–0.794) and 0.801(95% CI:0.778–0.825),and calibration χ~2 of 9.2(P = 0.418) and 5.6(P = 0.777) for men and women,respectively.Good external validation was also demonstrated with predicted rates closely matched to the observed ones.Compared with men having both low 10-year and low lifetime risk,men would develop ASCVD 3.0,4.6 and 8.6 years earlier if they had high 10-year risk alone,high lifetime risk alone,or both high 10-year and high lifetime risk at the index age of 35 years,respectively.We developed wellperformed lifetime risk prediction equations that will help to identify those with the greatest potential to avert ASCVD burden after implementation of innovative clinical and public health interventions in China. | Fangchao Liu Jianxin Li Jichun Chen Dongsheng Hu Ying Li Jianfeng Huang Xiaoqing Liu Xueli Yang Jie Cao Chong Shen Ling Yu Zhendong Liu Xianping Wu Liancheng Zhao Xigui Wu Dongfeng Gu Xiangfeng Lu | 2018 | Science Bulletin2018，63，12： | 30 |
| 2 | ZIKA virus isolated from mosquitoes:a field and laboratory investigation in China,2016显示文摘A field investigation of arboviruses was conducted in Dejiang, Guizhou Province in the summer of 2016. A total of 8,795 mosquitoes, belonging to four species of three genera, and 1,300 midges were collected. The mosquito samples were identified on site according to their morphology, and the pooled samples were ground and centrifuged in the laboratory. The supernatant was incubated with mosquito tissue culture cells(C6/36) and mammalian cells(BHK-21) for virus isolation. The results indicated that 40%(3,540/8,795) were Anopheles sinensis, 30%(2,700/8,795) were Culex pipiens quinquefasciatus, and 29%(2,530/8,795)were Armigeres subbalbeatus. Furthermore, a total of eight virus isolates were obtained, and genome sequencing revealed two Zika viruses(ZIKVs) isolated from Culex pipiens quinquefasciatus and Armigeres subbalbeatus, respectively; three Japanese encephalitis viruses(JEVs) isolated from Culex pipiens quinquefasciatus; two Banna viruses(BAVs) isolated from Culex pipiens quinquefasciatus and Anopheles sinensis, respectively; and one densovirus(DNV) isolated from Culex pipiens quinquefasciatus.The ZIKVs isolated from the Culex pipiens quinquefasciatus and Armigeres subbalbeatus mosquitoes represent the first ZIKV isolates in China's Mainland. This discovery presents new challenges for the prevention and control of ZIKV in China, and prompts international cooperation on this global issue. | Shihong Fu Song Song Hong Liu Yuanyuan Li Xiaolong Li Xiaoyan Gao Ziqian Xu Guoping Liu Dingming Wang Zhenzao Tian Jingzhu Zhou Ying He Wenwen Lei Huanyu Wang Bin Wang Xiaoqing Lu Guodong Liang | 2017 | Science China(Life Sciences)2017，60，12： | 25 |
| 3 | Prediction of cervical lymph node metastases in papillary thyroid microcarcinoma by sonographic features of the primary site显示文摘Objective: To study the sonographic features of the primary site of papillary thyroid microcarcinoma(PTMC) for the prediction of cervical lymph node metastasis during preoperative diagnosis.Methods: A total of 710 PTMC patients between 2013 and 2016 with a diagnosis of cervical lymph node metastases were reviewed.We analyzed the sonographic features of the PTMC primary site to predict ipsilateral or central lymph node metastases in univariate and multivariate models.The ratio of abutment/perimeter of the PTMC primary site was utilized to evaluate cervical lymph node status.Results: Regarding clinical characteristics, multifocality and extrathyroidal extension were associated with cervical lymph node involvement.In the multivariate regression model, calcification and the abutment/perimeter ratio of lesions were evaluated as independent factors in level Ⅵ, ipsilateral or skip cervical lymph node metastases.The cut-off value of the ratio of abutment/perimeter of the PTMC primary site(25%) was significantly correlated with cervical lymph node metastases(P = 0.000).Conclusions: Independent sonographic features, including lesion size, lesion location, calcification, and the ratio of abutment/perimeter of the primary site, were associated with cervical lymph node metastases in PTMC patients. | Xi Wei Meng Wang Xiaoqing Wang Xiangqian Zheng Ying Li Yi Pan Yueguo Li Jiali Mu Yang Yu Dapeng Li Ming Gao Sheng Zhang | 2019 | Cancer Biology & Medicine2019，16，3： | 22 |
| 4 | Mechanical properties and corrosion behavior of selective laser melted 316L stainless steel after different heat treatment processes显示文摘Irregular grains, high interfacial stresses and anisotropic properties widely exist in 3D-printed metallic materials, and this paper investigated the effects of heat treatment on the microstructural, mechanical and corrosion properties of 316 L stainless steel fabricated by selective laser melting. Sub-grains and low-angle boundaries exist in the as-received selective laser melted(SLMed) 316 L stainless steel. After heat treatment at 1050℃, the sub-grains and low-angle boundaries changed slightly, and the stress state and strength decreased to some extent due to the decrease of dislocation density. After heat treatment at 1200℃, the grains became uniform, and the dislocation cells vanished, which led to a sharp decline in the hardness and strength. However, the ductility was improved after recrystallization heat treatment.The passive film thickness and corrosion potential of the SLMed 316 L stainless steel decreased after heat treatment, and the pitting potential also decreased due to the accelerated transition from metastable to steady-state pitting;this accelerated transition was caused by the presence of weak passive films at the enlarged pores after heat treatment, especially for an adequate solid solution treatment. | Decheng Kong Chaofang Dong Xiaoqing Ni Liang Zhang Jizheng Yao Cheng Man Xuequn Cheng Kui Xiao Xiaogang Li | 2019 | Journal of Materials Science & Technology2019，35，7： | 23 |
| 5 | Applications of metal–organic frameworks for green energy and environment: New advances in adsorptive gas separation, storage and removal显示文摘The separation of gas molecules with similar physicochemical properties is of high importance but practically entails a substantial energy penalty in chemical industry. Meanwhile, clean energy gases such as H_2 and CH_4 are considered as promising candidates for the replacement of traditional fossil fuels. However, the technologies for the storage of these gases are still immature. In addition, the release of anthropogenic toxic gases into the atmosphere is a worldwide threat of growing concern. Both in academia and industry, considerable research efforts have been devoted to developing advanced porous materials for the effective and energy-efficient separation, storage, or capture of the related gases. In contrast to conventional inorganic porous materials such as zeolites and activated carbons, metal–organic frameworks(MOFs) are considered as a type of promising materials for gas separation and storage. In this contribution, we review the recent research advance of MOFs in some relevant applications, including CO_2 capture, O_2 purification, separation of light hydrocarbons, separation of noble gases, storage of gases(CH_4,H_2, and C_2 H_2) for energy, and removal of some gaseous air pollutants(NH_3, NO_2, and SO_2). Finally, an outlook regarding the challenges of the future research of MOFs in these directions is given. | Bin Wang Lin-Hua Xie Xiaoqing Wang Xiao-Min Liu Jinping Li Jian-Rong Li | 2018 | Green Energy & Environment2018，3，3： | 18 |
| 6 | The M_S7.1 Yushu earthquake surface rupture and large historical earthquakes on the Garzê-Yushu Fault显示文摘As revealed by field investigations,the co-seismic surface rupture zone of the 2010 MS7.1 Yushu earthquake,Qinghai is a characteristic sinistral strike-slip feature consisting of three distinct sinistral primary ruptures,with an overall strike of 310°-320° and a total length of 31 km.In addition,an approximately 2-km-long en-echelon tensile fissure zone was found east of Longbao Town;if this site is taken as the north end of the rupture zone,then the rupture had a total length of ~51 km.The surface rupture zone is composed of a series of fissures arranged in an en-echelon or alternating relationship between compressive bulges and tensile fissures,with a measured maximum horizontal displacement of 1.8 m.The surface rupture zone extends along the mapped Garzê-Yushu Fault,which implicates it as the seismogenic fault for this earthquake.Historically,a few earthquakes with a magnitude of about 7 have occurred along the fault,and additionally traces of paleoearthquakes are evident that characterize the short-period recurrence interval of large earthquakes here.Similar to the seismogenic process of the 2008 Wenchuan earthquake,the Yushu earthquake is also due to the stress accumulation and release on the block boundaries resulting from the eastward expansion of Qinghai-Tibet Plateau.However,in contrast with the Wenchuan earthquake,the Yushu earthquake had a sinistral strike-slip mechanism resulting from the uneven eastward extrusion of the Baryan Har and Sichuan-Yunnan fault blocks. | CHEN LiChun WANG Hu RAN YongKang SUN XinZhe SU GuiWu WANG Ji TAN XiBin LI ZhiMin ZHANG XiaoQing | 2010 | Chinese Science Bulletin2010，55，31： | 17 |
| 7 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 8 | The Generation of Magnetic Field by Transverse Plasmons in Laser-Produced Plasma显示文摘In this paper,it is studied that a quasisteady magnetic field could be generated in laserproduced plasmas with highfrequency electromagnetic radiation through wavewave and waveparticle interactions in the vicinity of critical point.The behavior of selfgenerated magnetic field can be described by nonlinear coupling equations. [ | LIU Shanqiu LI Xiaoqing | 2000 | 江西教育学院学报2000，21，3： | 13 |
| 9 | Clinical characteristics of human infection with a novel avian-origin influenza A(H10N8) virus显示文摘 | Zhang Wei Wan Jianguo Qian Kejian Liu Xiaoqing Xiao Zuke Sun Jian Zeng Zhenguo Wang Qi Zhang Jinxiang Jiang Guanghui Nie Cheng Jiang Rong Ding Chengzhi Li Ran Horby Peter Gao Zhancheng | 2014 | Chinese Medical Journal2014，，18： | 12 |
| 10 | Mega-shoaling in carbonate platform of the Middle Triassic Leikoupo Formation,Sichuan Basin, Southwest China显示文摘Shoaling is a common type of sedimentation in the evolution of carbonate platform,and commonly has poor continuity.This paper presents a newly discovered and rare type of shoaling,i.e.,mega-shoaling in nearly basin scale,which is developed in the Middle Triassic Leikoupo Formation of the Sichuan Basin,southwest China.During the Leikoupo time,the studied Sichuan Basin experienced hot and dry climate conditions and developed a carbonate platform within a restricted epicontinental sea.In B sub-layer of the Lei-1-1 sub-member of the Leikoupo Formation a series of grainstones of shoal facies accumulated throughout almost the entire basin,thereby generating features associated with basin-scale mega-shoaling.By detailed core examination and microscopic observation of thin sections,it is shown that the lithology of this set of grainstones is dominated by doloarenite(calcarenite)followed by oolitic dolomite(limestone).In addition,it contains three types of sedimentary sequences characterized by upward-coarsening and upward-shallowing as the followings:restricted lagoon to platform interior beach;restricted lagoon to platform interior beach and to platform flat;and tidal flat to peritidal beach.Subsequently,a multicyclic stratigraphic division and correlation revealed that this set of grainstones can be well traced and compared horizontally,and is generally isochronous.In addition,a template for logging facies,established based on core calibrations and logging data,was employed to analyze the 235 wells in the basin.The results demonstrate the shoal grainstones to be 10–40 m thick with a15×104km2continuous distribution area.These findings indicate that the carbonate platform developed mega-shoals within a short period of time.The genesis of such a mega-shoaling was investigated by focusing on various shoaling conditions,such as paleo-tectonics,paleo-geomorphology,paleo-climate,sea-level changes,and palaeo-hydrodynamics.A specific combination of independent geological factors creates beneficial geomorphologic conditions for the mega-shoaling including a quiescent paleo-tectonic environment,relatively flat paleo-geomorphology and evaporites filling up and leveling off.In addition,a stably settling carbonate platform underwent sea-level fluctuations through swift transgressions and protracted regressions,which is not only conducive to continuous,multicyclic and superimposed vertical development of grain beaches but also beneficial for the horizontal migration,coalescence and superimposition of individual grain beaches.As a consequence,large-scale and continuously-distributed grain beach sedimentation emerges and mega-shoals develop. | TAN XiuCheng LI Ling LIU Hong CAO Jian WU XiaoQing ZHOU SuYan SHI XueWen | 2014 | Science China Earth Sciences2014，57，3： | 12 |
| 11 | Exposure to polycyclic aromatic hydrocarbons and risk for premature ovarian failure and reproductive hormones imbalance显示文摘Polycyclic aromatic hydrocarbons(PAHs)are a typical class of persistent organic pollutants that is ubiquitous worldwide.Previous animal studies suggested that PAHs had adverse effects on female reproduction.However,the human data regarding relationship of PAHs exposure with women reproductive health,such as ovarian dysfunction,are scarce.In this case-control study,the associations of serum levels of PAHs with the risk of premature ovarian failure(POF)and reproductive hormones in Chinese women were investigated,with recruiting 157 POF patients and 217 healthy women.The serum levels of 12 types of PAHs,as well as reproductive hormones,including follicle-stimulating hormone,luteinizing hormone and anti-mullerian hormone,were determined.In the logistic regression models,most individual PAH congeners showed significantly positive correlations with the risk of POF(p<0.05),except for fluorine and pyrene.Benzo(a)pyrene(BaP),as the most carcinogenic PAH congener,was observed to be significantly positively associated with the risk of POF.After adjustment for age,body mass index,educational levels and household income,per one-unit increase in the log-transformed BaP concentration was significantly correlated with 2.191-fold increased risk of POF(OR=2.191,95%CI:1.634-2.938,p<0.05).To the best of our knowledge,this is the first study to report an association between internal exposure levels of PAHs and the increased risk of POF in women. | Xiaoqing Ye Wuye Pan Chunming Li Xiaochen Ma Shanshan Yin Jianhong Zhou Jing Liu | 2020 | Journal of Environmental Sciences2020，32，5： | 10 |
| 12 | Challenges and recent progress in thermal management with heat pipes for lithium-ion power batteries in electric vehicles显示文摘Electric vehicles(EVs)are globally undergoing rapid developments,and have great potentials to replace the traditional vehicles based on fossil fuels.Power-type lithium-ion batteries(LIBs)have been widely used for EVs,owing to high power densities,good charge/discharge stability,and long cycle life.The driving ranges and acceleration performances are gaining increasing concerns from customers,which depend highly on the power level of LIBs.With the increase in power outputs,rising heat generation significantly affects the battery performances,and in particular operation safety.Meanwhile,the cold-start performance is still an intractable problem under extreme conditions.These challenges put forward higher requirements for a dedicated battery thermal management system(BTMS).Compared to traditional BTMSs in EVs,the heat pipe-based BTMS has great application prospects owing to its compact structure,flexibility,low cost,and especially high thermal conductivity.Encompassing this topic,this review first introduces heat generation phenomena and temperature characteristics of LIBs.Multiple abuse conditions and thermal runaway issues are described afterward.Typical cooling and preheating methods for designing a BTMS are also discussed.More emphasis on this review is put on the use of various heat pipes for BTMSs to enhance the thermal performances of LIBs.For lack of wide application in actual EVs,more efforts should be made to extend the use of heat pipes for constructing an energy-efficient,cost-effective,and reliable BTMS to improve the performances and safety of EVs. | HUANG Yao TANG Yong YUAN Wei FANG GuoYun YANG Yang ZHANG XiaoQing WU YaoPeng YUAN YuHang WANG Chun LI JinGuang | 2021 | Science China(Technological Sciences)2021，64，5： | 10 |
| 13 | Exosomes: roles and therapeutic potential in osteoarthritis显示文摘Exosomes participate in many physiological and pathological processes by regulating cell–cell communication, which are involved in numerous diseases, including osteoarthritis(OA). Exosomes are detectable in the human articular cavity and were observed to change with OA progression. Several joint cells, including chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and secrete exosomes that influence the biological effects of targeted cells. In addition, exosomes from stem cells can protect the OA joint from damage by promoting cartilage repair, inhibiting synovitis, and mediating subchondral bone remodeling.This review summarizes the roles and therapeutic potential of exosomes in OA and discusses the perspectives and challenges related to exosome-based treatment for OA patients in the future. | Zhenhong Ni Siru Zhou Song Li Liang Kuang Hangang Chen Xiaoqing Luo Junjie Ouyang Mei He Xiaolan Du Lin Chen | 2020 | Bone Research2020，8，2： | 10 |
| 14 | A LuxR family transcriptional regulator AniF promotes the production of anisomycin and its derivatives in Streptomyces hygrospinosus var.beijingensis显示文摘The protein synthesis inhibitor anisomycin features a unique benzylpyrrolidine system and exhibits potent selective activity against pathogenic protozoa and fungi.It is one of the important effective components in Agricultural Antibiotic120,which has been widely used as naturally-originated agents for treatment of crop decay in China.The chemical synthesis of anisomycin has recently been reported,but the complex process with low productivity made the biosynthesis still to be a vital mainstay in efforts.The biosynthetic gene cluster(BGC)of anisomycin in Streptomyces hygrospinosus var.beijingensis has been identified in our previous work,while poor understanding of the regulatory mechanism limited the yield enhancement via regulation engineering of S.hygrospinosus var.beijingensis.In this study here,we characterized AniF as an indispensable LuxR family transcriptional regulator for the activation of anisomycin biosynthesis.The genetic manipulations of aniF and the real-time quantitative PCR(RT-qPCR)revealed that it positively regulated the transcription of the anisomycin BGC.Moreover,the overexpression of aniF contributed to the improvement of the production of anisomycin and its derivatives.Dissection of the mechanism underlying the function of AniF revealed that it directly activated the transcription of the genes aniR-G involved in anisomycin biosynthesis.Especially,one AniF-binding site in the promoter region of aniR was identified by DNase I footprinting assay and an inverted repeat sequence(5′-GGGC-3′)composed of two 4-nt half sites in the protected region was found.Taken together,our systematic study confirmed the positive regulatory role of AniF and might facilitate the future construction of engineering strains with high productivity of anisomycin and its derivatives. | Jufang Shen Lingxin Kong Yan Li Xiaoqing Zheng Qing Wang Weinan Yang Zixin Deng Delin You | 2019 | Synthetic and Systems Biotechnology2019，4，1： | 10 |
| 15 | Genome sequencing and phylogenetic analysis of Banna virus(genus Seadornavirus,family Reoviridae)isolated from Culicoides显示文摘In an investigation of blood-sucking insects and arboviruses, a virus(YN12243) was isolated from Culicoides samples collected in the Sino-Burmese border region of Yunnan Province, China. The virus caused cytopathic effect(CPE) in C6/36 cells and passaged stably. Polyacrylamide gel analysis showed that the genome of YN12243 was composed of 12 segments of double-stranded RNA(dsRNA), with a distribution pattern of 6-6. The nucleotide and amino acid sequences of the coding region(1.12 segments) were17,803 bp and 5,925 amino acids in length, respectively. The phylogenetic analysis of VP1 protein(RdRp) revealed that YN12243 belonged to genus Seadornavirus of family Reoviridae, and further analysis indicated that YN12243 belongs to the Banna virus(BAV) genotype A2. Additionally, YN12243 was located in the same evolutionary cluster as BAV strains isolated from different mosquito species, suggesting that the BAV isolated from Culicoides does not have species barriers. These results indicate that Culicoides can also be a vector for BAV. In view of the hematophagous habits of Culicoides on cattle, horses, deer, and other large animals, as well as the possibility of spreading and causing a variety of animal arboviral diseases, it is important to improve infection detection and monitor the BAV in large livestock. | Song Song Yuanyuan Li Shihong Fu Wenwen Lei Xiaofang Guo Yun Feng Xiaoyan Gao Xiaolong Li Zhonghua Yang Ziqian Xu Ying He Huanyu Wang Hongning Zhou Bin Wang Xiaoqing Lu Guodong Liang | 2017 | Science China(Life Sciences)2017，60，12： | 8 |
| 16 | Discriminated sgRNAs-Based SurroGate System Greatly Enhances the Screening Efficiency of Plant Base-Edited Cells显示文摘The development of CRISPR/Cas9-mediated base editing has made genomic modification more efficient. However, selection of genetically modified cells from millions of treated cells, especially plant cells, is still challenging. In this study, an efficient surrogate reporter system based on a defective hygromycin resistance gene was established in rice to enrich base-edited cells. After step-by-step optimization, the Discriminated sgRNAs-based SurroGate system (DisSUGs) was established by artificially differentiating the editing abilities of a wild-type single guide RNA (sgRNA) targeting the surrogate reporter gene and an enhanced sgRNA targeting endogenous sites. The DisSUGs enhanced the efficiency of screening base-edited cells by 3- to 5-fold for a PmCDA1-based cytosine-to-tyrosine base editor (PCBE), and 2.5- to 6.5-fold for an adenine base editor (ABE) at endogenous targets. These targets showed editing efficiencies of <25% in the conventional systems. The DisSUGs greatly enhanced the frequency of homozygous substitutions and expanded the activity window slightly for both a PCBE and an ABE. Analyses of the total number of single-nucleotide variants from whole-genome sequencing revealed that, compared with the no-enrichment PCBE strategy, the DisSUGs did not alter the frequency of genome-wide sgRNA-independent off-target mutations, but slightly increased the frequency of target-dependent off-target mutations. Collectively, the DisSUGs developed in this study greatly enhances the efficiency of screening plant base-edited cells and will be a useful system in future applications. | Wen Xu Yongxing Yang Ya Liu Guiting Kang Feipeng Wang Lu Li Xinxin Lv Si Zhao Shuang Yuan Jinling Song Ying Wu Feng Feng Xiaoqing He Chengwei Zhang Wei Song Jiuran Zhao Jinxiao Yang | 2020 | Molecular Plant2020，13，1： | 8 |
| 17 | Fruit and vegetable consumption,cardiovascular disease,and all-cause mortality in China显示文摘Evidence about the response patterns of fruit and vegetable consumption with the risk of cardiovascular disease(CVD)and allcause mortality was inconsistent.These associations were examined using a large-scale,population-based Chinese cohort comprising 100,728 participants.A food-frequency questionnaire was used to assess fruit and vegetable consumption.Outcomes were ascertained by interviewing individuals or their proxies and checking hospital records or death certificates.Cox proportional hazards regression was used to calculate hazard ratios(HRs)with 95% confidence intervals(CIs).At the 736,668 person-years of follow-up,3,677 CVD cases and 5,466 deaths were identified.The multivariable-adjusted HRs for CVD across increasing quartiles of total fruit and vegetable consumption were 1(reference),0.94(95%CI=0.85-1.04),0.89(95%CI=0.80-0.98),and 0.85(95%CI=0.77-0.95).Moreover,participants in the highest quartile displayed a 13% lower risk of all-cause mortality(HR=0.87;95%CI=0.80-0.95).A nonlinear dose-response relation was found for CVD,without additional benefits beyond a consumption of600 g d-1,whereas the all-cause mortality risk decreased along with higher consumption,with a linear trend.These associations remained significant for fruit consumption but not for vegetable consumption.Our findings indicated that greater fruit and vegetable consumption was significantly associated with a lower risk of CVD and all-cause mortality.Increasing fruit and vegetable consumption,especially fruit,in the general population would prevent CVD and premature mortality. | Jun Wang Fangchao Liu Jianxin Li Keyong Huang Xueli Yang Jichun Chen Xiaoqing Liu Jie Cao Shufeng Chen Chong Shen Ling Yu Fanghong Lu Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Jianfeng Huang Dongfeng Gu Xiangfeng Lu | 2022 | Science China(Life Sciences)2022，65，1： | 8 |
| 18 | Targeted metabolomics of sulfated bile acids in urine for the diagnosis and grading of intrahepatic cholestasis of pregnancy显示文摘Intrahepatic cholestasis of pregnancy(ICP)is related to cholestatic disorder in pregnancy.Total urinary sulfated bile acids(SBAs)were found increased in ICP.We distinguished the metabolic profiling of urinary SBAs in ICP to find potential biomarkers for the diagnosis and grading of ICP.The targeted metabolomics based on high-performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS)was used to analyze urinary SBAs profiling in mild and severe ICP cases,as well as healthy controls.16 kinds of urinary SBAs were determined by HPLC-MS/MS.Sulfated dihydroxy glycine bile acid(di-GBA-S),glycine cholic acid 3-sulfate(GCA-3S),sulfated dihydroxy taurine bile acid(di-TBA-S)and taurine cholic acid 3-sulfate(TCA-3S)increased significantly in ICP group compared with the control group.Seven kinds of SBAs were significantly different(p<0.05)between the ICP group and the control group,with the variable importance in the projection(VIP)value more than one by the orthogonal partial least squares discriminant analysis(OPLS-DA).GCA-3S was well-suited to be used as the biomarker for the diagnosis of ICP with the sensitivity of 100%and specificity of 95.5%.A multi-variable logistic regression containing GCA-3S and di-GBA-S-1 was constructed to distinguish severe ICP from mild ICP,with the sensitivity of 94.4%and specificity of 100%.The developed HPLC-MS/MS method is suitable for the measurement of urinary SBAs profiling.Moreover,the urinary SBAs in the metabolomic profiling have the potential to be used as non-intrusive biomarkers for the diagnosis and grading of ICP. | Yuchao Li Xiaoqing Zhang Jianbo Chen Chengya Feng Yifan He Yong Shao Min Ding | 2018 | Genes & Diseases2018，5，4： | 8 |
| 19 | Associations of egg consumption with incident cardiovascular disease and all-cause mortality显示文摘Eggs are nutrient-dense while also loaded with abundant cholesterol, thus making the public hesitant about their consumption.We conducted the study to investigate if egg consumption is associated with incident cardiovascular disease(CVD) and all-cause mortality. Using the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China, we included 102,136 adults free of CVD and assessed their egg consumption with food-frequency questionnaires. CVD endpoints and all-cause mortality were confirmed during follow-ups by interviewing participants or their proxies and checking hospital records/death certificates.The HRs(95% CIs) were calculated using the cohort-stratified Cox regression models. During 777,163 person-years of followup, we identified 4,848 incident CVD and 5,511 deaths. U-shaped associations of egg consumption with incident CVD and allcause mortality were observed. Compared with consumption of 3–<6/week, the multivariable-adjusted HRs(95% CIs) of <1/week and ≥10/week for incident CVD were 1.22(1.11 to 1.35) and 1.39(1.28 to 1.52), respectively. The corresponding HRs(95% CIs) for all-cause mortality were 1.29(1.18 to 1.41) and 1.13(1.04 to 1.24). Our findings identified that both low and high consumption were associated with increased risk of incident CVD and all-cause mortality, highlighting that moderate egg consumption of 3–<6/week should be recommended for CVD prevention in China. | Xue Xia Fangchao Liu Xueli Yang Jianxin Li Jichun Chen Xiaoqing Liu Jie Cao Chong Shen Ling Yu Yingxin Zhao Xianping Wu Liancheng Zhao Ying Li Jianfeng Huang Xiangfeng Lu Dongfeng Gu | 2020 | Science China(Life Sciences)2020，63，9： | 7 |
| 20 | Development and validation of an ocean wave retrieval algorithm for VV-polarization Sentinel-1 SAR data显示文摘The purpose is to study the accuracy of ocean wave parameters retrieved from C-band VV-polarization Sentinel-1Synthetic Aperture Radar(SAR) images, including both significant wave height(SWH) and mean wave period(MWP), which are both calculated from a SAR-derived wave spectrum. The wind direction from in situ buoys is used and then the wind speed is retrieved by using a new C-band geophysical model function(GMF) model,denoted as C-SARMOD. Continuously, an algorithm parameterized first-guess spectra method(PFSM) is employed to retrieve the SWH and the MWP by using the SAR-derived wind speed. Forty–five VV-polarization Sentinel-1 SAR images are collected, which cover the in situ buoys around US coastal waters. A total of 52 subscenes are selected from those images. The retrieval results are compared with the measurements from in situ buoys. The comparison performs good for a wind retrieval, showing a 1.6 m/s standard deviation(STD) of the wind speed, while a 0.54 m STD of the SWH and a 2.14 s STD of the MWP are exhibited with an acceptable error.Additional 50 images taken in China's seas were also implemented by using the algorithm PFSM, showing a 0.67 m STD of the SWH and a 2.21 s STD of the MWP compared with European Centre for Medium-range Weather Forecasts(ECMWF) reanalysis grids wave data. The results indicate that the algorithm PFSM works for the wave retrieval from VV-polarization Sentinel-1 SAR image through SAR-derived wind speed by using the new GMF C-SARMOD. | LIN Bo SHAO Weizeng LI Xiaofeng LI Huan DU Xiaoqing JI Qiyan CAI Lina | 2017 | Acta Oceanologica Sinica2017，36，7： | 7 |
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