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| 1 | Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration显示文摘The capacity of 3D organoids to mimic physiological tissue organization and functionality has provided an invaluable tool to model development and disease in vitro.However,conventional organoid cultures primarily represent the homeostasis of self-organizing stem cells and their derivatives.Here,we established a novel intestinal organoid culture system composed of 8 components,mainly including VPA,EPZ6438,LDN193189,and R-Spondin 1 conditioned medium,which mimics the gut epithelium regeneration that produces hyperplastic crypts following injury;therefore,these organoids were designated hyperplastic intestinal organoids(Hyper-organoids).Single-cell RNA sequencing identified different regenerative stem cell populations in our Hyper-organoids that shared molecular features with in vivo injury-responsive Lgr5+stem cells or Clu+revival stem cells.Further analysis revealed that VPA and EPZ6438 were indispensable for epigenome reprogramming and regeneration in Hyper-organoids,which functioned through epigenetically regulating YAP signaling.Furthermore,VPA and EPZ6438 synergistically promoted regenerative response in gut upon damage in vivo.In summary,our results demonstrated a new in vitro organoid model to study epithelial regeneration,highlighting the importance of epigenetic reprogramming that pioneers tissue repair. | Molong Qu Liang Xiong Yulin Lyu Xiannian Zhang Jie Shen Jingyang Guan Peiyuan Chai Zhongqing Lin Boyao Nie Cheng Li Jun Xu Hongkui Deng | 2021 | Cell Research2021，31，3： | 9 |
| 2 | New technology to examine and improve the purity of hybrid rice with herbicide resistant gene显示文摘The herbicide resistant bar gene has been widely used as selectable marker genes in the study on plant genetic transformation. Owing to the integration of the gene into rice genome, transgenic rice was resistant to the herbicide Basta. Therefore, selection of transgenic plant and genetic analysis became easier. In the studies, bar gene was introduced as a genetic marker gene into rice restore line variety of two-line or three-line. Combined with conventional breeding method, the good herbicide resistant individual plant was derived as the new restore line for hybrid combination. After sprayed with Basta at seedling phase, the real hybrid rice that had herbicide resistance could grow normally, while the fake hybrid rice and weeds, having no bar gene, were killed by herbicide. The method described above helped rapidly to examine and improve the purity of hybrid rice. | Danian Huang Jingyang Li Shanqing Zhang Rui Xue Wei Yang Zhihua Hua Xiaobo Xie Xiaoling Wang | 1998 | Chinese Science Bulletin1998，43，9： | 7 |
| 3 | Effects of Suction Side Squealer Tip on the Performance of a Low-Speed Axial Compressor显示文摘This paper presents the investigation of the effects of suction side squealer tip on the performance of an axial compressor.The experiment is carried out in a single-stage large-scale low-speed compressor.The investigated tip geometries include flat tip as the baseline and suction side squealer tip.The tip clearance of the baseline is 0.5% of the blade span.The static pressure rise characteristic curves of both the rotor and the stage are measured.The flow field at the exit of the rotor is measured by a 5-hole probe under design and off-design conditions.The static pressure on the endwall of the rotor passage is also obtained.The results show that the pressure rise characteristic curves obtained by measuring the pressure on the end wall are almost unchanged by using the suction side squealer tip.The measuring results of the 5-hole probe show the static pressure and the total pressure in tip region is slightly greater than that of the flat tip at the design condition at the exit of the rotor.It also leads to greater av-eraged static pressure rise and total pressure.At the near stall condition,the averaged static pressure and total pressure is lower than the baseline which is related to the redistribution of the blade load caused by the suction side squealer tip. | Jun Zhang Hongwei Ma Jingyang Li | 2012 | Journal of Thermal Science2012，21，3： | 5 |
| 4 | Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords显示文摘Due to the dificulty in spinal cord regeneration with biological methods,the microelectronic neural bridge,a new concept based on microelectronic technology,is presented.The microelectronic system has been realized in the forms of hybrid and integrated circuits.The integrated circuits forneural signal detection,stimulation,and regeneration are realized in a CMOS process.In animal experiments with 100 toads,48 rats,and 3 rabbits,nerve signals have been successfully detected from spinal cords and sciatic nerves,and functional electrical stimulation has been carried out for spinal cords and sciatic nerves.When the microelectronic system is bridged between the controlling and stimulated nerve,the relevant motion of legs and nerve signal waveforms,which are stimulated by the evoked or spontaneous nerve signal through such a system,have been observed.Therefore,the feasibility of the presented method was demonstrated. | Zhigong Wang Xiaosong Gu Xiaoying Lǔ Zhenglin Jiang Wenyuan Li Guangming Lǔ Yufeng Wang Xiaoyan Shen Xintai Zhao Huiling Wang Zhenyu Zhang Hongmei Shen Yang Wu Weixing Shen Jingyang Zhang Dong Chen Xiaoyi Mao Huaxiang Shen | 2009 | Progress in Natural Science:Materials International2009，19，10： | 5 |
| 5 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science2013，，6146： | 4 |
| 6 | Weathering-pedogenesis of Carbonate Rocks and Its Environmental Effects in Subtropical Region显示文摘我们在中国的副热带的区域调查了碳酸盐岩石和它的环境效果的天气成土作用。调查证明碳酸盐岩石的天气成土作用在副热带的区域是腐蚀和淀积作用和交代作用的一个联合行动的过程。它被描绘由多级式,多路径和多风格。与碳酸盐岩石的天气成土作用的坚持的发展,交代矿床成土作用日益增多地成为了天气成土作用和矿物质的形成的主导的风格的主要过程。并且它通过碳酸盐岩石的天气成土作用的进化的整个过程继续。碳酸盐岩石的天气成土作用的阶段进化和最新生产的矿物质的分别进化被描绘由明显垂直地 zoning 结构和在捱过侧面的碳酸盐岩石中的元素 geochemical 特征的阶段的规则。碳酸盐岩石的天气成土作用的 geochemical 过程能被划分成三个 geochemical 进化阶段,即, Ca, Mg 弄空和 Si, Al 丰富舞台;Fe, Mn 丰富阶段和在副热带的区域的 Al 丰富舞台。与三个 geochemical 进化阶段一致,形成的顺序和矿物质的进化能被划分成泥土矿物质阶段;Fe, Mn 氧化物和 gibbsite 阶段。重元素的化学形式上的碳酸盐岩石的天气成土作用的影响主要在天气成土作用的过程经由最新生产的部件和矿物质被影响,例如,氧化铁矿物质和有机物。为 F 并且作为的动员,运输和污染的重要机制被影响 F 并且作为在在副热带的石灰岩地区常见的地形地区的氧化铁矿物质的表面上的选择吸附和解吸附作用,即,在天气成土作用的进程的最新生产的矿物质的矿物质表面上的选择吸附和解吸附作用在副热带的区域在地球的表面和环境质量上控制元素的 geochemical 行为。 | ZHU Lijun HE Shouyang LI Jingyang | 2008 | Acta Geologica Sinica(English Edition)2008，82，5： | 4 |
| 7 | Summary of Laurasiatheria (Mammalia) Phylogeny显示文摘 | Jingyang HU Yaping ZHANG Li YU | 2012 | Zoological Research2012，33，6： | 4 |
| 8 | Studies on the inheritance of transgenic rice with bar gene显示文摘Bar gene driven under the control of CaMV 35s promotor was delivered into the immature embroys of a japonica rice cultivar Jingying 119 through biolistic approach. Two putative transgenic plants were produced, which ex-pressed Basra-resistance. One of the Basra-re-sistance transgenic rices was completely sterile(JY 119-3), the other was self-fertile (JY119-4). | HUANG Danian, LI Jingyang, XIAO Han, ZHANG Shanqing, XUE Rui, WANG Xiaoling, YANG Wei, HUA Zhi-hua, and XIE Xiaobo, CNRRI, Hangzhou 310006, China | 1997 | Chinese Rice Research Newsletter1997，5，4： | 3 |
| 9 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science . 2013 (6146)2013，，： | 2 |
| 10 | Redevelopment of urban brownfield sites in China:Motivation,history,policies and improved management显示文摘Rapid urbanisation in China has resulted in an increased demand for land in towns and cities.To upgrade and modernise,China has also moved many major industries from urban centres to less populated areas.With the high economic value of urban land,the transformation and utilisation of brownfield areas have become important economically and socially.The Chinese government has recognised the need for strong frameworks to safeguard soil and groundwater quality,with brownfield sites a key category for management.Strong scientific,regulatory and decision-making frameworks are needed and being adopted to ensure practical,careful and wise use of central and localised government resources,to manage the reuse and regeneration of these brownfield sites.This paper reviews the context,policies and management procedures of developing brownfield sites in countries with a history of brownfield management and discusses China’s current situation and priorities for brownfield governance and redevelopment.These include(1)clarification of brownfield site soil contamination risk control standards and risk assessment procedures,(2)the responsibilities of different national and local agencies,(3)the establishment of a national expert committee to advise on best practices,policy and process,(4)the use of registered brownfield databases at national,provincial,municipal and county levels,and(5)the set up of soil pollution prevention fund at the provincial level. | Yiming Sun Hong Li Shuo Lei Kirk TSemple Frederic Coulon Qing Hu Jingyang Gao Guanlin Guo Qingbao Gu Kevin C.Jones | 2022 | Eco-Environment & Health2022，1，2： | 2 |
| 11 | Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer显示文摘Chronic atrophic gastritis(CAG),a common disease of digestive system,is an extremely important cause of gastric cancer(GC).The occurrence and development of CAG involves the abnormality of multiple signaling pathways.Traditional Chinese medicines(TCMs)has the advantages of mild action,multi-target and small adverse reaction,etc.,which broadens the way for the treatment of the disease,and TCMs can play a therapeutic role by regulating multiple signaling pathways.In this review,based on the related experiments of TCMs and Chinese herbal compounds in recent years,the related literatures were searched and 10 kinds of signaling pathways involved were summarized,in order to provide a reference for further research on reversing or delaying the progress of CAG and preventing gastric cancer. | Xinnan Liu Shuping Wang Jingyang Li Jingze Zhang Dailin Liu | 2022 | Chinese Herbal Medicines2022，14，1： | 2 |
| 12 | A rapid method for validation and visualization of agile Earth-observation satellites scheduling显示文摘This paper describes a rapid method for validation and visualization of agile Earth-observation satellites scheduling.Benefited from the previous work,various algorithms are proposed for scheduling the observations of agile satellites.However,the satellite maneuvers are three-dimensional,this characteristic makes it difficult for the operation engineers to validate and interpret the scheduled solutions.They have to plot these attitude data to analyze different situations such as an observing phase or a slew maneuver.Finally,one tries to imagine the three-dimensional situations from many one-dimensional plots,which is time-consuming and susceptible to errors.Moreover,now it is low-efficiency to deal with the data about ephemeris,targets,etc.,because different software platforms are required.In this research,a validation and visualization method is suggested to overcome this barrier.It is successful to integrate the Satellite Tool Kit ActiveX and the C#programming language.Based on the embedded scheme,all the interaction and assessment can be visualized.Practical techniques for modelling satellite objects,sensor objects,target objects and satellite attitudes are presented.Such a method has been applied for Chinese agile satellites project,and a software interface has been developed.The simulation results indicate that the proposed method is intuitive and efficient.Note that this method is general,and thus it can be applied to other Earth observation missions.Enough details are provided for interested readers to develop the software interface. | Mingwei Yin Jingyang Li Xianyu Wang Hexi Baoyin | 2018 | Astrodynamics2018，2，4： | 2 |
| 13 | Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects显示文摘Using chemoproteomic techniques,we first identified EIF2AK2,eEF1A1,PRDX3 and VPS4B as direct targets of berberine(BBR)for its synergistically anti-inflammatory effects.Of them,BBR has the strongest affinity with EIF2AK2 via two ionic bonds,and regulates several key inflammatory pathways through EIF2AK2,indicating the dominant role of EIF2AK2.Also,BBR could subtly inhibit the dimerization of EIF2AK2,rather than its enzyme activity,to selectively modulate its downstream pathways including JNK,NF-κB,AKT and NLRP3,with an advantage of good safety profile.In EIF2AK2 gene knockdown mice,the inhibitory IL-1β,IL-6,IL-18 and TNF-a secretion of BBR was obviously attenuated,confirming an EIF2AK2-dependent anti-inflammatory efficacy.The results highlight the BBR's network mechanism on anti-inflammatory effects in which EIF2AK2 is a key target,and inhibition of EIF2AK2 dimerization has a potential to be a therapeutic strategy against inflammationrelated disorders. | Wei Wei Qingxuan Zeng Yan Wang Xixi Guo Tianyun Fan Yinghong Li Hongbin Deng Liping Zhao Xintong Zhang Yonghua Liu Yulong Shi Jingyang Zhu Xican Ma Yanxiang Wang Jiandong Jiang Danqing Song | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 2 |
| 14 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science2013，，6146： | 2 |
| 15 | Tunable strength of SiCf/β-Yb_(2)Si_(2)O_(7) interface for different requirements in SiCf/SiC CMC:Inspiration from model composite investigation显示文摘Model composites consisting of Si C fiber embedded inβ-Yb_(2)Si_(2)O_(7) matrix were processed by Spark Plasma Sintering method and the feasibility of tunable Si Cf/Yb_(2)Si_(2)O_(7) interface in Si C-based CMCs were estimated.Weak and strengthened Si Cf/Yb_(2)Si_(2)O_(7) interfaces were achieved by adjusting sintering temperatures.The indentation crack test and fiber push out experiments clearly demonstrated the different debonding mechanisms in the samples.Weak interfaces sintered at 1200 and 1250℃exhibited crack deflection at interface in indentation test.Their low debond energy at the interface,which were comparable to those of Py C or BN,satisfied the well-recognized interfacial debond and crack deflection criteria for CMCs.The interface was strengthened by atomic bonding in model composite sintered at 1450℃,leading to crack penetrating into Si C fiber and high debond energy.The strong interface may be promising in Si Cf/Si C CMC to withstand higher combustion temperature,because Yb_(2)Si_(2)O_(7) will provide plastic deformation capacity,which would serve as weak interphase for crack deflection and energy dissipation.Therefore,it is possible to design the capability of Si C_(f)/RE_(2)Si_(2)O_(7) interface for different requirements by adjusting interfacial strength or debond energy to reach optimal mechanical fuse mechanism in SiC_(f)/SiC CMC. | Xirui Lv Mengkun Yue Wenfan Yang Xue Feng Xiaoyan Li Yumin Wang Jiemin Wang Jie Zhang Jingyang Wang | 2021 | Journal of Materials Science & Technology2021，，8： | 2 |
| 16 | PM_(2.5) exposure associated with microbiota gut-brain axis:Multi-omics mechanistic implications from the BAPE study显示文摘Recent studies have shown that PM_(2.5) may activate the hypothalamus-pituitary-adrenal(HPA)axis by inducing hormonal changes,potentially explaining the increase in neurological and cardiovascular risks.In addition,an association between PM_(2.5) and gut microbiota and metabolites was established.The above evidence represents crucial parts of the gut-brain axis(GBA).In view of this evidence. | Tiantian Li Jianlong Fang Song Tang Hang Du Liang Zhao Yanwen Wang Fuchang Deng Yuanyuan Liu Yanjun Du Liangliang Cui Wanying Shi Yan Wang Jiaonan Wang Yingjian Zhang Xiaoyan Dong Ying Gao Yu Shen Li Dong Huichan Zhou Qinghua Sun Haoran Dong Xiumiao Peng Yi Zhang Meng Cao Hong Zhi Jingyang Zhou Xiaoming Shi | 2022 | The Innovation2022，3，2： | 2 |
| 17 | MoS_(2) reinforced PEEK composite for improved aqueous boundary lubrication显示文摘Polyether-etherketone(PEEK)is a corrosion-resistant material that has been widely used in aqueous lubrication.However,its anti-wear performance must be improved for its application in the industry.In this study,to improve the anti-wear performance of PEEK for aqueous boundary lubrication,PEEK/MoS_(2)composites were prepared by ball-milling and spark plasma sintering processes.A competitive MoS_(2)mechanism between the low shear strength property and the role of promoting wear debris generation influences the anti-wear performance of PEEK/MoS_(2)composites.Experiments demonstrated that the coefficients of friction(COF)and wear rate of PEEK composite with 0.25 wt%MoS_(2)were significantly reduced 68%and 94%,respectively.Furthermore,this was the first time that a PEEK composite could achieve a COF of less than 0.05 in aqueous boundary lubrication.Its anti-wear performance was verified to be better than that of PEEK/carbon fiber(CF)and Thordon composites.The PEEK/MoS_(2)composite may be a potential material for underwater equipment because of its outstanding anti-wear performance in aqueous boundary lubrication. | Xin HOU Pengpeng BAI Jingyang LI Yuanzhe LI Hui CAO Xiangli WEN Yonggang MENG Liran MA Yu TIAN | 2023 | Friction2023，11，9： | 2 |
| 18 | Achieving a stable COF with the combination of“flat”and“twist”large-size rigid synthons for selective gas adsorption and separation显示文摘A new type of covalent organic framework(COF)was achieved using combination of structrally rigid and conformationally othorganal building blocks.The N-2-aryl-substituted triazole derivative(NAT-CHO)was prepared with co-planar conformation among the three aromatic rings as the“flat”building block.The 4,4,4,4-(ethene-1,1,2,2-tetrayl)tetraaniline)(ETTA)was applied as the“twist”building block.A 2 D sheet of network was obtained through imine formation.The resulting NAT-COF gave excellent thermal and chemical stability,survived aqueous solutions from p H 5 to 13.With large-size building blocks,the porous framework NAT-COF gave efficient gas adsorption with excellent selectivity of C3 propane over C1 me-thane,suggesting its potential application for selective gas capture and separation. | Jingyang Li Ying He Yongcun Zou Yan Yan Zhiguang Song Xiaodong Shi | 2022 | Chinese Chemical Letters2022，33，6： | 1 |
| 19 | Summary of Laurasiatheria(Mammalia)Phylogeny显示文摘Laurasiatheria is one of the richest and most diverse superorders of placental mammals.Because this group had a rapid evolutionary radiation,the phylogenetic relationships among the six orders of Laurasiatheria remain a subject of heated debate and several issues related to its phylogeny remain open.Reconstructing the true phylogenetic relationships of Laurasiatheria is a significant case study in evolutionary biology due to the diversity of this suborder and such research will have significant implications for biodiversity conservation.We review the higher-level(inter-ordinal)phylogenies of Laurasiatheria based on previous cytogenetic,morphological and molecular data,and discuss the controversies of its phylogenetic relationship.This review aims to outline future researches on Laurasiatheria phylogeny and adaptive evolution. | Jingyang HU Yaping ZHANG Li YU | 2012 | Zoological Research2012，33，S03： | 1 |
| 20 | Recent advanced development of stabilizing sodium metal anodes显示文摘As the application of next-generation energy storage systems continues to expand,rechargeable secondary batteries with enhanced energy density and safety are imperative for energy iteration.Sodium-ion batteries(SIBs)have attracted extensive attention and are recognized as ideal candidates for large-scale energy storage due to the abundant sodium resources and low cost.Sodium metal anodes(SMAs)have been considered as one of the most attractive anode materials for SIBs owing to their high specific capacity(1166 mAh g^(-1)),low redox potential,and abundant natural resources.However,the uncontrollable dendrite growth and inevitable side reactions on SMA lead to the continuous deterioration of the electrochemical performance,causing serious safety concerns and limiting their practical application in the future.Therefore,the construction of stable dendrite-free SMAs is a pressing problem for advanced sodium metal batteries(SMBs).In this review,we comprehensively summarize the research progress in suppressing the formation of sodium dendrite,including artificial solid electrolyte interphase(SEI),liquid electrolyte modification,three-dimensional(3D)host materials,and solid-state electrolyte.Additionally,key aspects and prospects of future research directions for SMAs are highlighted.We hope that this timely review can provide an overall picture of sodium protection strategies and stimulate more research in the future. | Liyu Zhu Yucheng Li Jingyang Zhao Jing Liu Luying Wang Jiandu Lei | 2023 | Green Energy & Environment2023，8，5： | 1 |
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