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| 1 | Correction of β-thalassemia mutant by base editor in human embryos显示文摘 | Puping Liang Chenhui Ding Hongwei Sun Xiaowei Xie Yanwen Xu Xiya Zhang Ying Sun Yuanyan Xiong Wenbin Ma Yongxiang Liu Yali Wang Jianpei Fang Dan Liu Zhou Songyang Canquan Zhou Junjiu Huang | 2017 | Protein & Cell2017，8，11： | 34 |
| 2 | Liuwei Dihuang, a traditional Chinese herbal formula, suppresses chronic inflammation and oxidative stress in obese rats显示文摘OBJECTIVE: To investigate the anti-infl ammatory, anti-oxidative stress, and adipokine-ameliorating effects of Liuwei Dihuang(LWDH), a traditional Chinese herbal formula, in obese rats. METHODS: After 2 weeks of acclimation with free access to regular rodent chow and water, obese-prone-caesarean-derived(OP-CD) rats were fed a modified AIN-93 G diet containing 60% energy from fat. Treatment was performed twice daily by gavage feeding with 500, 1 500, or 3 500 mg/kg body weight LWDH suspended in water(n=12 rats per group). Twelve obese-resistant-CD(OR-CD) rats were fed the atherogenic diet and gavaged with water, and served as the normal control. Blood biomarkers of inflammation, oxidative stress and adiponectin were measured post-sacrifi ce and used to determine the treatment effect of LWDH and assess the suitability of OR/OP-CD rats for studying these parameters. RESULTS: After 9 weeks of treatment, LWDH lowered serum C-reactive protein(CRP) and tumour necrosis factor-α(TNF-α) levels. Serum interleukin-6(IL-6) levels showed a tendency towards reduction, but were not signifi cantly different from the OP-CD control. Liver superoxide dismutase(SOD) activity was increased in response to all three doses of LWDH, while the levels of reduced(GSH) and oxidized glutathione(GSSG) and thiobarbituric acid reactive substances(TBARS) were unchanged. Serum adiponectin levels were increased in response to oral administration of LWDH at the dose of either 500 or 1 500 mg/kg body weight. In addition, comparisons between OR-CD and OP-CD rats revealed differential, and for some biomarkers, conflicting characteristics of high-fat diet-fed OP-CD rats in reference to obese human subjects in terms of infl ammatory and oxidative stress biomarkers and circulating adiponectin levels. CONCLUSION: The results show, for the fi rst time, the anti-infl ammatory, anti-oxidative stress and adiponectin-ameliorating effects of LWDH in obese rats. The suitability of the OR/OP-CD rat model as a research tool to study infl ammation, oxidative stress, and adipokine production requires further investigation. | Benjamin Perry Junzeng Zhang Tarek Saleh Yanwen Wang | 2014 | Journal of Integrative Medicine2014，12，5： | 14 |
| 3 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 4 | Development and case study of a science-based software platform to support policy making on air quality显示文摘This article describes the development and implementations of a novel software platform that supports real-time, science-based policy making on air quality through a user-friendly interface. The software, RSM-VAT, uses a response surface modeling(RSM) methodology and serves as a visualization and analysis tool(VAT) for three-dimensional air quality data obtained by atmospheric models. The software features a number of powerful and intuitive data visualization functions for illustrating the complex nonlinear relationship between emission reductions and air quality benefits. The case study of contiguous U.S.demonstrates that the enhanced RSM-VAT is capable of reproducing the air quality model results with Normalized Mean Bias < 2% and assisting in air quality policy making in near real time. | Yun Zhu Yanwen Lao Carey Jang Chen-Jen Lin Jia Xing Shuxiao Wang Joshua S.Fu Shuang Deng Junping Xie Shicheng Long | 2015 | Journal of Environmental Sciences2015，27，1： | 10 |
| 5 | Abscisic Acid Antagonizes Ethylene Production through the ABI4-Mediated Transcriptional Repression of ACS4 and ACS8 in Arabidopsis显示文摘增加的证据表明了 abscisic 酸(骆驼毛的织物) 否定地调制乙烯生合成,尽管内在的机制仍然保持不清楚。为了识别因素,包含了,我们在 Arabidopsis 与改变的乙烯生产为骆驼毛的织物感觉迟钝的异种进行了一幅屏幕。ABI4 的主导的等位基因, abi4-152,在 ABI4 的 C 终点与 16-amino-acid 截断生产通常认为的蛋白质,减少乙烯生产。由对比, ABI4 的二后退的猛烈等位基因, abi4-102 和 abi4-103,导致增加的乙烯进化,显示 ABI4 否定地调整乙烯生产。进一步的分析证明乙烯生合成基因 ACS4, ACS8,和 ACO2 的 thatexpression 显著地在 abi4-152 被减少,但是在猛烈异种增加了,与骆驼毛的织物上的部分依赖。染色质 immunoprecipitation 量的 PCR 试金证明 ABI4 直接绑这些乙烯生合成基因的倡导者,那件骆驼毛的织物提高这个相互作用。包含截断的 ABI4-152 肽的熔化蛋白质在转基因的植物比它的全身的对应物积累了到高水平,建议 ABI4 被它的 C 终点使动摇。因此,我们的结果证明那件骆驼毛的织物否定地在 Arabidopsis 通过乙烯生合成基因 ACS4 和 ACS8 的调停 ABI4 的 transcriptional 压抑调整乙烯生产。 | Zhijun Dong Yanwen Yu Shenghui Li Juan Wang Saijun Tang Rongfeng Huang | 2016 | Molecular Plant2016，9，1： | 9 |
| 6 | Applicability and Generality of the Modified Grübler-Kutzbach Criterion显示文摘A generally applicable criterion for all mechanism mobility has been an active domain in mechanism theory lasting more than 150 years. It is stated that the Modified Grübler-Kutzbach criterion for mobility has been successfully used to solve the mobility of many more kinds of mechanisms, but never before has anyone proven the applicability and generality of the Modified Grübler-Kutzbach criterion in theory. In order to fill the gap, the applicability and generality of the Modified Grübler-Kutzbach Criterion of mechanism mobility is systematically demonstrated. Firstly, the mobility research background and the Modified Grübler-Kutzbach criterion are introduced. Secondly, some new definitions, such as half local freedom, non-common constraint space of a mechanism and common motion space of a mechanism, etc, are given to demonstrate the correctness and broad applicability of the Modified Grübler-Kutzbach criterion. Thirdly, the general applicability of the Modified Grübler-Kutzbach criterion is demonstrated based on screw theory. The mobilities of the classical DELASSUS mechanisms and a modern planar parallel mechanism, are determined through the Modified Grübler-Kutzbach criterion, which are as examples to show the practical application of the Modified Grübler-Kutzbach criterion. | LI Yanwen WANG Lumin LIU Jingfang HUANG Zhen | 2013 | Chinese Journal of Mechanical Engineering2013，26，2： | 6 |
| 7 | Phosphorus release potential and pollution characteristics of sediment in downstream Nansi Lake, China显示文摘The research aimed to evaluate present and potential phosphorous pollution due to high sedimentary phosphorus load and release from sediment, when external phosphorus was reduced in downstream Nansi Lake. Pollution load of the sediment and overlying water was investigated. Kinetics and isotherms of adsorption/release of sedimentary phosphorus were studied to determine equilibrium phosphate concentration (EPCo) and release potential. Kinetics of phosphorus adsorption on sediment and release from sediment were well described by both the pseudo-first-order rate equation and the pseudo-second- order rate equation, but more appropriate to the pseudo- second-order rate equation with the adsorption/release capacity more close to the measured values, suggesting that the processes were chemically rate controlled and dependent on adsorption capacity. Soluble reactive phosphorus (SRP) sorption isotherms on sediment were best fitted by the modified Langmuir model indicating a monolayer adsorption. By comparing EPC0 and SRP of water, the status (adsorption, releasing or in equilibrium) of sediment phosphorus could be determined. The sediments at site S l, S3, S4, S5, and S7 where the EPC0s were greater than the SRPs, had a potential to release phosphorus into the water column. However, those sediments at S9, S10, and S 12, where the EPC0s were approximately equal to the SRPs, were in impermanent equilibrium with overlying water in status of phosphorus, the sediments can be likely to release phosphorus to the water column once the equilibrium was broken. Therefore, sedimentary phos- phorus can be a secondary pollution source in downstream Nansi Lake. | Zhijian LI Qinyan YUE Baoyu GAO Yanwen WANG Qing LIU | 2012 | Frontiers of Environmental Science & Engineering2012，6，2： | 5 |
| 8 | Influence of B,Al and Nb addition on the glass forming ability and stability of mechanically alloyed Zr-Ni amorphous alloys显示文摘We investigated the influence of minor additions of B,Al and Nb that have representative atomic sizes on the glass forming ability (GFA) and stability of Zr-Ni amorphous alloys during mechanical alloying. The results show that the minor addition of B,Al or Nb does not shorten the initial time of the full amorphization reaction or improve the glass forming ability of the Zr-Ni alloys at a low rotation speed. However,B addition can effectively improve the mechanical stability of the amorphous phase against mechanically induced crystallization. Furthermore,the amorphous phase gradually transforms into a metastable fcc-phase with increasing milling time. The addition of Al and Nb that have similar atomic sizes has a similar effect on the GFA and the mechani-cal stability of the Zr-Ni amorphous phase. Moreover,Al and Nb addition can alter the crystallization behavior and improve the thermal stability of the Zr-Ni amorphous phase. | WANG Yan DING JunFeng BAI YanWen | 2011 | Chinese Science Bulletin2011，56，36： | 5 |
| 9 | Wafer-scale arrayed p-n junctions based on few-layer epitaxial GaTe显示文摘二维(2D ) 材料吸引了实质的注意在电子并且有灵活、透明、高度悦耳的优异优点的 optoelectronic 应用。当时,无差距的 graphene 展出极端宽带、快的 photoresponse 半导体的瞬间 2 和门高展出的 2D 敏感和悦耳的 responsivity 到可见的光。然而,设备收益和重覆性打电话让进一步的改进完成大规模一致性。这里,我们与 28.4 厘米 2/(V0 的高洞活动性报导晶片规模门的 layer-by-layer | Xiang Yuan Lei Tang Peng Wang Zhigang Chen Yichao Zou Xiaofeng Su Cheng Zhang Yanwen Liu Weiyi Wang Cong Liu Fansheng Chen Jin Zou Peng Zhou Weida Hu Faxian Xiu | 2015 | Nano Research2015，8，10： | 4 |
| 10 | A prospective study (SCOPE) comparing the cardiometabolic and respiratory effects of air pollution exposure on healthy and pre-diabetic individuals显示文摘Air pollution is known to be a major risk factor for cardiopulmonary disease, but this is unclear for cardiometabolic disease (e.g.diabetes). This is of considerable public health importance, given the nationwide epidemic of diabetes, accompanied by severe air pollution, in China. The evidence so far remained inadequate to answer questions of whether individuals with cardiometabolic dysfunctions are susceptible to air pollution and whether air pollution exacerbates diabetes development via certain biological pathways. In this manuscript, we summarize the results and limitations of studies exploring these two topics and elaborate our design of a prospective panel study (SCOPE) as a solution. We assessed and compared the health effect of air pollution among pre-diabetic individuals and matched healthy controls through four repeated clinical visits over 1 year. Comprehensive evaluation was made to both health endpoints and exposure. The primary biomarkers were assessed to reveal the impact on multiple biological pathways, including glycolipid metabolism and insulin resistance, endothelial function, and inflammation. Detailed chemical and size fractional components of particulate matter were measured in this study, along with the application of personal monitors.The work should increase our understanding of how air pollution affects individuals with cardiometabolic dysfunction and the underlying mechanisms. | Yanwen Wang Yiqun Han Tong Zhu Weiju Li Hongyin Zhang | 2018 | Science China(Life Sciences)2018，61，1： | 4 |
| 11 | Diagnostic value of negative enrichment and immune fluorescence in situ hybridization for intraperitoneal free cancer cells of gastric cancer显示文摘Objective:To explore the intraperitoneal free cancer cell(IFCC)detection value of negative enrichment and immune fluorescence in situ hybridization(NEimFISH)on chromosomes(CEN)8/17.Methods:To verify the reliability of NEimFISH,29 gastric cancer tumors,their adjacent tissues and greater omental tissues were tested.Our study then included 105 gastric cancer patients for IFCC.We defined patients as IFCC-positive if a signal was detected,regardless of the detailed cancer cell numbers.A comparison of clinicopathological features was conducted among IFCC groups.We also compared the diagnosis value and peritoneal recurrence predictive value among different detection methods.The comparison of IFCC number was also conducted among different groups.Results:A cutoff of 2.5 positive cells could distinguish all benign tissue samples and 97%of malignant tissue samples in our study.Compared to intestinal gastric cancer,patients with diffuse gastric cancer tended to have more IFCCs(6 vs.4,P=0.002).The IFCC counts were often higher in the lymphovascular invasion positive group than negative group(3 vs.1,P=0.022).All IFCC samples that were considered positive using conventional cytology were also found to be positive using NEimFISH.When compared to conventional cytology and paraffin pathology,NEimFISH had a higher IFCC positive rate(68.9%)and higher one-year peritoneal recurrence predictive value with area under the curve(AUC)of 0.922.Conclusions:Gastric cancer could be effectively diagnosed by NEimFISH.The IFCC number found using NEimFISH on CEN8/17 is closely associated with Lauren type and vascular invasion of cancer.NEimFISH is a reliable detection modality with a higher positive detection rate,higher one-year peritoneal recurrence predictive value and quantitative features for IFCC of gastric cancer. | Anqiang Wang Zhongwu Li Qian Wang Yali Bai Xin Ji Tao Fu Ke Ji Yanwen Xue Tingxu Han Xiaojiang Wu Ji Zhang Yingjie Yang Guobin Xu Zhaode Bu Jiafu Ji | 2019 | Chinese Journal of Cancer Research2019，31，6： | 3 |
| 12 | Fabrication of Periodic Nanostructures Using AFM Tip-Based Nanomachining:Combining Groove and Material Pile-Up Topographies显示文摘This paper presents an atomic force microscopy(AFM)tip-based nanomachining method to fabricate periodic nanostructures.This method relies on combining the topography generated by machined grooves with the topography resulting from accumulated pile-up material on the side of these grooves.It is shown that controlling the distance between adjacent and parallel grooves is the key factor in ensuring the quality of the resulting nanostructures.The presented experimental data show that periodic patterns with good quality can be achieved when the feed value between adjacent scratching paths is equal to the width between the two peaks of material pile-up on the sides of a single groove.The quality of the periodicity of the obtained nanostructures is evaluated by applying one-and two-dimensional fast Fourier transform(FFT)algorithms.The ratio of the area of the peak part to the total area in the normalized amplitude–frequency characteristic diagram of the cross-section of the measured AFM image is employed to quantitatively analyze the periodic nanostructures.Finally,the optical effect induced by the use of machined periodic nanostructures for surface colorization is investigated for potential applications in the fields of anti-counterfeiting and metal sensing. | Yanquan Geng Yongda Yan Jiqiang Wang Emmanuel Brousseau Yanwen Sun Yazhou Sun | 2018 | Engineering2018，4，6： | 3 |
| 13 | Optical superoscillatory waves without side lobes along a symmetric cut显示文摘Optical superoscillation refers to an intriguing phenomenon of a wave packet that can oscillate locally faster than its highest Fourier component,which potentially produces an extremely localized wave in the far field.It provides an alternative way to overcome the diffraction limit,hence improving the resolution of an optical microscopy system.However,the optical superoscillatory waves are inevitably accompanied by strong side lobes,which limits their fields of view and,hence,potential applications.Here,we report both experimentally and theoretically a new superoscillatory wave form,which not only produces significant feature size down to deep subwavelength,but also completely eliminates side lobes in a particular dimension.We demonstrate a new mechanism for achieving such a wave form based on a pair of moonlike sharp-edge apertures.The resultant superoscillatory wave exhibits Bessel-like forms,hence allowing long-distance propagation of subwavelength structures.The result facilitates the study of optical superoscillation and on a fundamental level eliminates the compromise between the superoscillatory feature size and the field of view. | Yanwen Hu Shiwang Wang Junhui Jia Shenhe Fu Hao Yin Zhen Li Zhenqiang Chen | 2021 | Advanced Photonics2021，3，4： | 3 |
| 14 | Synthesis,Characterization and Electromagnetic Studies on Nanocrystalline Nickel Zinc Ferrite by Polyacrylamide Gel显示文摘Nanocrystalline 镍锌铁酸盐粉末(Ni_xZni_(1-x ) Fe2O4,为 x=0 的 A,为 x=0.2 的 B,为 x=0.5 的 C,为 x-0.8 的 D 和为 x=1 的 E ) 被聚丙烯酰氨综合胶化方法。X 光检查衍射(XRD ) ,传播电子显微镜学(TEM ) 和波导被用来描绘作文。弄干的胶化粉末是非结晶的 XRD 结果表演,和特征尖晶石Ni_( 0.5 )Zn_( 0.5 ) Fe2O4 达到顶点在胶化为锻烧的温度是的 1 h.When 在 400 °C 被锻烧以后,出现 600 和 800 °C ,平均谷物尺寸被是 10 和 30 nm 的 TEM 识别, respectively.The Ni_xZn_( 1-x ) Fe2O4 粉末在Ni^(2+)离子的增加满足的 8.2-11.0GHz .With 的频率范围有绝缘的损失和磁性的损失,当时,绝缘的参数(epsilon')和Ni_xZn_( 1-x ) Fe2O4 粉末的渗透(mu')减少绝缘的损失( epsilon “),磁性的损失(亩”)并且思考损失增加。 | Ruiting MA Yi WANG Yanwen TIAN Chunli ZHANG Xikun LI | 2008 | Journal of Materials Science & Technology2008，24，3： | 2 |
| 15 | Efficient sequential harvesting of solar light by heterogeneous hollow shells with hierarchical pores显示文摘In nature,sequential harvesting of light widely exists in the old life entity,i.e.cyanobacteria,to maximize the light absorption and enhance the photosynthesis efficiency.Inspired by nature,we propose a brand new concept of temporally-spatially sequential harvesting of light in one single particle,which has purpose-designed heterogeneous hollow multi-shelled structures(HoMSs)with porous shells composed of nanoparticle subunits.Structurally,HoMSs consist of different band-gap materials outside-in,thus realizing the efficient harvesting of light with different wavelengths.Moreover,introducing oxygen vacancies into each nanoparticle subunit can also enhance the light absorption.With the benefit of sequential harvesting of light in HoMSs,the quantum efficiency at wavelength of 400 nm is enhanced by six times compared with the corresponding nanoparticles.Impressively,using these aforementioned materials as photocatalysts;highly efficient photocatalytic water splitting is realized,which cannot be achieved by using the nanoparticle counterparts.This new concept of temporally-spatially sequential harvesting of solar light paves the way for solving the ever-growing energy demand. | Yanze Wei Jiawei Wan Nailiang Yang Yu Yang Yanwen Ma Songcan Wang Jiangyan Wang Ranbo Yu Lin Gu Lianhui Wang Lianzhou Wang Wei Huang Dan Wang | 2020 | National Science Review2020，7，11： | 2 |
| 16 | Study on Corrosion Mechanism Between MgO-CaO Refractories and Slag显示文摘Magnesia-Calcia materials containing 22-53 wt% CaO have been investigated for refinery slag corrosion and penetration resistance by Scanning Electron Microscopy (SEM) and XRD. The corrosion and penetration resistance of MgO-CaO materials is enhanced with the increase of CaO content in specimens. It can be explained that, with increase of CaO content, the specimens reacted with slag form higher melting point minerals of C3S and C2S, creating a dense surface layer, which stopped others from penetrating further. Thus, the corrosion and penetration resistance was improved. No matter what kinds of slag were chosen, the depth of penetration decreased with increase of CaO content. | YU Yanwen WANG Ning | 2006 | China's Refractories2006，15，4： | 2 |
| 17 | PM_(2.5) exposure associated with microbiota gut-brain axis:Multi-omics mechanistic implications from the BAPE study显示文摘Recent studies have shown that PM_(2.5) may activate the hypothalamus-pituitary-adrenal(HPA)axis by inducing hormonal changes,potentially explaining the increase in neurological and cardiovascular risks.In addition,an association between PM_(2.5) and gut microbiota and metabolites was established.The above evidence represents crucial parts of the gut-brain axis(GBA).In view of this evidence. | Tiantian Li Jianlong Fang Song Tang Hang Du Liang Zhao Yanwen Wang Fuchang Deng Yuanyuan Liu Yanjun Du Liangliang Cui Wanying Shi Yan Wang Jiaonan Wang Yingjian Zhang Xiaoyan Dong Ying Gao Yu Shen Li Dong Huichan Zhou Qinghua Sun Haoran Dong Xiumiao Peng Yi Zhang Meng Cao Hong Zhi Jingyang Zhou Xiaoming Shi | 2022 | The Innovation2022，3，2： | 2 |
| 18 | Optimization of sampling frequency for routine river water quality monitoring显示文摘Sampling frequency is an important factor to be considered during the design of a water monitoring network,and the cost-effective selection of possible ways and means for the optimization of sampling frequency is still needed.This paper introduces water pollution index deviation ratio comparison(WPI DRC),a procedure for the optimization of sampling frequency for a routine river water quality monitoring system.Sampling frequency optimized using WPI DRC at monitoring station X5 in the mainstream of Xiangjiang River is compared with that established using the traditional Statistical Algorithm method.The result of comparison indicates that WPI DRC is more feasible than the traditional one.And then,the sampling frequencies for other 16 monitoring stations also have been optimized,and the results show the sampling frequencies of all the stations except that X4 are reduced,and there is no unacceptable difference between water quality evaluation results at 17 stations before and after the optimization.Therefore,it is concluded that WPI DRC is an effective optimization process with operable results,which can be used to fulfill the requirement of practical monitoring work. | LIU Yan ZHENG BingHui WANG Mei XU YanXue QIN YanWen | 2014 | Science China Chemistry2014，57，5： | 2 |
| 19 | Compound Gaoziban tablet(复方高滋斑片) alleviates depression via toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-kappa B pathway显示文摘OBJECTIVE: To evaluate the effect of compound Gaoziban tablet(复方高滋斑片, CGZBT) on depression, and to investigate the underlying mechanism. METHODS: The components of CGZBT were analysed by high-performance liquid chromatography. Then, we assessed the effects of varying doses of CGZBT on an established chronic unpredictable mild stress(CUMS) model in rats. Whether animals were depressed was evaluated by sucrose preference test, open field test and forced swimming test. Neurotransmitters of hippocampus were detected by liquid chromatography-mass spectrometry. Serum levels of tumor necrosis factor-alpha(TNF-α), interleukin(IL)-1β, IL-6, IL-4, and IL-10 were measured by enzyme-linked immunosorbent assay. Expressions of toll-like receptor 4(TLR4), myeloid differentiation factor 88(My D88), phospho-nuclear factorkappa B(p-NF-κB), cyclooxygenase-2(COX-2), ionized calcium binding adapter molecule-1(IBA-1) were assessed by immunohistochemical staining and western blotting. RESULTS: Eight compounds were identified from CGZBT, moreover, our results showed that CGZBT effectively reversed the CUMS-induced decrease in sucrose preference, shortened the movement distance and prolonged immobility time. CGZBT significantly increased levels of 5-hydroxytryptamine, dopamine, norepinephrine, 5-hydroxyindoleacetic acid levels, and reduced the expression of TNF-α, IL-1β, IL-6, yet increased IL-4 and IL-10. Furthermore, the expressions of TLR4, My D88, COX-2, p-NF-κB and IBA-1 in hippocampus were effectively reversed after treatment with CGZBT. CONCLUSIONS: These results indicated that CGZBT could, at least in part, alleviate depression induced by CUMS via the TLR4/My D88/NF-κB pathway, suggesting its potential as an antidepressant drug. | ZOU Xinshuang SHI Lei YIN Hailong LI Haiping WANG Mengheng SONG Wanci LUO Laichun WU Hezhen YANG Yanfang ZAN Junfeng LIU Yanwen DAN Hanxiong YIN Qiang YOU Pengtao | 2022 | Journal of Traditional Chinese Medicine2022，42，6： | 2 |
| 20 | Apple peel flavonoid- and triterpene-enriched extracts differentially affect cholesterol homeostasis in hamsters显示文摘 | Surangi H. Thilakarathna Yanwen Wang H.P. Vasantha Rupasinghe Khadija Ghanam | 2012 | Journal of Functional Foods2012，，4： | 2 |
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