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| 1 | Breast milk macronutrient composition and the associated factors in urban Chinese mothers显示文摘 | Yang Titi Zhang Yumei Ning Yibing You Lili Ma Defu Zheng Yingdong Yang Xiaoguang Li Wenjun Wang Junkuan Wang Peiyu | 2014 | Chinese Medical Journal2014，，9： | 17 |
| 2 | On-orbit Geometric Calibration of Linear Push-broom Optical Satellite Based on Sparse GCPs显示文摘The paper presents a geometric calibration method based on the sparse ground control points (GCPs), aiming to the linear push-broom optical satellite. This method can achieve the optimal estimate of internal and external parameters with two overlapped image pair along the charge-coupled device (CCD), and sparse GCPs in the image region, further get rid of the dependence on the expensive calibration site data. With the calibrated parameters, the line of sight (LOS) of all CCD detectors can be recovered. This paper firstly establishes the rigorous imaging model of linear push-broom optical satellite based on its imaging mechanism. And then the calibration model is constructed by improving the internal sensor model with a viewing-angle model after an analysis on systematic errors existing in the imaging model is performed. A step-wise solution is applied aiming to the optimal estimate of external and internal parameters. At last, we conduct a set of experiments on the ZY-3 NAD camera and verify the accuracy and effectiveness of the presented method by comparison. | Yingdong PI Baorong XIE Bo YANG Yiling ZHANG Xin LI Mi WANG | 2020 | Journal of Geodesy and Geoinformation Science2020，3，1： | 8 |
| 3 | Effects of Cd and Sn on double-peak age-hardening behaviors of Al-Si-Cu-Mg cast alloys显示文摘The effects of trace elements Cd and Sn on precipitation process of Al-Si-Cu-Mg cast alloys were investigated in the present research.It is shown that the addition of Cd and Sn not only increases remarkably the aging peak hardness and reduces the time to reach aging peak,but also eliminates the double-aging-peak phenomenon which appears in Al-Si-Cu-Mg alloys.In Al-Si-Cu-Mg alloys the first aging peak corresponds to GP zones(especially GPⅡ) ,and the second one is caused by metastable phases.The obvious time interval of transition from GPⅡ to metastable phases associates with the double-aging-peak phenomenon.The results of DSC and TEM show that Cd/Sn elements suppress the formation of GPⅠzone,stimulate the formation of θ',θ' and θ phases,and then shorten remarkably the temperature intervals of each exothermic peak.Because the transition interval between GPⅡzone and metastable phases is shortened by Cd/Sn in Al-Si-Cu-Mg cast alloys,θ' phase coexists with θ' phase in matrix of ageing peak condition,which causes effective hardening on the alloys,and at the same time,eliminates the double-aging-peak phenomenon. | Li Runxia Chen Yujin Yuan Xiaoguang Qu Yingdong Li Rongde | 2010 | China Foundry2010，7，1： | 7 |
| 4 | Effects of 12C6+ heavy ion beam irradiation on the p53 signaling pathway in HepG2 liver cancer cells显示文摘重离子横梁被认为是为放射疗法的理想的来源。细胞内部的 apoptosis 表明的 p53 肿瘤 suppressor 基因感觉 DNA 损坏和 transducts。以前的报告证明重离子横梁能触发细胞的 DNA 的损坏的复杂形式,导致房间周期拘捕和 HepG2 人的肝癌症房间的 apoptosis;然而,机制充分仍然保持不清楚。为了探索内在或外来的小径是否参与这,处理, HepG2 房间在 0 的剂量(控制)与12C6+ HIB 照耀被对待,有各种各样的方法的 1 , 2 , 4 ,和 6 Gy 采用了理解相关机制例如 apoptosis 的察觉,由流动 cytometry 的房间周期,和船边交货表示,由扫描共焦的显微镜学,并且屏蔽差别的电子显微镜学和激光的 apoptotic 形态学的分析表示了关于旁边表明小径的 p53 的基因这研究显示出在 6 Gy 的剂量的重离子横梁照耀导致的那 12C6+ 经由 synergistic 的人的 HepG2 房间的内长的 DNA 双海滨损坏, G2/M 房间周期拘捕,和 apoptosis 外来、内在的小径完成。差别在表明与 DNA 损坏修理, apoptosis,周期规定,转移,恶化和辐射抵抗有关的小径的 p53 表示了基因也被发现。因而,船边交货, TP53BP2, TP53AIP1,和 CASP9 的表情是在 12C6+ HIB 照耀处理以后的证实的 upregulated。在结论,这研究表明了 12C6+ 导致的抑制和 apoptosis 的机制 HepG2 癌症房间上的重离子横梁照耀被表明小径包括的 p53 的生物功能的开始调停外来、内在的 apoptosis 小径(吗?作者 2017。代表生物化学和房间生物学的研究所由牛津大学出版社出版了,为生物科学的上海研究所,中国科学院。版权所有。为权限,请发邮件:journals.permissions@oup.com。) | Kai Liu Xinke Zhao Jing Gu Jianjun Wu Hong Zhang Yingdong Li | 2017 | Acta Biochimica et Biophysica Sinica2017，49，11： | 5 |
| 5 | Temperature dependent Raman and photoluminescence of vertical WS2/MoS2 monolayer heterostructures显示文摘Heterostructures from two-dimensional transition-metal dichalcogenides MX_2 have emerged as a hot topic in recent years due to their various fascinating properties. Here, we investigated the temperature dependent Raman and photoluminescence(PL) spectra in vertical stacked WS_2/MoS_2 monolayer heterostructures. Our result shows that both E_(2g)~1 and A_(1g) modes of WS_2 and MoS_2 vary linearly with temperature increasing from 300 to 642 K. The PL measurement also reveals strong temperature dependencies of the PL intensity and peak position. The activation energy of the thermal quenching of the PL emission has been found to be equal to 69.6 meV. The temperature dependence of the peak energy well follows the bandgap shrinkage of bulk semiconductor. | Zhijian Hu Yanjun Bao Ziwei Li Yongji Gong Rui Feng Yingdong Xiao Xiaochun Wu Zhaohui Zhang Xing Zhu Pulickel M. Ajayan Zheyu Fang | 2017 | Science Bulletin2017，62，1： | 5 |
| 6 | Urban flood inundation and damage assessment based on numerical simulations of design rainstorms with different characteristics显示文摘In the context of global climate change and urbanization,urban flooding is an important type of natural disaster that affects urban development,especially in China,which is experiencing rapid urbanization.In the past 10 years,urban flooding events have caused huge disaster losses in Chinese cities.This has resulted in significant negative effects on the urban infrastructure,socioeconomic systems,and urban residents,thus causing widespread concern.Studies have confirmed the change in extreme rainstorms is due to the changing environments in many cities globally.Conducting studies on the impact of these rainstorms with different characteristics for urban flooding is valuable for coping with unfavorable situations.In addition,numerical simulations provide an economical and viable means to perform these studies.This paper presents a numerical model of Xiamen Island in China.Simulations were conducted for 12 design rainstorm events with different return periods,rain patterns,and durations.The results indicate that,in the case of an equal rainfall amount,the rainfall intensity is the key factor that affects the inundated area,depth,and damages.However,the rainfall intensity is not the only determining factor;the rainfall pattern also affects the inundations.In regard to the rainfall pattern,a higher rainfall peak coefficient usually leads to severe urban inundation and damage.As a result,the lag time would be shorter,which may further exacerbate the impact of urban flood disasters.The results of this study provide insights into managing flood risks,developing urban flood prevention strategies,and designing flood prevention measures. | MEI Chao LIU JiaHong WANG Hao LI ZeJin YANG ZhiYong SHAO WeiWei DING XiangYi WENG BaiSha YU YingDong YAN DianYi | 2020 | Science China(Technological Sciences)2020，63，11： | 5 |
| 7 | Caspase-1 inhibition attenuates activation of BV2 microglia induced by LPS-treated RAW264.7 macrophages显示文摘Neuroinflammation has been recognized as a factor in the pathogenesis of neurodegenerative diseases.Emerging evidence suggests that peripheral inflammation,besides neuroinflammation,functions as a modulator of disease progression and neuropathology in several neurodegenerative diseases.However,detailed correlations among peripheral inflammation,neuroinflammation and neurodegeneration remain unknown.In the present study,we prepared a peripheral inflammation model with lipopolysaccharides(LPS)-stimulated RAW264.7 macrophages to explore its activation on BV2 microglia.We found that LPS induced the production of IL-1 β,IL-6 and TNF-α in the culture medium of RAW264.7 macrophages.We further showed that LPS plus ATP activated inflammasome,evidenced by the upregulation of caspase-1 and IL-1β,which was suppressed by ZYVAD,a caspase-1 inhibitor.Furthermore,the conditioned medium obtained from LPS-treated RAW264.7 macrophages activated BV2 microglia,stimulating the release of IL-1β,IL-6 and TNF-a from BV2 cells.ZYVAD pretreatment markedly suppressed BV2 microglia activation induced by RAW264.7 cells conditioned medium.Taken together,our study indicates that macrophage-mediated peripheral inflammation subsequently evokes neuroinflammation and may aggravate neural damage.Inflammasome and caspase-1 may be potential targets for modulating systemic inflammatory responses in neurodegenerative diseases. | Yang Pan Bo Shen Qin Gao Jun Zhu Jingde Dong Li Zhang Yingdong Zhang | 2016 | The Journal of Biomedical Research2016，30，3： | 5 |
| 8 | Novel spectrum sensing and access in cognitive radio networks显示文摘The throughput, delay and collision probabilitybetween tim primary users (PUs) and secondaryusers (SUs) have been considered as the inain per-formance measures in cognitive radio (CR) net-works [1]. The longer the sensing period, the moreaccurate the spectrum sensing. But a longer sens-ing period will result in lower system throughput. | Shibing ZHANG Yingdong HU Li ZHANG Zhihua BAO | 2018 | Science China(Information Sciences)2018，61，8： | 2 |
| 9 | Logistics Regression Analysis between TCM Constitution Types of Patients with Hypertension,Insomnia and ABPM,PSQI显示文摘[Objectives]The research aimed to explore the distribution characteristics of TCM constitution types of patients with hypertension and insomnia,and study the clinical characteristics of patients with different constitutions,in order to provide new ideas for the treatment of patients with hypertension and insomnia.[Methods]Cross sectional observation method was used,and 420 patients with hypertension and insomnia were selected.Required information was collected,and the constitution type of traditional Chinese medicine was determined,and relevant data were recorded.SPSS and Logistic regression analysis method were used to explore the correlation between the distribution of TCM constitution types and gender,age,24 h-SBP,24 h-DBP,24 h-BPV,PSQI score,etc.[Results]Among 420 patients,the proportion of gentleness constitution was the most,and others in turn were Qi deficiency constitution>Yang deficiency constitution>phlegm dampness constitution>Qi stagnation constitution>Yin deficiency constitution>blood stasis constitution>damp heat constitution>special constitution.Among male patients,the proportion of gentleness constitution was the most.Among female patients,the proportion of Qi deficiency constitution was the most.In each constitution,the proportion of men and women was different,and the difference in gentleness constitution,Qi deficiency constitution and Yin deficiency constitution had statistical significance(P<0.05).The proportion of gentleness constitution for young and middle-aged patients was the most,while elderly patients with Qi deficiency constitution was the most.There was difference in the distribution of TCM constitution in different age groups,and the difference had statistical significance(P<0.05).Compared with the patients with gentleness constitution,the patients with Qi deficiency constitution,Yang deficiency constitution,Yin deficiency constitution,damp heat constitution,blood stasis constitution and Qi stagnation constitution had different differences in terms of age,24 h-SBP,24 h-DBP,24 h-BPV and PSQI score,and there was statistical significance(P<0.05).Except damp heat constitution,blood stasis constitution and special constitution,other constitutions had certain correlation with age,24 h-SBP,24 h-DBP,24 h-BPV and PSQI score.[Conclusions]TCM constitution types of patients with hypertension and insomnia were dominant by gentleness constitution,Qi deficiency constitution and Yang deficiency constitution.The distribution of TCM constitution in different gender and age groups was different,and different TCM constitution was related to ABPM and PSQI. | Xiaogang YU Qingsheng WANG Erdan XIN Yujun LU Yingdong LI | 2022 | Medicinal Plant2022，13，2： | 2 |
| 10 | Enhancement of Active Anticorrosion via Ce-doped Zn-Al Layered Double Hydroxides Embedded in Sol-Gel Coatings on Aluminum Alloy显示文摘Ce-doped Zn-Al layered double hydroxide(LDH) nanocontainer was synthesized by a co-precipitation method. X-ray diffraction(XRD), Fourier transform infrared spectroscopy(FT-IR), scanning electron microscopy(SEM) and transmission electron microscopy(TEM) methods were used for the characterization of the LDH nanocontainer. The anticorrosion activity of the LDH powders embedded in a hybrid sol-gel coating on aluminum alloy 2024 was investigated by electrochemical impendence spectroscopy(EIS). The results showed that Ce(III) ions were successfully incorporated into LDHs layers. The sol-gel coating modified with Ce-doped Zn-Al LDHs exhibited higher anticorrosion behavior compared with both unmodified and Ce-undoped LDHs containing coatings, which proved the applicability of Ce-doped LDHs in delaying coating degradation and their potential application as nanocontainers of corrosion inhibitors in self-healing coatings. | 张优 刘建华 LI Yingdong YU Mei YIN Xiaolin LI Songmei | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，5： | 2 |
| 11 | Subjective poor sleep quality in Chinese patients with Parkinson's disease without dementia显示文摘Parkinson's disease (PD) is a common progressive neurological disorder and is composed of motor and nonmotor symptoms. Sleep disturbances are frequent problems for patients with PD. The relationship between sleep disturbances with Hoehn and Yahr (H&Y) staging have been demonstrated. However, the relationship between sleep disorders and H&Y is still unclear in patients with PD without dementia in Chinese PD patients. In this study, we interviewed 487 non-demented PD patients of Chinese Han descents by H&Y classification. We found that night sleep quality was significantly associated with the severity of PD (P=0.008). Panic disorder severity scale (PDSS) total scores were correlated with PD non-motor symptoms scale (PDNMS) scores (r=-0.528, P<0.001), the Hamilton depression scale (HAMD) scores (r=-0.545, P<0.001) and the Hamilton anxiety scale (HAMA) scores (r=-0.498, P<0.001). Our results indicated that sleep quality deteriorated with the advancing of PD in Chinese non-demented patients with PD. Depression and anxiety may partly explain sleep disturbances in nondemented patients with PD. | Li Zhang Jingde Dong Weiguo Liu Yingdong Zhang | 2013 | The Journal of Biomedical Research2013，27，4： | 2 |
| 12 | Low temperature impact toughness and fracture mechanism of cast QT400-18L ductile iron with diferent Ni additions显示文摘Different contents of Ni(0.3wt.%to 1.2wt.%)were added to the QT400-18L ductile iron to investigate the effect of Ni addition on the impact toughness of cast ductile irons at low temperatures.The impact toughnesses of the samples at room and low temperatures were tested.The microstructures and fractographs were observed.Results show that with the increase of Ni addition there is a general trend of refinement of the ferrite matrix while the nodule density shows no obvious change.When the Ni content is 0.7wt.%,the matrix structure is the refined ferrite with a very small fraction(about 2%)of pearlite near the eutectic cell boundaries.When the Ni content is further increased,the fraction of pearlite increases significantly and reaches more than 5%when 1.2wt.%Ni is added.The impact toughness at room temperature increases as the content of Ni increases from 0.3 wt.%to 0.7 wt.%,but decreases as the Ni content further increases to 1.2wt.%due to the increase of pearlite fraction.The maximum value of the impact work is 18.5 J at room temperature with 0.7wt.%Ni addition.The average value of the impact work is still more than 13 J even at-30℃.In addition,the fracture mechanism changes from ductile manner to brittleness as the testing temperature decreases from 20℃to-60℃. | Zhang Xinning Qu Yingdong Yang Hongwang Li Rongde | 2013 | China Foundry2013，10，5： | 2 |
| 13 | On proactive eavesdropping using anti-relay-selection jamming in multi-relay communication systems显示文摘This paper considers a multi-relay legitimate surveillance system, where a suspicious link may transmit illegal information with the help of relays and a legitimate monitor aims at intercepting the information. We assume that the relay selection method is adopted by the suspicious link to improve the efficiency of the information transmission. We propose anti-relay-selection(ARS) jamming strategies for two different information transmission scenarios, namely the event-based information and content-based information. Beamforming vector of jamming is optimized and the iterative algorithms are used to improve the jamming efficiency. We demonstrate the effectiveness and the superiority of the ARS jamming strategies through numerical results and simulations. | Yingdong HU Ruifeng GAO Ye LI Shibing ZHANG | 2019 | Science China(Information Sciences)2019，62，4： | 2 |
| 14 | The influence of microtexture on the formation mechanism of nodules in Zircaloy-4 alloy tube显示文摘Corrosion re sistance of Zircaloy-4 alloy tube in superheated steam at 673 K/10.3 MPa is anisotropic.A part of the surface undergoes uniform corrosion while the other suffers nodular corrosion.Narrow and wide nodules are observed after an exposure period of 3 and 30 days,respectively.A new matrix transformation method is established in order to study the formation mechanism of nodules in the cross-section(CS) of Zircaloy-4 alloy tube using the EBSD technique,while the CS perpendicular to axial direction(AD).The results reveal that the microtexture is a key factor behind the two types of corrosion.Furthermore,the oxide layers grow anisotropically over the corroded surface.A thick oxide layer forms over the nodular corrosion region on the grains with c-axis oriented in the range of 40° around tangential direction(TD),whereas a thin oxide layer over the uniform corrosion region is detected on the grains with c-axis oriented in the range of 68° around TD.In short,the anisotropic growth of oxide layer was caused by the change of microtexture of the Zr-4 alloy tube,and this anisotropic growth of oxide layer contributed to the nodules formation. | Yingdong Zhang Fusen Yuan Fuzhou Han Muhammad Ali Wenbin Guo Geping Li Chengze Liu Hengfei Gu | 2020 | Journal of Materials Science & Technology2020，47，12： | 2 |
| 15 | Origin of High Efficiency and Long-Term Stability in Ionic Liquid Perovskite Photovoltaic显示文摘Environment-friendly protic amine carboxylic acid ionic liquids(ILs)as solvents is a significant breakthrough with respect to traditional highly coordinating and toxic solvents in achieving efficient and stable perovskite solar cells(PSCs)with a simple one-step air processing and without an antisolvent treatment approach.However,it remains mysterious for the improved efficiency and stability of PSCs without any passivation strategy.Here,we unambiguously demonstrate that the three functions of solvents,additive,and passivation are present for protic amine carboxylic acid ILs.We found that the ILs have the capability to dissolve a series of perovskite precursors,induce oriented crystallization,and chemically passivate the grain boundaries.This is attributed to the unique molecular structure of ILs with carbonyl and amine groups,allowing for strong interaction with perovskite precursors by forming C=O…Pb chelate bonds and N-H…I hydrogen bonds in both solution and film.This finding is generic in nature with extension to a wide range of IL-based perovskite optoelectronics. | Lingfeng Chao Tingting Niu Hao Gu Yingguo Yang Qi Wei Yingdong Xia Wei Hui Shouwei Zuo Zhaohua Zhu Chengjie Pei Xiaodong Li Jing Zhang Junfeng Fang Guichuan Xing Hai Li Xiao Huang Xingyu Gao Chenxin Ran Lin Song Li Fu Yonghua Chen Wei Huang | 2020 | Research2020，，1： | 2 |
| 16 | Protection of ultra-filtration extract from Danggui Buxuedecoction on pxidative damage in cardiomyocytes ofneonatal rats and its meChanism显示文摘 | LI Yingdong M A Yanhua ZHAO Jianxion | 2011 | Chin J Integr Med2011，17，11： | 1 |
| 17 | PtSerpin from the swimming crab Portunus trituberculatus , a putative regulator of prophenoloxidase activation with antibacterial activity显示文摘 | Yuan Liu Guohui Shi Zhaoxia Cui Danli Luo Chengwen Song Xihong Li Min Hui Yingdong Li | 2014 | Fish and Shellfish Immunology2014，，： | 1 |
| 18 | Bio based blends of starch and poly(butylene succinate)with improved misci- bility, mechanical properties, and reduced water absorption 显示文摘 | Zeng J ianbing Jiao Ling Li Yingdong | 2011 | Carbohydrate Polymers2011，83，5： | 1 |
| 19 | Negative effects of long-term feeding of high-grain diets to lactating goats on milk fat production and composition by regulating gene expression and DNA methylation in the mammary gland显示文摘Background: It is well known that feeding a high concentrate(HC) diet to lactating ruminants likely induces subacute ruminal acidosis(SARA) and leads to a decrease in milk fat production. However, the effects of feeding a HC diet for long periods on milk fatty acids composition and the mechanism behind the decline of milk fat still remains poorly understood. The aim of this study was to investigate the impact of feeding a HC diet to lactating dairy goats on milk fat yield and fatty acids composition with an emphasis on the mechanisms underlying the milk fat depression. Seventeen mid-lactating dairy goats were randomly allocated to three groups. The control treatment was fed a low-concentrate diet(35% concentrate, n = 5, LC) and there were two high-concentrate treatments(65% concentrate, HC), one fed a high concentrate diet for a long period(19 wks, n = 7, HL); one fed a high concentrate diet for a short period of time(4 wk, n = 5, HS). Milk fat production and fatty acids profiles were measured. In order to investigate the mechanisms underlying the changes in milk fat production and composition,the gene expression involved in lipid metabolism and DNA methylation in the mammary gland were also analyzed.Results: Milk production was increased by feeding the HC diet in the HS and HL groups compared with the LC diet(P < 0.01), while the percentage of milk fat was lower in the HL(P < 0.05) but not in the HS group. The total amount of saturated fatty acids(SFA) in the milk was not changed by feeding the HC diet, whereas the levels of unsaturated fatty acids(UFA) and monounsaturated fatty acids(MUFA) were markedly decreased in the HL group compared with the LC group(P < 0.05). Among these fatty acids, the concentrations of C15:0(P < 0.01), C17:0(P < 0.01), C17:1(P < 0.01), C18:1 n-9 c(P < 0.05), C18:3 n-3 r(P < 0.01) and C20:0(P < 0.01) were markedly lower in the HL group, and the concentrations of C20:0(P < 0.05) and C18:3 n-3 r(P < 0.01) were lower in the HS group compared with the LC group. However, the concentrations of C18:2 n-6 c(P < 0.05) and C20:4 n-6(P < 0.05) in the milk fat were higher in the HS group. Real-time PCR results showed that the m RNA expression of the genes involved in milk fat production in the mammary gland was generally decreased in the HL and HS groups compared with the LC group. Among these genes, ACSL1, ACSS1 & 2, ACACA, FAS, SCD, FADS2, and SREBP1 were downregulated in the mammary gland of the HL group(P < 0.05), and the expressions of ACSS2, ACACA, and FADS2 m RNA were markedly decreased in the HS goats compared with the LC group(P < 0.05). In contrast to the gene expression, the level of DNA methylation in the promoter regions of the ACACA and SCD genes was increased in the HL group compared with the LC group(P < 0.05). The levels of ACSL1 protein expression and FAS enzyme activity were also decreased in the mammary gland of the HL compared with the LC group(P < 0.05).Conclusions: Long-term feeding of a HC diet to lactating goats induced milk fat depression and FAs profile shift with lower MUFAs but higher SFAs. A general down-regulation of the gene expression involved in the milk fat production and a higher DNA methylation in the mammary gland may contribute to the decrease in milk fat production in goats fed a HC diet for long time periods. | Ping Tian Yanwen Luo Xian Li Jing Tian Shiyu Tao Canfeng Hua Yali Geng Yingdong Ni Ruqian Zhao | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 1 |
| 20 | Early-age feed restriction affects viability and gene expression of satellite cells isolated from the gastrocnemius muscle of broiler chicks显示文摘Background: Muscle growth depends on the fusion of proliferate satellite cells to existing myofibers. We reported previously that 0-14 day intermittent feeding led to persistent retardation in myofiber hypertrophy. However, how satellite cells respond to such nutritional insult has not been adequately elucidated. Results: One-day-old broiler chicks were allocated to control (Con, ad libitum feeding), intermittent feeding (IF, feed provided on alternate days) and re-feeding (RF, 2 days ad libitum feeding after 12 days of intermittent feeding) groups. Chickens were killed on Day 15 and satellite cells were isolated. When cultured, satellite cells from the IF group demonstrated significant retardation in proliferation and differentiation potential, while RF partly restored the proliferation rate and differentiation potential of the satellite cells. Significant up-regulation of insulin like growth factor I receptor (IGF-IR) (P<0.05) and thyroid hormone receptor α (TRα) (P<0.05), and down-regulation of growth hormone receptor (GHR) (P<0.01) and IGF-I (P<0.01) mRNA expression was observed in freshly isolated IF satellite cells when compared with Con cells. In RF cells, the mRNA expression of IGF-I was higher (P<0.05) and of TRα was lower (P<0.01) than in IF cells, suggesting that RF restored the mRNA expression of TRα and IGF-I, but not of GHR and IGF-IR. The Bax/Bcl-2 ratio tended to increase in the IF group, which was reversed in the RF group (P<0.05), indicating that RF reduced the pro-apoptotic influence of IF. Moreover, no significant effect of T 3 was detected on cell survival in IF cells compared with Con (P<0.001) or RF (P<0.05) cells. Conclusions: These data suggest that early-age feed restriction inhibits the proliferation and differentiation of satellite cells, induces changes in mRNA expression of the GH/IGF-I and thyroid hormone receptors in satellite cells, as well as blunted sensitivity of satellite cells to T3 , and that RF partially reverses these effects. Thus, a moderate nutritional strategy for feed restriction should be chosen in early chick rearing systems. | Yue Li Xiaojing Yang Yingdong Ni Eddy Decuypere Johan Buyse Nadia Everaert Roland Grossmann Ruqian Zhao | 2013 | Journal of Animal Science and Biotechnology2013，4，1： | 1 |
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