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| 1 | Spatiotemporal changes in vegetation coverage and its driving factors in the Three-River Headwaters Region during 2000-2011显示文摘The Three-River Headwaters Region(TRHR), which is the source area of the Yangtze River, Yellow River, and Lancang River, is of key importance to the ecological security of China. Because of climate changes and human activities, ecological degradation occurred in this region. Therefore, 'The nature reserve of Three-River Source Regions' was established, and 'The project of ecological protection and construction for the Three-River Headwaters Nature Reserve' was implemented by the Chinese government. This study, based on MODIS-NDVI and climate data, aims to analyze the spatiotemporal changes in vegetation coverage and its driving factors in the TRHR between 2000 and 2011, from three dimensions. Linear regression, Hurst index analysis, and partial correlation analysis were employed. The results showed the following:(1) In the past 12 years(2000–2011), the NDVI of the study area increased, with a linear tendency being 1.2%/10a, of which the Yangtze and Yellow River source regions presented an increasing trend, while the Lancang River source region showed a decreasing trend.(2) Vegetation coverage presented an obvious spatial difference in the TRHR, and the NDVI frequency was featured by a bimodal structure.(3) The area with improved vegetation coverage was larger than the degraded area, being 64.06% and 35.94%, respectively during the study period, and presented an increasing trend in the north and a decreasing trend in the south.(4) The reverse characteristics of vegetation coverage change are significant. In the future, degradation trends will be mainly found in the Yangtze River Basin and to the north of the Yellow River, while areas with improving trends are mainly distributed in the Lancang River Basin.(5) The response of vegetation coverage to precipitation and potential evapotranspiration has a time lag, while there is no such lag in the case of temperature.(6) The increased vegetation coverage is mainly attributed to the warm-wet climate change and the implementation of the ecological protection project. | LIU Xianfeng ZHANG Jinshui ZHU Xiufang PAN Yaozhong LIU Yanxu ZHANG Donghai LIN Zhihui | 2014 | Journal of Geographical Sciences2014，24，2： | 47 |
| 2 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 3 | Roles of a sustained activation of NCED3 and the synergistic regulation of ABA biosynthesis and catabolism in ABA signal production in Arabidopsis显示文摘ABA, acting as a stress signal, plays crucial roles in plant resistance to water stress. Because ABA signal production is based on ABA biosynthesis, the regulation of NCED, a key enzyme in the ABA biosynthesis pathway, is normally thought of as the sole factor controlling ABA signal production. Here we demonstrate that ABA catabolism in combination with a synergistic regulation of ABA biosynthesis plays a crucial role in governing ABA signal production. Water stress induced a significant accumulation of ABA, which exhibited different patterns in detached and attached leaves. ABA catabolism followed a temporal trend of exponential decay for both basic and stress ABA, and there was little difference in the catabolic half-lives of basic ABA and stress ABA. Thus, the absolute rate of ABA catabolism, i.e. the amount of ABA catabolized per unit time, increases with increased ABA accumulation. From the dynamic processes of ABA biosynthesis and catabolism, it can be inferred that stress ABA accumulation may be governed by a synergistic regulation of all the steps in the ABA biosynthesis pathway. Moreover, to maintain an elevated level of stress ABA sustained activation of NCED3 should be required. This inference was supported by further findings that the genes encoding major enzymes in the ABA biosynthesis pathway, e.g. NCED3, AAO3 and ABA3 were all activated by water stress, and with ABA accumulation progressing, the expressions of NCED3, AAO3 and ABA3 remained activated. Data on ABA catabolism and gene expression jointly indicate that ABA signal production is controlled by a sustained activation of NCED3 and the synergistic regulation of ABA biosynthesis and catabolism. | REN HuiBo FAN YiJian GAO ZhiHui WEI KaiFa LI GuiFen LIU Jing CHEN Lin LI BingBing HU JianFang JIA WenSuo | 2007 | Chinese Science Bulletin2007，52，4： | 12 |
| 4 | Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism显示文摘Amycolatopsis mediterranei 被用于 rifamycin 的工业规模生产,它在 antimycobacterial 治疗起一个重要作用。作为类 Amycolatopsis 的首先定序的染色体, 236 715 底配对的包括 10 的紧张 U32 的染色体,最大的原核生物的染色体之一到目前为止曾经被定序。不同于在 streptomycetes 发现的线性拓扑学,这个染色体是圆形的,特别地类似于 Saccharopolyspora erythraea 和奴卡氏菌属 farcinica,在发展史和分类代表他们的靠近的关系。尽管在 A 预言了 9 228 编码蛋白质的基因。mediterranei 染色体 S 与那些分享了 orthologs 的最大的数字。erythraea,它被 Streptomyces coelicolor 而非 N 出人意料地跟随。farcinica,显示不同新陈代谢的特征经由改编演变到多样的生态的壁龛。除类似于那的一个核心区域以外在 streptomycetes 普通,有典型核心特征的一个新奇“伪核心”在非核心区域以内被定义,在 21 从 26 基因为第二等的代谢物生产聚类的总数被定位的地方。位于核心的 rifamycin 生合成基因簇为 rifamycin SV 的变换编码细胞色素 P450 酶必需品到 B,由比作 rifamycin 生产 B 紧张 S699 的高度相应的簇揭示了并且进一步由基因互补证实了。A 的 genomic 信息。mediterranei 表明在看起来复杂的规章的机制的控制下面不仅为各种各样的碳来源和无机的氮混合物的广泛的利用而且为新陈代谢的中介的有效 funneling 安排进第二等的抗菌素合成进程的一个新陈代谢的网络。 | Wei Zhao Yi Zhong Hua Yuan Jin Wang Huajun Zheng Ying Wang Xufeng Cen Feng Xu Jie Bai Xiaobiao Han Gang Lu Yongqiang Zhu Zhihui Shao Han Yan Chen Li Nanqiu Peng Zilong Zhang Yunyi Zhang Wei Lin Yun Fan Zhongjun Qin Yongfei Hu Baoli Zhu Shengyue Wang Xiaoming Ding Guo-Ping Zbao | 2010 | Cell Research2010，20，10： | 10 |
| 5 | Analysis of the dynamic performance of an electro-hydrostatic actuator and improvement methods显示文摘As a kind of actuation mechanism for power-by-wire(PBW) actuation systems of more/all electrical aircraft, an electro-hydrostatic actuator(EHA) is a highly integrated local hydraulic actuation system. It is a volume control system consisting of a motor, a pump, an actuator, etc.,which has features of high efficiency and reliability. However, the poor dynamic characteristic is one of the main factors restricting its wide application in aircraft. In this paper, the reason for the poor dynamic characteristic of an EHA is revealed from the perspectives of the natural frequency characteristic and the power requirement, respectively. In other words, the insufficiency of the motor output power at a high frequency is the main factor causing the poor dynamic characteristic of the system, and methods which include increasing the maximum output torque of the motor, reducing the rotational inertia of the motor-pump group, and adopting a double-motorpump group configuration are proposed in this paper, by which the dynamic characteristic of the system can be improved. The feasibility of those methods are verified by simulations. Finally, the dynamic characteristic is tested on an EHA prototype, and results show that saturation of the output torque of the motor is the main factor restricting the dynamic characteristic of the EHA system. | Zhihui LI Yaoxing SHANG Zongxia JIAO Yan LIN Shuai WU Xiaobin LI | 2018 | Chinese Journal of Aeronautics2018，31，12： | 9 |
| 6 | PEEK modified PLA shape memory blends:towards enhanced mechanical and deformation properties显示文摘Polylactic acid(PLA)is one of the most promising shape memory polymers with outstanding biocompatibility,while poly(ether ether ketone)(PEEK)is a special engineering plastic with excellent mechanical performance.In this work,PEEK was selected to modify PLA,and a series of PLA blended with different PEEK contents(PLA/PEEK blends)were obtained.The effects of PEEK on thermodynamic,mechanical and shape memory properties of PLA/PEEK blends were investigated.The results showed that the thermal stabillity of the PL A/PEEK blend was improved with the PEEK content increase.The tensile strength reached the highest value of 20.6 MPa when the PEEK content was 10%.While the best shape memory performance occurred with the PEEK content of 15%,the shape recovery time was less than 2 s,and the shape fixation/recovery ratio was more than 99%.Furthermore,the programmable mimetic flower opening process was achieved by using PLA/PEEK blends with different PEEK content ratios.The above results indicated that the blend of an appropriate proportion of PEEK had positive effects on mechanical and deformation performances of PLA. | Lan ZHANG Zhaohua LIN Qiang ZHOU Suqian MA Yunhong LIANG Zhihui ZHANG | 2020 | Frontiers of Materials Science2020，14，2： | 8 |
| 7 | Restudy of the storage and migration model of the Quaternary groundwater in Beijing Plain area显示文摘Through a wide-spread groundwater sampling mainly at nested monitoring wells in the Beijing Plain area,combined with data collection,the study analyzes water level,hydrochemistry,temperature,tritium,deuterium,18O,14C and other aspects,and indicates that there exits an obvious stratification phenomenon of the groundwater in the alluvial plain area down in the middle part of alluvial-pluvial fans,and the hydraulic connection between layers is very weak.The analysis of the tritium concentration suggests that the average influence depth of the modern precipitation is approximately 120m.Based on the analysis of the 22 paleowater samples through the D18O method and 14C isotopic dating,the deep groundwater circulation in the fine sediments area of Beijing Plain down in the fringe part of alluvial-pluvial fans is relatively slow.On average the paleowater point occurs approximately below the 180m at these points.The main reasons for the formation of stratification and paleowater points are the water-blocking effect of the clay type strata and the compaction effect during the sedimentary process,especially the differential compaction,which could form closed or relatively closed stagnant aquifers.Groundwater in this kind of stagnant aquifers to some degree belongs to non-renewable resource,and should be reconsidered and re-arranged in the water resources management strategy. | LIU YuanZhang WU Qiang LIN Pei LIU JiuRong XING LiTing GAO ZhiHui | 2012 | Science China Earth Sciences2012，55，7： | 7 |
| 8 | An analytical study on nonequilibrium dissociating gas flow behind a strong bow shockwave under rarefied conditions显示文摘In this paper, an explicitly analytical shock mapping relation is approximately deduced based on the theoretical modeling of the chemical nonequilibrium stagnation flow towards a slightly blunted nose. Based on the relation, the complex reacting stagnation flow problem can be discussed under the framework of the simplest normal shockwave flow. Therefore, a quantita- tively meaningful criterion for dissociation nonequilibrium flow, that is a specific Damk hler number Da d , is naturally intro- duced as the ratio of the mapping length of the stagnation streamline and the characteristic nonequilibrium scale. Da d is found to be dependent on the flow's rarefaction criterion W r , that is a specific Knudsen number. Then, based on Da d , a normalized analytical formulation is obtained to quantitatively predict the actual degrees of dissociation at the outer edge of the stagnation point boundary layer (SPBL). At last, the direct simulation Monte Carlo (DSMC) method is employed to validate the analytical results, and the related flow mechanism is discussed. The present study not only shows nonequilibrium features of the flow problem, but also provides an indispensable basis for the following study on the nonequilibrium SPBL heat transfer. | WANG ZhiHui BAO Lin TONG BingGang | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，4： | 6 |
| 9 | Variation character of stagnation point heat flux for hypersonic pointed bodies from continuum to rarefied flow states and its bridge function study显示文摘This paper is a research on the variation character of stagnation point heat flux for hypersonic pointed bodies from continuum to rarefied flow states by using theoretical analysis and numerical simulation methods. The newly developed near space hypersonic cruise vehicles have sharp noses and wingtips,which desires exact and relatively simple methods to estimate the stagnation point heat flux. With the decrease of the curvature radius of the leading edge,the flow becomes rarefied gradually,and viscous interaction effects and rarefied gas effects come forth successively,which results in that the classical Fay-Riddell equation under continuum hypothesis will become invalid and the variation of stagnation point heat flux is characterized by a new trend. The heat flux approaches the free molecular flow limit instead of an infinite value when the curvature radius of the leading edge tends to 0. The physical mechanism behind this phenomenon remains in need of theoretical study. Firstly,due to the fact that the whole flow regime can be described by Boltzmann equation,the continuum and rarefied flow are analyzed under a uniform framework. A relationship is established between the molecular collision insufficiency in rarefied flow and the failure of Fourier's heat conduction law along with the increasing significance of the nonlinear heat flux. Then based on an inspiration drew from Burnett approximation,control factors are grasped and a specific heat flux expression containing the nonlinear term is designed in the stagnation region of hypersonic leading edge. Together with flow pattern analysis,the ratio of nonlinear to linear heat flux Wr is theoretically obtained as a parameter which reflects the influence of nonlinear factors,i.e. a criterion to classify the hypersonic rarefied flows. Ultimately,based on the characteristic parameter Wr,a bridge function with physical background is constructed,which predicts comparative reasonable results in coincidence well with DSMC and experimental data in the whole flow regime. | WANG ZhiHui BAO Lin TONG BingGang | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，12： | 6 |
| 10 | Gravitational wave astrophysics, data analysis and multimessenger astronomy显示文摘This paper reviews gravitational wave sources and their detection. One of the most exciting potential sources of gravitational waves are coalescing binary black hole systems. They can occur on all mass scales and be formed in numerous ways, many of which are not understood. They are generally invisible in electromagnetic waves, and they provide opportunities for deep investigation of Einstein's general theory of relativity. Sect. 1 of this paper considers ways that binary black holes can be created in the universe, and includes the prediction that binary black hole coalescence events are likely to be the first gravitational wave sources to be detected. The next parts of this paper address the detection of chirp waveforms from coalescence events in noisy data.Such analysis is computationally intensive. Sect. 2 reviews a new and powerful method of signal detection based on the GPUimplemented summed parallel infinite impulse response filters. Such filters are intrinsically real time alorithms, that can be used to rapidly detect and localise signals. Sect. 3 of the paper reviews the use of GPU processors for rapid searching for gravitational wave bursts that can arise from black hole births and coalescences. In sect. 4 the use of GPU processors to enable fast efficient statistical significance testing of gravitational wave event candidates is reviewed. Sect. 5 of this paper addresses the method of multimessenger astronomy where the discovery of electromagnetic counterparts of gravitational wave events can be used to identify sources, understand their nature and obtain much greater science outcomes from each identified event. | LEE Hyung Mok LE BIGOT Eric-Olivier DU ZhiHui LIN ZhangXi GUO XiangYu WEN LinQing PHUKON Khun Sang PANDEY Vihan BOSE Sukanta FAN Xi-Long HENDRY Martin | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 5 |
| 11 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 12 | Highly sensitive solar-blind deep ultraviolet photodetector based on graphene/PtSe_(2)/β-Ga_(2)O_(3)2D/3D Schottky junction with ultrafast speed显示文摘There is an emerging need for high-sensitivity solar-blind deep ultraviolet(DUV)photodetectors with an ultra-fast response speed.Although nanoscale devices based on Ga_(2)O_(3)nanostructures have been developed,their practical applications are greatly limited by their slow response speed as well as low specific detectivity.Here,the successful fabrication of two-/three-dimensional(2D/3D)graphene(Gr)/PtSe2/β-Ga_(2)O_(3)Schottky junction devices for high-sensitivity solar-blind DUV photodetectors is demonstrated.Benefitting from the high-quality 2D/3D Schottky junction,the vertically stacked structure,and the superior-quality transparent graphene electrode for effective carrier collection,the photodetector is highly sensitive to DUV light illumination and achieves a high responsivity of 76.2 mA/W,a large on/off current ratio of~105,along with an ultra-high ultraviolet(UV)/visible rejection ratio of 1.8×104.More importantly,it has an ultra-fast response time of 12µs and a remarkable specific detectivity of~1013 Jones.Finally,an excellent DUV imaging capability has been identified based on the Gr/PtSe2/β-Ga_(2)O_(3)Schottky junction photodetector,demonstrating its great potential application in DUV imaging systems. | Di Wu Zhihui Zhao Wei Lu Lukas Rogée Longhui Zeng Pei Lin Zhifeng Shi Yongtao Tian Xinjian Li Yuen Hong Tsang | 2021 | Nano Research2021，14，6： | 4 |
| 13 | Fine particulate matter(PM_(2.5)/PM_(1.0)) in Beijing,China: Variations and chemical compositions as well as sources显示文摘Particulate matter(i.e.,PM_(1.0) and PM_(2.5)),considered as the key atmospheric pollutants,exerts negative effects on visibility,global climate,and human health by associated chemical compositions.However,our understanding of PM and its chemical compositions in Beijing under the current atmospheric environment is still not complete after witnessing marked alleviation during 2013–2017.Continuous measurements can be crucial for further air quality improvement by better characterizing PM pollution and chemical compositions in Beijing.Here,we conducted simultaneous measurements on PM in Beijing during 2018–2019.Results indicate that annualmean PM_(1.0) and PM_(2.5) concentrations were 35.49±18.61μg/m^(3) and 66.58±60.17μg/m^(3),showing a positive response to emission controls.The contribution of sulfate,nitrate,and ammonium(SNA)played an enhanced role with elevated PM loading and acted as the main contributors to pollution episodes.Discrepancies observed among chemical species between PM_(1.0) and PM_(2.5) in spring suggest that sand particles trend to accumulate in the range of 1–2.5μm.Pollution episodes occurred accompanied with southerly clusters and high formation of SNA by heterogeneous reactions in summer and winter,respectively.Results from positive matrix factorization(PMF)combined with potential source contribution function(PSCF)models showed that potential areas were seasonal dependent,secondary and vehicular sources became much more important compared with previous studies in Beijing.Our study presented a continuous investigation on PM and sources origins in Beijing,which provides a better understanding for further emission control as well as a reference for other cities in developing countries. | Lining Luo Xiaoxuan Bai Shuhan Liu Bobo Wu Wei Liu Yunqian Lv Zhihui Guo Shumin Lin Shuang Zhao Yan Hao Jiming Hao Kai Zhang Aihua Zheng Hezhong Tian | 2022 | Journal of Environmental Sciences2022，34，11： | 3 |
| 14 | Spatial structure and seasonal changes of nekton assemblages in the Taiwan Strait显示文摘The Taiwan Strait is a transition zone between the East China Sea and the South China Sea with unique hydrology and a geographical environment that creates special marine community features.To analyze the spatial structure and seasonal changes of the nekton assemblages in the Taiwan Strait,seasonal experimental trawl surveys were conducted during 2006–2007.The results showed that there were two assemblages in the area with different sets of species,and the average similarity within each group varies between 39.38% and 74.20%.By using multivariate statistical analysis and analyzing the distribution of dominant species,we found that the structures of the assemblages had obvious seasonal variation.The middle region from the Putian transect to the Xiamen transect could be considered a mixing area for the two assemblages.The analysis of the relationship between species assemblages and environmental factors indicated that temperature was the most important factor affecting the community structure in cold seasons,and 22.5°C and 17°C could be considered dividing lines for spring and winter,respectively.In warm seasons,the most important factor was water depth,but the relationship with depth was not as significant,with a correlation between 0.264 and 0.399.The seasonal changes of nekton assemblages basically reflected the dynamic currents in the Taiwan Strait.The south coastal assemblage extended to nearly the entire area of the Taiwan Strait along with a strong and intense warm current that shrinks in spring and winter when the southward intrusion of the cold Zhejiang-Fujian coastal current becomes stronger.The impact of shortterm and long-term environmental changes,such as extreme weather,global warming and human activity on nekton assemblages,had been recognized but need further research.Our study on nekton assemblages could be used as a baseline for measuring future changes. | SONG Puqing LIN Longshan LI Yuan ZHONG Zhihui | 2016 | Acta Oceanologica Sinica2016，35，6： | 3 |
| 15 | Theoretical modeling of chemical nonequilibrium stagnation point boundary layer heat transfer under rarefied conditions显示文摘This paper theoretically studies the recombination-dominated nonequilibrium reacting flow inside the stagnation point boundary layer (SPBL) and the heat transfer characteristics under rarefied conditions. A general model is intuitively proposed to describe the energy transfer and conversion along the stagnation streamline towards a slightly blunted nose with non-catalytic wall surface. It is found that the atoms recombination effects inside the SPBL could be equivalent to a modification on the degree of dissociation in the external flow. As a result, a recombination nonequilibrium criterion Dar , that is a specific Damkhler number, is introduced to characterize the nonequilibrium degree of the reacting flow in the SPBL, and then, based on the general model and Dar , a bridging function indicating the nonequilibrium chemical effects on the SPBL heat transfer is established. By using the explicitly analytical bridging function, the flow and heat transfer mechanisms, including the real gas flow similarity law and the nonequilibrium flow regimes classification, are discussed. In addition, the direct simulation Monte Carlo (DSMC) method has also been employed to systematically validate the analytical results. | WANG ZhiHui BAO Lin TONG BingGang | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，5： | 3 |
| 16 | Petrogenesis of the Early Cretaceous Tiantangshan A-type Granite in northwestern Guangdong province, SE China and tectonic implications显示文摘1 Introduction During the late Mesozoic times,the SE China is characterized by extensive magmatism and mineralization.The widely distributed granitoids with different(I-,S-and A-)types have been inferred to be closely related to the large-scale polymetallic mineralization.The Nanling tungsten-tin polymetallic belt is endowed with | JIA Ruya WANG Guochang GENG Lin ZHANG Zhihui JIA Hongxiang | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 2 |
| 17 | Three new lignan glucosides from the roots of Scutellaria baicalensis显示文摘Three new lignan glucosides, baicalensinosides A–C(1–3), were isolated from the roots of Scutellaria baicalensis. The structural elucidation was achieved by in-depth spectroscopic examinations and qualitative chemical test. Structurally, these compounds belong to the 3,4-dibenzyltetrahydrofurantype lignan glycoside with a mono-hydroxyl substitution at the 70-position of benzylidene group on the numbering system of lignans being one of their shared critical features. The anti-osteoporotic activity of the isolated compounds was assessed in an in vitro osteoprotegerin(OPG) transcriptional activity assay using dual luciferase reporter detection. At 10 μmol/L, compounds 1–3 increased the relative activating ratio of OPG transcription to 1.83, 0.84 and 0.98 times that of the control group, respectively. | Hailin Long Haijing Zhang Anjun Deng Lin Ma Lianqiu Wu Zhihong Li Zhihui Zhang Wenjie Wang Jiandong Jiang Hailin Qin | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 2 |
| 18 | Hyaluronic acid-based hydrogels with tobacco mosaic virus containing cell adhesive peptide induce bone repair in normal and osteoporotic rats显示文摘Tobacco mosaic virus(TMV)has been studied as a multi-functional agent for bone tissue engineering.An osteo-inductive effect of wild-type TMV has been reported,as it can significantly enhance the bone differentiation potential of bone marrow stromal cells both on a two-dimensional substrate and in a three-dimensional(3D)hydrogel system.A TMV mutant(TMV-RGD1)was created which featured the adhesion peptide arginyl-glycyl-aspartic acid(RGD),the most common peptide motif responsible for cell adhesion to the extracellular matrix,on the surface of the virus particle to enhance the bio-functionality of the scaffold material.We hypothesised that the incorporation of either wild-type TMV or TMV-RGD1 in the 3D hydrogel scaffold would induce bone healing in critical size defects of the cranial segmental bone.We have previously tested the virus-functionalised scaffolds,in vitro,with a hyaluronic acid-based system as an in-situ hydrogel platform for 3D cell encapsulation,culture,and differentiation.The results of these experiments suggested the potential of the virus-functionalised hydrogel to promote in vitro stem cell differentiation.The hydrogel-forming system we employed was shown to be safe and biocompatible in vivo.Here,we further explored the physiological responses regarding bone regeneration of a calvarial defect in both normal and osteoporotic ovariectomized rat models.Our results,based on histological analysis in both animal models,suggested that both wild-type TMV and TMV-RGD1 functionalised hydrogels could accelerate bone regeneration,without systemic toxicity,evaluated by blood counts.New bone formation was intensified by the incorporation of the RGD-mutant viral particles.This finding increased the potential for use of the rodshaped plant virus as a platform for the addition of powerful biofunctionality for tissue engineering applications.This study was approved by the Ethics Committee on Animal Use of the Zhenjiang Affiliated First People’s Hospital affiliated to Jiangsu University. | Jishan Yuan Panita Maturavongsadit Zhihui Zhou Bin Lv Yuan Lin Jia Yang Jittima Amie Luckanagul | 2020 | Biomaterials Translational2020，1，1： | 2 |
| 19 | Effect of film types on thermal response,cellular structure,forming defects and mechanical properties of combined in-mold decoration and microcellular injection molding parts显示文摘Different types of polymer films were used in the combined in-mold decoration and microcellular injection molding(IMD/MIM)process.The multiphase fluid-solid coupled heat transfer model was established to study the thermal response at the melt filling stage in the IMD/MIM process.It was found that the temperature distributed asymmetrically along the thickness direction due to the changed heat transfer coefficient of the melt on the film side.When polyethylene terephthalate(PET)films were applied,the temperature of the melt-film interface increased faster and to be higher at the end of melt filling stage in comparison with the application of polycarbonate(PC)and thermoplastic polyurethane(TPU)films.And the effects of film types on the cellular structure,forming defects and mechanical properties of IMD/MIM parts were also studied experimentally.The results showed that the film types had no obvious effect on the cells size in the transition layer and the mechanical properties of the parts.Under certain film thickness,the offset distance of core layer was the largest with PET film used,while the offset distance was the smallest with TPU film used.And similar results were found for the warpage of the parts.However,an exactly opposite change occurred for the thickness of film-side transition layer and the bubble marks on the surface of the parts. | Wei Guo Zhihui Yu Wenting Wei Zhenghua Meng Huajie Mao Lin Hua | 2021 | Journal of Materials Science & Technology2021，，33： | 1 |
| 20 | MALE STERILITY 3 encodes a plant homeodomain-finger protein for male fertility in soybean显示文摘Male-sterile plants are used in hybrid breeding to improve yield in soybean(Glycine max(L.)Merr.).Developing the capability to alter fertility under different environmental conditions could broaden germplasm resources and simplify hybrid production.However,molecular mechanisms potentially underlying such a system in soybean were unclear.Here,using positional cloning,we identified a gene,MALE STERILITY 3(MS3),which encodes a nuclear-localized protein containing a plant homeodomain(PHD)-finger domain.A spontaneous mutation in ms3 causing premature termination of MS3 translation and partial loss of the PHD-finger.Transgenetic analysis indicated that MS3 knockout resulted in nonfunctional pollen and no selfpollinated pods,and RNA-seq analysis revealed that MS3 affects the expression of genes associated with carbohydrate metabolism.Strikingly,the fertility of mutant ms3 can restore under longd conditions.The mutant could thus be used to create a new,more stable photoperiod-sensitive genic male sterility line for two-line hybrid seed production,with significant impact on hybrid breeding and production. | Jingjing Hou Weiwei Fan Ruirui Ma Bing Li Zhihui Yuan Wenxuan Huang Yueying Wu Quan Hu Chunjing Lin Xingqi Zhao Bao Peng Limei Zhao Chunbao Zhang Lianjun Sun | 2022 | Journal of Integrative Plant Biology2022，64，5： | 1 |
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