|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Copy number alteration profiling facilitates differential diagnosis between ossifying fibroma and fibrous dysplasia of the jaws显示文摘Ossifying fibroma(OF)and fibrous dysplasia(FD)are two fibro-osseous lesions with overlapping clinicopathological features,making diagnosis challenging.In this study,we applied a whole-genome shallow sequencing approach to facilitate differential diagnosis via precise profiling of copy number alterations(CNAs)using minute amounts of DNA extracted from morphologically correlated microdissected tissue samples.Freshly frozen tissue specimens from OF(n=29)and FD(n=28)patients were obtained for analysis.Lesion fibrous tissues and surrounding normal tissues were obtained by laser capture microdissection(LCM),with~30–50 cells(5000–10000µm2)per sample.We found that the rate of recurrent CNAs in OF cases was much higher(44.8%,13 of 29)than that in FD cases(3.6%,1 of 28).Sixty-nine percent(9 of 13)of the CNA-containing OF cases involved segmental amplifications and deletions on Chrs 7 and 12.We also identified eight CNA-associated genes(HILPDA,CALD1,C1GALT1,MICALL2,PHF14,AIMP2,MDM2,and CDK4)with amplified expression,which was consistent with the copy number changes.We further confirmed a jaw lesion with a previous uncertain diagnosis due to its ambiguous morphological features and the absence of GNAS mutation as OF based on the typical Chr 12 amplification pattern in its CNA profile.Moreover,analysis of a set of longitudinal samples collected from an individual with a cellular lesion in suspicion of OF at the first surgery,recurrence and the latest malignant transformation revealed identical CNA patterns at the three time points,suggesting that copy number profiling can be used as an important tool to identify borderline lesions or lesions with malignant potential.Overall,CNA profiling of fibro-osseous lesions can greatly improve differential diagnosis between OF and FD and help predict disease progression. | Ming Ma Lu Liu Ruirui Shi Jianyun Zhang Xiaotian Li Xuefen Li Jiaying Bai Jianbin Wang Yanyi Huang Tiejun Li | 2021 | International Journal of Oral Science2021，13，2： | 3 |
| 2 | What kind of optical model potentials should be used for deuteron stripping reactions?显示文摘This paper presents the results of a study that compares CTOM, a microscopic optical model potential(OMP), which is an optical model co-created by the China Nuclear Data Center & Tuebingen University, to CH89, which is a typical phenomenological OMP.The respective OMPs were tested by applying them to the modelling of nucleon elastic scattering and(d,p) transfer reactions involving14C,36S, and58Ni targets at both low and relatively high energies. The results demonstrated that although both potentials successfully accounted for the angular distributions of both the elastic scattering and transfer cross sections, the absolute values of the transfer cross sections calculated using CTOM were approximately 25% larger than those calculated using CH89. This increased transfer cross sections allowed CTOM to produce single particle strength reduction factors for the three reactions that were consistent with those extracted from(e,e′p) reactions as well as with more recent(p,2p) and(p,pn) reactions. Notch tests suggested that nucleon elastic scattering and transfer reactions are sensitive to different regions of the OMP;accordingly,phenomenological OMPs, which are constrained only by elastic scattering cross sections, may not be sufficient for nucleon transfer reactions. Therefore, we suggest that microscopic OMPs, which reflect more theoretical considerations, should be preferred over phenomenological ones in calculations of direct nuclear reactions. | XiaoYan Yun DanYang Pang YiPing Xu Zhi Zhang RuiRui Xu ZhongYu Ma CenXi Yuan | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，2： | 2 |
| 3 | Import of Rift Valley fever to China:a potential new threat?显示文摘Several recent studies in Virologica Sinica and other journals have highlighted the enormous international challenge of emerging arboviral diseases,such as Zika virus disease,dengue,and chikungunya(Islam et al.,2015;Maurice et al.,2015;Dai et al.,2016;Deng et al.,2016;Song et al.,2016;Wang et al.,2016;Xu et al.,2016;Zhang et al.,2016;Zhou | Xinliang FU Lifang Wang Bo Fang Ruirui Ma Yun Zheng San Huang Pei Zhou Zongxi Cao Jin Tian Shoujun Li Guihong Zhang | 2016 | Virologica Sinica2016，31，5： | 2 |
| 4 | Energetic particles’fluxes and dose in the Radiation Gene Box measured by space radiation detector onboard SJ-10 satellite显示文摘Background To evaluate the hazard of space radiation posing to the tissues,it is important to obtain exact fluxes of different radiation particles.The Radiation Gene Box(RGB)onboard SJ-10 spacecraft was an instrument designed to investigate the effects of space environment on the mESCs and drosophila.To derive the dose received by the tissues inside the RGB,the Space Radiation Detector(SRD)was installed inside it.Purpose The SRD was designed to derive the fluxes of electron,proton,hellion and gamma rays around it.If the type of the particles,the energies,the fluxes and the conversion coefficients are known,the dose received by the tissues could be evaluated.Methods The SRDwas designed as a △E-E solid-state telescope.By measuring the energy deposited in the three subdetectors,the particles’type and their energies could be discriminated.The data of SRDwere divided into 15 bins by the types of particles and their energy ranges.Results The gamma ray flux was higher than any other particle flux inside the RGB,and the electron was the most intense charge particle,while the helium ion was the most harmful radiation to the cells inside the RGB.Conclusion The dose rate inside the Radiation Gene Box was much higher than in the ground,but the integral dose of 12 days inside the RGB was about 2.13 mSv.It seemed unlikely to have obvious biological effects on the tissues of mice and drosophila. | Xingzhu Cui Yaqing Liu Wenxi Peng Jinzhou Wang Min Gao Dongya Guo Xiaohua Liang Ruirui Fan Huanyu Wang Yunlong Zhang Zhongjian Ma Mingyang Yan Hong Xiao Yuanda Jiang Haiying Hang | 2018 | Radiation Detection Technology and Methods2018，2，2： | 2 |
| 5 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 6 | MALE STERILITY 3 encodes a plant homeodomain-finger protein for male fertility in soybean显示文摘Male-sterile plants are used in hybrid breeding to improve yield in soybean(Glycine max(L.)Merr.).Developing the capability to alter fertility under different environmental conditions could broaden germplasm resources and simplify hybrid production.However,molecular mechanisms potentially underlying such a system in soybean were unclear.Here,using positional cloning,we identified a gene,MALE STERILITY 3(MS3),which encodes a nuclear-localized protein containing a plant homeodomain(PHD)-finger domain.A spontaneous mutation in ms3 causing premature termination of MS3 translation and partial loss of the PHD-finger.Transgenetic analysis indicated that MS3 knockout resulted in nonfunctional pollen and no selfpollinated pods,and RNA-seq analysis revealed that MS3 affects the expression of genes associated with carbohydrate metabolism.Strikingly,the fertility of mutant ms3 can restore under longd conditions.The mutant could thus be used to create a new,more stable photoperiod-sensitive genic male sterility line for two-line hybrid seed production,with significant impact on hybrid breeding and production. | Jingjing Hou Weiwei Fan Ruirui Ma Bing Li Zhihui Yuan Wenxuan Huang Yueying Wu Quan Hu Chunjing Lin Xingqi Zhao Bao Peng Limei Zhao Chunbao Zhang Lianjun Sun | 2022 | Journal of Integrative Plant Biology2022，64，5： | 1 |
| 7 | DOCK2 regulates antifungal immunity by regulating RAC GTPase activity显示文摘Fungal infections cause~1.5 million deaths each year worldwide,and the mortality rate of disseminated candidiasis currently exceeds that of breast cancer and malaria.The major reasons for the high mortality of candidiasis are the limited number of antifungal drugs and the emergence of drug-resistant species.Therefore,a better understanding of antifungal host defense mechanisms is crucial for the development of effective preventive and therapeutic strategies.Here,we report that DOCK2(dedicator of cytokinesis 2)promotes indispensable antifungal innate immune signaling and proinflammatory gene expression in macrophages.DOCK2-deficient macrophages exhibit decreased RAC GTPase(Rac family small GTPase)activation and ROS(reactive oxygen species)production,which in turn attenuates the killing of intracellular fungi and the activation of downstream signaling pathways.Mechanistically,after fungal stimulation,activated SYK(spleen-associated tyrosine kinase)phosphorylates DOCK2 at tyrosine 985 and 1405,which promotes the recruitment and activation of RAC GTPases and then increases ROS production and downstream signaling activation.Importantly,nanoparticle-mediated delivery of in vitro transcribed(IVT)Rac1 mRNA promotes the activity of Rac1 and helps to eliminate fungal infection in vivo.Taken together,this study not only identifies a critical role of DOCK2 in antifungal immunity via regulation of RAC GTPase activity but also provides proof of concept for the treatment of invasive fungal infections by using IVT mRNA. | Xiaojian Ma Xi Tan Bingbing Yu Wanwei Sun Heping Wang Huijun Hu Yanyun Du Ruirui He Ru Gao Qianwen Peng Zhihui Cui Ting Pan Xiong Feng Junhan Wang Chengqi Xu Bin Zhu Wei Liu Chenhui Wang | 2022 | Cellular & Molecular Immunology2022，19，5： | 1 |
| 8 | Engineering the native methylotrophs for the bioconversion of methanol to value-added chemicals:current status and future perspectives显示文摘Methanol is becoming an attractive fermentation feedstock for large-scale bioproduction of chemicals,due to its natural abundance and mature production technology.Native methylotrophs,which can utilize methanol as the only source of carbon and energy,are ideal hosts for methanol bioconversion due to their high methanol utili-zation rate and have been extensively employed in the production of value-added chemicals from methanol.Here,we review the natural methanol utilization pathways in native methylotrophs,describing the available synthetic biology tools developed for engineering native methylotrophs,and discuss the strategies for improving their methanol utilization efficiency.Finally,the representative examples of engineering the native methylotrophs to produce value-added products from methanol are summarized.Furthermore,we also discuss the major challenges and possible solutions for the application of native methylotrophs in methanol-based biomanufacturing. | Jing Wang Ruirui Qin Yuanke Guo Chen Ma Xin Wang Kequan Chen Pingkai Ouyang | 2023 | Green Chemical Engineering2023，4，2： | 0 |
| 9 | Enhanced separation of tetrafluoropropanol from water via carbon nanotubes membranes:insights from molecular dynamics simulations显示文摘Fluorinated alcohols exhibit promising prospects in chemical industry because of their special structure and many exciting properties,in which tetrafluoropropanol(TFP)is extensive applied in synthesis of pesticides,dyestuffs,variety of solvents and detergents.However,the presence of TFP in water garners increasing attention globally because of their intrinsic potential to threat ecosystems and human health.Carbon nanotubes(CNTs)membranes are burgeoning candidates for TFP-water separation owing to well-endowed extraordinary structural and transport properties.However,a grand challenge lies in the rational design of CNTs for improving separation performance.Herein,molecular dynamics(MD)simulations were performed to investigate the effects of various parameters on the separation of TFP-water mixtures including feed temperature,CNTs pore diameters,and fluorine functionalization position.It was found that TFP was pre-selected in CNTs ranging from 9.48 to 18.98Ådue to preferential adsorption and diffusion mechanism.Excellent separation factor of 16 was achieved by(7,7)CNTs and the mass fraction of TFP was purified from 75%to 97.51%.Fluorine modified CNTs separated TFP and water by preferentially permeating water due to hydrogen bonding interaction.Simulation results showed that CNTs modified at both the entrance and interior had better separation performance than CNT modified only at one of these positions.The 100wt%water content in permeate was achieved by(11,11)CNTs modified with fluorine at the entrance and interior.These findings provide valuable insights for designing potential candidates for fluorinated alcohol-water azeotropic mixtures membrane separation,and promise extensive application aspects for the reclamation of fluorinated alcohol. | Qing Li Xiaomeng Wang Ying Liu Zhun Ma Qun Wang Dongmei Xu Jun Gao Ruirui Wu Hui Sun Xueli Gao | 2023 | Frontiers of Environmental Science & Engineering2023，17，11： | 0 |
| 10 | A reference-grade genome assembly for Astragalus mongholicus and insights into the biosynthesis and high accumulation of triterpenoids and flavonoids in its roots显示文摘Astragalus membranaceus var.mongholicus(AMM),a member of the Leguminosae,is one of the most important medicinal plants worldwide.The dried roots of AMM have a wide range of pharmacological effects and are a traditional Chinese medicine.Here,we report the first chromosome-level reference genome of AMM,comprising nine pseudochromosomes with a total size of 1.47 Gb and 27868 protein-encoding genes.Comparative genomic analysis reveals that AMM has not experienced an independent wholegenome duplication(WGD)event after the WGD event shared by the Papilionoideae species.Analysis of long terminal repeat retrotransposons suggests a recent burst of these elements at approximately 0.13 million years ago,which may explain the large size of the AMM genome.Multiple gene families involved in the biosynthesis of triterpenoids and flavonoids were expanded,and our data indicate that tandemduplication has been the main driver for expansion of these families.Among the expanded families,the phenylalanine ammonia-lyase gene family was primarily expressed in the roots of AMM,suggesting their roles in the biosynthesis of phenylpropanoid compounds.The functional versatility of 2,3-oxidosqualene cyclase genes in cluster Ⅲ may play a critical role in the diversification of triterpenoids in AMM.Our findings provide novel insights into triterpenoid and flavonoid biosynthesis and can facilitate future research on the genetics and medical applications of AMM. | Yi Chen Ting Fang He Su Sifei Duan Ruirui Ma Ping Wang Lin Wu Wenbin Sun Qichen Hu Meixia Zhao Lianjun Sun Xuehui Dong | 2023 | Plant Communications2023，4，2： | 0 |
| 11 | Polymer-based synthetic oncolytic virus-like nanoparticles for cancer immunotherapy显示文摘Oncolytic viruses have emerged as new powerful therapeutic agents for cancer therapy by specifically lysing cancer cells while activating innate immune responses at the same time.However,due to the thorny issues of safety concerns and host immune reaction,the clinical application of oncolytic viruses is still limited.Herein,we report a rationally designed oncolytic virus-like nanoparticles(OV-NPs)composed of stimulator of interferon genes(STING)-stimulating polymer loaded with therapeutic genes for cancer immunotherapy.After injection into tumor,the OV-NPs carrying OX40L plasmid could reprogram tumor cells to express OX40L immune checkpoint molecules and activate the STING pathway for cooperatively enhancing antitumor immunity,with a tumor suppression rate of 92.3%in B16F10 tumor model and 78.7%in MC38 tumor model without causing any toxicity.The OV-NPs could be further applied in carrying other plasmids(IL-12)and utilization in gene combination therapy.This study should inspire designing synthetic OV-NPs as alternative strategies for extending oncolytic virus application in cancer immunotherapy. | Yuxi Gao Hanqin Zhao Jiayu Zhao Sheng Ma Xinghui Si Liping Liu Ruirui Qiao Wantong Song Xuesi Chen | 2023 | Science China Chemistry2023，66，12： | 0 |
| 12 | Measurements of Reaction Cross Section and Fragment Momentum Distribution for Proton-rich Nucleus ^31Cl显示文摘 | Fang Deqing Ma Chunwang Fu Yaoa Ma Yugang Cai Xiangzhou Guo Wei Liu Guihua Shi Yu Tian Wendong Wang Hongwei Fan Ruirui Fu Fen Gao Hui Gao Qi Guo Wentao Han Jianlong Hu Zhengguo Huang Tianhen Jia Fei Lei Xiangguo Li Bo Sun Zhiyu Wang Meng Wang Jiansong Xiao Zhigang Xu Zhiguo Yao Xiangwu Zhang Hongbin Zhang Xueheng Zheng Chuan Xu Hushan Xiao Guoqing Zhan Wenlong | 2007 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2007，，1： | 0 |
| 13 | Research and Optimization of GPSR Routing Protocol for Vehicular Ad-Hoc Network显示文摘Security is one of the most critical issues to Vehicular Ad-hoc Networks (VANETs) since the information transmitted is asynchronous and distributed. Vulnerability and instability are two of the challenges remain to be addressed by the research community and the industry. In this paper, we first proposed a trust reliability based model and extended the GPSR protocol to TM-GPSR protocol. Then, we improved the LET-GPSR protocol based on the link connection time prediction. On this basis, combined the decision index of the TM-GPSR and LET-GPSR protocols, we proposed the RC-GPSR routing protocol. We built the standard testing platform on the NS2 and SUMO, the average end-to-end delay and packet delivery rate of GPSR protocol and the three updates protocols under different node density, node speed, and malicious node ratio are simulated and evaluated. The results showed that under the same conditions, compared with GPSR protocol, RC-GPSR protocol has a lower average end-to-end delay and a higher packet delivery rate, which effectively improves the link stability and security. | Jianming Cui Liang Ma Ruirui Wang Ming Liu | 2022 | China Communications2022，19，10： | 0 |
| 14 | Construction of the 'Three-integration' Rolling Development Mode in the Urban-rural Fringe from the Perspective of Thematic Business Engine : A Case Study of 'Zhucheng Dinosaur Eco-city' in Shandong Province显示文摘Starting from the transformation and upgrading of traditional culture,the optimization and development of traditional industries,and the innovation of traditional models,this paper used cultural entrepreneurship to trigger the thematic business engine,and explored Zhucheng City with its unique dinosaur culture.It proposed'Three-integration'rolling development mode to build Zhucheng into a new highland of cultural entrepreneurship and create new competitiveness under the background of agricultural and rural modernization development.This paper also explored from the perspective of multi-subject collaboration of cultural entrepreneurship.Government needs to establish rolling development pilot projects and promote their application;enterprises need to play the engine role of thematic business through the mode of'getting larger to help smaller ones';the masses need to pay attention to the reaction of culture to the economy,so as to promote the wave of high-level promotion of cultural inheritance and urban-rural integration. | Yanhong GE Ruhui MA Ruirui DUAN Yaxu CHEN Shuai SHANG | 2023 | Asian Agricultural Research2023，15，8： | 0 |
| 15 | Efficacy Differences of First-line EGFR-TKIs Alone vs in Combination with Chemotherapy in Advanced Lung Adenocarcinoma Patients with Sensitive EGFR Mutation and Concomitant Non-EGFR Genetic Alterations显示文摘Background and objective:Epidermal growth factor receptor(EGFR)mutations are often associated with non-EGFR genetic alterations,which maybe a reason for the poor efficacy of EGFR tyrosine kinase inhibitors(TKIs).Here we conducted this study to explore whether EGFR-TKIs combined with chemotherapy would benefit advanced lung adenocarcinoma patients with both sensitive EGFR mutation and concomitant non-EGFR genetic alterations.Materials and methods:Cases of advanced lung adenocarcinoma with EGFR mutation combined with concomitant nonEGFR genetic alterations were retrospectively collected.And the patients were required to receive first-line EGFR-TKIs and chemotherapy combination or EGFR-TKIs monotherapy.Demographic,clinical and pathological data were collected,and the electronic imaging data were retrieved to evaluate the efficacy and time of disease progression.Survival data were obtained through face-to-face or telephone follow-up.The differences between the two groups in objective response rate(ORR),disease control rate(DCR),progression-free survival(PFS)and overall survival(OS)were investigated.Results:107 patients were included,including 63 cases in the combination group and 44 cases in the monotherapy group.The ORR were 78%and 50%(P=0.003),and DCR were 97%and 77%(P=0.002),respectively.At a median follow-up of 13.7 mon,a PFS event occurred in 38.1%and 81.8%of patients in the two groups,with median PFS of18.8 mon and 5.3 mon,respectively(P<0.000,1).Median OS was unreached in the combination group,and 27.8 mon in the monotherapy group(P=0.31).According to the Cox multivariate regression analysis,combination therapy was an independent prognostic factor of PFS.Conclusion:In patients with EGFR-mutant advanced lung adenocarcinoma with concomitant non-EGFR genetic alterations,combination of TKIs and chemotherapy was significantly superior to EGFR-TKIs monotherapy,which should be the preferred treatment option. | Guowei ZHANG Ruirui CHENG Yuanyuan NIU Huijuan WANG Xiangtao YAN Mina ZHANG Xiaojuan ZHANG Jinpo YANG Chunhua WEI Zhiyong MA | 2022 | 中国肺癌杂志2022，25，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员