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| 1 | The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis显示文摘 | Fang Wang Wei Song Hongmei Zhao Yanni Ma Yuxia Li Di Zhai Jingnan Pi Yanmin Si Jiayue Xu Lei Dong Rui Su Mengmeng Zhang Yong Zhu Xiaoxia Ren Fei Miao Wenjie Liu Feng Li Junwu Zhang Aibin He Ge Shan Jingyi Hui Linfang Wang Jia Yu | 2017 | Cell Research2017，27，3： | 7 |
| 2 | Energy-balanced multiple-sensor collaborative scheduling for maneuvering target tracking in wireless sensor networks显示文摘An energy-balanced multiple-sensor collaborative scheduling is proposed for maneuvering target tracking in wireless sensor networks (WSNs). According to the position of the maneuvering target, some sensor nodes in WSNs are awakened to form a sensor cluster for target tracking collaboratively. In the cluster, the cluster head node is selected to implement tracking task with changed sampling interval. The distributed interactive multiple model (IMM) filter is employed to estimate the target state. The estimation accuracy is improved by collaboration and measurement information fusion of the tasking nodes. The balanced distribution model of energy in WSNs is constructed to prolong the lifetime of the whole network. In addition, the communication energy and computation resource are saved by adaptively changed sampling intervals, and the real-time performance is satisfactory. The simulation results show that the estimation accuracy of the proposed scheme is improved compared with the nearest sensor scheduling scheme (NSSS) and adaptive sensor scheduling scheme (ASSS). Under satisfactory estimation accuracy, it has better performance in saving energy and energy balance than the dynamic collaborative scheduling scheme (DCSS). | Liu, Yonggui Xu, Bugong Feng, Linfang | 2011 | 控制理论与应用(英文版)2011，9，1： | 7 |
| 3 | Silicon substrate-integrated hollow waveguide for miniaturized optical gas sensing显示文摘Gas sensors have a wide variety of applications.Among various existing gas sensing technologies,optical gas sensors have outstanding advantages.The development of the Internet of Things and consumer electronics has put stringent requirements on miniaturized gas sensing technology.Here,we demonstrate a chip-scale silicon substrate-integrated hollow waveguide(Si-iHWG) to serve as an optical channel and gas cell in an optical gas sensor.It is fabricated through silicon wafer etching and wafer bonding.The Si-i HWG chip is further assembled with an off-chip light source and detector to build a fully functional compact nondispersive infrared(NDIR) CO_(2) sensor.The chip size is 10 mm × 9 mm,and the dimension of the sensor excluding the microcontroller board is 50 mm × 25 mm × 16 mm.This chip solution with compactness,versatility,robustness,and low cost provides a cost-effective platform for miniaturized optical sensing applications ranging from air quality monitoring to con-sumer electronics. | SHAONAN ZHENG HONG CAI LINFANG XU NANXI LI ZHONGHUA GU YAO ZHANG WEIGUO CHEN YANYAN ZHOU QINGXIN ZHANG LENNON YAO TING LEE | 2022 | Photonics Research2022，10，1： | 2 |
| 4 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 5 | OPTIMUM DESIGN OF HIGH-SPEED RAILWAY LOCOMOTIVE TRACTION GEAR显示文摘OPTIMUMDESIGNOFHIGH-SPEEDRAILWAYLOCOMOTIVETRACTIONGEARLiLixing;WangXiuqi;HeWeidong;ZhaoWenzhong;QianYuanmei(DalianRailwayInst... | Li Lixing Wang Xiuqi He Weidong Zhao Wenzhong Qian Yuanmei (Dalian Railway Institute) Liu Youmei Gui Linfang Xiao Peng Pan Xiaoming Xu Zongxiang (Zhuzhou Electric Locomotive Works ) | 1996 | Chinese Journal of Mechanical Engineering1996，9，4： | 1 |
| 6 | Volitinib, a potent and highly selective c-Met inhibitor, effectively blocks c-Met signaling and growth in c-MET amplified gastric cancer patient-derived tumor xenograft models显示文摘 | Paul R. Gavine Yongxin Ren Lu Han Jing Lv Shiming Fan Wei Zhang Wen Xu Yuan Jie Liu Tianwei Zhang Haihua Fu Yongjuan Yu Huiying Wang Shirlian Xu Feng Zhou Xinying Su XiaoLu Yin Liang Xie Linfang Wang Weiguo Qing Longxian Jiao Weiguo Su Q. May Wang | 2014 | Molecular Oncology2014，，： | 1 |
| 7 | RING finger 138 deregulation distorts NF-κB signaling and facilities colitis switch to aggressive malignancy显示文摘Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling transduction.Here,we discovered the critical role of RING finger 138(RNF138)in CRC tumorigenesis through regulating the NF-кB signaling,which is independent of its Ubiquitin-E3 ligase activity involved in DNA damage response.RNF138^(−/−) mice were hyper-susceptible to the switch from colitis to aggressive malignancy,which coincided with sustained aberrant NF-кB signaling in the colonic cells.Furthermore,RNF138 suppresses the activation of NF-кB signaling pathway through preventing the translocation of NIK and IKK-Beta Binding Protein(NIBP)to the cytoplasm,which requires the ubiquitin interaction motif(UIM)domain.More importantly,we uncovered a significant correlation between poor prognosis and the downregulation of RNF138 associated with reinforced NF-кB signaling in clinical settings,raising the possibility of RNF138 dysregulation as an indicator for the therapeutic intervention targeting NF-кB signaling.Using the xenograft models built upon either RNF138-dificient CRC cells or the cells derived from the RNF138-dysregulated CRC patients,we demonstrated that the inhibition of NF-кB signaling effectively hampered tumor growth.Overall,our work defined the pathogenic role of aberrant NF-кB signaling due to RNF138 downregulation in the cascade events from the colitis switch to colonic neoplastic transformation and progression,and also highlights the possibility of targeting the NF-кB signaling in treating specific subtypes of CRC indicated by RNF138-ablation. | Yalan Lu Rong Huang Jianming Ying Xingchen Li Tao Jiao Lei Guo Haitao Zhou Han Wang Amannisa Tuersuntuoheti Jianmei Liu Qichen Chen Yanhong Wang Luying Su Changyuan Guo Fu Xu Ziyi Wang Yan Lu Kai Li Junbo Liang Zhen Huang Xiao Chen Jinjie Yao Hanjie Hu Xiaowen Cheng Yufeng Wan Xinyan Chen Ning Zhang Shiying Miao Jianqiang Cai Linfang Wang Changzheng Liu Wei Song Hong Zhao | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 0 |
| 8 | Mechanically scanned leaky-wave antenna based on a topological one-way waveguide显示文摘We propose a uniform backfire-to-endfire leaky-wave antenna(LWA)based on a topological one-way waveguide under external bias magnetic field.We systematically analyze the dispersion,showing that the proposed structure supports leaky mode arisen from total internal reflection.By means of tuning frequency or magnetic field,we obtain fixed-bias frequency and fixed-frequency bias LWA with continuous beam scanning from backward,broadside to forward direction.More importantly,we,for the first time,demonstrate that this proposed LWA shows mechanical tunability,allowing us to manipulate the radiation direction from backward,broadside to forward direction by mechanically tuning the air layer thickness.The simulated results show that our system exhibits super low 3dB beam width,high radiation efficiency as well as high antenna gain.Being provided such multiple controlled(especially mechanically)beam scanning manners,the present LWA paves an advanced approach for continuous beam scanning,holding a great potential for applications in modern communication and radar system. | Qian Shen Yun You Jie Xu Yun Shen Xiaohua Deng Zhuoyuan Wang Weidong Min Linfang Shen Sanshui Xiao | 2020 | Frontiers of physics2020，15，3： | 0 |
| 9 | SARS-CoV-2-specific antibody response characteristics in COVID-19 patients of different ages显示文摘Age has been found to be one of the main risk factors for the severity and outcome of COVID-19.However,differences in SARS-CoV-2 specific antibody responses among COVID-19 patients of different age groups remain largely unknown.In this study,we analyzed the IgG/IgM responses to 21 SARS-CoV-2 proteins and 197 peptides that fully cover the spike protein against 731 sera collected from 731 COVID-19 patients aged from 1 to 92 years.We show that there is no overall difference in SARS-CoV-2 antibody responses in COVID-19 patients in the 4 age groups.By antibody response landscape maps,we find that the IgG response profiles of SARS-CoV-2 proteins are positively correlated with age.The S protein linear epitope map shows that the immunogenicity of the S-protein peptides is related to peptide sequence,disease severity and age of the COVID-19 patients.Furthermore,the enrichment analysis indicates that low S1 IgG responses are enriched in patients aged<50 and high S1 IgG responses are enriched in mild COVID-19 patients aged>60.In addition,high responses of non-structural/accessory proteins are enriched in severe COVID-19 patients aged>70.These results suggest the distinct immune response of IgG/IgM to each SARS-CoV-2 protein in patients of different age,which may facilitate a deeper understanding of the immune responses in COVID-19 patients. | Linfang Lu Siqi Yu Min Liu Yang Li Qing Lei Mingxi Lin Danyun Lai Shujuan Guo Hewei Jiang Hongyan Hou Yunxiao Zheng Xuening Wang Mingliang Ma Bo Zhang Hong Chen Junbiao Xue Hainan Zhang Huan Qi Ziyong Sun Feng Wang Xionglin Fan Zhaowei Xu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，4： | 0 |
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