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| 1 | An EcoCity model for regulating urban land cover structure and thermal environment: Taking Beijing as an example显示文摘Urban land-use/cover changes and their effects on the eco-environment have long been an active research topic in the urbanization field. However, the characteristics of urban inner spatial heterogeneity and its quantitative relationship with thermal environment are still poorly understood, resulting in ineffective application in urban ecological planning and management.Through the integration of 'spatial structure theory' in urban geography and 'surface energy balance' in urban climatology, we proposed a new concept of urban surface structure and thermal environment regulation to reveal the mechanism between urban spatial structure and surface thermal environment. We developed the EcoCity model for regulating urban land cover structure and thermal environment, and established the eco-regulation thresholds of urban surface thermal environments. Based on the comprehensive analysis of experimental observation, remotely sensed and meteorological data, we examined the spatial patterns of urban habitation, industrial, infrastructure service, and ecological spaces. We examined the impacts of internal land-cover components(e.g., urban impervious surfaces, greenness, and water) on surface radiation and heat flux. This research indicated that difference of thermal environments among urban functional areas is closely related to the proportions of the land-cover components.The highly dense impervious surface areas in commercial and residential zones significantly increased land surface temperature through increasing sensible heat flux, while greenness and water decrease land surface temperature through increasing latent heat flux. We also found that different functional zones due to various proportions of green spaces have various heat dissipation roles and ecological thresholds. Urban greening projects in highly dense impervious surfaces areas such as commercial, transportation, and residential zones are especially effective in promoting latent heat dissipation efficiency of vegetation, leading to strongly cooling effect of unit vegetation coverage. This research indicates that the EcoCity model provides the fundamentals to understand the coupled mechanism between urban land use structure and surface flux and the analysis of their spatiotemporal characteristics. This model provides a general computational model system for defining urban heat island mitigation, the greening ratio indexes, and their regulating thresholds for different functional zones. | KUANG WenHui YANG TianRong LIU AiLin ZHANG Chi LU DengSheng CHI WenFeng | 2017 | Science China Earth Sciences2017，60，6： | 16 |
| 2 | Remote sensing-based artificial surface cover classification in Asia and spatial pattern analysis显示文摘Artificial surfaces, characterized with intensive land-use changes and complex landscape structures, are important indicators of human impacts on terrestrial ecosystems. Without high-resolution land-cover data at continental scale, it is hard to evaluate the impacts of urbanization on regional climate, ecosystem processes and global environment. This study constructed a hierarchical classification system for artificial surfaces, promoted a remote sensing method to retrieve subpixel components of artificial surfaces from 30-m resolution satellite imageries(Globe Land30) and developed a series of data products of high-precision urban built-up areas including impervious surface and vegetation cover in Asia in 2010. Our assessment, based on multisource data and expert knowledge, showed that the overall accuracy of classification was 90.79%. The mean relative error for the impervious surface components of cities was 0.87. The local error of the extracted information was closely related to the heterogeneity of urban buildings and vegetation in different climate zones. According to our results, the urban built-up area was 18.18×104 km2, accounting for 0.59% of the total land surface areas in Asia; urban impervious surfaces were 11.65×104 km2, accounting for 64.09% of the total urban built-up area in Asia. Vegetation and bare soils accounted for 34.56% of the urban built-up areas. There were three gradients: a concentrated distribution, a scattered distribution and an indeterminate distribution from east to west in terms of spatial pattern of urban impervious surfaces. China, India and Japan ranked as the top three countries with the largest impervious surface areas, which respectively accounted for 32.77%, 16.10% and 11.93% of the urban impervious surface area of Asia. We found the proportions of impervious surface and vegetation cover within urban built-up areas were closely related to the economic development degree of the country and regional climate environment. Built-up areas in developed countries had relatively low impervious surface and high public green vegetation cover, with 50–60% urban impervious surfaces in Japan, South Korea and Singapore. In comparison, the proportion of urban impervious surfaces in developing countries is approaching or exceeding 80% in Asia. In general, the composition and spatial patterns of built-up areas reflected population aggregation and economic development level as well as their impacts on the health of the environment in the sub-watershed. | KUANG WenHui CHEN LiJun LIU JiYuan XIANG WeiNing CHI WenFeng LU DengSheng YANG TianRong PAN Tao LIU AiLin | 2016 | Science China Earth Sciences2016，59，9： | 12 |
| 3 | Drug screening for influenza neuraminidase inhibitors显示文摘Neuraminidase (NA) is one of the most important targets to screen the drugs of anti-influenza virus A and B. After virtual screening approaches were applied to a compound database which possesses more than 10000 compound structures, 160 compounds were selected for bioactivity assay, then a High Throughput Screening (HTS) model established for influenza virus NA inhibitors was applied to detect these compounds. Finally, three compounds among them displayed higher inhibitory activities, the range of their IC50 was from 0.1 μmol/L to 3μmol/L. Their structural scaffolds are novel and different from those of NA inhibitors approved for influenza treatment, and will be useful for the design and research of new NA inhibitors. The resuit indicated that the combination of virtual screening with HTS was very significant to drug screening and drug discovery. | LIU Ailin, CAO Hongpeng & DU Guanhua Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China | 2005 | Science China(Life Sciences)2005，48，1： | 7 |
| 4 | Research Progress of the Antiviral Bioactivities of Natural Flavonoids显示文摘Flavonoids are now considered as an indispensable component in a variety of nutraceutical and pharmaceutical applications.Most recent researches have focused on the health aspects of flavonoids for humans.Especially,different flavonoids have been investigated for their potential antiviral activities,and several natural flavonoids exhibited significant antiviral properties both in vitro and in vivo.This review provides a survey of the literature regarding the evidence for antiviral bioactivities of natural flavonoids,highlights the cellular and molecular mechanisms of natural flavonoids on viruses,and presents the details of most reported flavonoids.Meanwhile,future perspectives on therapeutic applications of flavonoids against viral infections were discussed. | Lin Wang Junke Song Ailin Liu Bin Xiao Sha Li Zhang Wen Yang Lu Guanhua Du | 2020 | Natural Products and Bioprospecting2020，10，5： | 4 |
| 5 | Soil Microbial Community and Enzyme Activity Responses to Herbaceous Plant Expansion in the Changbai Mountains Tundra, China显示文摘As one of the most sensitive regions to global climate change, alpine tundra in many places around the world has been undergoing dramatic changes in vegetation communities over the past few decades.Herbaceous plant species in the Changbai Mountains area have significantly expanded into tundra shrub communities over the past 30 yr.Soil microbial communities, enzyme activities, and soil nutrients are intertwined with this expansion process.In order to understand the responses of the soil microbial communities to such an expansion, we analyzed soil microbial community structures and enzyme activities in shrub tundra as well as areas with three different levels of herbaceous plant expansion.Our investigation was based on phospholipid fatty acid(PLFA) analysis and 96-well microtiter plates.The results showed that herbs have expanded greatly in the tundra, and they have become the dominant species in herbaceous plant expansion areas.There were differences for community composition and appearance among the shrub tundra and the mild expansion, moderate expansion, and severe expansion areas.Except for soil organic matter, soil nutrients were increased in herbaceous plant expansion areas, and the total nitrogen(TN), total phosphorus(TP), available nitrogen(AN), and available phosphorus(AP) were greatest in moderate expansion areas(MOE), while soil organic matter levels were highest in the non-expanded areas(CK).The total soil PLFAs in the three levels of herbaceous plant expansion areas were significantly higher than those in the non-expanded areas, and total soil PLFAs were highest in the moderately expanded area and lowest in the severely expanded area(SEE).Bacteria increased significantly more than fungi and actinomycetes with herbaceous plant expansion.Soil hydrolase activities(β-1,4-glucosidase(βG) activity, β-1, 4-N-acetylglucosaminidase(NAG) activity, and acid phosphatase(aP) activity) were highest in MOE and lowest in the CK treatment.Soil oxidase activities(polyphenol oxidase(PPO) activities and peroxidase(PER) activities) were also highest in MOE, but they were lowest in the SEE treatment.The variations in total soil PLFAs with herbaceous plant expansion were mostly correlated with soil organic matter and available phosphorus concentrations, while soil enzyme activities were mostly correlated with the total soil nitrogen concentration.Our results suggest that herbaceous plant expansion increase the total soil PLFAs and soil enzyme activities and improved soil nutrients.However, soil microorganisms, enzyme activity, and nutrients responded differently to levels of herbaceous plant expansion.The soil conditions in mild and moderate expansion areas are more favorable than those in severe expansion areas. | JIN Yinghua ZHANG Yingjie XU Zhiwei GU Xiaonan XU Jiawei TAO Yan HE Hongshi WANG Ailin LIU Yuxia NIU Liping | 2019 | Chinese Geographical Science2019，29，6： | 4 |
| 6 | Pharmacokinetic study of gallocatechin-7-gallate from Pithecellobium clypearia Benth. in rats显示文摘The pharmacokinetic profile of gallocatechin-7-gallate(J10688)was studied in rats after intravenous administration.Male and female Sprague-Dawley(SD)rats received 1,3,and 10 mg/kg(i.v.)of J10688 and plasma drug concentrations were determined by a high performance liquid chromatography-mass spectrometry(LC–MS)method.The pharmacokinetic software Data Analysis System(Version 3.0)was used to calculate the pharmacokinetic parameters.For different i.v.doses of J10688,the mean peak plasma concentration(C_0)values ranged from 11.26 to 50.82 mg/L,and mean area under the concentration-time curve(AUC_(0–t))values ranged from 1.75 to 11.80(mg h/L).J10688 lacked dosedependent pharmacokinetic properties within doses between 1 and 10 mg/kg,based on the power model.The method developed in this study was sensitive,precise,and stable.The pharmacokinetic properties of J10688 in SD rats were shown to have rapid distribution and clearance values.These pharmacokinetic results may contribute to an improved understanding of the pharmacological actions of J10688. | Chao Li Xiaowei Song Junke Song Xiaocong Pang Zhe Wang Ying Zhao Wenwen Lian Ailin Liu Guanhua Du | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 4 |
| 7 | Damage of hippocampal neurons in rats with chronic alcoholism显示文摘Chronic alcoholism can damage the cytoskeleton and aggravate neurological deficits. However, the effect of chronic alcoholism on hippocampal neurons remains unclear. In this study, a model of chronic alcoholism was established in rats that were fed with 6% alcohol for 42 days. Endogenous hydrogen sulfide content and cystathionine-beta-synthase activity in the hippocampus of rats with chronic alcoholism were significantly increased, while F-actin expression was decreased. Hippocampal neurons in rats with chronic alcoholism appeared to have a fuzzy nuclear membrane, mitochondrial edema, and ruptured mitochondrial crista. These findings suggest that chronic alcoholism can cause learning and memory decline in rats, which may be associated with the hydrogen sulfide/cystathionine-beta-synthase system, mitochondrial damage and reduced expression of F-actin. | Ailin Du Hongbo Jiang Lei Xu Na An Hui Liu Yinsheng Li Ruiling Zhang | 2014 | Neural Regeneration Research2014，9，17： | 3 |
| 8 | Comparative Assessment of Tundra Vegetation Changes Between North and Southwest Slopes of Changbai Mountains, China, in Response to Global Warming显示文摘Vegetation in high altitude areas normally exhibits the strongest response to global warming. We investigated the tundra vegetation on the Changbai Mountains and revealed the similarities and differences between the north and the southwest slopes of the Changbai Mountains in response to global warming. Our results were as follows: 1) The average temperatures in the growing season have increased from 1981 to 2015, the climate tendency rate was 0.38℃/10 yr, and there was no obvious change in precipitation observed. 2) The tundra vegetation of the Changbai Mountains has changed significantly over the last 30 years. Specifically, herbaceous plants have invaded into the tundra zone, and the proportion of herbaceous plants was larger than that of shrubs. Shrub tundra was transforming into shrub-grass tundra. 3) The tundra vegetation in the north and southwest slopes of the Changbai Mountains responded differently to global warming. The southwest slope showed a significantly higher degree of invasion from herbaceous plants and exhibited greater vegetation change than the north slope. 4) The species diversity of plant communities on the tundra zone of the north slope changed unimodally with altitude, while that on the tundra zone of the southwest slope decreased monotonously with altitude. Differences in the degree of invasion from herbaceous plants resulted in differences in species diversity patterns between the north and southwest slopes. Differences in local microclimate, plant community successional stage and soil fertility resulted in differential responses of tundra vegetation to global warming. | JIN Yinghua ZHANG Yingjie XU Jiawei TAO Yan HE Hongshi GUO Meng WANG Ailin LIU Yuxia NIU Liping | 2018 | Chinese Geographical Science2018，28，4： | 3 |
| 9 | Electrochemical oxidation of luteolin at a glassy carbon electrode and its application in pharmaceutical analysis显示文摘 | Liu Ailin Zhang Shaobo Huang Liying | | 0，，06： | 1 |
| 10 | Electrochemical oxidation of luteolin at a glassy carbon electrode and its appli- cation in pharmaceutical analysis 显示文摘 | Liu Ailin Zhang Shaobo Huang Liying | 2008 | Chem Pharm Bull2008，56，6： | 1 |
| 11 | A Rapid-Ab/Desorption and Portable Photothermal MIL- 101(Cr) Nanofibrous Composite Membrane Fabricated by Spray-Electrospinning for Atmosphere Water Harvesting显示文摘MIL-101(Cr)is a promising moisture absorbent for solar-driven water harvesting from moisture to tackle the worldwide water shortage issue.However,the MIL-101(Cr)powder suffers from a long ab/desorption cycle due to the crystal aggregation caused by its inherent powder properties.Here,we demonstrate a MIL-101(Cr)nanofibrous composite membrane with a nanofibrous matrix where MIL-101(Cr)is monodisperse in the 3D porous nanofibrous matrix through a simple spray-electrospinning strategy.The continuous porous nanofibrous matrix not only offers sufficient sites for MIL-101(Cr)loading but also provides rapid moisture transport channels,resulting in a super-rapid ab/desorption duration of 50 min(including an absorption process for 40 min and a desorption process for 10 min)and multicycle daily water production of 15.9 L kg^(−1) d^(−1).Besides,the MIL-101(Cr)nanofibrous composite membrane establishes a high solar absorption of 92.8%,and excellent photothermal conversion with the surface temperature of 70.7°C under one-sun irradiation.In addition,the MIL-101(Cr)nanofibrous composite membrane shows excellent potential for practical application due to its flexibility,portability,and use stability.This work provides a new perspective of shortening MOF ab/desorption duration by introducing a porous nanofibrous matrix to improve the specific water production for the solar-driven ab/desorption water harvesting technique. | Ailin Li Jian Xiong Ye Liu Liming Wang Xiaohong Qin Jianyong Yu | 2023 | Energy & Environmental Materials2023，6，1： | 1 |
| 12 | Elevated levels of urinary 8-hydroxy-2 -deoxyguanosine, lymphocytic micronuclei, and serum glutathione S-transferase in workers exposed to coke oven emissions 显示文摘 | LIU Ailin LU Wenqing WANG Zengzhen | 2006 | Environ Health Perspect2006，114，5： | 1 |
| 13 | CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer显示文摘Background:Overexpression of Aurora-A(AURKA)is a feature of breast cancer and associates with adverse prognosis.The selective Aurora-A inhibitor alisertib(MLN8237)has recently demonstrated promising antitumor responses as a single agent in various cancer types but its phase III clinical trial was reported as a failure since MLN8237 did not show an apparent effect in prolonging the survival of patients.Thus,identification of potential targets that could enhance the activity of MLN8237 would provide a rationale for drug combination to achieve better therapeutic outcome.Methods:Here,we conducted a systematic synthetic lethality CRISPR/Cas9 screening of 507 kinases using MLN8237 in breast cancer cells and identified a number of targetable kinases that displayed synthetic lethality interactions with MLN8237.Then,we performed competitive growth assays,colony formation assays,cell viability assays,apoptosis assays,and xenograft murine model to evaluate the synergistic therapeutic effects of Haspin(GSG2)depletion or inhibition with MLN8237.For mechanistic studies,immunofluorescence was used to detect the state of microtubules and the localization of Aurora-B and mitotic centromere-associated kinesin(MCAK).Results:Among the hits,we observed that Haspin depletion or inhibition marginally inhibited breast cancer cell growth but could substantially enhance the killing effects of MLN8237.Mechanistic studies showed that co-treatment with Aurora-A and Haspin inhibitors abolished the recruitment of Aurora-B and mitotic centromere-associated kinesin(MCAK)to centromeres which were associated with excessive microtubule depolymerization,kinetochore-microtubule(KT-MT)attachment failure,and severe mitotic catastrophe.We further showed that the combination of MLN8237 and the Haspin inhibitor CHR-6494 synergistically reduced breast cancer cell viability and significantly inhibited both in vitro and in vivo tumor growth.Conclusions:These findings establish Haspin as a synthetic lethal target and demonstrate CHR-6494 as a potential combinational drug for promoting the therapeutic effects of MLN8237 on breast cancer. | Ailin Chen Shijun Wen Fang Liu Zijian Zhang Meiling Liu Yuanzhong Wu Bin He Min Yan Tiebang Kang Eric W-F Lam Zifeng Wang Quentin Liu | 2021 | Cancer Communications2021，41，2： | 1 |
| 14 | Peroxidase-like activity of cupric oxide nanoparticle显示文摘 | Chen Wei Chen Juan Liu Ailin | 2011 | Chern Cat Chern2011，3，7： | 1 |
| 15 | The ?409 C/T Genotype of PRSS1 Protects Against Pancreatic Cancer in the Han Chinese Population显示文摘 | Qicai Liu Xinhua Lin Jingfeng Liu Ailin Liu Feng Gao | 2012 | Digestive Diseases and Sciences2012，，2： | 1 |
| 16 | A bioinformatic evaluation of potential allergenicity of 85 candidate genes in transgenic organisms显示文摘The potential of genetically modified organisms(GMOs) to increase allergenicity or predispositions to allergies has attracted much attention.An approach that will properly and holistically evaluate the allergenicity of GMOs is yet to be found.Here,85 transgenes that have been reported in both international and domestic studies during recent years are summarized case by case;49 of the transformed genes were from plant sources and 36 were from animal sources.EVALLERTM,a web server for the in silico assessment of potential protein allergenicity,was used to evaluate the potential of the transgenic proteins as allergens.The biomedical journals listed in Highwire(http://gffzzd58bc32f34884012hq5wwv5q6wcou66qk.ffgz.tsg.suse.edu.cn/) were searched and reviewed to decipher whether any of the transformed genes were linked to allergenicity or human health.The EVALLER analysis identified 5 allergenic genes,whilst our literature review found 11 genes that were either related to allergic cases or to clinical adverse events;all 16 of these genes have been used in GMOs.The analysis pathway that we have developed can help guide the selection of genes to be used in genetic modification.The pathway also provides a paradigm for allergenicity analysis of transgene candidates. | ZOU ZeHong HE Ying RUAN Lin SUN BaoQing CHEN HuiFang CHEN De LIU ShiMing YANG XiaoGuang TAO AiLin | 2012 | Chinese Science Bulletin2012，57，15： | 1 |
| 17 | Simultaneous vohammetric determination of norepinephrine, ascorbic acid and uric acid on polycal-concarboxylie acid modified glassy carbon electrode 显示文摘 | Ailin Liu Shaobo Zhang Wei Chen | 2008 | Biosensors and Bioelectronics2008，23，： | 1 |
| 18 | Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities显示文摘 | Liu Ailin Wang Haidi Lee S M | 2008 | Bioorg Med Chem2008，16，15： | 1 |
| 19 | Research progress of p-type Fe-based skutterudite thermoelectric materials显示文摘Filled skutterudite is currently one of the most promising intermediate-temperature thermoelectric(TE)materials,having good thermoelectric transport performance and excellent mechanical properties.For the preparation of high-efficiency filled skutterudite TE devices,it is important to have p-and n-type filled skutterudite TE materials with matching performance.However,the current TE properties of p-type Fe-based filled skutterudite materials are worse than n-type filled skutterudite materials.Therefore,how to obtain high-performance p-type Fe-based filled skutterudite materials is the key to preparation of high-efficiency skutterudite-based TE devices.This review summarizes some methods for optimizing the thermal transport performance of p-type filled skutterudite materials at the atomic-molecular and nano-mesoscopic scale that have been used in recent years.These methods include doping,multi-atom filling,and use of low-dimensional structure and of nanocomposite.In addition,the synergistic optimization methods of the electrical and thermal transport parameters and advanced preparation technologies of p-type filled skutterudite materials in recent years are also briefly summarized.These optimizational methods and advanced preparation technologies can significantly improve the TE properties of p-type Fe-based filled skutterudite materials. | Xin TONG Zhiyuan LIU Jianglong ZHU Ting YANG Yonggui WANG Ailin XIA | 2021 | Frontiers of Materials Science2021，15，3： | 1 |
| 20 | Enhanced chemiluminescence of the luminol-hydrogen peroxide system by colloidal cupric oxide nanoparticles as peroxidase mimic 显示文摘 | Chen Wei Hong Lei Liu Ailin | 2012 | Talanta2012，99，： | 1 |
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