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| 1 | Additive manufacturing of metals:Microstructure evolution and multistage control显示文摘As a revolutionary industrial technology,additive manufacturing creates objects by adding materials layer by layer and hence can fabricate customized components with an unprecedented degree of freedom.For metallic materials,unique hierarchical microstructures are constructed during additive manufacturing,which endow them with numerous excellent properties.To take full advantage of additive manufacturing,an in-depth understanding of the microstructure evolution mechanism is required.To this end,this review explores the fundamental procedures of additive manufacturing,that is,the formation and binding of melt pools.A comprehensive processing map is proposed that integrates melt pool energy-and geometry-related process parameters together.Based on it,additively manufactured microstructures are developed during and after the solidification of constituent melt pool.The solidification structures are composed of primary columnar grains and fine secondary phases that form along the grain boundaries.The post-solidification structures include submicron scale dislocation cells stemming from internal residual stress and nanoscale precipitates induced by intrinsic heat treatment during cyclic heating of adjacent melt pool.Based on solidification and dislocation theories,the formation mechanisms of the multistage microstructures are thoroughly analyzed,and accordingly,multistage control methods are proposed.In addition,the underlying atomic scale structural features are briefly discussed.Furthermore,microstructure design for additive manufacturing through adjustment of process parameters and alloy composition is addressed to fulfill the great potential of the technique.This review not only builds a solid microstructural framework for metallic materials produced by additive manufacturing but also provides a promising guideline to adjust their mechanical properties. | Zhiyuan Liu Dandan Zhao Pei Wang Ming Yan Can Yang Zhangwei Chen Jian Lu Zhaoping Lu | 2022 | Journal of Materials Science & Technology2022，，5： | 27 |
| 2 | Exosomes from Suxiao Jiuxin pill-treated cardiac mesenchymal stem cells decrease H3K27 demethylase UTX expression in mouse cardiomyocytes in vitro显示文摘Suxiao Jiuxin 药片(SJP ) 是为在中国的急性冠的症候群的处理的繁体中文药,它包含二个主要部件, tetramethylpyrazine (TMP ) 和龙脑(BOR ) 。因此远然而,在心脏的微型环境上位于 SJP 的有益的效果下面的分子的机制是未知的。心脏的间充质的干细胞(C-MSCs ) 通过 microvesicles (exosomes ) 的版本与 cardiomyocytes (厘米) 交流恢复心脏的动态平衡并且得到修理,部分地通过 epigenetic 规章的机制。在这研究,我们检验了 SJP 处理是否改变了 C-MSC-derived exosomes (SJP-Exos ) 引起 epigenetic 在接受者厘米的色彩的改变。从老鼠心孤立的 C-MSC 是有 SJP (SJP-Exos ) 的 pretreated, TMP (TMP-Exos ) 或 BOR (BOR-Exos ) 。然后, HL-1 房间,一根鼠标 cardiomyocyte 线,从控制与 exosomes 被对待 C-MSCs (Ctrl-Exos ) , SJP-Exos, TMP-Exos 或 BOR-Exos。有 SJP-Exos 的处理显著地增加了 histone 的蛋白质层次 3 离氨酸 27 trimethylation (H3K27me3 ) ,为心脏的 transcriptional 抑制的一个关键 epigenetic 染色质标记,在 HL-1 房间。为了推进,探索 SJP-Exo-mediated H3K27me3 upregulation 的机制,我们在对待 exosome 的 HL-1 房间估计了关键 histone methylases (EZH1, EZH2 和 EED ) 和 demethylases (JMJD3 和 UTX ) 的 mRNA 表示层次。有 SJP-Exo 的处理有选择地在接受者 HL-1 房间压制了 UTX 表示。而且, PCNA,房间复制的一个内长的标记,比在 Ctrl-Exo-treated HL-1 房间在 SJP-Exo-treated HL-1 房间是显著地更高的。这些结果证明 SJP-Exos 增加 cardiomyocyte 增长并且证明 SJP 能调制 C-MSC-derived exosomes 引起 epigenetic 染色质在接受者 cardiomyocytes 改变;因而, SJP-Exos 可能被用来支持 cardiomyocyte 增长。 | Xiao-fen RUAN Yongdun LI Cheng-wei JU Yan SHEN Wei LEI Can CHEN Yang LI Hong YU Yu-tao LIU II-man KIM Xiao-long WANG Neal L WEINTRAUB Yaoliang TANG | 2018 | Acta Pharmacologica Sinica2018，39，4： | 23 |
| 3 | A novel micro-straw for cryopreservation of sma number of human spermatozoon显示文摘很少精子的 Cryopreservation 仍然是为男富饶保藏的主要挑战。这研究报导使用一新微稻草(LSL 稻草) 为为 intracytoplasmic 精子注射(ICSI ) 冻结很少精子。从 22 个肥沃的施主的精液样品被收集,并且每件精液样品被冲淡并且在 1:1 的比率与 cryoprotectant 混合了,然后结冰使用象 LSL 稻草(50-100 l ) 那样的三根不同稻草,传统 0.25 ml 和 0.5 根 ml 稻草。为结冰,所有稻草与液体氮被熏蒸,与直接归结为 130-140 的温度 ??? , | Feng Liu Sha-Sha Zou Yong Zhu Can Sun Yu-Fei Liu Shan-Shan Wang Wen-Bo Shi Jing-Jing Zhu Yong-Hua Huang Zheng Li | 2017 | Asian Journal of Andrology2017，19，3： | 19 |
| 4 | Can mean platelet volume play a role in evaluating the severity of acute pancreatitis?显示文摘AIM To investigate serum mean platelet volume(MPV) levels in acute pancreatitis(AP) patients and assess whether MPV effectively predicts the disease severity of AP.METHODS We included 117 consecutive patients with AP as the AP group and 34 consecutive patients with colorectal polyps(before endoscopic treatment) as the control group. Complete blood counts, liver function, platelet indices(MPV), coagulation parameters, lactate dehydrogenase(LDH) and C-reactive protein(CRP) were measured on days 1, 2, 3 and 7 after admission. Receiver operating characteristic curves were used to compare the sensitivity and specificity of MPV, white blood cell(WBC), LDH and CRP in predicting AP severity. The Modified Glasgow Prognostic Score(m GPS) and the 2012 revised Atlanta criteria were used to evaluate disease severity in AP.RESULTS MPV levels were significantly lower in the AP group than in the control group on day 1(P = 0.000), day 2(P = 0.029) and day 3(P = 0.001) after admission.In addition, MPV values were lower on day 1 after admission than on day 2(P = 0.012), day 3(P = 0.000) and day 7(P = 0.002) in all AP patients. Based on the m GPS, 78 patients(66.7%) were diagnosed with mild and 39 patients(33.3%) with severe AP. There was no significant difference in mean MPV levels between patients diagnosed with mild and severe AP based on the m GPS(P = 0.424). According to the 2012 revised Atlanta criteria, there were 98 patients(83.8%) without persistent organ failure(OF) [non-severe acute pancreatitis(non-SAP) group] and 19 patients(16.2%) with persistent OF(SAP group). MPV levels were significantly lower in the SAP group than in the non-SAP group on day 1 after admission(P = 0.002). On day 1 after admission using a cut-off value of 6.65 f L, the overall accuracy of MPV for predicting SAP according to the 2012 revised Atlanta criteria(AUC = 0.716) had a sensitivity of 91.8% and a specificity of 47.4% and was superior to the accuracy of the traditional markers WBC(AUC = 0.700) and LDH(AUC = 0.697).CONCLUSION MPV can be used at no additional cost as a useful, noninvasive biomarker that distinguishes AP with persistent OF from AP without persistent OF on day 1 of hospital admission. | Jing-Jing Lei Li Zhou Qi Liu Can Xiong Chun-Fang Xu | 2017 | World Journal of Gastroenterology2017，23，13： | 15 |
| 5 | Rupture process of the M_s 7.0 Lushan earthquake, 2013显示文摘On April 20, 2013 at 8:02 am, a magnitude 7.0 earthquake occurred in Lushan County, Sichuan Province, China, which induces massive landslides, causes great losses to life and property. Based on the locations of aftershocks provided by the China Earthquake Network Center and the characteristic of Longmenshan active faults system, combined with the current preliminary focal mechanism solution, the fault rupture direction is determined. With the finite fault inversion method, we invert the rupture process of the Lushan M s 7.0 earthquake by teleseismic waveforms data. The inversion results indicate that the main shock is dominated by thrust fault component and the rupture initiated at depth of 15 km, and most of slip ruptured around the hypocenter with the peak slip of about 1.5 m. Most of rupture slips released at the first 20 s and the main rupture occurred at the first 10 s after the onsets of the mainshock. Most of seismic energy released near the hypocenter with a length of 28 km, especially on both sides of the hypocenter with the range of 20 km, and the seismic energy released relatively smaller in other areas. There is a large area with weak slip between the main rupture and another two asperities on both sides of the hypocenter; it may imply that the accumulated strain on the rupture fault has not been completely released. Therefore, there is a significant possibility of having strong aftershocks in the areas where energy is not fully released. This is also the main reason why there are a lot of moderate to strong aftershocks in the Lushan aftershock sequence. In addition, there is an earthquake vacant zone with a length of about 50 km between the Wenchuan M w 7.9 earthquake and this event, which is of high earthquake risk and is deserved to be paid close attention to. | LIU ChengLi ZHENG Yong GE Can XIONG Xiong HSU HouTze | 2013 | Science China Earth Sciences2013，56，7： | 15 |
| 6 | Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells显示文摘AIM: To determine the underlying mechanisms of action and influence of Xiaotan Sanjie(XTSJ) decoction on gastric cancer stem-like cells(GCSCs). METHODS: The gastric cancer cell line MKN-45 line was selected and sorted by FACS using the cancer stem cell marker CD44; the stemness of these cells was checked in our previous study. In an in vitro study, the expression of Notch-1, Hes1, Vascular endothelial growth factor(VEGF), and Ki-67 in both CD44-positive gastric cancer stem-like cells(GCSCs) and CD44-negative cells was measured by Western blot. The effect of XTSJ serum on cell viability and on the above markers was measured by MTT assay and Western blot, respectively. In an in vivo study, the ability to induce angiogenesis and maintenance of GCSCs in CD44-positive-MKN-45- and CD44-negative-engrafted mice were detected by immunohistochemical staining using markers for CD34 and CD44, respectively. The role of XTSJ decoction in regulating the expression of Notch-1, Hes1, VEGF and Ki-67 was measured by Western blot and real-time polymerase chain reaction.RESULTS: CD44+ GCSCs showed more cell proliferation and VEGF secretion than CD44-negative cells in vitro, which were accompanied by the high expression of Notch-1 and Hes1 and positively associated with tumor growth(GCSCs vs CD44-negative cells, 2.72 ± 0.25 vs 1.46 ± 0.16, P < 0.05) and microvessel density(MVD)(GCSCs vs CD44-negative cells, 8.15 ± 0.42 vs 3.83 ± 0.49, P < 0.001) in vivo. XTSJ decoction inhibited the viability of both cell types in a dose-dependent manner in vitro. Specifically, a significant difference in the medium-(82.87% ± 6.53%) and high-dose XTSJ groups(77.43% ± 7.34%) was detected at 24 h in the CD44+ GCSCs group compared with the saline group(95.42% ± 5.76%) and the low-dose XTSJ group(90.74% ± 6.57%)(P < 0.05). However, the efficacy of XTSJ decoction was reduced in the CD44- groups; significant differences were only detected in the high-dose XTSJ group at 48 h(78.57% ± 6.94%) and 72 h(72.12% ± 7.68%) when compared with the other CD44- groups(P < 0.05). Notably, these differences were highly consistent with the Notch-1, Hes1, VEGF and Ki-67 expression in these cells. Similarly, in vivo, XTSJ decoction inhibited tumor growth in a dose-dependent manner. A significant difference was observed in the medium(1.76 ± 0.15) and high-dose XTSJ(1.33 ± 0.081) groups compared with the GCSCs control group(2.72 ± 0.25) and the low-dose XTSJ group(2.51 ± 0.25)(P < 0.05). We also detected a remarkable decrease of MVD in the medium-(7.10 ± 0.60) and high-dose XTSJ(5.99 ± 0.47) groups compared with the GCSC control group(8.15 ± 0.42) and the low-dose XTSJ group(8.14 ± 0.46)(P < 0.05). Additionally, CD44 expression was decreased in these groups [medium-(4.43 ± 0.45) and high-dose XTSJ groups(3.56 ± 0.31) vs the GCSC control(5.96 ± 0.46) and low dose XTSJ groups(5.91 ± 0.38)](P < 0.05). The significant differences in Notch-1, Hes1, VEGF and Ki-67 expression highly mirrored the results of XTSJ decoction in inhibiting tumor growth, MVD and CD44 expression.CONCLUSION: Notch-1 may play an important role in regulating the proliferation of GCSCs; XTSJ decoction could attenuate tumor angiogenesis, at least partially, by inhibiting Notch-1. | Bing Yan Long Liu Ying Zhao Li-Juan Xiu Da-Zhi Sun Xuan Liu Ye Lu Jun Shi Yin-Cheng Zhang Yong-Jin Li Xiao-Wei Wang Yu-Qi Zhou Shou-Han Feng Can Lv Pin-Kang Wei Zhi-Feng Qin | 2014 | World Journal of Gastroenterology2014，20，36： | 14 |
| 7 | Migration of Depocenters and Accumulation Centers and its Indication of Subsidence Centers in the Mesozoic Ordos Basin显示文摘与岩性学和岩相在联合基于结构归属的综合学习和原来的盆的特征,中生代 Ordos 盆的沉积起源分析和厚度分发, depocenters 从东南逆时针方向移居了到北方然后到西南从,这被表明中间迟了对早白垩纪三叠纪。有不统一了并且除了在早白垩纪前的几个小孤立的累积中心的大规模累积中心。相对厚的阶层的带很好在几个阶段在西方的盆被开发的原因是这个区域在原来的 Ordos 盆的西方边界附近,有丰富的沉积供应,水动力学效果是强壮的。因此,他们代表本地累积中心。直到早白垩纪, depocenters,累积中心和沉淀,中心在 Ordos 盆的西南部分作为一个实体被迭加。直到中间的侏罗记的结束,仍然在那里出现了在到黄河的西方的剩余盆的一个 paleogeographic 和 paleostructural higher-in-west 和 lower-in-east 框架。从对中间的侏罗记晚三叠纪的中间的 Ordos 盆的 depocenters 一致地被迭加。在 depocenters 和他们的邻居的中生代和古生代的阶层的相对高的热成熟在这些区域建议活跃深效果。通常,在有高热的进化区域的几个时期和他们的一致性的 depocenters 的重叠揭示沉淀进程的控制。因此, depocenters 可以代表沉淀中心的位置。沉淀中心(或 depocenters ) 位于大规模 cratonic Ordos 盆的南方。这与低岬的曲折沉淀被联系,源于强壮的集中和与 Qinling 造山运动同时期的 orogenic 活动。 | ZHAO Junfeng LIU Chiyang WANG Xiaomei ZHANG Can | 2009 | Acta Geologica Sinica(English Edition)2009，83，2： | 12 |
| 8 | The levels, sources and reactivity of volatile organic compounds in a typical urban area of Northeast China显示文摘Air concentrations of volatile organic compounds(VOCs) were continually measured at a monitoring site in Shenyang from 20 August to 16 September 2017. The average concentrations of alkanes, alkenes, aromatics and carbonyls were 28.54, 6.30, 5.59 and9.78 ppbv, respectively. Seven sources were identified by the Positive Matrix Factorization model based on the measurement data of VOCs and CO. Vehicle exhaust contributed the most(36.15%) to the total propene-equivalent concentration of the measured VOCs,followed by combustion emission(16.92%), vegetation emission and secondary formation(14.33%), solvent usage(10.59%), petrochemical industry emission(9.89%), petrol evaporation(6.28%), and liquefied petroleum gas(LPG) usage(5.84%). Vehicle exhaust, solvent usage and combustion emission were found to be the top three VOC sources for O_3 formation potential, accounting for 34.52%, 16.55% and 11.94%, respectively. The diurnal variation of the total VOCs from each source could be well explained by their emission characteristics,e.g., the two peaks of VOC concentrations from LPG usage were in line with the cooking times for breakfast and lunch. Wind rose plots of the VOCs from each source could reveal the possible distribution of the sources around the monitoring site. The O_3 pollution episodes during the measurement period were found to be coincident with the elevation of VOCs, which was mainly due to the air parcel from the southeast direction where petrochemical industry emission was found to be dominant, suggesting that the petrochemical industry emission from the southeast was probably a significant cause of O_3 pollution in Shenyang. | Zhuobiao Ma Chengtang Liu Chenglong Zhang Pengfei Liu Can Ye Chaoyang Xue Di Zhao Jichen Sun Yiming Du Fahe Chai Yujing Mu | 2019 | Journal of Environmental Sciences2019，31，5： | 12 |
| 9 | Exosome-functionalized polyetheretherketone-based implant with immunomodulatory property for enhancing osseointegration显示文摘The host immune response effecting on biomaterials is critical to determine implant fates and bone regeneration property.Bone marrow stem cells(BMSCs)derived exosomes(Exos)contain multiple biosignal molecules and have been demonstrated to exhibit immunomodulatory functions.Herein,we develop a BMSC-derived Exos-functionalized implant to accelerate bone integration by immunoregulation.BMSC-derived Exos were reversibly incorporated on tannic acid(TA)modified sulfonated polyetheretherketone(SPEEK)via the strong interaction of TA with biomacromolecules.The slowly released Exos from SPEEK can be phagocytosed by co-cultured cells,which could efficiently improve the biocompatibilities of SPEEK.In vitro results showed the Exos loaded SPEEK promoted macrophage M2 polarization via the NF-κB pathway to enhance BMSCs osteogenic differentiation.Further in vivo rat air-pouch model and rat femoral drilling model assessment of Exos loaded SPEEK revealed efficient macrophage M2 polarization,desirable new bone formation,and satisfactory osseointegration.Thus,BMSC-derived Exos-functionalized implant exerted osteoimmunomodulation effect to promote osteogenesis. | Lei Fan Pengfei Guan Cairong Xiao Huiquan Wen Qiyou Wang Can Liu Yian Luo Limin Ma Guoxin Tan Peng Yu Lei Zhou Chengyun Ning | 2021 | Bioactive Materials2021，6，9： | 11 |
| 10 | Treatment of CD20-directed Chimeric Antigen Receptor-modified T cells in patients with relapsed or refractory B-cell non-Hodgkin lymphoma:an early phase IIa trial report显示文摘Patients with relapsed or refractory non-Hodgkin lymphoma have a dismal prognosis.Chimeric Antigen Receptor(CAR)-modified T cells(CART cells)that targeted CD20 were effective in a phase I clinical trial for patients with advanced B-cell lymphomas.We performed a phase IIa trial to further assess the safety and efficacy of administering autologous anti-CD20 CART(CART-20)cells to patients with refractory or relapsed CD20^(+)B-cell lymphoma.Eleven patients were enrolled,and seven patients underwent cytoreductive chemotherapy to debulk the tumors and deplete the lymphocytes before receiving T-cell infusions.The overall objective response rate was 9 of 11(81.8%),with 6 complete remissions(CRs)and 3 partial remissions;no severe toxicity was observed.The median progression-free survival lasted for 46 months,and 1 patient had a 27-month continuous CR.A significant inverse correlation between the levels of the CAR gene and disease recurrence or progression was observed.Clinically,the lesions in special sites,specifically the spleen and testicle,were refractory to CART-20 treatment.Collectively,these results together with our data from phase I strongly demonstrated the feasibility and efficacy of CART-20 treatment in lymphomas and suggest large-scale patient recruitment in a future study.This study was registered at www.clinicaltrials.org as NCT01735604. | Wen-ying Zhang Yao Wang Ye-lei Guo Han-ren Dai Qing-ming Yang Ya-jing Zhang Yan Zhang Mei-xia Chen Chun-meng Wang Kai-chao Feng Su-xia Li Yang Liu Feng-xia Shi Can Luo Wei-dong Han | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 11 |
| 11 | OsRFPH2-10, a RING-H2 Finger E3 Ubiquitin Ligase, Is Involved in Rice Antiviral Defense in the Early Stages of Rice dwarf virus Infection显示文摘 | Lifang Liu Lian Jin Xiahe Huang Yongtao Geng Feng Li Qingqing Qin Rui Wang Shaoyi Ji Shanshan Zhao Qi Xie Chunhong Wei Can Xie Biao Ding Yi Li | 2014 | Molecular Plant2014，7，6： | 11 |
| 12 | Dynamic changes of behaviors, dentate gyrus neurogenesis and hippocampal miR-124 expression in rats with depression induced by chronic unpredictable mild stress显示文摘The depression-like behavior phenotype,neurogenesis in the dentate gyrus and miR-124 expression in the hippocampus are the focus of current research on the pathogenesis of depression and antidepressant therapy.The present study aimed to clarify the dynamic changes of depression-like behavior,dentate gyrus neurogenesis and hippocampal miR-124 expression during depression induced by chronic stress to reveal pathological features at different stages of depression and to further provide insight into depression treatment.Chronic unpredictable mild stress depression models were established by exposing Sprague-Dawley rats to various mild stressors,including white noise,thermal swimming,stroboscopic illumination,soiled cages,pairing with three other stressed animals,cold swimming,tail pinch,restraint and water and food deprivation.Chronic unpredictable mild stress model rats underwent dynamic observation from 1 to 8 weeks and were compared with a control group(normal feeding without any stressors).To observe changes in the depression-like behavior phenotype during chronic unpredictable mild stress-induced depression,a sucrose preference test was used to evaluate the degree of anhedonia.An open-field test was used to evaluate locomotor activity and anxiety status.Compared with the control group,chronic unpredictable mild stress rats lost weight but did not have a depression-like behavioral phenotype at 1-4 weeks.Chronic unpredictable mild stress rats presented decreased sucrose preference and locomotor activity at 5-8 weeks.In addition,chronic unpredictable mild stress rats did not have significant anxiety-like behavior during 1-8 weeks of modeling.To observe neurogenesis dysfunctions and changes in neuronal number in the dentate gyrus during chronic unpredictable mild stress-induced depression,markers(DCX and DCX/BrdU)of neural proliferation and differentiation and the neuronal marker NeuN were assessed by immunofluorescence.Compared with the control group,neurogenesis and the neuronal number in the dentate gyrus did not change from 2 to 6 weeks;however,neural proliferation and differentiation in the dentate gyrus decreased,and the number of neurons decreased until the eighth week in the chronic unpredictable mild stress group.Real-time quantitative reverse transcription polymerase chain reaction assays and fluorescence in situ hybridization were used to measure the expression of hippocampal miR-124 during chronic unpredictable mild stress-induced depression.The results showed that the expression of hippocampal miR-124 was unchanged during the first 4 weeks but increased from 5 to 6 weeks and decreased from 7 to 8 weeks compared with the control group.These findings indicate that during chronic unpredictable mild stress-induced depression,the behavioral phenotype,miR-124 expression in the hippocampus,neurogenesis in the dentate gyrus and neuronal numbers showed dynamic changes,which suggested that various pathological changes occur at different stages of depression.All experimental procedures and protocols were approved by the Experimental Animal Ethics Committee of Guangzhou University of Chinese Medicine of China in March 2015. | Yun-Ling Huang Ning-Xi Zeng Jie Chen Jie Niu Wu-Long Luo Ping Liu Can Yan Li-Li Wu | 2020 | Neural Regeneration Research2020，15，6： | 10 |
| 13 | Early warning for geo-hazards based on the weather condition in China显示文摘According to national early warning practice for geo-hazards from 2003 to 2005,it is systematically concluded that the basic characteristics of geo-hazards,early warning method and forecast result based on the geological maps of China in a scale 1∶6 000 000.With the contrast of different characters between sustained rainfall and typhoon rainfall inducing geo-hazards,the disaster reduction result and some problems are preliminarily analyzed.Some basic recognition is that early warning to geo-hazards is feasible,national scale forecast is only to call attention,but can't immediately be used to disaster reduction decision-making.And,the future direction is to build a united disaster reduction framework of early warning system including national,provincial and county levels based on weather factors in different scale of area. | Chuanzheng LIU Yanhui LIU Mingsheng WEN Can TANG Tiefeng LI Jianfa LIAN | 2006 | Global Geology2006，9，2： | 9 |
| 14 | Polarization-maintaining few mode fiber composed of a central circular-hole and an elliptical-ring core显示文摘We propose a novel waveguide design of polarization-maintaining few mode fiber(PM-FMF) supporting ≥10non-degenerate modes, utilizing a central circular air hole and a circumjacent elliptical-ring core. The structure endows a new degree of freedom to adjust the birefringence of all the guided modes, including the fundamental polarization mode. Numerical simulations demonstrate that, by optimizing the air hole and elliptical-ring core,a PM-FMF supporting 10 distinctive polarization modes has been achieved, and the effective index difference Δn_(eff) between the adjacent guided modes could be kept larger than 1.32 × 10^(-4) over the whole C +L band. The proposed fiber structure can flexibly tailored to support an even larger number of modes in PM-FMF(14-mode PM-FMF has been demonstrated as an example), which can be readily applicable to a scalable mode division multiplexing system. | JIAJIA ZHAO MING TANG KYUNGHWAN OH ZHENHUA FENG CAN ZHAO RUOLIN LIAO SONGNIAN FU PERRY PING SHUM DEMING LIU | 2017 | Photonics Research2017，5，3： | 9 |
| 15 | Studies and advances on joint source-channel encoding/decoding techniques in flow media communications显示文摘Joint source-channel coding/decoding (JSCC/JSCD) techniques in flow media communications have become a state-of-the-art and one of the challenging research subjects in the spatial communication area. They have great application prospective and deep impact in various manned space flights, satellite missions, mobile radio communications and deep-space explorations. In the last few years, there have been influential achievements in JSCC/JSCD studies. This paper aims at an introduction to the basic principles of joint source-channel optimal design. A general summarization and classification for various existing JSCC/JSCD methods is addressed. Also presented is a JSCD scheme based on variable-length coding, capable of providing reliable resolutions for flow media data transmission in spatial communications. | TU GuoFang LIU JianJun ZHANG Can GAO ShaoShuai LI ShiDong | 2010 | Science China(Information Sciences)2010，53，1： | 8 |
| 16 | Polyploid organisms显示文摘Polyploids are organisms with three or more complete chromosome sets. Polyploidization is widespread in plants and animals, and is an important mechanism of speciation. Genome sequencing and related molecular systematics and bioinformatics studies on plants and animals in recent years support the view that species have been shaped by whole genome duplication during evolution. The stability of polyploids depends on rapid genome recombination and changes in gene expression after formation. The formation of polyploids and subsequent diploidization are important aspects in long-term evolution. Polyploids can be formed in various ways. Among them, hybrid organisms formed by distant hybridization could produce unreduced gametes and thus generate offspring with doubled chromosomes, which is a fast, efficient method of polyploidization. The formation of fertile polyploids not only promoted the interflow of genetic materials among species and enriched the species diversity, but also laid the foundation for polyploidy breeding. The study of polyploids has both important theoretical significance and valuable applications. The production and application of polyploidy breeding have brought remarkable economic and social benefits. | SONG Can LIU ShaoJun XIAO Jun HE WeiGuo ZHOU Yi QIN QinBo ZHANG Chun LIU Yun | 2012 | Science China(Life Sciences)2012，55，4： | 7 |
| 17 | Molecular Characterization and Drug-resistance of Mycobacterium tuberculosis Strains in Xuzhou, China显示文摘To understand the genetic diversity and drug resistance status of Mycobacterium tuberculosis(M tuberculosis)circulating in Xuzhou of China,the spacer-oligonucleotide typing(Spoligotyping)and multi-loci VNTRs(variable number tandem repeats)analysis(MLVA)were utilized for the genotyping of the isolates.Drug susceptibility test(DST) | PANG Hui TONG Jing LIU Hai Can DU Yang Guang ZHAO Xiu Qin JIANG Yi WU Xiao Cui YANG Jin Chuan WAN Kang Lin | 2014 | Biomedical and Environmental Sciences2014，27，12： | 7 |
| 18 | Jiaweisinisan facilitates neurogenesis in the hippocampus after stress damage显示文摘The traditional Chinese medicine Jiaweisinisan has antidepressant effects, and can inhibit hypothalamus-pituitary-adrenal gland axis hyperactivity in stress-induced depression. In this study, rat hippocampal neural precursor cells were cultured in serum-free medium in vitro and a stress damage model was established with 120 μM corticosterone. Cells were treated with 10% (v/v) Jiaweisinisan drug-containing serum and the corticosterone antagonist RU38486. Results of the 3-(4,5-dimethylthiazol-2-yl)-3,5-di-phenytetrazoliumromide assay showed that both Jiaweisinisan drug-containing serum and RU38486 promoted the proliferation of neural precursor cells after corticosterone exposure. Immunofluorescence detection showed that after Jiaweisinisan drug-containing serum and RU38486 treatment, the 5-bromo-2-deoxyuridine/terminal deoxynucleotidyl transferase dUTP nick end labeling ratio in hippocampal neural precursor cells significantly increased, and the apoptotic rates of glial cells reduced, and neuron-like cell differentiation from neural precursor cells significantly increased. Our experimental findings indicate that Jiaweisinisan promotes hippocampal neurogenesis after stress damage. | Lili Wu Chuanlian Ran Shukao Liu Lizhen Liao Yanling Chen Hualei Guo Weikang Wu Can Yan | 2013 | Neural Regeneration Research2013，8，12： | 7 |
| 19 | The spatial pattern of farming and factors influencing it during the Peiligang culture period in the middle Yellow River valley, China显示文摘The Peiligang culture(ca.7000–5000 cal BC)is the earliest Neolithic culture in the middle Yellow River valley and represents the emergence of cereal farming in the region[1].It has long been considered representative of millet farming[2],which requires a dry field,a certain amount of rainfall,and minimal crop management,but new records reveal that mixed farming of millet and rice(Oryza sp.)took place during this period[3].Therefore,it is possible | Can Wang Houyuan Lu Wanfa Gu Naiqin Wu Jianping Zhang Xinxin Zuo Fengjiang Li Daojing Wang Yajie Dong Songzhi Wang Yanfeng Liu Yingjian Bao Yayi Hu | 2017 | Science Bulletin2017，62，23： | 6 |
| 20 | Numerical and experimental investigation on dynamic performance of bump foil journal bearing based on journal orbit显示文摘Widespread usage of bump-type foil journal bearing(BFJB) in oil-free microturbomachinery requires accurate predictions of dynamic performance characteristics, although it remains a challenging issue because BFJB reflects nonlinear both structurally and aerodynamically.This paper presented a simple experimental method to semi-directly obtain the minimum film thickness and dynamic stiffness of BFJB using the journal orbit. Numerical calculations and simulations are conducted to validate the experimental method. The micro-deformation and interaction of various foils are taken into consideration to improve the model precision. The results from the numerical model regarding the BFJB dynamic characteristics are compared with the experimental results coming from a dedicated test rig, which shows that the experimental results fluctuate obviously and agree not well with the numerical results at the start stage due to the presence of dry friction at that time, nevertheless, they show fantastic agreement as soon as a gas film is gradually generated to separate the shaft from the top foil. Therefore, the proposed experimental method is effective to predict film thickness and dynamic characteristics during the period from the lift-off time to the land-off time. The dynamic characteristics, along with the journal orbits also can be used to rapidly predict the dynamics behavior of rotor-bearing systems. | Yu ZHOU Longtao SHAO Can ZHANG Fenzhu JI Jiang LIU Guo LI Shuiting DING Qi ZHANG Farong DU | 2021 | Chinese Journal of Aeronautics2021，34，2： | 6 |
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