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| 1 | Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies显示文摘Chronicity of hepatitis B(CHB)infection is characterized by a weak immune response to the virus.Entecavir(ETV)and adefovir dipivoxil(ADV)are effective in suppressing hepatitis B virus(HBV)replication.However,the underlying immune mechanism in the antiviral response of patients treated with nucleoside or nucleotide analogs is not clearly understood.In this study,regulatory T cells(Tregs)and intracellular cytokines,including IL-2,interferon(IFN)-γ,tumor-necrosis factor(TNF)-α and IL-4,were measured prior to and at 12,24,36 and 48 weeks after treatment with ETV or ADV.The cytokines were increased from 24 to 48 weeks after treatment.Higher levels of Th1 cytokines were observed with ETV(n=29)versus ADV(n=28)treatment.By contrast,the numbers of Tregs in both groups were decreased.The altered cytokine profile and cellular component was accompanied by a decrease in HBV DNA levels in both groups,which may contribute to their therapeutic effect in CHB infection.Our findings suggest that the antiviral effect of the drugs may be attributed not only to their direct effect on virus suppression but also to their immunoregulatory capabilities. | Yanfang Jiang Wanyu Li Lei Yu Jingjing Liu Guijie Xin Hongqing Yan Pinghui Sun Hong Zhang Damo Xu Junqi Niu | 2011 | Cellular & Molecular Immunology2011，8，1： | 16 |
| 2 | Design and control of methyl acetate-methanol separation via heat-integrated pressure-swing distillation显示文摘Design and control of pressure-swing distillation(PSD) with different heat integration modes for the separation of methyl acetate/methanol azeotrope are explored using Aspen Plus and Aspen Dynamics. First, an optimum steady-state separation configuration conditions are obtained via taking the total annual cost(TAC) or total reboiler heat duty as the objective functions. The results show that about 27.68% and 25.40% saving in TAC can be achieved by the PSD with full and partial heat integration compared to PSD without heat integration. Second,temperature control tray locations are obtained according to the sensitivity criterion and singular value decomposition(SVD) analysis and the single-end control structure is effective based on the feed composition sensitivity analysis. Finally, the comparison of dynamic controllability is made among various control structures for PSD with partial and full heat integration. It is shown that both control structures of composition/temperature cascade and pressure-compensated temperature have a good dynamic response performance for PSD with heat integration facing feed flowrate and composition disturbances. However, PSD with full heat integration performs the poor controllability despite of a little bit of economy. | Zhishan Zhang Qingjun Zhang Guijie Li Meiling Liu Jun Gao | 2016 | Chinese Journal of Chemical Engineering2016，24，11： | 12 |
| 3 | Genetic variation and selection of introduced provenances of Siberian Pine(Pinus sibirica) in frigid regions of the Greater Xing'an Range,Northeast China显示文摘Siberian Pine(Pinus sibirica) is an ecologically and economically important species in pristine forests throughout northern Russia. Four provenances of P. sibirica were introduced from Mongolia and Russia to the Greater Xing'an Range(the Daxing'anling), northeast China in 1993. The aim of this research was to study genetic variation and selection of the introduced four Pinus sibirica provenances. Heights(H), basal diameters(BD), survival rates(SR) and crown lengths(CL) of different families were measured as primary outcomes in different growth years. Results of data analyses demonstrated high coefficients of phenotypic variation(PCV) and heritability(H2) for H, BD and CL at 18 years after introduction. PCV and H2 increased with age. Correlations of growth traits between any two growth years were all significantly positive, but the correlation coefficient was smaller when the growth year interval was larger. Correlations between H and the original environment factors decreased gradually, indicating that with long-term subsistence in the new environment, the influence of the source environment declined. Colligation of multiple traits to estimate provenances showed that Novosibirsk, Tomsk, and Altai Mountains had higher survival rates and biomass, and proved more suitable for introduction and plantation in the Greater Xing'an Range in China. | Xiyang Zhao Cheng Wang Shuchun Li Wei Hou Shiqing Zhang Guijie Han Deng Pan Ping Wang Yufei Cheng Guifeng Liu | 2014 | Journal of Forestry Research2014，25，3： | 6 |
| 4 | Research on Artificial Lateral Line Perception of Flow Field based on Pressure Difference Matrix显示文摘In nature,with the help of lateral lines,fish is capable of sensing the state of the flow field and recognizing the surrounding near-fleld hydrodynamic environment in the condition of weak light or even complete darkness.In order to study the application of lateral lines,an improved pressure distribution model was proposed in this paper,and the pressure distributions of the lateral line carrier under different working conditions were obtained using hydrodynamic simulations.Subsequently,a visualized pressure difference matrix was constructed to identify the flow fields under different working conditions.The role of the lateral lines was investigated from a visual image perspective.Instinct features of different flow velocities,flow angles and obstacle offset distances were mapped into the pressure difference matrix.Lastly,a four-layer Convolutional Neural Network(CNN)model was built as a recognition tool to evaluate the effectiveness of the pressure difference matrix method.The recognition results demonstrate that the CNN can identify the flow field state with 2 s earlier than the current time.Hence,the proposed method provides a new way to identify flow field information in engineering applications. | Guijie Liu Shuikuan Liu Shirui Wang Huanhuan Hao Mengmeng Wang | 2019 | Journal of Bionic Engineering2019，16，6： | 5 |
| 5 | Dynamic microwave-assisted extraction combined with liquid phase microextraction based on the solidification of a floating drop for the analysis of organochlorine pesticides in grains followed by GC显示文摘A convenient,cost-effective and fast method using dynamic microwave-assisted extraction and liquid phase microextraction based on the solidification of a floating drop was proposed to analyze organochlorine pesticides in grains including rice,maize and millet.Twelve samples can be processed simultaneously in the method.During the extraction process,10%acetonitrile-water solutions containing 110μL of n-hexadecane were used to extract organochlorine pesticides.Subsequently,1.0 g sodium chloride was placed in the extract,and then centrifuged and cooled.The n-hexadecane drops containing the analytes were solidifi ed and transferred for determination by gas chromatography-electron capture detector without any further filtration or cleaning process.Limits of detection for organochlorine pesticides were 0.97–1.01μg/kg and the RSDs were in the range of 2.6%–8.5%.The developed technology has succeeded in analyzing six real grains samples and the recoveries of the organochlorine pesticides were 72.2%–94.3%.Compared with the published extraction methods,the developed method was used to analyze organochlorine pesticides in grains,being more environmentally friendly,which is suitable for the daily determination of organochlorine pesticides. | Guijie Li Xu Zhang Tingting Liu Hongxiu Fan Hongcheng Liu Shangyu Li Dawei Wang Lan Ding | 2021 | Food Science and Human Wellness2021，10，3： | 4 |
| 6 | Fermentation characteristics and probiotic activity of a purified fraction of polysaccharides from Fuzhuan brick tea显示文摘Polysaccharides from Fuzhuan brick tea(FBTPS),one of most important bioactive components in tea,showed various health-promoting functions.Our previous work demonstrated that the crude FBTPS(CFBTPS)could modulate the gut microbiota.However,which purified fraction in CFBTPS contributing to the modulation of gut microbiota remains unclear.Thus,the fermentation characteristics and probiotic activity of a purified fraction(FBTPS-2-1)of CFBTPS were evaluated in this work.The results showed that gut microbiota could utilize FBTPS-2-1 to produce short-chain fatty acids including acetic,propionic,n-butyric and n-valeric acids.FBTPS-2-1 could modulate the structure and metabolic pathways of gut microbiota.FBTPS-2-1 could increase the health-promoting gut microbiota such as Prevotellaceae and Bifidobacteriaceae,and decreased the harmful bacteria such as Enterobacteriaceae and Fusobacteriaceae.The results of metagenomics showed that Prevotella copri and Megamonas funiformis were the dominant bacteria after fermentation of FBTPS-2-1.Furthermore,FBTPS-2-1 could regulate the biosynthesis and metabolism pathways of gut microbiota.Thus,the enrichment of food with FBTPS-2-1 is expected as a potential strategy for promoting human health due to modulation of gut microbiota. | Guijie Chen Ziqi Zeng Minhao Xie Yujia Peng Wangting Zhou Weiqi Xu Yi Sun Xiaoxiong Zeng Zhonghua Liu | 2022 | Food Science and Human Wellness2022，11，3： | 4 |
| 7 | Depletion of VPS35 attenuates metastasis of hepatocellular carcinoma by restraining the Wnt/PCP signaling pathway显示文摘Vesicle Protein Sorting 35(VPS35)is a novel oncogene that promotes tumor growth through the PI3K/AKT signaling in hepatocellular carcinoma(HCC).However,the role of VPS35 in HCC metastasis and the underlying mechanisms remain largely unclear.In this study,we observed that overexpression of VPS35 enhanced hepatoma cell invasion and metastasis by inducing epithelialemesenchymal transition(EMT)-related gene expression.Conversely,knockout of VPS35 significantly inhibited hepatoma cell migration and invasion.Furthermore,depletion of VPS35 decreased the lung metastasis of HCC in nude mice.By transcriptome analysis,we determined that VPS35 promoted HCC metastasis by activating the Wnt/non-canonical planar cell polarity(PCP)pathway.Mechanistically,VPS35 activated the PCP pathway by regulating membrane sorting and trafficking of Frizzled-2(FZD2)and ROR1 in hepatoma cells.Collectively,our results indicate that VPS35 promotes HCC metastasis via enhancing the Wnt/PCP signaling,thus providing a potential prognostic marker and therapeutic target for HCC. | Yi Liu Haijun Deng Li Liang Guiji Zhang Jie Xia Keyue Ding Ni Tang Kai Wang | 2021 | Genes & Diseases2021，8，2： | 2 |
| 8 | Development of Nucleic Acid Sequence-Based Amplification Assay for Detection of Macrobrachium rosenbergii Nodavirus显示文摘A nucleic acid sequence-based amplification(NASBA)assay was established for the detection of Macrobrachium rosenbergii Nodavirus(MrNV).The specific primers were designed according to the high conserved region of RNA2 sequence of MrNV.The 224 bp specific amplification product was obtained in positive sample determined with 3%agarose gel electrophoresis,while no product was generated from shrimp infected with other viruses including DNA viruses(IHHNV,WSSV)and RNA viruses(TSV,IMNV,YHV).The detecting limit of the assay was 8pg nucleic acid,which is more sensitive than that of PCR method. | Feng LIN Li LIU Dong QIAN Guijie HAO Pengcheng SHENG Zheng CAO Xuemei YUAN Jinyu SHEN | 2014 | Agricultural Biotechnology2014，3，3： | 2 |
| 9 | Research on web based remote monitor and control system for grinding process显示文摘 | Liu Guijie Mei Ning | 2007 | Materials Science Forum2007，，： | 1 |
| 10 | An approach to analyzing taxonomic patterns of protozoan communities for monitoring water quality in Songhua River, Northeast China显示文摘 | Tan Xiaoli Shi Xinlu Liu Guijie | 2010 | Hydrobiology2010，638，： | 1 |
| 11 | Eco-friendly and Cleaner Process Using Online Microwave-assisted Steam Extraction Coupled with Solid-phase Extraction for Trace Analysis of Sulfonamides in Animal Feed显示文摘 | LI Guijie LIU Chang WANG Dawei DING Lan | 2018 | Chemical Research in Chinese Universities2018，34，6： | 1 |
| 12 | Study on the Thermal Insulation Performance of a New Seabed Sediment Fidelity Sampler Based on ANSYS显示文摘A new seabed sediment fidelity sampler was developed and its thermal insulation performance was studied and analyzed. The temperature distribution simulation indicated that the sample quality could be insured by using this new sampler. Based on ANSYS10, the temperature finite element model of the sample cylinder was established. According to the law of conservation of energy, the unsteady heat transmit equation of the sampler under solid-liquid coupling condition was derived, then the mathematical model calculation was carried out by using a mixed finite-element finite-difference method, and two thermal insulation methods were used. The simulation was carried out by using the thickness of the thermal insulation layer and heat conductivity as the variable parameters and the temperature distribution of the sampler and related influencing factors were obtained. Optimization analysis was conducted using the simulation data and related parameters and the magnitude ranges of the parameters were obtained that could meet the design temperature requirements. The experimental data and simulation results indicated that the results were in good agreement with the realities, and this sampler might be of value for seabed sediment sampler design and manufacture. | LIU Guoying LIU Guijie YUAN Weijie | 2009 | Journal of Ocean University of China2009，8，3： | 1 |
| 13 | Microwave-assisted hydrothermal synthesis of perovskite Na-Ta0 3 nanocrystals and their photocatalytic properties显示文摘 | SHI Jingying LIU Guiji WANG Nan | 2012 | Journal of Materials Chemistry2012，2，18： | 1 |
| 14 | Groups-dependent phosphines as the organic redox for point defects elimination in hybrid perovskite solar cells显示文摘Lead(Pb)^(0) and iodine(I)^(0) point defects generated during perovskite solar cell(PSC)fabrication and photoconversion form deep band energy levels as the carriers’recombination centers.These defects not only deteriorate device efficiency,but also facilitate chemical degradation with ion migration,resulting in restricted device lifetime.Herein,we present a novel type of phosphines as the point defects stabilizer for hybrid perovskite solar cells with enhanced performances.Three phosphines with varied side groups of tributyl,trioctyl and triphenyl are exampled as the dopants in perovskite films.The group dependent redox properties were observed in the perovskite film,dependent on their molecular weights and steric hinderances of phosphines.The partially oxidized tributyl phosphine(TBUP)with additional tributyl phosphine oxides(TBPO)is efficient in reduction of lead(Pb)^(0) and iodine(I)^(0) concentrations during the device fabrication and operation.The device with TBUP-TBPO pair showed enhanced power conversion efficiency(PCE)to 20.48% and maintain 91.7% of their initial PCEs after 500 h at 65℃ thermal annealing.Thus,this work presents an efficient route of utilize the phosphine species to reduce point defects in the perovskite film,which promoting further development of novel phosphorous additives with defects stabilization,interface passivation and encapsulation for low-cost solution processed PSCs. | Zhengli Wu Miao Zhang Yifan Liu Yuxi Dou Yinjie Kong Lin Gao Weitao Han Guijie Liang Xiao Li Zhang Fuzhi Huang Yi-Bing Cheng Jie Zhong | 2021 | Journal of Energy Chemistry2021，30，3： | 1 |
| 15 | Improvement of the homogeneity of protein-imprinted polymer films by orientated immobilization of the template显示文摘 | Liu Lijian Zheng Jingjing Fang Guijie | 2012 | Analytica Chimica Acta2012，726，： | 1 |
| 16 | Research on web based remote monitor and control system for grinding process 显示文摘 | Guijie Liu Ning Mei Junzhe Tan | 2006 | Materials Science Forum (S0255-5476)2006，，26： | 1 |
| 17 | Abnormal gonad development in Kit^(W-2Bao) mice caused by a Kit gene missense mutation显示文摘KitW-2Bao mice are single-gene autosomal dominant mutation mice with a B6 background that were bred in our laboratory. Heterozygotes had morphological characteristics including albinism of the abdomen, extremities, and tail, whereas the homozygotes had albinism of the body, black eyes, and infertility. The homozygous mutants showed small, structurally abnormal gonads, and lacked germ cells. Heterozygous male mice lacked germ cells in some contorted seminiferous tubules. This mutation has been mapped at 43.8 cM from the centromere in chromosome 5 by linkage analysis and Kit has been identified as the candidate gene. After Kit full-length mRNA amplification, it was found that a G to T conversion at position 1228 in the ORF changed the 410th amino acid from V to F. This amino acid change could affect the protein’s secondary structure. Heterozygous mutant mice were intercrossed and homozygous mutant mice were bred and genotyped. We found that no primordial germ cells (PGCs) appeared in the urogenital ridge area at fetus day 11.5 in the homozygotes. The number of PGCs also significantly decreased in heterozygotes. At fetus day 15.5, the differentiation of the testis tubule structure was unclear; as well, they contained no spermatogonia. Female homozygotes contained no primordial follicles in the ovary. The numbers of PGCs and primordial follicles were significantly decreased in heterozygous mice. W-2Bao is the only mutated site in the extracellular 4th Ig-like domain and this mutant mouse model provides new material for the study of the mechanism of reproductive system development. | WU BaoJin YIN LiJing LU ZhengLan YIN YuShu YANG WeiWei YANG Rong KANG XiaoDong LIU GuiJie YIN HongPing YU LiPing Gu MeiEr WU PeiLin | 2010 | Chinese Science Bulletin2010，55，36： | 1 |
| 18 | A New approach to Estimated Rotor Position for PMSM Based on Sliding Mode Observer显示文摘 | Liu Jiaxi Yang Guijie Li Tiecai | | 0，，： | 1 |
| 19 | Cultural Transmission and the Building of a Community with Shared Future for Mankind显示文摘As one of the key concepts of Xi Jinping’s Theory,“A Community with Shared Future for Man-kind”(CSFM hereafter) caters for the need of the epoch. Hence,how to build a CSFM has become an important theoretical and practical issue urgently needed to be considered and demonstrated in academic circles. This paper,from the perspectives of philosophical rationale,cultural confidence,ecological civilization and the mode of cultural transmis-sion,probes into the fact that the concept of CSFM has surmounted the cultural barrier and is one of the elements of consensus in cross - cultural transmission,which demonstrates that CSFM is the key to making cultural transmission successful and highlights the overall concern for humankind. | Liu Guijie | 2019 | 学术界2019，，9： | 0 |
| 20 | Double-ended passivator enables dark-current-suppressed colloidal quantum dot photodiodes for CMOS-integrated infrared imagers显示文摘Lead sulfide(PbS)colloidal quantum dot(CQD)photodiodes integrated with silicon-based readout integrated circuits(ROICs)offer a promising solution for the next-generation short-wave infrared(SWIR)imaging technology.Despite their potential,large-size CQD photodiodes pose a challenge due to high dark currents resulting from surface states on nonpassivated(100)facets and trap states generated by CQD fusion.In this work,we present a novel approach to address this issue by introducing double-ended ligands that supplementally passivate(100)facets of halidecapped large-size CQDs,leading to suppressed bandtail states and reduced defect concentration.Our results demonstrate that the dark current density is highly suppressed by about an order of magnitude to 9.6 nA cm^(2) at^(-1)0 mV,which is among the lowest reported for PbS CQD photodiodes.Furthermore,the performance of the photodiodes is exemplary,yielding an external quantum efficiency of 50.8%(which corresponds to a responsivity of 0.532 A W^(-1))and a specific detectivity of 2.5×10^(12) Jones at 1300 nm.By integrating CQD photodiodes with CMOS ROICs,the CQD imager provides high-resolution(640512)SWIR imaging for infrared penetration and material discrimination. | Peilin Liu Shuaicheng Lu Jing Liu Bing Xia Gaoyuan Yang Mo Ke Xuezhi Zhao Junrui Yang Yuxuan Liu Ciyu Ge Guijie Liang Wei Chen Xinzheng Lan Jianbing Zhang Liang Gao Jiang Tang | 2024 | InfoMat2024，6，1： | 0 |
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