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| 1 | Changing Proportions of HIV-1 Subtypes and Transmitted Drug Resistance Among Newly Diagnosed HIV/AIDS Individuals—China,2015 and 2018显示文摘Introduction:With the expansion of human immunodeficiency virus(HIV)antiretroviral therapy(ART),HIV drug resistance is becoming more and more serious.This study describes the changing prevalence of HIV-1 subtypes and transmitted drug resistance(TDR)among newly diagnosed individuals in China,2015 and 2018.Methods:A total of 8,980 individuals in 2015 and 2018 from 31 provincial-level administrative divisions(PLADs)were enrolled in this study.Viral RNAs were amplified and sequenced using an in-house polymerase chain reaction(PCR)protocol.The Stanford HIV Drug Resistance Database(HIVdb)was used to predict susceptibility to 12 antiretroviral drugs.Results:The prevalence of TDR was not significantly increased over time.The prevalence of TDR was 3.8%and 4.4%in 2015 and 2018,respectively(P=0.13).The prevalence of CRF55_01B increased from 2.3%in 2015 to 3.9%in 2018(P<0.001).The drug resistance prevalence of nonnucleoside reverse transcriptase inhibitors(NNRTI)increased from 2.4%in 2015 to 3.3%in 2018(P<0.01).The prevalence of E138(P<0.001),H221(P=0.03),and V179(P<0.001)mutations increased from 0.30%,0.09%,and 0.70%in 2015 to 1.10%,0.30%,and 1.70%in 2018,respectively.Conclusions:HIV drug resistance affects the effect of antiretroviral treatment,so the monitoring of HIV TDR should be strengthened to control the transmission of HIV drug resistance. | Jingjing Hao Shan Zheng Mengze Gan Aobo Dong Ruihua Kang Miaomiao Li Shuai Zhao Jing Hu Chang Song Lingjie Liao Yi Feng Yiming Shao Yuhua Ruan Hui Xing | 2021 | China CDC weekly2021，3，53： | 13 |
| 2 | Two-dimensional ultrathin MoS2-modified black Ti^3+-TiO2 nanotubes for enhanced photocatalytic water splitting hydrogen production显示文摘Two-dimensional (2D) ultrathin MoS2-modified black Ti^3+-TiO2 nanotubes were fabricated using an electrospinning-hydrothermal treatment-reduction method.Bare TiO2 nanotubes were fabricated via electrospinning.Then,2D MoS2 lamellae were grown on the surface of the nanotubes and Ti^3+/Ov ions were introduced by reduction.The photocatalytic performance of the 2D MoS2/Ti^3+-TiO2 nanotubes was^15 times better than that of TiO2.The HER enhancement of the MoS2/Ti^3+-TiO2 nanotubes can be attributed to the Pt-like behavior of 2D MoS2 and the presence of Ti^3+-ions,which facilitated the quick diffusion of the photogenerated electrons to water,reducing the H2 activation barrier.The presence of Ov ions in the nanotubes and their hollow structure increased their solar utilization. | Wei Ou Jiaqi Pan Yanyan Liu Shi Li Hongli Li Weijie Zhao Jingjing Wang Changsheng Song Yingying Zheng Chaorong Li | 2020 | Journal of Energy Chemistry2020，29，4： | 7 |
| 3 | Histone Deacetylase HDA9 and WRKY53 Transcription Factor Are Mutual Antagonists in Regulation of Plant Stress Response显示文摘Epigenetic regulation of gene expression is important for plant adaptation to environm ental changes.Previous results showed that Arabidopsis RPD3-like histone deacetylase HDA9 is known to function in repressing plant response to stress in Arabidopsis.However,how HDA9 targets to specific chromatin loci and controls gene expression netw orks involved in plant response to stress remains largely unclear.Here,we show that HDA9 represses stress tolerance response by interacting with and regulating the DNA binding and transcriptional activity of WRKY53,which functions as a high-hierarchy positive regulator of stress response.We found that WRKY53 is post-translationally modified by lysine acetylation at multiple sites,some of which are removed by HDA9,resulting in inhibition of WRKY53 transcription activity.Conversely,WRKY53 negatively regulates HDA9 histone deacetylase activity.Collectively,our results indicate that HDA9 and WRK53 are reciprocal negative regulators of each other's activities,illustrating how the functional interplay between a chromatin regulator and a transcription factor regulates stress tolerance in plants. | Yu Zheng Jingyu Ge Chun Bao Wenwen Chang Jingjing Liu Jingjie Shao Xiaoyun Liu Lufang Su Lei Pan Dao-Xiu Zhou | 2020 | Molecular Plant2020，13，4： | 6 |
| 4 | Zr-MOFs loaded on polyurethane foam by polydopamine for enhanced dye adsorption显示文摘Zirconium-based metal-organic frameworks(Zr-MOFs)have attracted widespread attention due to their high specific surface area,high porosity,abundant metal active sites and excellent hydrothermal stability.However,Zr-MOFs materials are mostly powdery in nature and thus difficult to separate from aqueous media,which limits their application in wastewater treatment.In this study,PDA/Zr-MOFs/PU foam was constructed by growing Zr-MOFs nanoparticles on a dopamine-modified polyurethane foam substrate by in-situ hydrothermal synthesis as an adsorbent for removing dyes from wastewater.The results demonstrated that the polydopamine coating improves the dispersion of the Zr-MOFs nanoparticles on the substrate and enhances the interaction between the Zr-MOFs nanoparticles and the PU foam substrate.As a result,compared with Zr-MOFs/PU foam,the prepared PDA/ZrMOFs/PU foam exhibits higher adsorption capacity for crystal violet(CV)(63.38 mg/g)and rhodamine B(RB)(67.73 mg/g),with maximum adsorption efficiencies of CV and RB of 98.4%(pH=11)and 93.5%(pH=7),respectively,at a concentration of 10 mg/L.The PDA/Zr-MOFs/PU foam can simultaneously remove CV and RB from the mixed solution.Moreover,the PDA/ZrMOFs/PU foam still exhibits high stability and reusability after five cycles. | Jingjing Zhao Linqiong Xu Yaozhuo Su Hongwei Yu Hui Liu Shaoping Qian Wenge Zheng Yongqing Zhao | 2021 | Journal of Environmental Sciences2021，33，3： | 6 |
| 5 | esveratrol inhibits necroptosis by mediating the TNF-α/RIP1/RIP3/MLKL pathway in myocardial hypoxia/reoxygenation injury显示文摘Resveratrol(RES)protects myocardial cells from hypoxia/reoxygenation(H/R)-caused injury.However,the mechanism of this effect has not been clarified.Thus,in this study,we aimed to determine whether RES attenuates H/R-induced cell necroptosis by inhibiting the tumor necrosis factor-alpha(TNF-α)/receptor-interacting protein kinase 1(RIP1)/RIP3/mixed-lineage kinase domain-like(MLKL)signaling pathway.Rat myocardial ischemia/reperfusion(I/R)models and H/R-injured cell models were constructed.Our study showed that myocardial H/R injury significantly increased the levels of TNF-α,RIP1,RIP3,and p-MLKL/MLKL by western blot analysis.Cell viability assay and 4,6-dianmidino-2-phenylindole(DAPI)-propidium iodide staining showed that the cell viability was decreased,and necroptosis was increased after myocardial H/R injury.The expressions of TNF-α,RIP1,RIP3,and p-MLKL/MLKL in H/R myocardial cells treated with different concentrations of RES were significantly downregulated.In addition,we also found that the cell viability was increased and necroptosis was decreased in dose-dependent manners when H/R-injured cells were treated with RES.In addition,the enhanced effect of TNF-αon necroptosis in myocardial H/R-injured cells was improved by RES,and the effect of RES was confirmed in vivo in I/R rats.This study also showed that RES suppresses necroptosis in H9c2 cells,which may occur through the inhibition of the TNF-α/RIP1/RIP3/MLKL signaling pathway.Our data suggest that necroptosis is a promising therapeutic target and may be a promising therapeutic target for the treatment of myocardial I/R injury. | Yongjun Hu Hongwei Pan Jianqiang Peng Jin He Mingxiang Tang Sulan Yan Jingjing Rong Junshan Li Zhaofen Zheng Haijun Wang Yanfu Liu Xin Zhong | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 6 |
| 6 | Application of an analytic hierarchy process to hydrocarbon accumulation coefficient estimation显示文摘The hydrocarbon accumulation coefficient is a key parameter in resources evaluation by genetic techniques. Methods of obtaining its value scientifically have always been an important factor influencing evaluation credibility. In this paper, the hydrocarbon accumulation system is evaluated quantitatively by establishing a hierarchy structure model based on an analytical hierarchy process. The hydrocarbon accumulation system of a higher exploration degree is selected as a calibration area and its hydrocarbon accumulation coefficient can be calculated using methods of hydrocarbon generation potential and reservoir-scale sequence. The hydrocarbon accumulation coefficient of a petroleum accumulation system can be gained by analogy of reservoir forming comprehensive evaluation results with the calibration area. The hydrocarbon accumulation coefficient of each petroleum accumulation system in the upper reservoir-forming combination of the Liaohe Western Sag can be obtained with this method. Practice shows that using the analytical hierarchy process to quantitatively evaluate the hydrocarbon accumulation system and then quantitatively predict the hydrocarbon accumulation coefficient decreases the influence of human factors in resources evaluation, and makes the resources assessment more objective and closer to the actual geological condition. | Gao Yongjin Liu Lifeng Liu Huimin Zheng Feifei Wu Li Zhou Jingjing Qu Dongfang | 2010 | Petroleum Science2010，7，3： | 5 |
| 7 | Effects of uniconazole rate on agronomic traits and physiological indexes of rapeseed blanket seedling显示文摘Mechanized transplanting of rapeseed(Brassica napus L.)blanket seedling is an innovative cultivation technology.Cultivating high quality blanket seedling to ensure high survival rate of seedling after transplanting is the key of the technology.The effects of different uniconazole rates of 0,0.5,1.0,1.5 and 2.0 mg/tray,spraying at one leaf and one heart stage,on selected agronomic traits,physiological indexes and survival rate of two rapeseed cultivars(‘Qinyou 100 and’Yangyou 90)were investigated in 2018 and 2019.Our results showed that the plant height decreased significantly with the increase of uniconazole rate.However,the collar diameter increased significantly with the increase of uniconazole rate up to 1.5 mg/tray,and the leaf area,dry weights of root and shoot increased with increased uniconazole rate up to 1.0 mg/tray.The root to shoot ratios,N concentrations of root and shoot with the uniconazole rates of 1.0 and 1.5 mg/tray were higher than those with other treatments.As uniconazole rate increasing,gibberellin(GA)and auxin(IAA)concentrations of root and shoot decreased,while abscisic acid(ABA)concentrations increased,and cytokinin(CTK)concentrations topped at uniconazole rate of 1.0 mg/tray and decreased thereafter.The seedling survival rates with 1.0 and 1.5 mg/tray were greatly higher than those in other treatments.Regression analysis suggested plant survival rate was positively related to CTK concentrations and negatively to GA concentrations of root and shoot.To achieve high survival rate after mechanized transplanting,our study revealed that the uniconazole applied at a rate of 1.0 mg/tray was recommended as the best,followed by 1.5 mg/tray.The findings would help to enhance qualities of rapeseed blanket seedling and to promote popularization of mechanized transplanting of rapeseed production. | Qingsong Zuo Long Wang Jingdong Zheng Jingjing You Guang Yang Suohu Leng Jingyi Liu | 2020 | Oil Crop Science2020，5，4： | 5 |
| 8 | Morphological Characteristics of Sand Waves in the Middle Taiwan Shoal Based on Multi-beam Data Analysis显示文摘A DTM map of the study area in the Taiwan Shoal was drawn based on precise and highdensity data acquired in a field survey by a multi-beam sounding system(R2Sonic2024). We identified sand waves in the study area at water depths of 13.89–49.12 m; the main sand waves had heights of 5–25 m, lengths of 0.1–2.0 km, and crest lines 0.1–6.5 km long. The spatial distribution of the sand waves on the seabed is dense in the north and sparse in the south and the directions range between 50°–80° and 90°–135°. Between the main sand waves, secondary sand waves develop with heights of 0.1–5.0 m and lengths of 10–100 m, which are difficult to detect by satellite remote sensing. By comparing the evolution structures of the secondary and main sand waves, we identified three evolution modes of the secondary sand waves: parallel, oblique, and divergent modes according to the relative crest directions. Suitable water depth, reciprocating current speeds between 40 and 100 cm/s, and abundant sediment supply create favorable conditions for the formation of linear sand waves. Comparing the DTM maps and profiles of the June 2012 and June 2013 surveys of the same area, we found that the shape and morphology of the sand waves remained mostly unchanged under normal hydrodynamic conditions. | BAO Jingjing CAI Feng REN Jianye ZHENG Yongling WU Chengqiang LU Huiquan XU Yan | 2014 | Acta Geologica Sinica(English Edition)2014，88，5： | 5 |
| 9 | Whole-genome resequencing of Osmanthus fragrans provides insights into flower color evolution显示文摘Osmanthus fragrans is a well-known ornamental plant that has been domesticated in China for 2500 years.More than 160 cultivars have been found during this long period of domestication,and they have subsequently been divided into four cultivar groups,including the Yingui,Jingui,Dangui,and Sijigui groups.These groups provide a set of materials to study genetic evolution and variability.Here,we constructed a reference genome of O.fragrans‘Liuyejingui’in the Jingui group and investigated its floral color traits and domestication history by resequencing a total of 122 samples,including 119 O.fragrans accessions and three other Osmanthus species,at an average sequencing depth of 15×.The population structure analysis showed that these 119 accessions formed an apparent regional cluster.The results of linkage disequilibrium(LD)decay analysis suggested that varieties with orange/red flower color in the Dangui group had undergone more artificial directional selection;these varieties had the highest LD values among the four groups,followed by the Sijigui,Jingui,and Yingui groups.Through a genome-wide association study,we further identified significant quantitative trait loci and genomic regions containing several genes,such as ethylene-responsive transcription factor 2 and Arabidopsis pseudoresponse regulator 2,that are positively associated with petal color.Moreover,we found a frameshift mutation with a 34-bp deletion in the first coding region of the carotenoid cleavage dioxygenase 4 gene.This frameshift mutation existed in at least one site on both alleles in all varieties of the Dangui group.The results from this study shed light on the genetic basis of domestication in woody plants,such as O.fragrans. | Hongguo Chen Xiangling Zeng Jie Yang Xuan Cai Yumin Shi Riru Zheng Zhenqi Wang Junyi Liu Xinxin Yi Siwei Xiao Qiang Fu Jingjing Zou Caiyun Wang | 2021 | Horticulture Research2021，8，1： | 5 |
| 10 | Safety and superior immunogenicity of heterologous boosting with an RBD-based SARS-CoV-2 mRNA vaccine in Chinese adults显示文摘Dear Editor,To May 2022,the COVID-19 pandemic has claimed more than 6.28 million lives,with more than 524 million confirmed cases worldwide.The recent emergence of highly transmissible Omicron variant of severe acute respiratory syndrome coronavirus 2(SARSCoV-2)has triggered another major surge in both confirmed cases and deaths.1 Ten COVID-19 vaccines have been approved by the World Health Organization(WHO)for emergency use,including the two mRNA vaccines,BNT162b2 and mRNA-1273,and two Chinese inactivated vaccines,CoronaVac and BBIBP-CorV.However,the rapid waning of vaccine-induced virus-neutralizing antibody titers and the continuous emergence of variants of concern(VOCs),including Alpha,Beta,Delta and Omicron,have created unprecedented challenges in the eradication of COVID-19 pandemic.2–4. | Xiaoqiang Liu Yuhua Li Zhongfang Wang Shouchun Cao Weijin Huang Lin Yuan Yi-Jiao Huang Yan Zheng Jingjing Chen Bo Ying Zuoyun Xiang Jin Shi Jincun Zhao Zhen Huang Cheng-Feng Qin | 2022 | Cell Research2022，32，8： | 5 |
| 11 | Radar group target recognition based on HRRPs and weighted mean shift clustering显示文摘When range high-resolution radar is applied to target recognition,it is quite possible for the high-resolution range profiles(HRRPs)of group targets in a beam to overlap,which reduces the target recognition performance of the radar.In this paper,we propose a group target recognition method based on a weighted mean shift(weighted-MS)clustering method.During the training phase,subtarget features are extracted based on the template database,which is established through simulation or data acquisition,and the features are fed to the support vector machine(SVM)classifier to obtain the classifier parameters.In the test phase,the weighted-MS algorithm is exploited to extract the HRRP of each subtarget.Then,the features of the subtarget HRRP are extracted and used as input in the SVM classifier to be recognized.Compared to the traditional group target recognition method,the proposed method has the advantages of requiring only a small amount of computation,setting parameters automatically,and having no requirement for target motion.The experimental results based on the measured data show that the method proposed in this paper has better recognition performance and is more robust against noise than other recognition methods. | GUO Pengcheng LIU Zheng WANG Jingjing | 2020 | Journal of Systems Engineering and Electronics2020，31，6： | 5 |
| 12 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 13 | Influence of Ni interlayer on interfacial microstructure and mechanical properties of Ti-6Al-4V/AZ91D bimetals fabricated by a solid–liquid compound casting process显示文摘The solid–liquid compound casting of Mg-AZ91D and Ti-TC4 alloys was developed by using pure Ni electro-deposited coating.The pouring temperatures of 660℃,690℃,720℃and 750℃were chosen to investigated the effects of casting temperatures on microstructural evolution,properties,and fracture behaviors of Ni-coated TC4/AZ91D bimetals by the solid–liquid compound casting(SLCC).The scanning electron microscopy(SEM)and the energy dispersive spectroscopy(EDS)results showed that the interfacial zone mainly composed of nickel,Mg_(2)Ni and Mg-Al-Ni in the bimetals cast at 660℃.As the pouring temperature was increased to 750℃,the width of the interface zone,which mainly composed ofδ(Mg),Mg_(2)Ni,Mg-Al-Ni,Mg_(3)TiNi_(2) and Al_(3)Ni,gradually increased.The microhardness tests showed that the micro-hardness of the interface zone was smaller than that of TC4 substrate but larger than that of the cast AZ91D matrix.At the pouring temperature of 720℃,the Ni-coated TC4/AZ91D bimetals had the most typical homogeneous interface,which had granular Mg-Al-Ni ternary phase but no ribbon-like Al3Ni binary phase,and achieved the highest shear strength of 97.35MPa.Meanwhile,further fracture behavior analysis showed that most fracture failure of Ni-coated TC4/AZ91D bimetals occurred at the Mg_(2)Ni+δ(Mg)eutectic structure and Al_(3)Ni hard intermetallic. | Fulin Wen Jianhua Zhao Miaowang Yuan Jingfeng Wang Dengzhi Zheng Jinyong Zhang Ke He Jingjing Shangguan Yu Guo | 2021 | Journal of Magnesium and Alloys2021，9，4： | 3 |
| 14 | Highly sensitive phototransistors based on twodimensional GaTe nanosheets with direct bandgap显示文摘 | Pingan Hu Jia Zhang Mina Yoon Xiao-Fen Qiao Xin Zhang Wei Feng Pingheng Tan Wei Zheng Jingjing Liu Xiaona Wang Juan C. Idrobo David B. Geohegan Kai Xiao | 2014 | Nano Research2014，7，5： | 3 |
| 15 | CPTA treatment reveals potential transcription factors associated with carotenoid metabolism in flowers of Osmanthus fragrans显示文摘Osmanthus fragrans is one of the top ten traditional flowers in China.It is divided into three different groups according to its color.α-Carotene and β-carotene are the main determinants to distinguish the color differences between three groups.However,the dominant genes and transcription factors involved in carotenoid metabolism remain unclear.CPTA treatment(0.7mmol·L−1)remarkably promoted lycopene,α-carotene and β-carotene contents in flowers.Transcriptome sequencing analysis revealed that CPTA treatment could trigger chain reactions in carotenoid metabolism pathway genes.Four up-regulated and 10 down-regulated transcription factors which have close association with carotenoid variation were significantly induced by CPTA treatment.The up-regulated TFs such as MYB43,MYB123,HSF,were further subjected to transcript expression determination in different cultivars with drastic colors.Among them,transcript expression of four up-regulated TFs coincided with the carotenoid accumulation in different cultivars.We selected up-regulated OfMYB43 to verify its function,which is related to stress tolerance and transcriptional regulation.Transient overexpression of OfMYB43 in O.fragrans flowers showed that it could remarkably promote the expression of PDS,ZISO,LCYE and CCD4,leading to increased accumulation of β-branch carotenoids.OfMYB43 was a potential positive regulator of carotenoid biosynthesis in O.fragrans flowers.This study provides insight into the molecular mechanism of carotenoid metabolism in O.fragrans. | Wan Xi Yanhong He Linlin Zhu Shiyang Hu Shuyi Xiong Yi Zhang Jingjing Zou Hongguo Chen Caiyun Wang Riru Zheng | 2021 | Horticultural Plant Journal2021，7，5： | 3 |
| 16 | Evaluation of multidecadal and longer-term temperature changes since 850 CE based on Northern Hemisphere proxy-based reconstructions and model simulations显示文摘The temperature variability over multidecadal and longer timescales(e.g., the cold epochs in the late 15 th, 17 th, and early 19 th centuries) is significant and dominant in the millennium-long, large-scale reconstructions and model simulations;however, their temporal patterns in the reconstructed and simulated temperature series are not well understood and require a detailed assessment and comparison. Here, we compare the reconstructed and simulated temperature series for the Northern Hemisphere(NH) at multidecadal and longer-term timescales(>30 years) by evaluating their covariance, climate sensitivity and amplitude of temperature changes. We found that covariances between different reconstructions or between reconstructions and simulations are generally high for the whole period of 850–1999 CE, due to their similar long-term temporal patterns. However,covariances between different reconstructions or between reconstructions and simulations steadily decline as time series extends further back in time, becoming particularly small during Medieval times. This is related to the large uncetainties in the reconstructions caused by the decreased number of proxy records and sample duplication during the pre-instrumental periods.Reconstructions based solely on tree-ring data show higher skill than multiproxy reconstructions in capturing the amplitude of volcanic cooling simulated by models. Meanwhile, climate models have a shorter recovery(i.e., lag) in response to the cooling caused by volcanic eruptions and solar activity minima, implying the lack of some important feedback mechanisms between external forcing and internal climate processes in climate models. Amplitudes of temperature variations in the latest published tree-ring reconstructions are comparable to those of the multiproxy reconstructions. We found that the temperature difference between the Medieval Climate Anomaly(950–1250 CE) and the Little Ice Age(1450–1850 CE) is generally larger in proxybased reconstructions than in model simulations, but the reason is unclear. | Jianglin WANG Bao YANG Jingyun ZHENG Xuezhen ZHANG Zhiyuan WANG Miao FANG Feng SHI Jingjing LIU | 2020 | Science China Earth Sciences2020，63，8： | 3 |
| 17 | Ultra-reliable and low-latency communications:applications,opportunities and challenges显示文摘In the upcoming 5G and beyond systems,ultra-reliable and low latency communication(URLLC)has been considered as the key enabler to support diverse mission-critical services,such as industrial automation,remote healthcare,and intelligent transportation.However,the two stringent requirements of URLLC:extremely low latency and ultra-strict reliability have posed great challenges in system designing.In this article,the basic concepts and the potential applications of URLLC are first introduced.Then,the state-ofthe-art research of URLLC in the physical layer,link layer and the network layer are overviewed.In addition,some potential research topics and challenges are also identified. | Daquan FENG Lifeng LAI Jingjing LUO Yi ZHONG Canjian ZHENG Kai YING | 2021 | Science China(Information Sciences)2021，64，2： | 3 |
| 18 | Rare-earth based materials:an effective toolbox for brain imaging,therapy,monitoring and neuromodulation显示文摘Brain diseases, including tumors and neurodegenerative disorders, are among the most serious health problems. Non-invasively high-resolution imaging methods are required to gain anatomical structures and information of the brain. In addition, efficient diagnosis technology is also needed to treat brain disease. Rare-earth based materials possess unique optical properties, superior magnetism, and high X-ray absorption abilities, enabling high-resolution imaging of the brain through magnetic resonance imaging, computed tomography imaging, and fluorescence imaging technologies. In addition, rare-earth based materials can be used to detect, treat, and regulate of brain diseases through fine modulation of their structures and functions. Importantly, rare-earth based materials coupled with biomolecules such as antibodies, peptides, and drugs can overcome the blood-brain barrier and be used for targeted treatment. Herein, this review highlights the rational design and application of rare-earth based materials in brain imaging, therapy, monitoring, and neuromodulation. Furthermore, the development prospect of rare-earth based materials is briefly introduced. | Zheng Wei Yawei Liu Bo Li Jingjing Li Shuang Lu Xiwen Xing Kai Liu Fan Wang Hongjie Zhang | 2022 | Light(Science & Applications)2022，11，8： | 3 |
| 19 | The Clinical Study of Healon 5 in Phacoemulsification and IOL Implantation显示文摘Purpose: To compare a new ophthalmic viscoelastic device (OVD) Healon 5 with twoother kinds of OVDs commonly used in China during phacoemulsification and intraocularlens (IOL) implantation in terms of removal time, intraocular pressure, corneal andanterior chamber response.Methods: This prospective randomized study, in which patients and observers aremasked, comprises niety eyes. They were randomly divided into 3 groups with differentOVDs. Healon 5 (sodium hyaluronate 5 000 2.3 % ) was compared with Healon GV(sodium hyaluronate 7 000 1.4 % ) and Iviz (sodium hyaluronate 1.0 % ) . Thesurgeries were performed with temporal corneal incision, phacoemulsification in situ andfoldable lens intracapsular implantation. The characteristic and the removal time of theviscoelastic material as well as the postoperative IOP, corneal reaction and anteriorchamber reactions of the eyes were observed preoperatively and 24 hrs postoperatively.Exclusion criteria were glaucoma, a preoperative dilated pupil diameter smaller than 5.0mm, proliferative diabetic retinopathy, significant corneal pathology or a history ofuveitis.Results: The removal time was 47.42 ± 13.09 seconds in Healon 5, 16. 50 ± 5.45 inHealon GV and 15.83±7.40 in Iviz. The removal time of Healon 5 group wassignificantly longer than that of the other groups ( P =0. 000) . There is no significantIOP change 24 hours postoperatively and the difference of intraocular pressure amongthree groups was not significant ( P > 0.05). Healon 5 group had the slightest cornealand anterior chamber response, followed by Healon GV and Iviz.Conclusion: Although takes longer time to remove, Healon 5 is an ideal viscoelasticmaterial for its superior space maintenance capacity and high dispersity which providessuperior protection of endothelial cells compared to Healon GV and Iviz. | Hui Yang, Danying Zheng, Jingjing Huang, Yongsheng Huang, Zhenping ZhangZhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China | 2001 | 眼科学报2001，17，3： | 2 |
| 20 | Comparative Study on the Efficacies of 11 Chemical Agents against Taro Soft Rot Caused by Pectobacterium aroidearum显示文摘[Objective]The paper was to screen the effective agents for effectively controlling the occurrence and prevalence of taro soft rot.[Method]The fungicidal effects of 11 fungicides on taro soft rot were determined by inhibition zone method.[Result]0.3%Tetramycin,25%bromothalonil,3%Zhongshengmycin and 30%zinc thiazole had better antifungal effect on Pectobacterium aroidearum at recommended concentration.The indoor toxicity of four fungicides showed that the EC50 of 0.3%tetramycin AS was the smallest of 0.6μg/mL,indicating that tetramycin had the largest toxicity and the best inhibitory effect against P.aroidearum;followed by 25%bromothalonil EC and 3%Zhongshengmycin WP,with the EC_(50) of 2.57 and 97.72μg/mL,respectively;the inhibitory effect of 30%zinc thiazole SC against P.aroidearum was the poorest.[Conclusion]The study provides a reference for screening out new and efficient chemical agents against taro soft rot. | Dongkun Wang Xiuting Ji Huaixu Zhan Chengpeng Zheng Hao Zong Xiaolei Tan Xiuchun Du Weimin Wang Jingjing Wu Fenglong Wang Xiaoqiang Wang | 2021 | Plant Diseases and Pests2021，12，2： | 2 |
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