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| 1 | Clinical efficacy and safety of moxifloxacin versus levofloxacin plus metronidazole for community-acquired pneumonia with aspiration factors显示文摘 | Sun Tieying Sun Li Wang Rongmei Ren Xiaoping Sui Dong-jiang Pu Chun Ren Yajuan Liu Ying Yang Zhuo Li Fengzhi | 2014 | Chinese Medical Journal2014，，7： | 34 |
| 2 | Green synthesis of fluorescent carbon quantum dots and carbon spheres from pericarp显示文摘An economical idea was developed to synthesize fluorescent carbon quantum dots(CQDs) directly from the refluxing extraction of orange pericarp via a hydrothermal technique. Hydrothermal temperatures and times were adjusted to control the particle sizes and the quantum yields of the obtained CQDs. The as-prepared carbon quantum dots showed narrow particle size distribution, good water solubility, and acceptable fluorescence lifetimes. Due to their high stability, these obtained carbon quantum dots have great application potential in nano-biotechnology. Furthermore, carbon spheres with uniform morphology and size can be easily obtained as the reaction byproducts of this green synthesis process. | Wei Du Xiaoqian Xu Han Hao Rongmei Liu Di Zhang Feng Gao Qingyi Lu | 2015 | Science China Chemistry2015，58，5： | 8 |
| 3 | Lipid rafts participate in aberrant degradative autophagic-lysosomal pathway of amyloid-beta peptide in Alzheimer's disease显示文摘Amyloid-beta peptide is the main component of amyloid plaques,which are found in Alzheimer’s disease.The generation and deposition of amyloid-beta is one of the crucial factors for the onset and progression of Alzheimer’s disease.Lipid rafts are glycolipid-rich liquid domains of the plasma membrane,where certain types of protein tend to aggregate and intercalate.Lipid rafts are involved in the generation of amyloid-beta oligomers and the formation of amyloid-beta peptides.In this paper,we review the mechanism by which lipid rafts disturb the aberrant degradative autophagic-lysosomal pathway of amyloid-beta,which plays an important role in the pathological process of Alzheimer’s disease.Moreover,we describe this mechanism from the view of the Two-system Theory of fasciology and thus,suggest that lipid rafts may be a new target of Alzheimer’s disease treatment. | Xin Zhou Chun Yang Yufeng Liu Peng Li Huiying Yang Jingxing Dai Rongmei Qu Lin Yuan | 2014 | Neural Regeneration Research2014，9，1： | 4 |
| 4 | Synthesis of polyhedral iron oxide nanocrystals bound by high-index facets显示文摘High surface energy of high-index facets endows nanocrystals with high activities and thus promotes potential applications such as highly efficient catalysts,special optical,electrical and magnetic devices.But the high surface energy of the high-index facets usually drives them to grow faster than the other facets and finally disappear during the crystal growth,which leads the synthesis of nanocrystals with high-indexed facets exposed to be a great challenge.Herein,we introduced two routes to control the synthesis of-Fe2O3polyhedrons with different sets of high-index facets,one using different metal ions(Ni2+,Cu2+or Zn2+)as structure-directing agents and the other applying polymer surfactant sodium carboxymethyl cellulose(CMC)as additive.The growth process of high-index-Fe2O3polyhedrons was also discussed and possible growth mechanism was proposed. | GAO Feng LIU RongMei YIN JingZhou LU QingYi | 2014 | Science China Chemistry2014，57，1： | 2 |
| 5 | Controlled Synthesis of Monodispersed Sub-50 nm Nanoporous In203 Spheres and Their PhotoeleetrochemicalPerformance显示文摘 | LIU Qi ZhANG Wen LIU Rongmei | 2015 | EurJInorgChem2015，，： | 1 |
| 6 | Impact of repeated intravenous bone marrow mesenchymal stem cells infusion on myocardial collagen network remodeling in a rat model of doxorubicin-induced dilated cardiomyopathy显示文摘 | Qin Yu Qianxiao Li Rongmei Na Xiaofei Li Baiting Liu Lili Meng Hanyu Liutong Weiyi Fang Ning Zhu Xiaoqun Zheng | 2014 | Molecular and Cellular Biochemistry (-)2014，，1： | 1 |
| 7 | A population genetics model of linkage disequilibrium in admixed populations显示文摘Understanding linkage disequilibrium (LD) created in admixed population and the rate of decay in the disequilibrium over evolution is an important subject in population genetics theory and in disease gene mapping in human populations. The present study represents the theoretical investigation of effects of gene frequencies, levels of LD and admixture proportions of donor populations on the evolutionary dynamics of the LD of the admixed population. We examined the conditions under which the admixed population reached linkage equilibrium or the peak level of the LD. The study reveals the inappropriateness in approximating the dynamics of the LD generated by population admixture by the commonly used formula in literature. An appropriate equation for the dynamics isproposed. The distinct feature of the newly suggested formula is that the value of the nonlinear component of the LD remains constant in the first generation of the population evolution. Comparison between the predicted disequilibrium dynamics | Shiheng Tao Rongmei Zhang Jianhua Chu Xiaoming Liu Liping Du Qingyuan Qi Zewei Luo | 2001 | Chinese Science Bulletin2001，46，3： | 1 |
| 8 | A single-cell transcriptome atlas of the aging human and macaque retina显示文摘The human retina is a complex neural tissue that detects light and sends visual information to the brain.However,the molecular and cellular processes that underlie aging primate retina remain unclear.Here,we provide a comprehensive transcriptomic atlas based on 119520 single cells of the foveal and peripheral retina of humans and macaques covering different ages.The molecular features of retinal cells differed between the two species,suggesting distinct regional and species specializations of the human and macaque retinae.In addition,human retinal aging occurred in a region-and cell-type-specific manner.Aging of human retina exhibited a foveal to peripheral gradient.MYO9A-rods and a horizontal cell subtype were greatly reduced in aging retina,indicating their vulnerability to aging.Moreover,we generated a dataset showing the cell-type-and region-specific gene expression associated with 55 types of human retinal disease,which provides a foundation to understanding of the molecular and cellular mechanisms underlying human retinal diseases.Such datasets are valuable to understanding of the molecular characteristics of primate retina,as well as molecular regulation of aging progression and related diseases. | Wenyang Yi Yufeng Lu Suijuan Zhong Mei Zhang Le Sun Hao Dong Mengdi Wang Min Wei Haohuan Xie Hongqiang Qu Rongmei Peng Jing Hong Ziqin Yao Yunyun Tong Wei Wang Qiang Ma Zeyuan Liu Yuqian Ma Shouzhen Li Chonghai Yin Jianwei Liu Chao Ma Xiaoqun Wang Qian Wu Tian Xue | 2021 | National Science Review2021，8，4： | 1 |
| 9 | Loading Localization by Small-Diameter Optical Fiber Sensors显示文摘Structural health monitoring(SHM)in service has attracted increasing attention for years.Load localization on a structure is studied hereby.Two algorithms,i.e.,support vector machine(SVM)method and back propagation neural network(BPNN)algorithm,are proposed to identify the loading positions individually.The feasibility of the suggested methods is evaluated through an experimental program on a carbon fiber reinforced plastic laminate.The experimental tests involve in application of four optical fiber-based sensors for strain measurement at discrete points.The sensors are specially designed fiber Bragg grating(FBG)in small diameter.The small-diameter FBG sensors are arrayed in 2-D on the laminate surface.The testing results indicate that the loading position could be detected by the proposed method.Using SVM method,the 2-D FBG sensors can approximate the loading location with maximum error less than 14 mm.However,the maximum localization error could be limited to about 1 mm by applying the BPNN algorithm.It is mainly because the convergence conditions(mean square error)can be set in advance,while SVM cannot. | Liu Rongmei Zhu Lujia Lu Jiyun Liang Dakai | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，2： | 1 |
| 10 | Improving toxicity of Bacillus thuringiensis strain contains the cry8Ca gene specific to Anomala corpulenta larvae显示文摘 | Shu Changlong Liu Rongmei Wang Rongyan | 2007 | Current Microbiology2007，55，6： | 1 |
| 11 | Study on the Tissue Culture of Coleus blumei显示文摘This paper studied on the way of Coleus blumei,the leaf was chosen as explants and was inoculated on 1/2 MS medium with different combinations of 6-benzyladenine(6-BA),α-naphthaleneacetic acid(NAA)and indole-3-butyric acid(IBA).The optimal conditions of callus induction from explants were achieved on the medium containing 6-BA(2.0 mg.L-1)and NAA(1.0 mg.L-1).Shoot tips were induced on the medium containing 6-BA(4.0 mg.L-1)and NAA(0.5 mg.L-1).The same media conditions were found suitable for shoot multiplication,we multiplied shoots rooted best on1/2 MS medium supplemented with IBA(0.1 mg.L-1). | WEN Jing CHE Ye LIU Rongmei HU Baozhong | 2008 | Journal of Northeast Agricultural University(English Edition)2008，15，1： | 1 |
| 12 | High-resolution gene mapping using admixture linkage disequilibrium显示文摘This note reports simulation study on the rate of decay in linkage disequilibrium (LD) in mixed populations over multiple discrete generations and explores the usefulness of the LD analysis in high-resolution gene mapping. The results indicate that the smaller the recombination fraction and the fewer generations since admixture event, the higher power of the approach in gene mapping. The expected estimate of recombination fraction would give an estimate that is slightly biased upwards, if relevant genes are in tight linkage. The estimated recombination fraction is usually larger than the true value within 2-5 generations. From generations 10-20, the mean estimates are in good agreement with the true value. The method presented here enables estimation of means and corresponding confidence intervals of the recombination fraction at any number of generations. | TAO Shiheng CHU Jianhua LIU Xiaoming ZHANG Rongmei ZHANG Zhen LUO Zewei | 2002 | Chinese Science Bulletin2002，47，20： | 1 |
| 13 | Rate of decay in admixture linkage disequilibrium and its implication in gene mapping显示文摘Modeling linkage disequilibria (LD) between genes usually observed in admixed natural populations has been shown an effective approach in high-resolution mapping of disease genes in humans. A prerequisite to obtain accurate estimation of recombination fraction between genesat a marker locus and the disease locus using the approach is a reliable prediction of the proportion of the admixture populations. The present study suggested the use of gene frequencies to predict the estimate of the admixture proportion based on the observation that the gene frequencies are much more stable quantities than the haplotype frequencies over evolution of the population. In this paper, we advanced the theory and methods by which the decay rate of nonlinear term of LD in admixed population may be used to estimate the recombination fraction between the genes. Theoretical analysis and simulation study indicate that, the larger the difference of gene frequencies between parental populations and the more closely the | Shiheng Tao Xiaoming Liu Jianhua Chu Rongmei Zhang Liping Du Zewei Luo | 2001 | Chinese Science Bulletin2001，46，5： | 1 |
| 14 | Effects of deficit irrigation on soil microorganisms and growth of Arabica coffee(Coffea arabica L.)under different shading cultivation modes显示文摘In the present research,the rational coupling mode of irrigation and shading cultivation for rapid growth and water saving of young Arabica coffee shrubs was investigated from 2016 to 2017.Taking full irrigation(FI,1.2Ep)as the control,the effects of three deficit irrigation(DI)(DI1,DI2 and DI3,with 1.0Ep,0.8Ep and 0.6Ep)on soil water content,temperature,microorganism population density,photosynthetic characteristics,canopy structure and dry mass of Arabica coffee under three shading cultivation modes(S0,monoculture coffee;S1,mild shading cultivation,intercropping with one line of Arabica coffee and one line of castor(Ricinus communis L.);S2,severe shading cultivation,intercropping with one line of Arabica coffee and two lines of castor)were investigated using plot experiments.Compared to FI,DI1 not obviously changed the population density of soil bacteria and actinomycetes,but increased net photosynthetic rate(Pn),crown area and dry mass of Arabica coffee by 7.0%,9.53%and 10.46%,respectively.In addition,DI1 also decreased total radiation under canopy(TRUC)by 5.51%.DI2 and DI3 reduced the population density of soil bacteria,fungi and actinomycetes ranging 8.94%-47.06%.Compared to S0,S1 increased the population density of soil fungi,bacteria and actinomycetes by 13.99%,30.77%and 9.72%,respectively.S1 also increased Pn,transpiration rate(Tr),leaf apparent radiation use efficiency(ARUE),leaf area index(LAI)and dry mass by 9.29%,5.39%,60.98%,10.31%and 30.02%,respectively.DI1S1 obtained the highest Pn and dry mass and higher LAI and the lowest TRUC.DI1S1 increased Pn,ARUE and dry mass by 18.98%,72.37%and 62.90%respectively but decreased TRUC by 21.77%when compared to FIS0.Thus,DI1S1 was found to be the rational mode of irrigation and shading cultivation for young Arabica coffee. | Xiaogang Liu Rongmei Li Zhihui Han Qiliang Yang Zeyin Jiang | 2021 | International Journal of Agricultural and Biological Engineering2021，14，6： | 0 |
| 15 | A Cell-Anchored and Self-Calibrated DNA Nanoplatform for in Situ Imaging and Quantification of Endogenous MicroRNA in Live Cells:Introducing Two Controls to Normalize the Sensing Signals显示文摘Quantifying the microRNAs(miRNAs)levels in living cells,while essential for the study of fundamental biology and medical diagnostics,has barely been achieved due to insufficient probe delivery and unquantifiable signals.We report a cell-anchored and self-calibrated DNA nanoplatform,a cholesterol-headed DNA nanowire that is capable of efficiently delivering to various cells and simultaneously detecting two target miRNAs.One miRNA target can be utilized as an endogenous control against cell-to-cell variations.Moreover,the photocleavable linkers inserted in the nanostructures allow us to precisely regulate the probe structure and fluorescence signaling at the desired time and location in vivo.As a second control,the maximum fluorescence can be elicited by UV light,which further facilitates the normalization of the absolute fluorescence signal.With two introduced internal controls,the maximum fluorescence and endogenous control gene,this approach displays excellent stability and self-calibration performance,effectively avoiding the interference from operating conditions and cellto-cell variations,such as the laser powers and intracellular probe concentrations.Importantly,this design is capable of unifying the output signal intensity between in vitro test and cell imaging,making the in vitro linear calibration curve appropriate for the quantification of miRNA expression in living cells. | Wenjuan Song Zhi-Ling Song Qian Li Chengwen Shang Qiqi Chao Xingfu Liu Rongmei Kong Gao-Chao Fan Xiliang Luo | 2023 | CCS Chemistry2023，5，1： | 0 |
| 16 | CeO2 quantum dots doped Ni-Co hydroxide nanosheets for ultrahigh energy density asymmetric supercapacitors显示文摘By integrating the merits of lanthanide elements and quantum dots,we firstly design CeO2 quantum dots doped Ni-Co hydroxide nanosheet via a controllable synthetic strategy,which exhibits a large specific capacitance(1370.7 F/g at 1.0 A/g) and a good cyclic stability(90.6% retention after 4000 cycles).Moreover,we assemble an aqueous asymmetric supercapacitor with the obtained material,which has an extremely high energy density(108.9 Wh/kg at 378 W/kg) and outstanding cycle stability(retaining88.1% capacitance at 2.0 A/g after 4000 cycles). | Huiyu Duan Tong Wang Xinyi Wu Ziyun Su Jing Zhuang Suli Liu Rongmei Zhu Changyun Chen Huan Pang | 2020 | Chinese Chemical Letters2020，31，9： | 0 |
| 17 | Antiviral spirooliganones C and D with a unique spiro[bicyclo[2.2.2]octane-2,2′-bicyclo[3.1.0]hexane]carbon skeleton from the roots of Illicium oligandrum显示文摘Two unprecedented polycyclic spirooliganones C and D(1 and 2)with a novel spiro[bicyclo[2.2.2]octane-2,2′-bicyclo[3.1.0]hexane]carbon skeleton,one known dimeric prenylated C_(6)single bondC_(3)compound(3),and a pair of new enantiomeric prenylated C_(6)single bondC_(3)compounds(+)-5 and(−)-5 together with their direct precursors(+)-4 and(−)-4 were isolated from the roots of Illicium oligandrum.Their structures and absolute configurations were elucidated by spectroscopic analysis,single crystal X-ray diffraction data,and electronic circular dichroism calculations.A possible biosynthetic pathway for compounds 1 and 2 involving the Diels-Alder reaction between(−)-sabinene and cyclic prenylated tetrahydropyrano-type C_(6)single bondC_(3)compounds was proposed.The characteristic prenylated C_(6)single bondC_(3)compounds(+)-4 and(−)-4 were separated on a chiral stationary phase and their absolute configurations were determined by calculated ECD for the first time.In the antiviral bioassays,compounds 1 and(+)-5 exhibited significant inhibitory activity against CVB3 with IC_(50)values of 11.11μmol/L and 1.11μmol/L,respectively.Compounds 1 and 2 also showed moderate inhibition against influenza A(H1N1)virus. | Shuanggang Ma Rubing Wang Rongmei Gao Xiaojing Wang Yunbao Liu Yong Li Li Li Yuhuan Li Jing Qu Shishan Yu | 2022 | Chinese Chemical Letters2022，33，9： | 0 |
| 18 | Ductility of metal thin films in flexible electronics显示文摘Flexible, large area electronics using various organic and inorganic materials are beginning to show great promise. During manufacture and service, large deforma- tion of these hybrid materials will pose significant challenges in terms of high performance and reliability. A deep understanding of the ductility or flexibility of macroelectronics becomes one of the major issues that must be addressed ur- gently. This paper describes the current level of understanding on the thin-film ductility, both free-standing and substrate-supported, and relevant influencing factors. | NIU RongMei LIU Gang DING XiangDong SUN Jun | 2008 | Science China(Technological Sciences)2008，51，11： | 0 |
| 19 | Plant-derived nanovesicles: Further exploration of biomedical function and application potential显示文摘Extracellular vesicles(EVs)are phospholipid bilayer vesicles actively secreted by cells,that contain a variety of functional nucleic acids,proteins,and lipids,and are important mediums of intercellular communication.Based on their natural properties,EVs can not only retain the pharmacological effects of their source cells but also serve as natural delivery carriers.Among them,plant-derived nanovesicles(PNVs)are characterized as natural disease therapeutics with many advantages such as simplicity,safety,eco-friendliness,low cost,and low toxicity due to their abundant resources,large yield,and low risk of immunogenicity in vivo.This review systematically introduces the biogenesis,isolation methods,physical characterization,and components of PNVs,and describes their administration and cellular uptake as therapeutic agents.We highlight the therapeutic potential of PNVs as therapeutic agents and drug delivery carriers,including anti-inflammatory,anticancer,wound healing,regeneration,and antiaging properties as well as their potential use in the treatment of liver disease and COVID-19.Finally,the toxicity and immunogenicity,the current clinical application,and the possible challenges in the future development of PNVs were analyzed.We expect the functions of PNVs to be further explored to promote clinical translation,thereby facilitating the development of a new framework for the treatment of human diseases. | Aixue Li Dan Li Yongwei Gu Rongmei Liu Xiaomeng Tang Yunan Zhao Fu Qi Jifu Wei Jiyong Liu | 2023 | Acta Pharmaceutica Sinica B2023，13，8： | 0 |
| 20 | Mechanical sensor PDLIM5 promotes the osteogenesis of human adipose-derived stem cells through microfilament alterations显示文摘Bone regeneration is a multifaceted,abstract,and wellcoordinated physiological progression of bone formation that participates in continuous regeneration and remodeling throughout life.However,when it comes to complex clinical situations requiring extensive bone regeneration,such as massive bone defects caused by injuries,infection,or tumor removal,traditional methods do not often yield good treatment strategies or protocols due to their limitations. | Yuchao Yang Shutong Wu Rongmei Qu Congrong Wang Jinyang Wang Asmat Ullah Khan You Pan Wenqing Liu Jinhui Zhu Muhammad Akram Khan Chujiang Xu Jingxing Dai Jun ouyang | 2024 | Genes & Diseases2024，11，3： | 0 |
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