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| 1 | Single-cell transcriptomic atlas of primate cardiopulmonary aging显示文摘Aging is a major risk factor for many diseases,especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease 2019(COVID-19).Resolving cellular and molecular mechanisms associated with aging in higher mammals is therefore urgently needed.Here,we created young and old non-human primate single-nucleus/cell transcriptomic atlases of lung,heart and artery,the top tissues targeted by SARS-CoV-2.Analysis of cell type-specific aging-associated transcriptional changes revealed increased systemic inflammation and compromised virus defense as a hallmark of cardiopulmonary aging.With age,expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2(ACE2)was increased in the pulmonary alveolar epithelial barrier,cardiomyocytes,and vascular endothelial cells.We found that interleukin 7(IL7)accumulated in aged cardiopulmonary tissues and induced ACE2 expression in human vascular endothelial cells in an NF-κB-dependent manner.Furthermore,treatment with vitamin C blocked IL7-induced ACE2 expression.Altogether,our findings depict the first transcriptomic atlas of the aged primate cardiopulmonary system and provide vital insights into age-linked susceptibility to SARS-CoV-2,suggesting that geroprotective strategies may reduce COVID-19 severity in the elderly. | Shuai Ma Shuhui Sun Jiaming Li Yanling Fan Jing Qu Liang Sun Si Wang Yiyuan Zhang Shanshan Yang Zunpeng Liu Zeming Wu Sheng Zhang Qiaoran Wang Aihua Zheng Shuguang Duo Yang Yu Juan Carlos Izpisua Belmonte Piu Chan Qi Zhou Moshi Song Weiqi Zhang Guang-Hui Liu | 2021 | Cell Research2021，31，4： | 10 |
| 2 | Telomere-dependent and telomereindependent roles of RAP1 in regulating human stem cell homeostasis显示文摘RAP1 is a well-known telomere-binding protein, but its functions in human stem cells have remained unclea匚 Here we generated RAP1 -deficient human embryonic stem cells (hESCs) by using CRISPR/Cas9 technique and obtained RAP1-deficient human mesenchymal stem cells (hMSCs) and neural stem cells (hNSCs) via directed differentiation. In both hMSCs and hNSCs, RAP1 not only negatively regulated telomere length but also acted as a transcriptional regulator of RELN by tuning the methylation status of its gene promoter. RAP1 deficiency enhanced self-renewal and delayed senescence in hMSCs, but not in hNSCs, suggesting complicated lineage-specific effects of RAP1 in adult stem cells.Altogether, these results demonstrate for the first time that RAP1 plays both telomeric and nontelomeric roles in regulating human stem cell homeostasis. | Xing Zhang Zunpeng Liu Xiaoqian Liu Si Wang Yiyuan Zhang Xiaojuan He Shuhui Sun Shuai Ma Ng Shyh-Chang Feng Liu Qiang Wang Xiaoqun Wang Lin Liu Weiqi Zhang Moshi Song Guang-Hui Liu Jing Qu | 2019 | Protein & Cell2019，10，9： | 7 |
| 3 | Development of Selenium-rich Passion Fruit Industry in Guangxi显示文摘According to the understanding of current situation of Guangxi selenium-containing passion fruit products and the advantages and disadvantages of related product markets,the corresponding improvement plans were proposed for the supply and demand of products and the adjustment of industrial development,so as to provide theoretical data support for optimizing the industrial structure and increasing the market share of selenium-rich passion fruit in Guangxi. | Xinhui SU Jun TAN Xiu LAN Yiyuan YANG Liping PAN Qiong ZHOU Yongxian LIU | 2019 | Agricultural Biotechnology2019，8，3： | 4 |
| 4 | CAS FGOALS-g3 Model Datasets for the CMIP6 Scenario Model Intercomparison Project(ScenarioMIP)显示文摘This paper describes the datasets from the Scenario Model Intercomparison Project(ScenarioMIP)simulation experiments run with the Chinese Academy of Sciences Flexible Global Ocean–Atmosphere–Land System Model,GridPoint version 3(CAS FGOALS-g3).FGOALS-g3 is driven by eight shared socioeconomic pathways(SSPs)with different sets of future emission,concentration,and land-use scenarios.All Tier 1 and 2 experiments were carried out and were initialized using historical runs.A branch run method was used for the ensemble simulations.Model outputs were three-hourly,six-hourly,daily,and/or monthly mean values for the primary variables of the four component models.An evaluation and analysis of the simulations is also presented.The present results are expected to aid research into future climate change and socio-economic development. | Ye PU Hongbo LIU Ruojing YAN Hao YANG Kun XIA Yiyuan LI Li DONG Lijuan LI He WANG Yan NIE Mirong SONG Jinbo XIE Shuwen ZHAO Kangjun CHEN Bin WANG Jianghao LI and Ling ZUO | 2020 | Advances in Atmospheric Sciences2020，37，10： | 3 |
| 5 | Precipitation modification in cast Mg-1Nd-1Ce-Zr alloy by Zn addition显示文摘The effects of different Zn addition(0,0.2,0.5,1.0 wt%)on the microstructure and mechanical properties of cast Mg-1Nd-1Ce-Zr alloy in as-cast,solution-treated and 200℃peak-aged conditions were studied.Precipitates in cast Mg-1Nd-1Ce-Zr alloy are significantly modified by the Zn addition.In the Zn-free alloy,the disk-shaped prismatic precipitates and the point-like precipitates are the main strengthening phases.When 0.2 Zn is added,the disk-shaped precipitates are refined and very fine basal precipitates form additionally.When 0.5 Zn is added,the basal precipitates become the main strengthening phase.Further increasing the Zn addition to 1.0%,only spare basal precipitates and point-like precipitates exist.The 0.5 Zn addition alloy has the highest strength at room temperature,whose yield strength,ultimate tensile strength and elongation in T6 condition are 136 MPa,237 MPa and 9%,respectively. | Yiyuan Zhou Penghuai Fu Liming Peng Dan Wang Yingxin Wang Bin Hu Ming Liu Anil K.Sachdev Wenjiang Ding | 2019 | Journal of Magnesium and Alloys2019，7，1： | 2 |
| 6 | Construction thoughts and practice of Traditional Chinese Medicine nursing inheritance work显示文摘Master-apprentice system is a main mode of talent cultivation for Traditional Chinese medicine(TCM). To vigorously push forward inheritance and innovation of TCM nursing, Beijing Administration of Traditional Chinese Medicine carried out TCM nursing inheritance work in 2016, establishing 3 studios and 1 workstation. In this paper, we summarized constructional methods and achievements in TCM nursing inheritance studios and workstation, raised issues during working, and thought about how to work in the next stage, in hoping to lay a good foundation for carrying out in-depth work about TCM nursing inheritance. | TANG Ling MA Xueling ZHANG Xuejian DENG Jianhua ZHANG Jing LIU Yiyuan ZHU Jing | 2019 | 中西医结合护理(中英文)2019，5，12： | 2 |
| 7 | Heat exchanger network synthesis integrated with flexibility and controllability显示文摘Over the last three decades,flexibility and controllability considerations for heat exchanger networks(HENs)have received great attention,respectively.However,they should be simultaneously incorporated in HEN synthesis to allow the economic performance to be achievable in a practical operating environment.This paper proposes a method for simultaneous synthesis of flexible and controllable HEN by considering their coupling.The key idea is to add the bypasses with optimized initial fractions and positions to explore such coupling,and consequently enabling HENs to be operated successfully over a range of disturbance variations.These are implemented by identifying and quantifying disturbance propagations,and then examining the sensitivity of bypasses to the entire HEN.In this way,the superstructurebased mixed integer non-linear programming(MINLP)with objective function of minimizing the total annual cost is formulated.A case study is used to demonstrate the application of the proposed method.Quantitative measures and dynamic simulation show the ability to provide the satisfactory flexibility and controllability of the obtained HEN. | Siwen Gu Linlin Liu Lei Zhang Yiyuan Bai Shaojing Wang Jian Du | 2019 | Chinese Journal of Chemical Engineering2019，27，7： | 2 |
| 8 | Zero-valent iron nanopar- ticles (nZVI) for the treatment of smelting wastewater: A pilot-scale demonstration 显示文摘 | Li Shaolin Wang Wei Liu Yiyuan | 2014 | Chemical Engineering Journal2014，254，7： | 1 |
| 9 | The visual word form area: evidence from an fMRI study of implicit processing of Chinese characters显示文摘 | Liu Chao Zhang Wutian Tang Yiyuan | 2008 | Neuroimage2008，40，3： | 1 |
| 10 | Numbers in the cultural brain显示文摘 | Tang Yiyuan Liu Yijun | 2009 | Progress in brain research2009，，178： | 1 |
| 11 | A tandem segmental duplication (TSD) in green revolution gene Rht‐D1b region underlies plant height variation显示文摘 | Yiyuan Li Jianhui Xiao Jiajie Wu Jialei Duan Yue Liu Xingguo Ye Xin Zhang Xiuping Guo Yongqiang Gu Lichao Zhang Jizeng Jia Xiuying Kong | 2012 | New Phytologist2012，，1： | 1 |
| 12 | A tandem segmental duplication (TSD) in green revolution gene Rht‐D1b region underlies plant height variation显示文摘 | Yiyuan Li Jianhui Xiao Jiajie Wu Jialei Duan Yue Liu Xingguo Ye Xin Zhang Xiuping Guo Yongqiang Gu Lichao Zhang Jizeng Jia Xiuying Kong | 2012 | New Phytologist2012，，1： | 1 |
| 13 | Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry显示文摘The outbreak of coronavirus disease 2019(COVID-19) caused by SARS-CoV-2 has created a global health crisis. SARS-CoV-2 infects varieties of tissues where the known receptor ACE2 is low or almost absent, suggesting the existence of alternative viral entry pathways. Here, we performed a genome-wide barcoded-CRISPRa screen to identify novel host factors that enable SARS-CoV-2 infection. Beyond known host proteins, i.e., ACE2, TMPRSS2, and NRP1, we identified multiple host components,among which LDLRAD3, TMEM30A, and CLEC4G were confirmed as functional receptors for SARS-CoV-2. All these membrane proteins bind directly to spike’s N-terminal domain(NTD). Their essential and physiological roles have been confirmed in either neuron or liver cells. In particular, LDLRAD3 and CLEC4G mediate SARS-CoV-2 entry and infection in an ACE2-independent fashion. The identification of the novel receptors and entry mechanisms could advance our understanding of the multiorgan tropism of SARS-CoV-2, and may shed light on the development of COVID-19 countermeasures. | Shiyou Zhu Ying Liu Zhuo Zhou Zhiying Zhang Xia Xiao Zhiheng Liu Ang Chen Xiaojing Dong Feng Tian Shihua Chen Yiyuan Xu Chunhui Wang Qiheng Li Xuran Niu Qian Pan Shuo Du Junyu Xiao Jianwei Wang Wensheng Wei | 2022 | Science China(Life Sciences)2022，65，4： | 1 |
| 14 | A Light Source System of Multi-star Simulator with Adjustable Background and Controllable Magnitude显示文摘A light source of multi-star simulator capable of background adjustment and magnitude control has been designed.Two integrating spheres are employed as the star-point light source and the background light source respectively.A beam splitter prism has been designed to serve as the beam combiner for the star-point and the background light sources,and a mathematical model has been constructed respectively to compute the light flux of the two integrating spheres.A magnitude testing system and a background testing system have been created using low-light illuminometer,luminance meter,and testing instruments to measure the star-point magnitude and the background luminance of the multi-star simulator.The test results suggest that the star-point magnitude is adjustable from0 to+5 m_v,with a simulation precision superior to ±0.026 m_v.The maximum background luminance is 3.8×10~5 cd·m^(-2),and the minimum background luminance is6.4×10^(-2)cd·m^(-2).The designed light source system can meet the requirements for simulating the stellar map with a sky background. | SUN Gaofei LIU Shi ZHANG Guoyu ZHANG Yu LEI Jie MA Yiyuan | 2017 | 空间科学学报2017，37，6： | 0 |
| 15 | Hyperthermia differentially affects specific human stem cells and their differentiated derivatives显示文摘Dear Editor,The human body operates optimally at a core temperature of 37 degrees Celsius.Homeostasis at this temperature is essential for cellular and physiological functions(Cheshire,2016).However,infectious diseases,inflammation,injury,neoplasia,and elevated climate temperature can cause a regulated rise in body core temperature,i.e.,fever(Pasi-khova et al,2017).Indeed,an acute or chronic increase in temperature leads to detrimental effects on vasculature by altering a number of indices of vascular structure and function(DuBose et al.,1998). | Si Wang Fang Cheng Qianzhao Ji Moshi Song Zeming Wu Yiyuan Zhang Zhejun Ji Huyi Feng Juan Carlos Izpisua Belmonte Qi Zhou Jing Qu Wei Li Guang-Hui Liu Weiqi Zhang | 2022 | Protein & Cell2022，13，8： | 0 |
| 16 | Bioresorbable Multilayer Photonic Cavities as Temporary Implants for Tether-Free Measurements of Regional Tissue Temperatures显示文摘Objective and Impact Statement.Real-time monitoring of the temperatures of regional tissue microenvironments can serve as the diagnostic basis for treating various health conditions and diseases.Introduction.Traditional thermal sensors allow measurements at surfaces or at near-surface regions of the skin or of certain body cavities.Evaluations at depth require implanted devices connected to external readout electronics via physical interfaces that lead to risks for infection and movement constraints for the patient.Also,surgical extraction procedures after a period of need can introduce additional risks and costs.Methods.Here,we report a wireless,bioresorbable class of temperature sensor that exploits multilayer photonic cavities,for continuous optical measurements of regional,deep-tissue microenvironments over a timeframe of interest followed by complete clearance via natural body processes.Results.The designs decouple the influence of detection angle from temperature on the reflection spectra,to enable high accuracy in sensing,as supported by in vitro experiments and optical simulations.Studies with devices implanted into subcutaneous tissues of both awake,freely moving and asleep animal models illustrate the applicability of this technology for in vivo measurements.Conclusion.The results demonstrate the use of bioresorbable materials in advanced photonic structures with unique capabilities in tracking of thermal signatures of tissue microenvironments,with potential relevance to human healthcare. | Wubin Bai Masahiro Irie Zhonghe Liu Haiwen Luan Daniel Franklin Khizar Nandoliya Hexia Guo Hao Zang Yang Weng Di Lu Di Wu Yixin Wu Joseph Song Mengdi Han Enming Song Yiyuan Yang Xuexian Chen Hangbo Zhao Wei Lu Giuditta Monti Iwona Stepien Irawati Kandela Chad R.Haney Changsheng Wu Sang Min Won Hanjun Ryu Alina Rwei Haixu Shen Jihye Kim Hong-Joon Yoon Wei Ouyang Yihan Liu Emily Suen Huang-yu Chen Jerry Okina Jushen Liang Yonggang Huang Guillermo A.Ameer Weidong Zhou John A.Rogers | 2021 | Biomedical Engineering Frontiers2021，2，1： | 0 |
| 17 | Internet of Cultural Things: Current Research, Challenges and Opportunities显示文摘Driven by the visions of the Internet of Things(IoT),Artificial Intelligence(AI),and 5G communications,the Internet of Cultural Things(IoCT)realize the comprehensive interconnection among cultural products,cultural services,cultural resources,and cultural platforms,bringing individuals with richer humanistic experience,increasing economic benefits for the cultural sector,and promoting the development of cultural heritage protection and education.At present,IoCT has received widespread attention in both industry and academia.To explore new research opportunities and assist users in constructing suitable IoCT systems for specific applications,this survey provides a comprehensive overview of the IoCT components and key technologies.A comparison study of representative IoCT systems is presented according to their applicability.A general platform architecture of IoCT is proposed to link cultural objects with the internet and human.Finally,open issues for research challenges and future opportunities of IoCT are also studied in this paper. | Xiaoting Liang Fang Liu Linqi Wang Baoying Zheng Yiyuan Sun | 2023 | Computers, Materials & Continua2023，，1： | 0 |
| 18 | All-electrical switching of a topological non-collinear antiferromagnet at room temperature显示文摘Non-collinear antiferromagnetic Weyl semimetals,combining the advantages of a zero stray field and ultrafast spin dynamics,as well as a large anomalous Hall effect and the chiral anomaly of Weyl fermions,have attracted extensive interest.However,the all-electrical control of such systems at room temperature,a crucial step toward practical application,has not been reported.Here,using a small writing current density of around 5×10^(6)A·cm^(-2),we realize the all-electrical current-induced deterministic switching of the non-collinear antiferromagnet Mn_(3)Sn,with a strong readout signal at room temperature in the Si/SiO_(2)/Mn_(3)Sn/AlO_(x)structure,and without external magnetic field or injected spin current.Our simulations reveal that the switching originates from the current-induced intrinsic non-collinear spin-orbit torques in Mn_(3)Sn itself.Our findings pave the way for the development of topological antiferromagnetic spintronics. | Yongcheng Deng Xionghua Liu Yiyuan Chen Zongzheng Du Nai Jiang Chao Shen Enze Zhang Houzhi Zheng Hai-Zhou Lu Kaiyou Wang | 2023 | National Science Review2023，10，2： | 0 |
| 19 | A multi-terminal ion-controlled transistor with multifunctionality and wide temporal dynamics for reservoir computing显示文摘Reservoir computing(RC)is an energy-efficient computational framework with low training cost and high efficiency in processing spatiotemporal information.The state-of-the-art fully memristor-based hardware RC system suffers from bottlenecks in the computation efficiencies and accuracy due to the limited temporal tunability in the volatile memristor for the reservoir layer and the nonlinearity in the nonvolatile memristor for the readout layer.Additionally,integrating different types of memristors brings fabrication and integration complexities.To overcome the challenges,a multifunctional multi-terminal electrolyte-gated transistor(MTEGT)that combines both electrostatic and electrochemical doping mechanisms is proposed in this work,integrating both widely tunable volatile dynamics with high temporal tunable range of 10^(2) and nonvolatile memory properties with high long-term potentiation/long-term depression(LTP/LTD)linearity into a single device.An ion-controlled physical RC system fully implemented with only one type of MTEGT is constructed for image recognition using the volatile dynamics for the reservoir and nonvolatility for the readout layer.Moreover,an ultralow normalized mean square error of 0.002 is achieved in a time series prediction task.It is believed that the MTEGT would underlie next-generation neuromorphic computing systems with low hardware costs and high computational performance. | Kekang Liu Jie Li Fangzhou Li Yiyuan Lin Hongrui Liu Linzi Liang Zhiyuan Luo Wei Liu Mengye Wang Feichi Zhou Yanghui Liu | 2024 | Nano Research2024，17，5： | 0 |
| 20 | Single-nucleus transcriptomics reveals a gatekeeper role for FoxP1 in primate cardiac aging显示文摘Aging poses a major risk factor for cardiovascular diseases,the leading cause of death in the aged population.However,the cell type-specific changes underlying cardiac aging are far from being clear.Here,we performed single-nucleus RNA-sequencing analysis of left ventricles from young and aged cynomolgus monkeys to define cell composition changes and transcriptomic alterations across different cell types associated with age.We found that aged cardiomyocytes underwent a dramatic loss in cell numbers and profound fluctuations in transcriptional profles.Via transcription regulatory network analysis,we identified FOxP1,a core transcription factor in organ development,as a key downregulated factor in aged cardiomyocytes,concomitant with the dysregulation of FoxP1 target genes associated with heart function and cardiac diseases.Consistently,the deficiency of FOxP1 led to hypertrophic and senescent phenotypes in human embryonic stem cell-derived cardiomyocytes.Altogether,our findings depict the celiular and molecular landscape of ventricular aging at the single-cell resolution,and identify drivers for primate cardiac aging and potential targets for intervention against cardiac aging and associated diseases. | Yiyuan Zhang Yandong Zheng Si Wang Yanling Fan Yanxia Ye Yaobin Jing Zunpeng Liu Shanshan Yang Muzhao Xiong Kuan Yang Jinghao Hu Shanshan Che Qun Chu Moshi Song Guang-Hui Liu Weiqi Zhang Shuai Ma Jing Qu | 2023 | Protein & Cell2023，14，4： | 0 |
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